Detection of p53 mutations in precancerous gastric tissueC Morgan
Human Molecular Pathology Group, Swansea Clinical School, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
Br J Cancer 89:1314-9. 2003
..pylori-positive and -negative groups. However, a small subpopulation of the H. pylori-negative patients had much higher levels of free radicals. This suggests a more prominent role for other factors in ROS production...
The in vitro anti-tumour activity of zoledronic acid and docetaxel at clinically achievable concentrations in prostate cancerClaire Morgan
Human Cancer Studies Group, School of Medicine, Swansea University, UK
Acta Oncol 46:669-77. 2007
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Is there a role for ibandronate in the treatment of prostate cancer patients with bony metastases?Claire Morgan
Human Cancer Studies Group, Institute of Life Sciences, Swansea University, Singleton Park, UK
Acta Oncol 48:882-9. 2009
..One possibility could be ibandronate which is also a potent third generation, nitrogen-containing bisphosphonate and is an attractive choice for some patients due to the fact it is available in both intravenous and oral preparations...
- Quantum dots for multiplexed detection and characterisation of prostate cancer cells using a scanning near-field optical microscope
Kelly Ann D Walker
College of Engineering, Multidisciplinary Nanotechnology Centre, Swansea University, Singleton Park, Swansea, United Kingdom
PLoS ONE 7:e31592. 2012
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- Metronomic administration of ibandronate and its anti-angiogenic effects in vitro
Claire Morgan
Human Cancer Studies Group, Institute of Life Sciences, Swansea University, Singleton Park, SA2 8PP, UK
Microvasc Res 78:453-8. 2009
..They have been shown to inhibit proliferation, induce apoptosis and decrease capillary-like tube formation, but often the in vitro concentrations and dosing schedules used do not reflect drug pharmacokinetics or clinical dosing regimens...
- The detection of mutations induced in vitro in the human p53 gene by hydrogen peroxide with the restriction site mutation (RSM) assay
G J Jenkins
Human Molecular Pathology Group, Swansea Clinical School, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
Mutat Res 498:135-44. 2001
..Hence, this methodology may allow the detection of early p53 mutations in pre-malignant tissues...
- In vitro acid exposure has a differential effect on apoptotic and proliferative pathways in a Barrett's adenocarcinoma cell line
Claire Morgan
MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
Am J Gastroenterol 99:218-24. 2004
..CONCLUSIONS: Microarray analysis of gene expression changes in a Barrett's adenocarcinoma cell line has identified cellular pathways that may be disrupted following acid exposure...
- iMARS--mutation analysis reporting software: an analysis of spontaneous cII mutation spectra
Claire Morgan
South West Wales Cancer Institute, Singleton Hospital, Swansea SA2 8QA, UK
Mutat Res 603:15-26. 2006
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- Clinical course of kidney transplant patients with acute rejection and BK virus replication following Campath therapy
Liise K Kayler
Department of Pathology, the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Clin Transplant 22:348-53. 2008
..Kidney transplant recipients with active BK virus (BKV) replication are generally treated with reduction in immunosuppression to allow a successful immune response against the virus...
