Marcia L Moss

Summary

Publications

  1. ncbi request reprint Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases
    Fred H Rasmussen
    BioZyme, Inc, Apex, North Carolina 27523, USA
    Biochemistry 43:2987-95. 2004
  2. ncbi request reprint Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping
    Millard H Lambert
    Department of Computational Chemistry, GlaxoSmithKline Research and Development, 5 Moore Drive, RTP, NC 27709, USA
    Comb Chem High Throughput Screen 8:327-39. 2005
  3. ncbi request reprint Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening
    Marcia L Moss
    BioZyme, Inc, Apex, NC 27523 9299, USA
    Anal Biochem 366:144-8. 2007
  4. ncbi request reprint The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events
    Marcia L Moss
    BioZyme Incorporated, Apex, North Carolina 27523, USA
    J Biol Chem 282:35712-21. 2007
  5. doi request reprint Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis
    Marcia L Moss
    BioZyme, Apex, NC 27523, USA
    Nat Clin Pract Rheumatol 4:300-9. 2008
  6. ncbi request reprint Fluorescent substrates useful as high-throughput screening tools for ADAM9
    Marcia L Moss
    BioZyme, Inc, 1513 Old White Oak Church Road, Apex, NC 27523, USA
    Comb Chem High Throughput Screen 13:358-65. 2010
  7. ncbi request reprint Therapeutic benefits from targeting of ADAM family members
    Marcia L Moss
    BioZyme Inc, 1513 Old White Oak Church Road, Apex, North Carolina 27523, USA
    Biochemistry 43:7227-35. 2004
  8. ncbi request reprint ADAM10 as a target for anti-cancer therapy
    Marcia L Moss
    BioZyme Inc, 1513 Old White Oak Church Road, Apex, NC 27523, USA
    Curr Pharm Biotechnol 9:2-8. 2008
  9. pmc ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein
    Marcia L Moss
    BioZyme Inc, Apex, North Carolina 27523, USA
    J Biol Chem 286:40443-51. 2011
  10. pmc The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10
    George A Lemieux
    Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, California 94143, USA
    J Biol Chem 282:14836-44. 2007

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases
    Fred H Rasmussen
    BioZyme, Inc, Apex, North Carolina 27523, USA
    Biochemistry 43:2987-95. 2004
    ..Some of the best substrates tested have specific activities for collagenase 3 that are 37,000-, 17,000-, 90-, and 200-fold selective over stromelysin 1, collagenase 1, and gelatinases A and B, respectively...
  2. ncbi request reprint Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping
    Millard H Lambert
    Department of Computational Chemistry, GlaxoSmithKline Research and Development, 5 Moore Drive, RTP, NC 27709, USA
    Comb Chem High Throughput Screen 8:327-39. 2005
    ..These substrate preferences were used in the design of novel reverse hydroxamate TACE inhibitors with phenethyl and 5-methyl-thiophene-methyl side-chains at P1', and threonine and nitro-arginine at P2'...
  3. ncbi request reprint Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening
    Marcia L Moss
    BioZyme, Inc, Apex, NC 27523 9299, USA
    Anal Biochem 366:144-8. 2007
    ..The Wyeth Aerst compound, TMI-1, is a potent inhibitor against all of the ADAMs tested and is slow binding against ADAM17...
  4. ncbi request reprint The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events
    Marcia L Moss
    BioZyme Incorporated, Apex, North Carolina 27523, USA
    J Biol Chem 282:35712-21. 2007
    ..In cell-based assays we show that the ADAM10 prodomain inhibits betacellulin shedding, demonstrating that it could be of potential use as a therapeutic agent to treat cancer...
  5. doi request reprint Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis
    Marcia L Moss
    BioZyme, Apex, NC 27523, USA
    Nat Clin Pract Rheumatol 4:300-9. 2008
    ..This article summarizes preclinical and clinical findings regarding the use of inhibitors of TNF-converting enzyme for the treatment of rheumatoid arthritis...
  6. ncbi request reprint Fluorescent substrates useful as high-throughput screening tools for ADAM9
    Marcia L Moss
    BioZyme, Inc, 1513 Old White Oak Church Road, Apex, NC 27523, USA
    Comb Chem High Throughput Screen 13:358-65. 2010
    ..These results demonstrate that sensitive substrates for ADAM9 can be developed that are useful in high-throughput screening assays for ADAM9...
  7. ncbi request reprint Therapeutic benefits from targeting of ADAM family members
    Marcia L Moss
    BioZyme Inc, 1513 Old White Oak Church Road, Apex, North Carolina 27523, USA
    Biochemistry 43:7227-35. 2004
    ..In addition, ADAMs are discussed as potential therapeutic targets...
  8. ncbi request reprint ADAM10 as a target for anti-cancer therapy
    Marcia L Moss
    BioZyme Inc, 1513 Old White Oak Church Road, Apex, NC 27523, USA
    Curr Pharm Biotechnol 9:2-8. 2008
    ....
  9. pmc ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein
    Marcia L Moss
    BioZyme Inc, Apex, North Carolina 27523, USA
    J Biol Chem 286:40443-51. 2011
    ....
  10. pmc The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10
    George A Lemieux
    Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, California 94143, USA
    J Biol Chem 282:14836-44. 2007
    ..ADAM10 contributes to CD23 shedding and thus could be considered a potential therapeutic target for the treatment of allergic disease...
  11. ncbi request reprint Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8
    Silvia Naus
    Entwicklungsbiologie und Molekulare Pathologie, W7, Universitat Bielefeld, D 33615 Bielefeld, Germany
    Biol Chem 387:337-46. 2006
    ..Taken together, the results allowed us to identify novel candidate substrates that could be cleaved by ADAM8 in vivo under pathologic conditions...
  12. ncbi request reprint Multiple metalloproteinases process protransforming growth factor-alpha (proTGF-alpha)
    C Leann Hinkle
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Biochemistry 42:2127-36. 2003
    ..A model that accounts for these findings and the requirement for TACE in TGF-alpha shedding is proposed...
  13. ncbi request reprint Metalloproteinases revisited
    Marcia L Moss
    Curr Pharm Biotechnol 9:1. 2008
  14. ncbi request reprint Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163
    Katharine A Hintz
    Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire, USA
    J Leukoc Biol 72:711-7. 2002
    ..As hemoglobin can bind LPS and enhance its toxicity, it will be important to determine how cell surface and soluble CD163 influence inflammatory processes during sepsis...
  15. ncbi request reprint The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity
    Mohita J Mohan
    Department of Biochemistry and Biophysics and Johnson Research Foundation, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biochemistry 41:9462-9. 2002
    ..All of these results indicate that TACE is unique in terms of its specificity requirements for substrate cleavage...