Malcolm A S Moore

Summary

Publications

  1. ncbi request reprint Cytokine and chemokine networks influencing stem cell proliferation, differentiation, and marrow homing
    Malcolm A S Moore
    Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute for Cancer Research, New York, New York 10021, USA
    J Cell Biochem Suppl 38:29-38. 2002
  2. ncbi request reprint Enforced activation of STAT5A facilitates the generation of embryonic stem-derived hematopoietic stem cells that contribute to hematopoiesis in vivo
    Jan Jacob Schuringa
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Stem Cells 22:1191-204. 2004
  3. pmc Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation
    Jan Jacob Schuringa
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Exp Med 200:623-35. 2004
  4. ncbi request reprint Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro
    Pierre Feugier
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Stem Cells Dev 14:505-16. 2005
  5. ncbi request reprint Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells
    Malcolm A S Moore
    Moore Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Exp Hematol 35:105-16. 2007
  6. ncbi request reprint The effect of cantharidins on leukemic stem cells
    David C Dorn
    Moore Laboratory, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 124:2186-99. 2009
  7. ncbi request reprint Increased plasma levels of stromal-derived factor-1 (SDF-1/CXCL12) enhance human thrombopoiesis and mobilize human colony-forming cells (CFC) in NOD/SCID mice
    Lia E Perez
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Exp Hematol 32:300-7. 2004
  8. ncbi request reprint Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation
    Ki Y Chung
    Department of Medicine and Moore Laboratory, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Res 66:11781-91. 2006
  9. pmc Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin
    Nicolas Lecomte
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:15074-8. 2011
  10. ncbi request reprint Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis
    Kai Da Wu
    James Ewing Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Immunol Immunother 56:343-57. 2007

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Cytokine and chemokine networks influencing stem cell proliferation, differentiation, and marrow homing
    Malcolm A S Moore
    Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute for Cancer Research, New York, New York 10021, USA
    J Cell Biochem Suppl 38:29-38. 2002
    ....
  2. ncbi request reprint Enforced activation of STAT5A facilitates the generation of embryonic stem-derived hematopoietic stem cells that contribute to hematopoiesis in vivo
    Jan Jacob Schuringa
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Stem Cells 22:1191-204. 2004
    ..These data indicate that a persistent activation of STAT5A allows the generation of ES-derived HSCs that can, at least for an intermediate period, contribute to hematopoiesis in vivo...
  3. pmc Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation
    Jan Jacob Schuringa
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Exp Med 200:623-35. 2004
    ..Our data indicate that a persistent activation of STAT5A in human hematopoietic stem and progenitor cells results in their enhanced self-renewal and diverts differentiation to the erythroid lineage...
  4. ncbi request reprint Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro
    Pierre Feugier
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Stem Cells Dev 14:505-16. 2005
    ....
  5. ncbi request reprint Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells
    Malcolm A S Moore
    Moore Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Exp Hematol 35:105-16. 2007
    ..To model human leukemogenesis by transduction of human hematopoietic stem cells (HSC) with genes associated with leukemia and expressed in leukemic stem cells...
  6. ncbi request reprint The effect of cantharidins on leukemic stem cells
    David C Dorn
    Moore Laboratory, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 124:2186-99. 2009
    ..However, its potent in vitro LSC activity and pathway targeting may still be exploited clinically with a new generation of cantharidin derivatives or formulations and with appropriate drug combinations...
  7. ncbi request reprint Increased plasma levels of stromal-derived factor-1 (SDF-1/CXCL12) enhance human thrombopoiesis and mobilize human colony-forming cells (CFC) in NOD/SCID mice
    Lia E Perez
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Exp Hematol 32:300-7. 2004
    ..Herein, we studied the in vivo effects of ad-SDF-1 and of an analogue peptide of SDF-1 (CTCE-0214) on human hematopoiesis in a xenotransplant model...
  8. ncbi request reprint Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation
    Ki Y Chung
    Department of Medicine and Moore Laboratory, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Res 66:11781-91. 2006
    ..The resulting protein stabilization may contribute to the leukemogenic activity of the fusion protein...
  9. pmc Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin
    Nicolas Lecomte
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:15074-8. 2011
    ..2% and 99.3%, respectively). Together these very encouraging findings suggest that these analogs have promise as potent antimetastatic agents in lung cancer...
