- Analysis of differential gene expression supports a role for amyloid precursor protein and a protein kinase C substrate (MARCKS) in long-term memory
R O Solomonia
Institute of Physiology, Georgian Academy of Sciences, 14 Gotua St, Tbilisi 38600, Republic of Georgia
Eur J Neurosci 17:1073-81. 2003
- The sodium channel beta-subunit SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart
A I Fahmi
Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, UK
J Physiol 537:693-700. 2001
- beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics
Departments of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom CB2 1QW
Proc Natl Acad Sci U S A 97:2308-13. 2000
..The expression of beta3 within the central nervous system differs significantly from beta1. Our results strongly suggest that beta3 performs a distinct neurophysiological function...
- A PC12 variant lacking regulated secretory organelles: aberrant protein targeting and evidence for a factor inhibiting neuroendocrine gene expression
Department of Biochemistry, University of Cambridge, England, UK
J Neurochem 73:21-30. 1999
..It is surprising that hybrid cells created by fusing normal PC12 cells with A35C cells exhibited the variant phenotype, suggesting that A35C cells express an inhibitory factor that represses neuroendocrine-specific gene expression...
- Differential distribution of angiotensin AT2 receptors in the normal and failing human heart
Department of Histochemistry, Imperial College School of Medicine, Hammersmith Hospital, London, UK
J Pharmacol Exp Ther 284:323-36. 1998
- A crucial role for Galphaq/11, but not Galphai/o or Galphas, in gonadotropin-releasing hormone receptor-mediated cell growth inhibition
Colin D White
The Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
Mol Endocrinol 22:2520-30. 2008
- Antiproliferative effects of GnRH agonists: prospects and problems for cancer therapy
Colin D White
Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, UK
Neuroendocrinology 88:67-79. 2008
- Diversity of actions of GnRHs mediated by ligand-induced selective signaling
Robert P Millar
MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Front Neuroendocrinol 29:17-35. 2008
..This ligand-induced selective-signaling recruits certain pathways while by-passing others and has implications in developing more selective GnRH analogs for highly specific therapeutic intervention...
- Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology
Robert P Millar
Medical Research Council Human Reproductive Sciences Unit, Edinburgh, UK
Brain Res 1364:81-9. 2010
..These studies establish that kisspeptin antagonists are powerful investigative tools and set the scene for more extensive physiological and pathophysiological studies as well as therapeutic intervention...
- Elevated GnRH receptor expression plus GnRH agonist treatment inhibits the growth of a subset of papillomavirus 18-immortalized human prostate cells
Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Little France Crescent, Edinburgh, UK
Prostate 71:915-28. 2011
..Human metastatic prostate cancer cell growth can be inhibited by GnRH analogs but effects on virus-immortalized prostate cells have not been investigated...
- Prokineticin 1 modulates IL-8 expression via the calcineurin/NFAT signaling pathway
Human Reproductive Sciences Unit, Medical Research Council, Edinburgh EH16 4TJ, UK
Biochim Biophys Acta 1793:1315-24. 2009
..Our findings show that in endometrial cells PROK1 can activate the calcineurin/NFAT pathway to induce IL-8 expression and that this is negatively modulated by the induction of expression of RCAN1-4...
- Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation
Antonia K Roseweir
Medical Research Council Human Reproductive Sciences Unit, The Queens Medical Research Institute, Edinburgh EH16 4TJ, UK
J Neurosci 29:3920-9. 2009
- Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues
Alan J Stewart
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, UK
Neuroendocrinology 86:243-8. 2007
..PLCeta enzymes therefore represent novel proteins influencing intracellular Ca2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of GPCR regulation...
- Prokineticin 1 signaling and gene regulation in early human pregnancy
Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
Endocrinology 149:2877-87. 2008
..These data demonstrate that PROK1 and PROKR1 expression is elevated in human decidua during early pregnancy and that PROK1-PROKR1 interaction regulates expression of a host of implantation-related genes...
- Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated
Medical Research Council, Human Reproductive Sciences Unit, The Queens Medical Research Institute, Little France Crescent, Old Dalkeith Road, Edinburgh, Scotland EH16 4TJ, United Kingdom
Endocrinology 147:5041-51. 2006
- GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines
Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
BMC Cancer 11:476. 2011
..GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells. The applicability of GnRH anti-proliferation to breast cancer was therefore analyzed...