Fusion and retrotransposition events in the evolution of the sea anemone Anemonia viridis neurotoxin genesYehu Moran
Department of Plant Sciences, Tel Aviv University, Ramat Aviv, Israel
J Mol Evol 69:115-24. 2009
..Overall, the retrotransposition and gene fusion events suggest that the genes of both Types I and III neurotoxins evolved in a similar fashion and share a partial common ancestry...
Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemonesYehu Moran
Department of Molecular Biology and Ecology of Plants, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel
Proc Biol Sci 279:1351-8. 2012
....
- Sea anemone toxins affecting voltage-gated sodium channels--molecular and evolutionary features
Yehu Moran
Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
Toxicon 54:1089-101. 2009
....
- Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na+ channels
Yehu Moran
Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel
Biochem J 406:41-8. 2007
..All in all, the present study provides further evidence for the heterogeneity of receptor site-3, and raises Av3 as a unique model for design of selective anti-insect compounds...
- Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis
Yehu Moran
Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
J Mol Biol 380:437-43. 2008
..This rare phenomenon of intron retention at the early developmental stages is intriguing and raises the question as to the mechanism enabling such differential expression in sea anemones...
- Positions under positive selection--key for selectivity and potency of scorpion alpha-toxins
Hagar Weinberger
Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
Mol Biol Evol 27:1025-34. 2010
....
- Concerted evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome
Yehu Moran
Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
Mol Biol Evol 25:737-47. 2008
..Furthermore, in 2 of the species (A. viridis and A. equina) we found genes that evolved under diversifying selection, suggesting that concerted evolution and accelerated evolution may occur simultaneously...
Expression and mutagenesis of the sea anemone toxin Av2 reveals key amino acid residues important for activity on voltage-gated sodium channelsYehu Moran
Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel
Biochemistry 45:8864-73. 2006
....
- Convergent evolution of sodium ion selectivity in metazoan neuronal signaling
Maya Gur Barzilai
Department of Molecular Biology and Ecology of Plants, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
Cell Rep 2:242-8. 2012
..The identification of Cnidarian Na(+)-selective ion channels distinct from the channels of bilaterian animals indicates that selectivity for Na(+) in neuronal signaling emerged independently in these two animal lineages...
- Drosomycin, an innate immunity peptide of Drosophila melanogaster, interacts with the fly voltage-gated sodium channel
Lior Cohen
Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
J Biol Chem 284:23558-63. 2009
..As for drosomycin, we discuss the intriguing possibility that it has additional functions in the fly, as implied by its tight interaction with DmNa(v)1...
- When positive selection of neurotoxin genes is missing. The riddle of the sea anemone Nematostella vectensis
Yehu Moran
Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
FEBS J 273:3886-92. 2006
..This assumption still awaits further verification as soon as the various contigs are assigned within larger genomic fragments...
