Adult Changes in Thought study: dementia is an individually varying convergent syndrome with prevalent clinically silent diseases that may be modified by some commonly used therapeuticsThomas J Montine
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Curr Alzheimer Res 9:718-23. 2012
....
- Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease
Jake G Hoekstra
Department of Pathology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA
Alzheimers Res Ther 3:21. 2011
..Recent discoveries pertaining to mitochondrial dynamics reveal that regulation of mitochondrial fission and fusion may play a key role in the pathogenesis of these diseases and consequently could be novel future therapeutic targets...
- Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT
Thomas J Montine
Department of Pathology, University of Washington, Seattle, Washington, United States of America
PLoS ONE 5:e9340. 2010
....
- Prevalence estimates for latent neurodegenerative disease
Thomas J Montine
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Toxicol Pathol 39:99-102. 2011
..The latent stage of diseases that commonly cause dementia is highly prevalent in the adult population, highlighting the need for prevention strategies and longitudinal studies...
- National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach
Thomas J Montine
Department of Pathology, University of Washington School of Medicine, Box 359791, Seattle, WA 98104, USA
Acta Neuropathol 123:1-11. 2012
..Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations...
- Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
Min Shi
Department of Pathology, University of Washington School of Medicine, Seattle, 98104, USA
Ann Neurol 69:570-80. 2011
..We and others have demonstrated that a decrease in DJ-1 and/or α-synuclein in the cerebrospinal fluid (CSF) is a potential index for Parkinson disease diagnosis, but not for PD severity...
Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunityFeng Shiun Shie
Department of Pathology, University of Washington, Seattle, Washington, USA
Glia 52:70-7. 2005
..EP2 should be considered as a therapeutic target for suppression of microglial innate immunity-mediated damage in neurodegenerative diseases...
- Different patterns of cerebral injury in dementia with or without diabetes
Joshua A Sonnen
Department of Pathology, University of Washington, Seattle, USA
Arch Neurol 66:315-22. 2009
..Diabetes mellitus (DM) increases the risk of dementia in the elderly. However, its underlying mechanisms, its connection with Alzheimer disease and vascular cognitive impairment, and effects of therapy remain unclear...
- Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease
Randall L Woltjer
Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA
FASEB J 19:1923-5. 2005
..These results are consistent with the amyloid hypothesis of AD and extend it to include widespread protein insolubility, not exclusively Abeta insolubility, early in AD pathogenesis even before the onset of clinical dementia...
- Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity
Randall L Woltjer
Department of Pathology, University of Washington, Seattle, 98104, USA
J Neurochem 93:1047-56. 2005
..These data suggest that antioxidants may serve as 'Abeta targeting' therapies that suppress toxic protein aggregation rather than simply acting as downstream radical scavengers...
- Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent
Thomas J Montine
Department of Pathology, Vanderbilt University, Nashville, Tennessee, USA
J Neurochem 83:463-70. 2002
..These results suggest the EP2 receptor as a therapeutic target to limit oxidative damage from activation of innate immunity in cerebrum...
Neuropathology in the adult changes in thought study: a reviewJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA 98104 2420, USA
J Alzheimers Dis 18:703-11. 2009
..This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease...
- Blood pressure and brain injury in older adults: findings from a community-based autopsy study
Lucy Y Wang
Mental Illness Research and Education Clinical Center, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington 98108, USA
J Am Geriatr Soc 57:1975-81. 2009
..To examine correlations between blood pressure (BP) and dementia-related pathological brain changes in a community-based autopsy sample...
- Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects
Ge Li
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
PLoS ONE 4:e5424. 2009
..01). CONCLUSIONS/SIGNIFICANCE: Reduced CSF BDNF was associated with age-related cognitive decline, suggesting a potential mechanism that may contribute in part to cognitive decline in older individuals...
- Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment
Randall L Woltjer
Department of Pathology, University of Washington, Box 359645, Harborview Medical Center, 300 Ninth Avenue, Seattle, WA 98104, USA
Neurobiol Dis 25:427-37. 2007
..These results suggest that protein misfolding associated with overexpression of APP CTFs promotes oxidative stress and cytotoxicity and contributes to formation of detergent-insoluble species that appear unrelated to cytotoxicity...
- Detergent-insoluble EAAC1/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer's disease patients
Kevin Duerson
Geriatric Research Education and Clinical Center, VA Medical Center, 1660 S Columbian Way, Seattle, WA 98108, USA
Brain Pathol 19:267-78. 2009
....
- ADAM10 expression and promoter haplotype in Alzheimer's disease
Lynn M Bekris
Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA, USA
Neurobiol Aging 33:2229.e1-2229.e9. 2012
..Taken together, these findings suggest that ADAM10 expression is modulated according to a promoter haplotype that is influenced in a brain region- and cell type-specific manner...
