Responsive cortical stimulation for the treatment of medically intractable partial epilepsyMartha J Morrell
NeuroPace, Inc, 1375 Shorebird Way, Mountain View, CA 94043, USA
Neurology 77:1295-304. 2011
..This multicenter, double-blind, randomized controlled trial assessed the safety and effectiveness of responsive cortical stimulation as an adjunctive therapy for partial onset seizures in adults with medically refractory epilepsy...
- Sexual dysfunction, sex steroid hormone abnormalities, and depression in women with epilepsy treated with antiepileptic drugs
Martha J Morrell
The Neurological Institute, College of Physicians and Surgeons of Columbia University, New York, NY, USA
Epilepsy Behav 6:360-5. 2005
..The mechanisms of sexual dysfunction in women with epilepsy are multifactorial, but AED choice appears to be one cause that is modifiable...
- Brain stimulation for epilepsy: can scheduled or responsive neurostimulation stop seizures?
Martha Morrell
Stanford University Medical Center, Mountain View, CA 94043, USA
Curr Opin Neurol 19:164-8. 2006
..Scheduled and responsive direct brain stimulation may be an effective and safe therapy for medically intractable epilepsy...
- Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine
Martha J Morrell
Stanford University, Stanford and Neuropace, Mountain View, CA 94043, USA
Ann Neurol 64:200-11. 2008
..To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy...
- Predictors of ovulatory failure in women with epilepsy
Martha J Morrell
The Neurological Institute, Department of Neurology, Columbia University, 710 West 168th Street, New York, NY 10032, USA
Ann Neurol 52:704-11. 2002
..WWE with anovulatory cycles may have no other signs of reproductive dysfunction. Therefore, clinicians must be alert to this potential complication of epilepsy...
- Treatment of women with epilepsy
Alison M Pack
Department of Neurology, The Neurological Institute, Columbia University, New York, New York, USA
Semin Neurol 22:289-98. 2002
..Seizure frequency may change during pregnancy, seizures may cause pregnancy complications, some AEDs are teratogenic, and many cross into breast milk. The treatment of a woman with epilepsy must consider all these issues...
- Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy
Alison M Pack
Department of Neurology, Columbia University, New York, NY 10032, USA
Ann Neurol 57:252-7. 2005
..Subjects receiving lamotrigine had no significant reductions in calcium or increases in markers of bone turnover, suggesting this agent is less likely to have long-term adverse effects on bone...
- Reproductive disturbances in patients with epilepsy
Martha J Morrell
College of Physicians and Surgeons, Columbia University, New York, NY, USA
Cleve Clin J Med 71:S19-24. 2004
..To provide the best care for patients with epilepsy, particularly women of reproductive age, clinicians must consider both the gender-based biology of epilepsy and the effects of antiepileptic drugs on reproductive health...
- Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy
Martha J Morrell
Columbia University, New York, NY, USA
Epilepsy Res 54:189-99. 2003
..e. women with concerns about weight gain, diabetes, hirsutism, polycystic ovary syndrome, menstrual dysfunction or infertility...
- Reproductive and metabolic disorders in women with epilepsy
Martha J Morrell
College of Physicians and Surgeons of Columbia University, and Columbia Comprehensive Epilepsy Center, New York Presbyterian Health System, New York, New York, USA
Epilepsia 44:11-20. 2003
..In the meantime, practitioners can be alert to signs and symptoms of reproductive or metabolic health disturbances and participate in pregnancy registry efforts...
- Epilepsy in women
Martha J Morrell
Columbia University, New York City, New York, USA
Am Fam Physician 66:1489-94. 2002
..This risk is reduced by using a single antiepileptic drug at the lowest effective dose and by providing preconceptional folic acid supplementation. Breastfeeding is generally thought to be safe for women using antiepileptic medications...
- Review of lamotrigine and its clinical applications in epilepsy
Hyunmi Choi
Department of Neurology, Columbia University, New York, USA
Expert Opin Pharmacother 4:243-51. 2003
..Its small risk of serious skin rash should be weighed against its potential benefits when choosing lamotrigine on an individual basis. Lamotrigine is an excellent therapeutic option in epilepsy...
- Endocrine and metabolic responses to long-term monotherapy with the antiepileptic drug valproate in the normally cycling rhesus monkey
Michel Ferin
Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Endocrinol Metab 88:2908-15. 2003
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- Treatment of epilepsy in adults: expert opinion, 2005
Steven Karceski
Columbia Epilepsy Center, Columbia University College of Physicians and Surgeons, 710 W 168th Street, NI 7, New York, NY 10032, USA
Epilepsy Behav 7:S1-64; quiz S65-7. 2005
..We surveyed a group of US epileptologists again in 2004 and compared the results of the two surveys...
- Sex-steroid hormones in women with epilepsy
Nathalie Jette
Neurological Institute of New York, Comprehensive Epilepsy Center, Columbia University, New York, New York 10032, USA
Am J Electroneurodiagnostic Technol 45:36-48. 2005
..By understanding the effects of hormones on seizures, clinicians are better equipped to treat hormonally mediated epilepsy...
- Epilepsy and bone health in adults
Alison M Pack
Epilepsy Division, Department of Neurology, Columbia University, 710 West 168th Street, New York, NY 10032, USA
Epilepsy Behav 5:S24-9. 2004
..Physicians should counsel patients taking AEDs about good bone health practices, and evaluation of bone health by measuring BMD is warranted after 5 years of AED treatment or before treatment in postmenopausal women...
- Bone mineral density in an outpatient population receiving enzyme-inducing antiepileptic drugs
Alison M Pack
Department of Neurology, Columbia University, New York, NY 10032, USA
Epilepsy Behav 4:169-74. 2003
..There were no statistically significant differences found in the T or Z scores by gender; therefore all analyses combined both men and women. Significant reductions in both T and Z scores were present in men and women <50 and >or=50...
- Antiepileptic medications for the treatment of epilepsy
Martha J Morrell
Department of Neurology, The Neurological Institute, Columbia University, New York, New York 10032, USA
Semin Neurol 22:247-58. 2002
..Contained herein is a review of the mechanism of action of AEDs, individual drugs and their potential drug interactions, and general principles to guide the clinician in selection, implementation, and long-term monitoring of AEDs...
- Women with epilepsy: current treatment strategies
Steven Karceski
Neurological Institute, College of Physicians and Surgeons of Columbia University, 710 W 168th St, NI-7, New York, NY 10032, USA
J Gend Specif Med 5:22-6. 2002
..When this method is used to analyze opinion regarding the treatment of women with epilepsy, it is clear that the selection of therapy is influenced by the sex of the patient...
- Working toward an epilepsy cure
Martha J Morrell
Neurological Institute, Columbia University College of Physicians and Surgeons, 710 West 168th Street, New York, NY 10032, USA
Curr Neurol Neurosci Rep 3:323-4. 2003
- Responsive cortical stimulation for the treatment of epilepsy
Felice T Sun
NeuroPace, Mountain View, California 94043, USA
Neurotherapeutics 5:68-74. 2008
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- Intracranial stimulation therapy for epilepsy
Tara L Skarpaas
NeuroPace, Inc, Mountain View, California 94043, USA
Neurotherapeutics 6:238-43. 2009
..We will also discuss the optimization and safety of therapeutic parameters used in neurostimulation for epilepsy...