  10. ncbi request reprint Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis
    Kai Da Wu
    James Ewing Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Immunol Immunother 56:343-57. 2007
    ..Inhibition of IGF-IR by the A12 in vitro suppressed both constitutive and IGF-I-induced secretion of VEGF, indicating that a putative anti-angiogenic mechanism associated with the A12 treatment may contribute to its anti-tumor effect...
  11. ncbi request reprint Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras
    Karen L MacKenzie
    James Ewing Laboratory of Developmental Haematopoiesis and Department of Human Genetics, Sloan Kettering Cancer Institute, New York, NY, USA
    Oncogene 21:4200-11. 2002
    ..This model will be useful for understanding mechanisms underlying vascular and angiogenic neoplasias, as well as for testing drugs designed to curtail aberrant EC growth...
  12. pmc Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
    ..Release of sKitL by MMP-9 enables BM repopulating cells to translocate to a permissive vascular niche favoring differentiation and reconstitution of the stem/progenitor cell pool...
  13. ncbi request reprint Angiogenic factors reconstitute hematopoiesis by recruiting stem cells from bone marrow microenvironment
    Shahin Rafii
    Cornell University Medical College, New York, New York 10021, USA
    Ann N Y Acad Sci 996:49-60. 2003
    ..PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative microenvironment within the BM, favoring differentiation, mobilization, and reconstitution of hematopoiesis...
  14. pmc Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor
    Benedikt Bosbach
    Developmental Biology, Sloan Kettering Institute, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:E2276-83. 2012
    ..This mouse model should be useful for preclinical studies of drug candidates designed to overcome imatinib resistance in GIST and to investigate the consequences of oncogenic KIT signaling in hematopoietic as well as other cell lineages...
  15. ncbi request reprint Methotrexate selection of long-term culture initiating cells following transduction of CD34(+) cells with a retrovirus containing a mutated human dihydrofolate reductase gene
    Naoko Takebe
    Program of Molecular Pharmacology and Experimental Therapeutics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Gene Ther 9:308-20. 2002
    ..These are the first investigations to demonstrate selection for transduced long-term culture initiating cells using MTX. The DHFR/MTX system holds promise for improving selection of gene-transduced hematopoietic progenitor cells in vivo...
  16. ncbi request reprint Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo
    Eunice S Wang
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Blood 104:2893-902. 2004
    ..12, methotrexate) consistently improved tumor responses over those of single-agent therapy. These data support the further clinical development of VEGFR-targeted approaches for the therapy of aggressive DLBCL...
  17. pmc Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4
    Jennifer Lee
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA
    Blood 121:4082-9. 2013
    ..Our studies demonstrate the feasibility of engineering a stable HOXB4 variant to overcome a major technical hurdle in the ex vivo expansion of adult HSCs and early progenitors for human therapeutic use...
  18. ncbi request reprint Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma
    Eunice S Wang
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 103:258-66. 2004
    ..These data demonstrate that telomerase is important for the replication of mature B-cell neoplasia by stabilizing short telomeres, and they suggest that telomerase inhibition represents a novel therapeutic approach to MM and NHL...
  19. ncbi request reprint Stromal cell lines from the aorta-gonado-mesonephros region are potent supporters of murine and human hematopoiesis
    Katja C Weisel
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Exp Hematol 34:1505-16. 2006
    ..In addition, extensive phenotypic analysis should elucidate possible mechanisms involved in maintenance of hematopoietic stem cell function...
  20. pmc KIT receptor gain-of-function in hematopoiesis enhances stem cell self-renewal and promotes progenitor cell expansion
    Shayu Deshpande
    Developmental Biology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Stem Cells 31:1683-95. 2013
    ..Our study demonstrates that signaling from the Kit(V558Δ;T669I/+) receptor has important consequences in hematopoiesis enhancing HSC self-renewal and resulting in increased erythropoiesis...
  21. pmc Nrf2 regulates haematopoietic stem cell function
    Jennifer J Tsai
    Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nat Cell Biol 15:309-16. 2013
    ..We further show that Nrf2 modulates both migration and retention of HSCs in their niche. Moreover, we identify a previously unrecognized link between Nrf2 and CXCR4, contributing, at least partially, to the maintenance of HSC function...