- Complement 3 and factor h in human cerebrospinal fluid in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy
Yu Wang
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
Am J Pathol 178:1509-16. 2011
..Both C3 and FH correlated with the severity of impairment in AD as indicated using Mini-Mental State Examination scores...
- Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease
Jing Zhang
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
J Alzheimers Dis 7:125-33; discussion 173-80. 2005
....
- High-intensity physical activity modulates diet effects on cerebrospinal amyloid-β levels in normal aging and mild cognitive impairment
Laura D Baker
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 28:137-46. 2012
..Exercise may thus interact with diet to alter pathological processes that ultimately modify risk of Alzheimer's disease...
- CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases
Jing Zhang
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
Am J Clin Pathol 129:526-9. 2008
..This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD...
- DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
Zhen Hong
Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
Brain 133:713-26. 2010
..We have demonstrated that total DJ-1 and alpha-synuclein in human cerebrospinal fluid are helpful diagnostic markers for Parkinson's disease, if variables such as blood contamination and age are taken into consideration...
- Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid
Robert G Riekse
Department of Medicine, Division of Geriatric Medicine, University of Washington School of Medicine, and VA Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 10:399-406. 2006
..CONCLUSIONS: Statins may modulate the phosphorylation of tau in humans and this effect may depend on the CNS availability of the statin. These results suggest another mechanism by which statins may act to reduce the risk of AD...
- CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment
Thomas J Montine
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Mov Disord 25:2682-5. 2010
..01), whereas average CSF T-tau and P181-tau were unchanged or decreased. One-third of PD-CIND and one-half of PD-D patients had the biomarker signature of AD. Abnormal metabolism of Aβ(42) may be a common feature of PD-CIND and PD-D...
- Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
Joshua A Sonnen
Department of Pathology, University of Washington, Seattle, USA
Ann Neurol 65:226-9. 2009
....
- Association between lifetime cigarette smoking and lewy body accumulation
Debby Tsuang
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98104, USA
Brain Pathol 20:412-8. 2010
..Although cigarette smoking is too toxic to suggest as a treatment, if confirmed, these findings may guide future therapeutic strategies that attempt to suppress LRP in human brain by other means...
- Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation
Eiron Cudaback
Department of Pathology, University of Washington, Seattle, WA 98104, USA
J Neuroinflammation 9:192. 2012
..Here we tested the hypothesis that APOE-genotype dependent innate immunomodulation may be mediated in part by apoC-I...
- Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein
Qin Wang
Department of Pathology, Division of Neuropathology, University of Washington, Seattle, Washington 98105, USA
FASEB J 19:869-71. 2005
....
- Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial
Suzanne Craft
Geriatric Research, Education, and Clinical Center, S 182, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Arch Neurol 69:29-38. 2012
..To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD)...
- Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein
Jinghua Jin
Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
J Neuroinflammation 4:2. 2007
..It has been demonstrated that aggregated alpha-synuclein potently activates microglia and causes neurotoxicity. However, the mechanisms by which aggregated alpha-synuclein activates microglia are not understood fully...
- The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration
Chang En Yu
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Arch Neurol 67:161-70. 2010
..However, it is unclear whether some rare FTD-related GRN variants are pathogenic and whether neurodegenerative disorders other than FTD can also be caused by GRN mutations...
- Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK
Izumi Maezawa
Department of Pathology, University of Washington, Seattle, Washington 98104, USA
FASEB J 20:797-9. 2006
..These findings suggest a new mechanism by which inheritance of different APOE alleles may influence the outcome of neurodegenerative diseases associated with microglial innate immune response...
- Cerebrospinal fluid biomarkers and cognitive performance in non-demented patients with Parkinson's disease
James B Leverenz
Mental Illness Research, Education, and Clinical Center of Veterans Administration, Seattle, WA, USA
Parkinsonism Relat Disord 17:61-4. 2011
....
- Proteomic identification of novel proteins in cortical lewy bodies
James B Leverenz
Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98104, USA
Brain Pathol 17:139-45. 2007
..Further investigation of these novel candidates is also necessary to ensure that the potential proteins in cortical LBs are not identified incorrectly because of incomplete current human protein database...
- APOE ε4 increases risk for dementia in pure synucleinopathies
Debby Tsuang
Veterans Affairs Puget Sound Health Care System, Seattle, WA98108, USA
JAMA Neurol 70:223-8. 2013
..The elevated ϵ4 frequency in the pDLB and PDD groups, in which the overall brain neuritic plaque burden was low, indicates that apoE might contribute to neurodegeneration through mechanisms unrelated to amyloid processing...
