Yehu Moran

Summary

Publications

  1. doi request reprint Fusion and retrotransposition events in the evolution of the sea anemone Anemonia viridis neurotoxin genes
    Yehu Moran
    Department of Plant Sciences, Tel Aviv University, Ramat Aviv, Israel
    J Mol Evol 69:115-24. 2009
  2. pmc The evolution of microRNA pathway protein components in Cnidaria
    Yehu Moran
    Department for Molecular Evolution and Development, Center for Organismal Systems Biology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
    Mol Biol Evol 30:2541-52. 2013
  3. pmc Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones
    Yehu Moran
    Department of Molecular Biology and Ecology of Plants, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel
    Proc Biol Sci 279:1351-8. 2012
  4. pmc Sea anemone toxins affecting voltage-gated sodium channels--molecular and evolutionary features
    Yehu Moran
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Toxicon 54:1089-101. 2009
  5. pmc Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na+ channels
    Yehu Moran
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel
    Biochem J 406:41-8. 2007
  6. ncbi request reprint Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis
    Yehu Moran
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Biol 380:437-43. 2008
  7. doi request reprint Positions under positive selection--key for selectivity and potency of scorpion alpha-toxins
    Hagar Weinberger
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Mol Biol Evol 27:1025-34. 2010
  8. doi request reprint Concerted evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome
    Yehu Moran
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Mol Biol Evol 25:737-47. 2008
  9. ncbi request reprint Expression and mutagenesis of the sea anemone toxin Av2 reveals key amino acid residues important for activity on voltage-gated sodium channels
    Yehu Moran
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel
    Biochemistry 45:8864-73. 2006
  10. pmc Convergent evolution of sodium ion selectivity in metazoan neuronal signaling
    Maya Gur Barzilai
    Department of Molecular Biology and Ecology of Plants, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Cell Rep 2:242-8. 2012

Collaborators

Detail Information

Publications12

  1. doi request reprint Fusion and retrotransposition events in the evolution of the sea anemone Anemonia viridis neurotoxin genes
    Yehu Moran
    Department of Plant Sciences, Tel Aviv University, Ramat Aviv, Israel
    J Mol Evol 69:115-24. 2009
    ..Overall, the retrotransposition and gene fusion events suggest that the genes of both Types I and III neurotoxins evolved in a similar fashion and share a partial common ancestry...
  2. pmc The evolution of microRNA pathway protein components in Cnidaria
    Yehu Moran
    Department for Molecular Evolution and Development, Center for Organismal Systems Biology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
    Mol Biol Evol 30:2541-52. 2013
    ..This finding raises questions regarding the independent evolution of the microRNA pathway in plants and animals, and together with the other results shed new light on the evolution of an important regulatory pathway. ..
  3. pmc Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones
    Yehu Moran
    Department of Molecular Biology and Ecology of Plants, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel
    Proc Biol Sci 279:1351-8. 2012
    ....
  4. pmc Sea anemone toxins affecting voltage-gated sodium channels--molecular and evolutionary features
    Yehu Moran
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Toxicon 54:1089-101. 2009
    ....
  5. pmc Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na+ channels
    Yehu Moran
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel
    Biochem J 406:41-8. 2007
    ..All in all, the present study provides further evidence for the heterogeneity of receptor site-3, and raises Av3 as a unique model for design of selective anti-insect compounds...
  6. ncbi request reprint Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis
    Yehu Moran
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Biol 380:437-43. 2008
    ..This rare phenomenon of intron retention at the early developmental stages is intriguing and raises the question as to the mechanism enabling such differential expression in sea anemones...
  7. doi request reprint Positions under positive selection--key for selectivity and potency of scorpion alpha-toxins
    Hagar Weinberger
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Mol Biol Evol 27:1025-34. 2010
    ....
  8. doi request reprint Concerted evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome
    Yehu Moran
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Mol Biol Evol 25:737-47. 2008
    ..Furthermore, in 2 of the species (A. viridis and A. equina) we found genes that evolved under diversifying selection, suggesting that concerted evolution and accelerated evolution may occur simultaneously...
  9. ncbi request reprint Expression and mutagenesis of the sea anemone toxin Av2 reveals key amino acid residues important for activity on voltage-gated sodium channels
    Yehu Moran
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel
    Biochemistry 45:8864-73. 2006
    ....
  10. pmc Convergent evolution of sodium ion selectivity in metazoan neuronal signaling
    Maya Gur Barzilai
    Department of Molecular Biology and Ecology of Plants, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Cell Rep 2:242-8. 2012
    ..The identification of Cnidarian Na(+)-selective ion channels distinct from the channels of bilaterian animals indicates that selectivity for Na(+) in neuronal signaling emerged independently in these two animal lineages...
  11. ncbi request reprint When positive selection of neurotoxin genes is missing. The riddle of the sea anemone Nematostella vectensis
    Yehu Moran
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    FEBS J 273:3886-92. 2006
    ..This assumption still awaits further verification as soon as the various contigs are assigned within larger genomic fragments...
  12. pmc Drosomycin, an innate immunity peptide of Drosophila melanogaster, interacts with the fly voltage-gated sodium channel
    Lior Cohen
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    J Biol Chem 284:23558-63. 2009
    ..As for drosomycin, we discuss the intriguing possibility that it has additional functions in the fly, as implied by its tight interaction with DmNa(v)1...