  22. pmc Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4
    Xiangao Huang
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Blood 120:1095-106. 2012
    ..Reversible inhibition of CDK4/CDK6 in sequential combination therapy thus represents a novel mechanism-based cancer therapy...
  23. ncbi request reprint Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway
    Wei He
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell 125:929-41. 2006
    ..Thus, Smad2/3-TIF1gamma and Smad2/3-Smad4 function as complementary effector arms in the control of hematopoietic cell fate by the TGFbeta/Smad pathway...
  24. ncbi request reprint Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis
    Ki Young Chung
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 105:77-84. 2005
    ..Flt3-ITD+ acute myeloid leukemia (AML) blasts from patients invariably generated early AG1295-sensitive CAs in MS-5 cocultures, further validating the phenotype observed in transduced CD34+ cells...
  25. pmc Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo
    Kai Da Wu
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:10640-5. 2005
    ..mice treated with dEpoB or vehicle control, indicating that Flu may be a promising agent for MM therapy...
  26. ncbi request reprint Hematopoietic cells
    Malcolm A S Moore
    Moore Laboratory, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Methods Enzymol 418:208-42. 2006
    ....
  27. pmc Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
    Koichi Hattori
    Department of Medicine, Cornell University Medical College, New York, New York, USA
    Nat Med 8:841-9. 2002
    ..Thus, PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative BM microenvironment, favoring differentiation, mobilization and reconstitution of hematopoiesis...
  28. ncbi request reprint Commentary: the role of cell migration in the ontogeny of the lymphoid system
    Malcolm A S Moore
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Stem Cells Dev 13:1-21. 2004
    ....
  29. pmc Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog
    Thordur Oskarsson
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    J Am Chem Soc 132:3224-8. 2010
    ..Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells...
  30. ncbi request reprint Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand
    Pierre Feugier
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 101, New York, NY 10021, USA
    J Hematother Stem Cell Res 11:127-38. 2002
    ....
  31. ncbi request reprint A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6
    Linda B Baughn
    Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Cancer Res 66:7661-7. 2006
    ..PD 0332991, therefore, represents the first promising and specific inhibitor for therapeutic targeting of Cdk4/6 in multiple myeloma and possibly other B-cell cancers...
  32. ncbi request reprint Determination of telomerase activity and telomere length
    Kai Da Wu
    Cell Biology Program, Sloan Kettering Cancer Institute, New York, NY, USA
    Methods Mol Med 113:207-23. 2005
    ..We also discuss comparison with related assay methods...
  33. ncbi request reprint Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibroblasts
    Jessica Boklan
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 62:2104-14. 2002
    ..Moreover, the murine model used here should prove useful in further evaluating telomerase inhibition as an anticancer therapy...
  34. ncbi request reprint Converging pathways in leukemogenesis and stem cell self-renewal
    Malcolm A S Moore
    James Ewing Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Exp Hematol 33:719-37. 2005
    ....
  35. pmc Airway basal cells of healthy smokers express an embryonic stem cell signature relevant to lung cancer
    Renat Shaykhiev
    Department of Genetic Medicine, Weill Cornell Medical College, New York, New York
    Stem Cells 31:1992-2002. 2013
    ..These data provide transcriptome-based evidence that smoking-induced reprogramming of airway BC toward the hESC-like phenotype might represent a common early molecular event in the development of aggressive lung carcinomas in humans...
  36. pmc Synthesis of granulocyte-macrophage colony-stimulating factor as homogeneous glycoforms and early comparisons with yeast cell-derived material
    Qiang Zhang
    Laboratory for Bio Organic Chemistry and Cell Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065
    Proc Natl Acad Sci U S A 111:2885-90. 2014
    ..We describe herein a convergent total synthesis of GM-CSF aglycone and two homogeneous glycoforms. Analytical and biological studies confirm the structure and activity of these synthetic congeners. ..
  37. ncbi request reprint Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression
    Eunice S Wang
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 6306, USA
    Leuk Lymphoma 44:1027-35. 2003
    ..These results demonstrate that the PDX has markedly greater potential activity against human NHL than MTX and warrants further preclinical and clinical evaluation...