- Pathological correlates of dementia in a longitudinal, population-based sample of aging
Joshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA, USA
Ann Neurol 62:406-13. 2007
..Our goal was to determine the independent pathological correlates associated with dementia in a typical US population...
- Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults
Nadia Postupna
Department of Pathology, University of Washington, Seattle, USA
Brain Pathol 22:472-84. 2012
....
- Apolipoprotein E isoform-dependent microglia migration
Eiron Cudaback
Department of Pathology, Neuropathology Division, University of Washington, Seattle, Washington, USA
FASEB J 25:2082-91. 2011
..This study, for the first time, demonstrates apoE dependence and apoE isoform-specific modulation of microglial migration in response to distinct chemotactic stimuli commonly associated with neurodegenerative disease...
- Ecology of the aging human brain
Joshua A Sonnen
Department of Pathology, University of Washington, Seattle, 98104, USA
Arch Neurol 68:1049-56. 2011
..Alzheimer disease, cerebral vascular brain injury, and isocortical Lewy body disease (LBD) are the major contributors to dementia in community- and population-based studies...
- Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease
Randall L Woltjer
Department of Pathology, Oregon Health and Sciences Univ, Portland, Oregon, USA
J Neuropathol Exp Neurol 69:667-76. 2010
..These findings lend further support to the idea that dysregulation of the glutamatergic system may play a significant role in AD pathogenesis...
- Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice
Jamil A Haque
Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
Lab Invest 90:1704-17. 2010
..Thus, metabolic adaptations resulting from severe GSH deficiency seem to protect against the development of steatohepatitis...
- Increased cerebrospinal fluid F2-isoprostanes are associated with aging and latent Alzheimer's disease as identified by biomarkers
Thomas J Montine
Department of Pathology, University of Washington, Seattle, WA, USA
Neuromolecular Med 13:37-43. 2011
..01). These results show that CSF F(2)-IsoPs increased across the human lifespan and that this age-related increase in free radical injury to brain persisted after culling those with laboratory evidence of latent AD...
- Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype
Suman Jayadev
Department of Neurology, University of Washington, Seattle, WA, USA
Ann Neurol 69:712-20. 2011
..To describe the Alzheimer disease (AD)-like clinical and pathological features, including marked neurofibrillary tangle (NFT) pathology, of a familial prion disease due to a rare nonsense mutation of the prion gene (PRNP)...
- Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid
Jing Zhang
Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
Neurobiol Aging 26:207-27. 2005
..These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases...
- Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy
Wan Yang
Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
Am J Pathol 171:993-1002. 2007
..These results show that frontal and temporal cortex in PDC is distinguished from AD and PSP by its accumulation of abnormal SNCA and suggest that PDC be considered a synucleinopathy as well as a tauopathy...
- Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease
Thomas J Montine
Department of Pathology, University of Washington, Seattle, WA 98104, USA
J Alzheimers Dis 8:359-67. 2005
..In addition, measurement of CSF F2-IsoPs can increase the accuracy of laboratory-based classification of geriatric dementias, and have been used to assess objectively the response to anti-oxidant interventions in AD...
- Microglial EP2 as a new target to increase amyloid beta phagocytosis and decrease amyloid beta-induced damage to neurons
Feng-Shiun Shie
Department of Pathology, University of Washington, Seattle 98104, USA
Brain Pathol 15:134-8. 2005
..These data point to microglial EP2 as a more focused target within the PG pathway for therapy in AD...
- F2-isoprostanes in Alzheimer and other neurodegenerative diseases
Thomas J Montine
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Antioxid Redox Signal 7:269-75. 2005
..These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD, and that CSF F2-IsoPs may aid in the assessment of antioxidant experimental therapeutics and laboratory diagnosis of AD...
- Suppression of murine cerebral F2-isoprostanes and F4-neuroprostanes from excitotoxicity and innate immune response in vivo by alpha- or gamma-tocopherol
Dejan Milatovic
Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
J Chromatogr B Analyt Technol Biomed Life Sci 827:88-93. 2005
..These data imply that AT may be more broadly protective of cerebrum from oxidative damage in different disease contexts...
- Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum
Dejan Milatovic
Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
J Neurochem 87:1518-26. 2003
....
- Analysis of alpha-synuclein-associated proteins by quantitative proteomics
Yong Zhou
Department of Pathology and Medicinal Chemistry, University of Washington School of Medicine, Seattle, Washington 98104, USA
J Biol Chem 279:39155-64. 2004
..Furthermore, the protection afforded by hsp70 transfection appeared to be related to suppression of rotenone-induced oxidative stress as well as mitochondrial and proteasomal dysfunction...
