M Jeffrey Mphahlele

Summary

Publications

  1. doi request reprint Immunising the HIV-infected child: a view from sub-Saharan Africa
    M Jeffrey Mphahlele
    Department of Virology, Medunsa Campus, University of Limpopo NHLS Dr George Mukhari Tertiary Laboratory, Pretoria, South Africa
    Vaccine 30:C61-5. 2012
  2. ncbi request reprint High risk of occult hepatitis B virus infection in HIV-positive patients from South Africa
    M Jeffrey Mphahlele
    The HIV AIDS and Viral Hepatitis Research Laboratory, Department of Virology, P O Box 173, University of Limpopo, Medunsa Campus 0204, South Africa
    J Clin Virol 35:14-20. 2006
  3. doi request reprint Increased detection of HBV DNA in HBsAg-positive and HBsAg-negative South African HIV/AIDS patients enrolling for highly active antiretroviral therapy at a Tertiary Hospital
    Azwidowi Lukhwareni
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo, Medunsa Campus, Pretoria, South Africa
    J Med Virol 81:406-12. 2009
  4. doi request reprint Frequent detection of hepatitis B virus variants associated with lamivudine resistance in treated South African patients infected chronically with different HBV genotypes
    S Gloria Selabe
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo, Medunsa Campus, Pretoria, South Africa
    J Med Virol 81:996-1001. 2009
  5. doi request reprint Reduced detection and levels of protective antibodies to hepatitis B vaccine in under 2-year-old HIV positive South African children at a paediatric outpatient clinic
    Omphile E Simani
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo, Medunsa Campus, Pretoria, South Africa
    Vaccine 27:146-51. 2009
  6. doi request reprint Hepatitis B virus infection in post-vaccination South Africa: occult HBV infection and circulating surface gene variants
    Edina Amponsah-Dacosta
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo Medunsa Campus and National Health Laboratory Service, Pretoria, South Africa
    J Clin Virol 63:12-7. 2015
  7. doi request reprint Variability of the preC/C region of hepatitis B virus genotype A from a South African cohort predominantly infected with HIV
    Simnikiwe H Mayaphi
    Department of Medical Virology, University of Pretoria Tshwane Academic Division of NHLS, Pretoria, South Africa
    J Med Virol 85:1883-92. 2013
  8. ncbi request reprint HBV/HIV co-infection: the dynamics of HBV in South African patients with AIDS
    Simnikiwe H Mayaphi
    Department of Medical Virology, University of Pretoria Tshwane Academic Division National Health Laboratory Service, Pretoria, South Africa
    S Afr Med J 102:157-62. 2012
  9. doi request reprint Hepatitis B vaccination coverage in healthcare workers in Gauteng Province, South Africa
    Rosemary J Burnett
    Department of Public Health, University of Limpopo, Medunsa Campus, Pretoria, South Africa rosemary
    Vaccine 29:4293-7. 2011
  10. doi request reprint Whole genome analyses of G1P[8] rotavirus strains from vaccinated and non-vaccinated South African children presenting with diarrhea
    Nonkululeko B Magagula
    Medical Research Council Diarrhoeal Pathogens Research Unit, Department of Virology, University of Limpopo, Medunsa Campus National Health Laboratory Service, Pretoria, South Africa
    J Med Virol 87:79-101. 2015

Collaborators

  • Jason T Blackard
  • Simnikiwe H Mayaphi
  • S Gloria Selabe
  • Jason M Mwenda
  • Rosemary J Burnett
  • Guido François
  • Carolyn Williamson
  • Geert Leroux-Roels
  • Khuzwayo C Jere
  • L Mapaseka Seheri
  • Siyazi Mda
  • Helba Bredell
  • Maemu P Gededzha
  • Martin M Nyaga
  • Andrew M Musyoki
  • Edina Amponsah-Dacosta
  • Ramokone L Lebelo
  • Omphile E Simani
  • Mapaseka L Seheri
  • Azwidowi Lukhwareni
  • Thembeni L Msibi
  • Mojakgomo H Motswaledi
  • Nonkululeko B Magagula
  • Karla M Stucker
  • Mathew D Esona
  • David E Wentworth
  • Timothy B Stockwell
  • Rebecca A Halpin
  • J Nare Rakgole
  • A Duncan Steele
  • Vidula Nalini Pursem
  • Andrew Musyoki
  • Andre Meheus
  • Eleanor A Powell
  • Tshweu S Monokoane
  • Annie Shonhai
  • Enyonam Tsolenyanu
  • Augustine Mulindwa
  • John Paul Bogers
  • Chipo Berejena
  • Taj Ignace Mangar
  • Sunando Roy
  • Bakari Mwinyi
  • Bhye Mohammud Cassam Peeroo
  • Cornelius M Nkosi
  • Julia N Chibumbya
  • Fazal Mohammad Abdul Latiff Sohawon
  • Mechack N Bida
  • Thanda Kyaw
  • Gaëlle Boulet
  • Shyam Shunker Manraj
  • Hokororo Adolfine
  • Luwanika Mlera
  • Alberdina A van Dijk
  • Ina Peenze
  • Johnny Rakgole
  • Gloria Selabe
  • Khutso Mothapo
  • Pascal Bessong
  • M Olga Mzileni
  • Herbert R Basetse