  38. pmc Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development
    Valter Agosti
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    J Exp Med 199:867-78. 2004
    ..Therefore, Kit-mediated PI 3-kinase signaling and Src kinase family signaling is highly specific for different cellular contexts in vivo...
  39. pmc Erythropoietin derived by chemical synthesis
    Ping Wang
    Laboratory for Bioorganic Chemistry, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA
    Science 342:1357-60. 2013
    ..This homogeneous erythropoietin glycosylated at the three wild-type aspartates with N-linked high-mannose sialic acid-containing oligosaccharides and O-linked glycophorin exhibits Procrit-level in vivo activity in mice. ..
  40. pmc Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma
    Emil Lou
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 7:e33093. 2012
    ..We provide the first evidence of tunneling nanotubes in human primary tumors and cancer cells and propose that these structures play an important role in cancer cell pathogenesis and invasion...
  41. ncbi request reprint The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis
    Christoph Gaul
    Laboratory for Bioorganic Chemistry, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA
    J Am Chem Soc 126:11326-37. 2004
    ....
  42. ncbi request reprint Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells
    Stephen D Nimer
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 23:4249-54. 2004
    ..The direct effects of AML1-ETO on human and murine HSCs, and the potentially cooperating events that may contribute to its leukemogenic properties, are discussed...
  43. ncbi request reprint Total synthesis of peribysin E necessitates revision of the assignment of its absolute configuration
    Angie R Angeles
    The Laboratory for Bioorganic Chemistry, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA
    Angew Chem Int Ed Engl 46:1451-4. 2007
  44. doi request reprint Waking up HSCs: a new role for E-selectin
    Malcolm A S Moore
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Nat Med 18:1613-4. 2012
    ..A new role in stem cell proliferation has now been identified for the adhesion molecule E-selectin expressed by bone marrow endothelial cells at the vascular niche (pages 1651-1657)...
  45. ncbi request reprint The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells
    James C Mulloy
    Laboratory of Molecular Hematopoiesis, Sloan Kettering Institute, New York, NY, USA
    Blood 99:15-23. 2002
    ..Thus, AML1-ETO enhances the self-renewal of pluripotent stem cells, the physiological target of many acute myeloid leukemias...
  46. ncbi request reprint Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice
    Tiziano Barberi
    Laboratory of Stem Cell and Tumor Biology, Division of Neurosurgery and Developmental Biology Program, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Biotechnol 21:1200-7. 2003
    ..Furthermore, transplantation of ES and ntES cell-derived dopaminergic neurons corrected the phenotype of a mouse model of Parkinson disease, demonstrating an in vivo application of therapeutic cloning in neural disease...
  47. ncbi request reprint Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival
    Kai Da Wu
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 101:4982-9. 2003
    ..004). The 2-year survival rate for patients with TA levels lower than 25% was 81%, and it was 52% in those with higher TA levels (P <.0001)...
  48. pmc Putting the neo into neoangiogenesis
    Malcolm A S Moore
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    J Clin Invest 109:313-5. 2002
  49. pmc Benign mesenchymal stromal cells in human sarcomas
    Alexei Morozov
    Departments of Cell Biology, Memorial Sloan Kettering Cancer Center, New York 10065, USA
    Clin Cancer Res 16:5630-40. 2010
    ..Recent evidence suggests that at least some sarcomas arise through aberrant differentiation of mesenchymal stromal cells (MSCs), but MSCs have never been isolated directly from human sarcoma specimens...
  50. pmc At last: erythropoietin as a single glycoform
    Ping Wang
    Laboratory for Bioorganic Chemistry, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065 USA
    Angew Chem Int Ed Engl 51:11576-84. 2012
    ..Wild thing: The first total synthesis of wild-type erythropoietin glycoprotein has been accomplished. The erythropoietic activity of the synthetic folded protein has been demonstrated...
  51. ncbi request reprint Differences in the transmigration of different dendritic cells
    Anja Moldenhauer
    Institute for Transfusion Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Hematol 34:745-52. 2006
    ..Their ability to migrate to the adjacent lymphatic system is relevant since their efficacy does also rely on their potential to interact with lymphocytes...
  52. ncbi request reprint Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element
    James C Mulloy
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Mail Location 7013, Cincinnati, OH 45229, USA
    Blood 102:4369-76. 2003
    ....
