Alessandro Morandi

Summary

Publications

  1. pmc Delirium superimposed on dementia strongly predicts worse outcomes in older rehabilitation inpatients
    Alessandro Morandi
    Department of Rehabilitation and Aged Care of the Ancelle Hospital, Cremona, Italy Geriatric Research Group, Brescia, Italy Electronic address
    J Am Med Dir Assoc 15:349-54. 2014
  2. pmc Consensus and variations in opinions on delirium care: a survey of European delirium specialists
    A Morandi
    Rehabilitation and Aged Care Unit Hospital Ancelle, Cremona, Italy
    Int Psychogeriatr 25:2067-75. 2013
  3. ncbi request reprint Predictors of rehospitalization among elderly patients admitted to a rehabilitation hospital: the role of polypharmacy, functional status, and length of stay
    Alessandro Morandi
    Department of Rehabilitation and Aged Care Hospital Ancelle, Cremona, Italy Geriatric Research Group, Brescia, Italy Center for Quality Aging, Department of Medicine, Vanderbilt University, Nashville, TN Electronic address
    J Am Med Dir Assoc 14:761-7. 2013
  4. pmc Inappropriate medication prescriptions in elderly adults surviving an intensive care unit hospitalization
    Alessandro Morandi
    Rehabilitation and Aged Care Unit Hospital Ancelle, Cremona, Italy
    J Am Geriatr Soc 61:1128-34. 2013
  5. pmc Vitamin D and delirium in critically ill patients: a preliminary investigation
    Alessandro Morandi
    Department of Rehabilitation and Aged Care Unit, Ancelle Hospital, 26100 Cremona, Italy
    J Crit Care 28:230-5. 2013
  6. pmc Tools to detect delirium superimposed on dementia: a systematic review
    Alessandro Morandi
    Department of Rehabilitation and Aged Care, Hospital Ancelle, Cremona, Italy
    J Am Geriatr Soc 60:2005-13. 2012
  7. doi request reprint Understanding terminology of delirium and long-term cognitive impairment in critically ill patients
    A Morandi
    Department of Rehabilitation and Aged Care Unit Hospital Ancelle, Cremona, Italy
    Best Pract Res Clin Anaesthesiol 26:267-76. 2012
  8. doi request reprint Delirium in the intensive care unit: a review
    Alessandro Morandi
    Center for Health Services Research, Vanderbilt Medical Center, 1215 21st Avenue South MCE Suite 6100, Nashville, TN 37232 1269, USA
    Neurol Clin 29:749-63. 2011
  9. pmc Statins and brain dysfunction: a hypothesis to reduce the burden of cognitive impairment in patients who are critically ill
    Alessandro Morandi
    Center for Quality of Aging, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Chest 140:580-5. 2011
  10. pmc The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*
    Alessandro Morandi
    Center for Quality of Aging, Vanderbilt University Medical Center, Department of Medicine, Division of Allergy, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 40:2182-9. 2012