Detail Information

Publications23

  1. doi request reprint Immunising the HIV-infected child: a view from sub-Saharan Africa
    M Jeffrey Mphahlele
    Department of Virology, Medunsa Campus, University of Limpopo NHLS Dr George Mukhari Tertiary Laboratory, Pretoria, South Africa
    Vaccine 30:C61-5. 2012
    ..Immunisation against influenza virus, a common cause of respiratory illness, is also discussed as multiple guidelines recommend influenza vaccination for number of groups at high risk such as patients infected with HIV...
  2. ncbi request reprint High risk of occult hepatitis B virus infection in HIV-positive patients from South Africa
    M Jeffrey Mphahlele
    The HIV AIDS and Viral Hepatitis Research Laboratory, Department of Virology, P O Box 173, University of Limpopo, Medunsa Campus 0204, South Africa
    J Clin Virol 35:14-20. 2006
    ..In conclusion, these findings strongly support that HIV infection is a risk factor for occult HBV infections...
  3. doi request reprint Increased detection of HBV DNA in HBsAg-positive and HBsAg-negative South African HIV/AIDS patients enrolling for highly active antiretroviral therapy at a Tertiary Hospital
    Azwidowi Lukhwareni
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo, Medunsa Campus, Pretoria, South Africa
    J Med Virol 81:406-12. 2009
    ..The findings strongly support HBV screening in all HIV-positive patients initiating ART in South Africa, considering that current ART regimens include drugs with anti-HBV activity (e.g., lamivudine)...
  4. doi request reprint Frequent detection of hepatitis B virus variants associated with lamivudine resistance in treated South African patients infected chronically with different HBV genotypes
    S Gloria Selabe
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo, Medunsa Campus, Pretoria, South Africa
    J Med Virol 81:996-1001. 2009
    ....
  5. doi request reprint Reduced detection and levels of protective antibodies to hepatitis B vaccine in under 2-year-old HIV positive South African children at a paediatric outpatient clinic
    Omphile E Simani
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo, Medunsa Campus, Pretoria, South Africa
    Vaccine 27:146-51. 2009
    ..123). Interestingly, no HBsAg or anti-HBc marker was detected in the OPD group, compared to total exposure rate of 4.9% (HBsAg carriage was 1.2%) in the EPI group...
  6. doi request reprint Hepatitis B virus infection in post-vaccination South Africa: occult HBV infection and circulating surface gene variants
    Edina Amponsah-Dacosta
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo Medunsa Campus and National Health Laboratory Service, Pretoria, South Africa
    J Clin Virol 63:12-7. 2015
    ....
  7. doi request reprint Variability of the preC/C region of hepatitis B virus genotype A from a South African cohort predominantly infected with HIV
    Simnikiwe H Mayaphi
    Department of Medical Virology, University of Pretoria Tshwane Academic Division of NHLS, Pretoria, South Africa
    J Med Virol 85:1883-92. 2013
    ..These data suggest that subgenotype A1 may be more involved in severe HBV-related diseases...
  8. ncbi request reprint HBV/HIV co-infection: the dynamics of HBV in South African patients with AIDS
    Simnikiwe H Mayaphi
    Department of Medical Virology, University of Pretoria Tshwane Academic Division National Health Laboratory Service, Pretoria, South Africa
    S Afr Med J 102:157-62. 2012
    ....
  9. doi request reprint Hepatitis B vaccination coverage in healthcare workers in Gauteng Province, South Africa
    Rosemary J Burnett
    Department of Public Health, University of Limpopo, Medunsa Campus, Pretoria, South Africa rosemary
    Vaccine 29:4293-7. 2011
    ....
  10. doi request reprint Whole genome analyses of G1P[8] rotavirus strains from vaccinated and non-vaccinated South African children presenting with diarrhea
    Nonkululeko B Magagula
    Medical Research Council Diarrhoeal Pathogens Research Unit, Department of Virology, University of Limpopo, Medunsa Campus National Health Laboratory Service, Pretoria, South Africa
    J Med Virol 87:79-101. 2015
    ..This is the first report to describe full genomic analyses of G1P[8] RVA strains collected from both non-vaccinated and vaccinated children in South Africa. J. Med. Virol. 87: 79-101, 2015. © 2014 Wiley Periodicals, Inc. ..
  11. ncbi request reprint Mutations associated with lamivudine-resistance in therapy-naïve hepatitis B virus (HBV) infected patients with and without HIV co-infection: implications for antiretroviral therapy in HBV and HIV co-infected South African patients
    S Gloria Selabe
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo, Medunsa Campus, Pretoria, South Africa
    J Med Virol 79:1650-4. 2007
    ....
  12. doi request reprint Active co-infection with HBV and/or HCV in South African HIV positive patients due for cancer therapy
    Andrew M Musyoki
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo Medunsa Campus and National Health Laboratory Service, Pretoria, South Africa
    J Med Virol 87:213-21. 2015
    ....
  13. doi request reprint Evidence for a change in the epidemiology of hepatitis B virus infection after nearly two decades of universal hepatitis B vaccination in South Africa