  53. ncbi request reprint Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells
    Heather M Bond
    Department of Experimental and Clinical Medicine Gaetano Salvatore, University of Catanzaro Magna, Graecia, Italy
    Blood 103:2062-70. 2004
    ..Taken together, our data suggest that EHZF is likely to play a relevant role in the control of human hematopoiesis and might be implicated in the development of hematopoietic malignancies...
  54. ncbi request reprint Elevated telomerase activity and minimal telomere loss in cord blood long-term cultures with extensive stem cell replication
    Loretta Gammaitoni
    Department of Oncological Sciences, IRCC Institute for Cancer Research and Treatment, Laboratory of Clinical Oncology, University of Turin Medical School, Prov 142, 10060 Candiolo, Turin, Italy
    Blood 103:4440-8. 2004
    ..There is clearly a clinical value for a system that provides extensive stem cell expansion without concomitant telomere erosion...
  55. ncbi request reprint Long-term bovine hematopoietic engraftment with clone-derived stem cells
    Robert Lanza
    Advanced Cell Technology, Worcester, Massachusetts, USA
    Cloning Stem Cells 7:95-106. 2005
    ..The fetal HSC showed a 10-fold competition advantage over adult HSC. Cloning generated histocompatible HSC capable of long-term multilineage engraftment in a large animal model...
  56. ncbi request reprint Genetic and functional characterization of isolated stromal cell lines from the aorta-gonado-mesonephros region
    Katja C Weisel
    University of Tubingen, Department of Hematology, Oncology, and Immunology, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    Ann N Y Acad Sci 1044:51-9. 2005
    ..Stromal gene array analysis has identified genes that could play a role in hematopoietic support...
  57. ncbi request reprint Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53-competent immortal endothelial cells
    Victoria W Wen
    Children s Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia
    Cancer Res 66:10691-700. 2006
    ..These investigations provide new insight to the role of p16(INK4a) as a tumor suppressor...
  58. ncbi request reprint Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins
    Anja Moldenhauer
    Institute for Transfusion Medicine and Immunehaematology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Leukoc Biol 76:623-33. 2004
    ..This model system suggests that the Hdi supports the in vitro differentiation of DC from leukemic blasts with AML1-containing fusion proteins...
  59. pmc Generation of functional hemangioblasts from human embryonic stem cells
    Shi Jiang Lu
    Advanced Cell Technology, Worcester, Massachusetts 01605, USA
    Nat Methods 4:501-9. 2007
    ..Our data suggest that hES-derived blast cells (hES-BCs) could be important in vascular repair...
  60. ncbi request reprint Early hematopoietic zinc finger protein-zinc finger protein 521: a candidate regulator of diverse immature cells
    Heather M Bond
    Laboratory of Molecular Haematopoiesis, Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, 88100 Catanzaro, Italy
    Int J Biochem Cell Biol 40:848-54. 2008
    ..EHZF/ZNF521 is also abundant in medulloblastomas and other brain tumours. Taken together, the data available suggest a possible role for this factor in development, stem cell regulation and oncogenesis...
  61. ncbi request reprint Tumor necrosis factor alpha-stimulated endothelium: an inducer of dendritic cell development from hematopoietic progenitors and myeloid leukemic cells
    Anja Moldenhauer
    Institute for Transfusion Medicine, Charite, Universitätsmedizen Berlin, Berlin, Germany
    Stem Cells 22:144-57. 2004
    ..We conclude that, via the action of TNF-alpha, inflamed human endothelium can induce CD34+ and leukemic cells to differentiate into dendritic cells...
  62. ncbi request reprint Regeneration of the infarcted heart with stem cells derived by nuclear transplantation
    Robert Lanza
    Advanced Cell Technology, Worcester, Mass, USA
    Circ Res 94:820-7. 2004
    ..Importantly, the magnitude of myocardial regeneration obtained in this study is significantly superior to that achieved with adult bone marrow cells...
  63. ncbi request reprint STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalpha
    Albertus T J Wierenga
    Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Blood 107:4326-33. 2006
    ..Our data indicate that down-modulation of C/EBPalpha is a prerequisite for STAT5-induced effects on self-renewal and myelopoiesis...