Detail Information

Publications32

  1. pmc Delirium superimposed on dementia strongly predicts worse outcomes in older rehabilitation inpatients
    Alessandro Morandi
    Department of Rehabilitation and Aged Care of the Ancelle Hospital, Cremona, Italy Geriatric Research Group, Brescia, Italy Electronic address
    J Am Med Dir Assoc 15:349-54. 2014
    ..The study aim was to evaluate the association between DSD and related adverse outcomes at discharge from rehabilitation and at 1-year follow-up in older inpatients undergoing rehabilitation...
  2. pmc Consensus and variations in opinions on delirium care: a survey of European delirium specialists
    A Morandi
    Rehabilitation and Aged Care Unit Hospital Ancelle, Cremona, Italy
    Int Psychogeriatr 25:2067-75. 2013
    ..There are still substantial uncertainties over best practice in delirium care. The European Delirium Association (EDA) conducted a survey of its members and other interested parties on various aspects of delirium care...
  3. ncbi request reprint Predictors of rehospitalization among elderly patients admitted to a rehabilitation hospital: the role of polypharmacy, functional status, and length of stay
    Alessandro Morandi
    Department of Rehabilitation and Aged Care Hospital Ancelle, Cremona, Italy Geriatric Research Group, Brescia, Italy Center for Quality Aging, Department of Medicine, Vanderbilt University, Nashville, TN Electronic address
    J Am Med Dir Assoc 14:761-7. 2013
    ..Nonetheless, we have limited information on unplanned rehospitalizations and the related risk factors in elderly patients admitted to in-hospital rehabilitation facilities after an acute hospitalization...
  4. pmc Inappropriate medication prescriptions in elderly adults surviving an intensive care unit hospitalization
    Alessandro Morandi
    Rehabilitation and Aged Care Unit Hospital Ancelle, Cremona, Italy
    J Am Geriatr Soc 61:1128-34. 2013
    ....
  5. pmc Vitamin D and delirium in critically ill patients: a preliminary investigation
    Alessandro Morandi
    Department of Rehabilitation and Aged Care Unit, Ancelle Hospital, 26100 Cremona, Italy
    J Crit Care 28:230-5. 2013
    ..25-OH vitamin D (25-OHD) has neuroprotective properties but a relationship between serum 25-OHD and delirium has not been examined. We tested the hypothesis that low serum 25-OHD is associated with delirium during critical illness...
  6. pmc Tools to detect delirium superimposed on dementia: a systematic review
    Alessandro Morandi
    Department of Rehabilitation and Aged Care, Hospital Ancelle, Cremona, Italy
    J Am Geriatr Soc 60:2005-13. 2012
    ..To identify valid tools to diagnose delirium superimposed on dementia...
  7. doi request reprint Understanding terminology of delirium and long-term cognitive impairment in critically ill patients
    A Morandi
    Department of Rehabilitation and Aged Care Unit Hospital Ancelle, Cremona, Italy
    Best Pract Res Clin Anaesthesiol 26:267-76. 2012
    ..Future research is needed to interpret the trajectories of LTCI-CI, to differentiate it from neurodegenerative diseases and to provide a formal disease classification...
  8. doi request reprint Delirium in the intensive care unit: a review
    Alessandro Morandi
    Center for Health Services Research, Vanderbilt Medical Center, 1215 21st Avenue South MCE Suite 6100, Nashville, TN 37232 1269, USA
    Neurol Clin 29:749-63. 2011
    ..Future studies should evaluate target interventions to prevent delirium in the ICU...
  9. pmc Statins and brain dysfunction: a hypothesis to reduce the burden of cognitive impairment in patients who are critically ill
    Alessandro Morandi
    Center for Quality of Aging, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Chest 140:580-5. 2011
    ....
  10. pmc The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*
    Alessandro Morandi
    Center for Quality of Aging, Vanderbilt University Medical Center, Department of Medicine, Division of Allergy, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 40:2182-9. 2012
    ..Relationships between 1) delirium duration and brain white matter integrity, and 2) white matter integrity and long-term cognitive impairment are poorly understood and could be explored using magnetic resonance imaging...
  11. pmc The effect of cognitive impairment on the accuracy of the presenting complaint and discharge instruction comprehension in older emergency department patients
    Jin H Han
    Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 4700, USA
    Ann Emerg Med 57:662-671.e2. 2011
    ..We seek to determine how delirium and dementia affect the accuracy of the presenting illness and discharge instruction comprehension in older emergency department (ED) patients...
  12. pmc Association between endothelial dysfunction and acute brain dysfunction during critical illness
    Christopher G Hughes
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, 1211 21st Ave South, 526 MAB, Nashville, Tennessee 37212, USA
    Anesthesiology 118:631-9. 2013
    ..This study sought to determine whether systemic endothelial dysfunction is associated with acute brain dysfunction during critical illness...
  13. pmc Delirium in older emergency department patients is an independent predictor of hospital length of stay
    Jin H Han
    Department of Emergency Medicine JHH, ABS, Division of General Internal Medicine and Public Health JS, RSD, Vanderbilt University Medical Center, Nashville, TN, USA
    Acad Emerg Med 18:451-7. 2011
    ..The consequences of delirium in the emergency department (ED) remain unclear. This study sought to determine if delirium in the ED was an independent predictor of prolonged hospital length of stay (LOS)...
  14. pmc The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study*
    Max L Gunther
    Department of Psychiatry, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232 8300, USA
    Crit Care Med 40:2022-32. 2012
    ....
  15. doi request reprint Delirium in older emergency department patients: recognition, risk factors, and psychomotor subtypes
    Jin H Han
    Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Acad Emerg Med 16:193-200. 2009
    ....
  16. ncbi request reprint Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study
    James C Jackson
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA Research Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN, USA Electronic address
    Lancet Respir Med 2:369-79. 2014
    ..We aimed to assess associations of age and duration of delirium with mental health and functional disabilities in this group...
  17. pmc Delirium in the emergency department: an independent predictor of death within 6 months
    Jin H Han
    Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 4700, USA
    Ann Emerg Med 56:244-252.e1. 2010