    Edina Amponsah-Dacosta
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo Medunsa Campus and National Health Laboratory Services, Pretoria, South Africa
    J Med Virol 86:918-24. 2014
    ..The observation that HBV chronic carriage increases as immunity wanes over time calls into question whether the time has come to consider a pre-adolescence vaccine booster dose policy...
  14. doi request reprint Genetic characterization of HIV before widespread testing of HIV vaccine candidates at a clinical trial site in Pretoria, South Africa
    Andrew Musyoki
    HIV and Hepatitis Research Unit, Department of Virology, Medunsa Campus, University of Limpopo National Health Laboratory Service, Pretoria, South Africa
    AIDS Res Hum Retroviruses 28:1131-8. 2012
    ..The study asserted the predominance of HIV-1 subtype C within the catchment population...
  15. pmc Prediction of T-cell epitopes of hepatitis C virus genotype 5a
    Maemu P Gededzha
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo, Medunsa Campus National Health Laboratory Service, Pretoria, South Africa
    Virol J 11:187. 2014
    ..Because of the high diversity of HCV, protective vaccines will have to overcome significant viral antigenic diversities. The objective of this study was to predict T-cell epitopes from HCV genotype 5a sequences...
  16. doi request reprint Sequence analysis of the whole genomes of five African human G9 rotavirus strains
    Martin M Nyaga
    Medical Research Council Diarrhoeal Pathogens Research Unit, Department of Virology, University of Limpopo Medunsa Campus and National Health Laboratory Service, P O Box 173, Medunsa 0204, Pretoria, South Africa
    Infect Genet Evol 16:62-77. 2013
    ..Rotavirus strain MRC-DPRU9317 is the first G9P[6] to be characterised on a DS-1-like genetic backbone with a reassortant segment 8 (NSP2) and fourth G9P[6] to be fully sequenced globally...
  17. doi request reprint Whole-genome analyses of DS-1-like human G2P[4] and G8P[4] rotavirus strains from Eastern, Western and Southern Africa
    Martin M Nyaga
    South African Medical Research Council UL Diarrhoeal Pathogens Research Unit MRC DPRU, Department of Virology, University of Limpopo Medunsa Campus and National Health Laboratory Service, PO Box 173, Medunsa, Pretoria, 0204, South Africa
    Virus Genes 49:196-207. 2014
    ....
  18. doi request reprint Sustained favourable HIV viral load response in South African patients during concomitant HAART and cancer therapy
    Andrew M Musyoki
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo Medunsa Campus and National Health Laboratory Service, Pretoria, South Africa
    J Med Virol 87:192-8. 2015
    ..0439). This pilot study supports concomitant treatment of HIV/AIDS and cancer in HIV endemic regions irrespective of the type of cancer diagnosed, prescribed cancer therapy or other viral (HBV, HCV or both) co-infections...
  19. doi request reprint Diversity of HPV types in cancerous and pre-cancerous penile lesions of South African men: implications for future HPV vaccination strategies
    Ramokone L Lebelo
    Department of Virology, University of Limpopo, Medunsa Campus and National Health Laboratory Service, Pretoria, South Africa
    J Med Virol 86:257-65. 2014
    ..The data suggest that boys could directly benefit from vaccination as they are exposed to variety of HPV types as early as 10 years of age in Africa...
  20. doi request reprint Near full-length genome analysis of HCV genotype 5 strains from South Africa
    Maemu P Gededzha
    HIV and Hepatitis Research Unit, Department of Virology, University of Limpopo, Medunsa Campus National Health Laboratory Service, Pretoria, South Africa Electronic address
    Infect Genet Evol 21:118-23. 2014
    ....
  21. doi request reprint Epidemiology of rotavirus diarrhea and diversity of rotavirus strains among children less than 5 years of age with acute gastroenteritis in Mauritius: June 2008 to December 2010
    Vidula Nalini Pursem
    From the Central Health Laboratory, Victoria Hospital, Candos, Mauritius Ministry of Health and Quality of Life, Port Louis, Mauritius Regional Rotavirus Reference Laboratory, MRC Medunsa Diarrheal Pathogens Research Unit, University of Limpopo, Pretoria, South Africa and World Health Organization, Regional Office for Africa WHO AFRO, Brazzaville, Republic of Congo
    Pediatr Infect Dis J 33:S49-53. 2014
    ..To describe the epidemiology of rotavirus disease and circulating rotavirus strains in Mauritius, surveillance for rotavirus diarrhea was conducted at 2 regional hospitals from June 2008 through December 2010...
  22. doi request reprint Rotavirus vaccination within the South African Expanded Programme on Immunisation
    L Mapaseka Seheri
    MRC UL Diarrhoeal Pathogens Research Unit, Department of Virology, Medunsa Campus, University of Limpopo National Health Laboratory Service, Pretoria, South Africa
    Vaccine 30:C14-20. 2012
    ....
  23. ncbi request reprint Oral fluid detection of hepatitis B vaccine-induced antibodies can improve vaccination programmes
    Omphile E Simani
    S Afr Med J 98:608-9. 2008