Vitamin D and delirium in critically ill patients: a preliminary investigationAlessandro Morandi
Department of Rehabilitation and Aged Care Unit, Ancelle Hospital, 26100 Cremona, Italy Geriatric Research Group, 25100 Brescia, Italy Center for Quality Aging, Nashville, TN 37232, USA Electronic address
J Crit Care 28:230-5. 2013
..25-OH vitamin D (25-OHD) has neuroprotective properties but a relationship between serum 25-OHD and delirium has not been examined. We tested the hypothesis that low serum 25-OHD is associated with delirium during critical illness...
- Tools to detect delirium superimposed on dementia: a systematic review
Alessandro Morandi
Department of Rehabilitation and Aged Care, Hospital Ancelle, Cremona, Italy
J Am Geriatr Soc 60:2005-13. 2012
..To identify valid tools to diagnose delirium superimposed on dementia...
Understanding terminology of delirium and long-term cognitive impairment in critically ill patientsA Morandi
Department of Rehabilitation and Aged Care Unit Hospital Ancelle, Cremona, Italy
Best Pract Res Clin Anaesthesiol 26:267-76. 2012
..Future research is needed to interpret the trajectories of LTCI-CI, to differentiate it from neurodegenerative diseases and to provide a formal disease classification...
- Delirium in the intensive care unit: a review
Alessandro Morandi
Center for Health Services Research, Vanderbilt Medical Center, 1215 21st Avenue South MCE Suite 6100, Nashville, TN 37232 1269, USA
Neurol Clin 29:749-63. 2011
..Future studies should evaluate target interventions to prevent delirium in the ICU...
- Statins and brain dysfunction: a hypothesis to reduce the burden of cognitive impairment in patients who are critically ill
Alessandro Morandi
Center for Quality of Aging, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Chest 140:580-5. 2011
....
- The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*
Alessandro Morandi
Center for Quality of Aging, Vanderbilt University Medical Center, Department of Medicine, Division of Allergy, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Crit Care Med 40:2182-9. 2012
..Relationships between 1) delirium duration and brain white matter integrity, and 2) white matter integrity and long-term cognitive impairment are poorly understood and could be explored using magnetic resonance imaging...
- Association between endothelial dysfunction and acute brain dysfunction during critical illness
Christopher G Hughes
Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, 1211 21st Ave South, 526 MAB, Nashville, Tennessee 37212, USA
Anesthesiology 118:631-9. 2013
..This study sought to determine whether systemic endothelial dysfunction is associated with acute brain dysfunction during critical illness...
- The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study*
Max L Gunther
Department of Psychiatry, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232 8300, USA
Crit Care Med 40:2022-32. 2012
....
- The effect of cognitive impairment on the accuracy of the presenting complaint and discharge instruction comprehension in older emergency department patients
Jin H Han
Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 4700, USA
Ann Emerg Med 57:662-671.e2. 2011
..We seek to determine how delirium and dementia affect the accuracy of the presenting illness and discharge instruction comprehension in older emergency department (ED) patients...
- Delirium in older emergency department patients is an independent predictor of hospital length of stay
Jin H Han
Department of Emergency Medicine JHH, ABS, Division of General Internal Medicine and Public Health JS, RSD, Vanderbilt University Medical Center, Nashville, TN, USA
Acad Emerg Med 18:451-7. 2011
..The consequences of delirium in the emergency department (ED) remain unclear. This study sought to determine if delirium in the ED was an independent predictor of prolonged hospital length of stay (LOS)...
- Delirium in older emergency department patients: recognition, risk factors, and psychomotor subtypes
Jin H Han
Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Acad Emerg Med 16:193-200. 2009
....
- Delirium in the emergency department: an independent predictor of death within 6 months
Jin H Han
Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 4700, USA
Ann Emerg Med 56:244-252.e1. 2010
..As a result, we seek to determine whether delirium in the ED is independently associated with 6-month mortality in older patients and whether this relationship is modified by nursing home status...
- Delirium and sedation recognition using validated instruments: reliability of bedside intensive care unit nursing assessments from 2007 to 2010
Eduard E Vasilevskis
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee, USA
J Am Geriatr Soc 59:S249-55. 2011
..To describe the reliability and sustainability of delirium and sedation measurements of bedside intensive care unit (ICU) nurses...
- The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*
Jessica R Adams Wilson
Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 40:835-41. 2012
....
- Pathophysiology of delirium in the intensive care unit
Max L Gunther
VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN 37212 2637, USA
Crit Care Clin 24:45-65, viii. 2008
..The review concludes by highlighting potential future directions in molecular genetics for the elucidation of delirium and its long-term consequences...
- Sedation, delirium and mechanical ventilation: the 'ABCDE' approach
Alessandro Morandi
Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Curr Opin Crit Care 17:43-9. 2011
..We review recent findings on the management of mechanically ventilated patients focusing on strategies that may improve neurologic and functional outcomes in critically ill patients...
- Delirium in the nursing home patients seen in the emergency department
Jin H Han
Department of Emergency Medicine, Vanderbilt University Medical Center, 703 Oxford House, Nashville, TN 37232 4700, USA
J Am Geriatr Soc 57:889-94. 2009
....
- Delirium in the intensive care unit
Alessandro Morandi
Center for Health Services Research, Vanderbilt Medical Center, Nashville, Tennessee 37232 8300, USA
Int Rev Psychiatry 21:43-58. 2009
..When delirium is diagnosed the use of typical and atypical antipsychotics may be effective for its treatment. Future studies should evaluate target interventions to prevent delirium in the ICU...
- Effect of preinjury statin use on mortality and septic shock in elderly burn patients
Mary D Fogerty
Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Trauma 69:99-103. 2010
..This has been ascribed to the pleiotropic, anti-inflammatory effects of HMG-CoA reductase inhibitors. This association has not been investigated in burn victims...
- Neuroimaging in delirious intensive care unit patients: a preliminary case series report
Alessandro Morandi
Center for Health Services Research Center, Vanderbilt Center for Quality of Aging, Nashville, Tennesee, USA
Psychiatry (Edgmont) 7:28-33. 2010
..e. white matter hyperintensities) and short- and long-term neurological outcomes...
- Documentation and management of words associated with delirium among elderly patients in postacute care: a pilot investigation
Alessandro Morandi
Center for Health Services Research, Vanderbilt Medical Center, 1215 21st Avenue South Nashville, Nashville, TN 37205, USA
J Am Med Dir Assoc 10:330-4. 2009
..To describe in a pilot investigation the frequency that keywords associated with delirium were documented by providers and to study the effect of reporting such observations on physician orders...
- The effect of poststroke delirium on short-term outcomes of elderly patients undergoing rehabilitation
Renato Turco
1Department of Rehabilitation and Aged Care, Ancelle della Carita Hospital, Cremona, Italy
J Geriatr Psychiatry Neurol 26:63-8. 2013
..61) as outcome measures. Conclusions: In elderly patients undergoing poststroke rehabilitation, delirium is an independent predictor of institutionalization and inhospital death, but it does not affect functional recovery...
- Insulin-like growth factor-1 and delirium in critically ill mechanically ventilated patients: a preliminary investigation
A Morandi
Center for Quality of Aging, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Int Psychogeriatr 23:1175-81. 2011
..We sought to test the hypothesis that low IGF-1 concentrations are associated with delirium during critical illness...