    ..As a result, we seek to determine whether delirium in the ED is independently associated with 6-month mortality in older patients and whether this relationship is modified by nursing home status...
  18. doi request reprint Functional trajectories during hospitalization: a prognostic sign for elderly patients
    Intissar Sleiman
    Department of Internal Medicine and Geriatrics, Poliambulanza Hospital, Brescia, Italy
    J Gerontol A Biol Sci Med Sci 64:659-63. 2009
    ..Clinicians have used measurements of pathological conditions and functional status to capture the heterogeneity of older individuals for prognostic purposes. However, the literature pays low attention to physical functional changes...
  19. doi request reprint The effect of poststroke delirium on short-term outcomes of elderly patients undergoing rehabilitation
    Renato Turco
    Department of Rehabilitation and Aged Care, Ancelle della Carita Hospital, Cremona, Italy
    J Geriatr Psychiatry Neurol 26:63-8. 2013
    ..We retrospectively assessed the prevalence of delirium in elderly patients undergoing poststroke rehabilitation and its association with short-term outcomes...
  20. pmc Delirium and sedation recognition using validated instruments: reliability of bedside intensive care unit nursing assessments from 2007 to 2010
    Eduard E Vasilevskis
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee, USA
    J Am Geriatr Soc 59:S249-55. 2011
    ..To describe the reliability and sustainability of delirium and sedation measurements of bedside intensive care unit (ICU) nurses...
  21. ncbi request reprint Statins and delirium during critical illness: a multicenter, prospective cohort study*
    Alessandro Morandi
    1Rehabilitation and Aged Care Unit, Hospital Ancelle, Cremona, Italy 2Geriatric Research Group, Brescia, Italy 3Center for Quality Aging, Vanderbilt University School of Medicine, Nashville, TN 4Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 5Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 6Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 7Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 8Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 9Geriatric Research, Education and Clinical Center Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 10Department of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, TN 11Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 12Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 13Research Service, Department of Veterans Affairs Medical Center, South San Francisco
    Crit Care Med 42:1899-909. 2014
    ....
  22. doi request reprint Documentation and management of words associated with delirium among elderly patients in postacute care: a pilot investigation
    Alessandro Morandi
    Center for Health Services Research, Vanderbilt Medical Center, 1215 21st Avenue South Nashville, Nashville, TN 37205, USA
    J Am Med Dir Assoc 10:330-4. 2009
    ..To describe in a pilot investigation the frequency that keywords associated with delirium were documented by providers and to study the effect of reporting such observations on physician orders...
  23. pmc The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*
    Jessica R Adams Wilson
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 40:835-41. 2012
    ....
  24. pmc Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people
    Giuseppe Bellelli
    Department of Health Sciences, University of Milano Bicocca and S Gerardo Hospital, Geriatric Clinic, Monza, Italy Geriatric Research Group, via Romanino 1, Brescia, Italy
    Age Ageing 43:496-502. 2014
    ..to evaluate the performance of the 4 'A's Test (4AT) in screening for delirium in older patients. The 4AT is a new test for rapid screening of delirium in routine clinical practice...
  25. doi request reprint Delirium in the nursing home patients seen in the emergency department
    Jin H Han
    Department of Emergency Medicine, Vanderbilt University Medical Center, 703 Oxford House, Nashville, TN 37232 4700, USA
    J Am Geriatr Soc 57:889-94. 2009
    ....
  26. ncbi request reprint Hyperglycemia as a predictor of in-hospital mortality in elderly patients without diabetes mellitus admitted to a sub-intensive care unit
    Intissar Sleiman
    Department of Internal Medicine and Geriatrics, Poliambulanza Hospital, Brescia, Italy
    J Am Geriatr Soc 56:1106-10. 2008
    ..To investigate the association between hyperglycemia and in-hospital and 45-day mortality in acutely ill elderly patients...
  27. doi request reprint Pathophysiology of delirium in the intensive care unit
    Max L Gunther
    VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN 37212 2637, USA
    Crit Care Clin 24:45-65, viii. 2008
    ..The review concludes by highlighting potential future directions in molecular genetics for the elucidation of delirium and its long-term consequences...
  28. doi request reprint Sedation, delirium and mechanical ventilation: the 'ABCDE' approach
    Alessandro Morandi
    Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Curr Opin Crit Care 17:43-9. 2011
    ..We review recent findings on the management of mechanically ventilated patients focusing on strategies that may improve neurologic and functional outcomes in critically ill patients...
  29. doi request reprint Delirium in the intensive care unit
    Alessandro Morandi
    Center for Health Services Research, Vanderbilt Medical Center, Nashville, Tennessee 37232 8300, USA
    Int Rev Psychiatry 21:43-58. 2009
    ..When delirium is diagnosed the use of typical and atypical antipsychotics may be effective for its treatment. Future studies should evaluate target interventions to prevent delirium in the ICU...
  30. pmc Neuroimaging in delirious intensive care unit patients: a preliminary case series report
    Alessandro Morandi
    Center for Health Services Research Center, Vanderbilt Center for Quality of Aging, Nashville, Tennesee, USA
    Psychiatry (Edgmont) 7:28-33. 2010
    ..e. white matter hyperintensities) and short- and long-term neurological outcomes...
  31. doi request reprint Effect of preinjury statin use on mortality and septic shock in elderly burn patients
    Mary D Fogerty
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Trauma 69:99-103. 2010
    ..This has been ascribed to the pleiotropic, anti-inflammatory effects of HMG-CoA reductase inhibitors. This association has not been investigated in burn victims...
  32. pmc Insulin-like growth factor-1 and delirium in critically ill mechanically ventilated patients: a preliminary investigation
    A Morandi
    Center for Quality of Aging, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Int Psychogeriatr 23:1175-81. 2011
    ..We sought to test the hypothesis that low IGF-1 concentrations are associated with delirium during critical illness...