Jorge Moscat

Summary

Publications

  1. pmc Feedback on fat: p62-mTORC1-autophagy connections
    Jorge Moscat
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 147:724-7. 2011
  2. pmc p62: a versatile multitasker takes on cancer
    Jorge Moscat
    Sanford Burnham Medical Research Institute, 10901N Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Biochem Sci 37:230-6. 2012
  3. pmc K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells
    Juan F Linares
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 51:283-96. 2013
  4. ncbi Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis
    Tania Valencia
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cancer Cell 26:121-35. 2014
  5. pmc c-Myc phosphorylation by PKCζ represses prostate tumorigenesis
    Ji Young Kim
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:6418-23. 2013
  6. pmc Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice
    Ning Li
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, UCSD, La Jolla, California 92093 0723, USA
    J Clin Invest 123:2231-43. 2013
  7. pmc The atypical PKCs in inflammation: NF-κB and beyond
    Maria T Diaz-Meco
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 246:154-67. 2012
  8. pmc p62 is a key regulator of nutrient sensing in the mTORC1 pathway
    Angeles Duran
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92307, USA
    Mol Cell 44:134-46. 2011
  9. pmc Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis
    Li Ma
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 152:599-611. 2013

Collaborators

Detail Information

Publications9

  1. pmc Feedback on fat: p62-mTORC1-autophagy connections
    Jorge Moscat
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 147:724-7. 2011
    ..Recent in vivo studies explore the molecular basis for metabolic homestasis, showing that p62 links autophagy and mTORC1 activation to regulate adipogenesis and energy control...
  2. pmc p62: a versatile multitasker takes on cancer
    Jorge Moscat
    Sanford Burnham Medical Research Institute, 10901N Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Biochem Sci 37:230-6. 2012
    ....
  3. pmc K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells
    Juan F Linares
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 51:283-96. 2013
    ..Interfering with the p62-TRAF6 interaction serves to modulate autophagy and nutrient sensing...
  4. ncbi Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis
    Tania Valencia
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cancer Cell 26:121-35. 2014
    ..Thus, p62 is an anti-inflammatory tumor suppressor that acts through the modulation of metabolism in the tumor stroma. ..
  5. pmc c-Myc phosphorylation by PKCζ represses prostate tumorigenesis
    Ji Young Kim
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:6418-23. 2013
    ..Collectively, these results establish PKCζ as an important tumor suppressor and regulator of c-Myc function in prostate cancer...
  6. pmc Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice
    Ning Li
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, UCSD, La Jolla, California 92093 0723, USA
    J Clin Invest 123:2231-43. 2013
    ....
  7. pmc The atypical PKCs in inflammation: NF-κB and beyond
    Maria T Diaz-Meco
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 246:154-67. 2012
    ..Many questions remain to be answered, not just from the point of view of the implication for NF-κB activation but also with regard to the in vivo interplay between these pathways in pathophysiological processes like obesity and cancer...
  8. pmc p62 is a key regulator of nutrient sensing in the mTORC1 pathway
    Angeles Duran
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92307, USA
    Mol Cell 44:134-46. 2011
    ..Interestingly, p62 colocalizes with Rags at the lysosomal compartment and is required for the interaction of mTOR with Rag GTPases in vivo and for translocation of the mTORC1 complex to the lysosome, a crucial step for mTOR activation...
  9. pmc Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis
    Li Ma
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 152:599-611. 2013
    ..Furthermore, PKCζ and caspase-3 activities are correlated with PHGDH levels in human intestinal tumors. Taken together, this demonstrates that PKCζ is a critical metabolic tumor suppressor in mouse and human cancer...