Alexandre Mourot

Summary

Publications

  1. pmc Light at the end of the channel: optical manipulation of intrinsic neuronal excitability with chemical photoswitches
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California Berkeley, CA, USA Department of Neurobiology of Adaptive Processes, UMR7102 CNRS, Université Pierre et Marie Curie Paris, France
    Front Mol Neurosci 6:5. 2013
  2. doi request reprint Photochromic potassium channel blockers: design and electrophysiological characterization
    Alexandre Mourot
    Department of Molecular and Cellular Biology, University of California Berkeley, Berkeley, CA, USA
    Methods Mol Biol 995:89-105. 2013
  3. pmc Tuning photochromic ion channel blockers
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    ACS Chem Neurosci 2:536-43. 2011
  4. doi request reprint Rapid optical control of nociception with an ion-channel photoswitch
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA
    Nat Methods 9:396-402. 2012
  5. doi request reprint Optogenetic pharmacology for control of native neuronal signaling proteins
    Richard H Kramer
    University of California, Berkeley, California, USA
    Nat Neurosci 16:816-23. 2013
  6. doi request reprint Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors
    Ivan Tochitsky
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Chem 4:105-11. 2012

Collaborators

Detail Information

Publications6

  1. pmc Light at the end of the channel: optical manipulation of intrinsic neuronal excitability with chemical photoswitches
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California Berkeley, CA, USA Department of Neurobiology of Adaptive Processes, UMR7102 CNRS, Université Pierre et Marie Curie Paris, France
    Front Mol Neurosci 6:5. 2013
    ..In addition, this strategy may also be used in the clinic for the direct treatment of some neuronal disorders...
  2. doi request reprint Photochromic potassium channel blockers: design and electrophysiological characterization
    Alexandre Mourot
    Department of Molecular and Cellular Biology, University of California Berkeley, Berkeley, CA, USA
    Methods Mol Biol 995:89-105. 2013
    ..Our focus is on K v channels but in principle, the techniques described here can be applied to other ion channels and signaling proteins...
  3. pmc Tuning photochromic ion channel blockers
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    ACS Chem Neurosci 2:536-43. 2011
    ..Photochromic blockers of this type could be useful for the photopharmacological control of neuronal activity under mild conditions...
  4. doi request reprint Rapid optical control of nociception with an ion-channel photoswitch
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA
    Nat Methods 9:396-402. 2012
    ..Because intracellular QAQ accumulation is a consequence of nociceptive ion-channel activity, QAQ-mediated photosensitization is a platform for understanding signaling mechanisms in acute and chronic pain...
  5. doi request reprint Optogenetic pharmacology for control of native neuronal signaling proteins
    Richard H Kramer
    University of California, Berkeley, California, USA
    Nat Neurosci 16:816-23. 2013
    ..Now that the tools for manipulating endogenous neuronal signaling proteins are available, they can be implemented in vivo to enhance our understanding of the molecular bases of brain function and dysfunctions. ..
  6. doi request reprint Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors
    Ivan Tochitsky
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Chem 4:105-11. 2012
    ..The generation of these engineered receptors should facilitate investigation of the physiological and pathological functions of neuronal nAChRs and open a general pathway to photosensitizing pentameric ligand-gated ion channels...