- Characterization of proteome of human cerebrospinal fluid
Jing Xu
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Int Rev Neurobiol 73:29-98. 2006
- Proteomics of human neurodegenerative diseases
Jing Zhang
Department of Pathology, University of Washington, Harborview Medical Centre, Seattle, Washington 98104, USA
J Neuropathol Exp Neurol 67:923-32. 2008
..Here, we review the fundamentals of commonly used proteomic approaches and the outcomes of these investigations with autopsy and cerebrospinal fluid samples from patients with neurodegenerative diseases...
- APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure
Lynn M Bekris
Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
Am J Med Genet B Neuropsychiatr Genet 153:409-17. 2010
....
- Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases
Kathleen S Montine
Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, 325 9th Ave, Seattle, WA 98104, USA
Chem Phys Lipids 128:117-24. 2004
..These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD and HD, that CSF IsoPs may aid in the assessment of anti-oxidant experimental therapeutics and laboratory diagnosis of AD...
- Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2
C Dirk Keene
Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104, USA
Am J Pathol 174:2300-9. 2009
....
- Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment
Jennifer L Bayer-Carter
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Arch Neurol 68:743-52. 2011
....
- Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity
Izumi Maezawa
Department of Pathology, University of Washington, Seattle, Washington 98104, USA
J Neurochem 91:1312-21. 2004
....
- Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease
C Dirk Keene
Department of Pathology, University of Washington, Seattle, WA, United States
Curr Opin Neurobiol 21:920-8. 2011
....
- Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity
Feng Shiun Shie
Department of Pathology, University of Washington, Box 359645, Harborview Medical Center, 325 9th Ave, Seattle, WA 98104, USA
Am J Pathol 166:1163-72. 2005
..These data demonstrate that blockade of microglial EP2 is a highly desirable mechanism for AD therapy that can maximize neuroprotective actions while minimizing bystander damage to neurons...
- Liquid chromatography with tandem mass spectrometry-based proteomic discovery in aging and Alzheimer's disease
Thomas J Montine
Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
NeuroRx 3:336-43. 2006
..As protocols and methods for improved quantitative high-throughput proteomics constantly improve, this approach will likely continue to provide deeper insight into human brain aging and neurodegenerative diseases...
- Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progression
Min Shi
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
Am J Pathol 175:54-65. 2009
..These results have, for the first time, suggested that the levels of glutathione S-transferase Pi may play an important role in modulating the progression of PD...
- Glycoproteomics in neurodegenerative diseases
Hyejin Hwang
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Mass Spectrom Rev 29:79-125. 2010
....
- Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor subtype 2-null bone marrow
C Dirk Keene
Harborview Medical Center, Box 359645, 325 Ninth Ave, Seattle, WA 98104, USA
Am J Pathol 177:346-54. 2010
..Our results provide a foundation for an adult stem cell-based therapy to suppress soluble Abeta peptide and plaque accumulation in the cerebrum of patients with AD...
- A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectrometry
Sheng Pan
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Proteomics 7:469-73. 2007
..In total, 2594 proteins were identified in well-characterized pooled human CSF samples using stringent proteomics criteria. This report summarizes our efforts to comprehensively characterize the human CSF proteome to date...
- A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesions
C Dirk Keene
Department of Pathology, Harborview Medical Center, University of Washington Medical Center, Seattle, 98104, USA
Acta Neuropathol 117:329-38. 2009
..This report, for the first time, highlights the potential for graft overgrowth in a patient receiving fetal neural transplantation...
- Biomarkers for cognitive impairment and dementia in elderly people
Joshua A Sonnen
Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104, USA
Lancet Neurol 7:704-14. 2008
..An approach that efficiently combines independent information from risk-factor assessment, neuroimaging measures, and biomarkers might soon guide clinicians in the early diagnosis and management of cognitive impairment in elderly people...
- Parkinson-dementia complex and development of a new stable isotope dilution assay for BMAA detection in tissue
Laura R Snyder
Department of Chemistry, University of Washington, Seattle, WA, USA
Toxicol Appl Pharmacol 240:180-8. 2009
..These studies demonstrate the importance of a sensitive and specific assay for tissue BMAA and seriously challenge the proposal that BMAA is accumulating in human brain...
- Lewy body pathology in late-onset familial Alzheimer's disease: a clinicopathological case series
Debby W Tsuang
Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 9:235-42. 2006
..Lewy body pathology (LBP) is a common finding in Alzheimer's disease (AD), but the pathophysiology for this coexistent pathology remains unclear...
- Pathologic correlates of dementia in individuals with Lewy body disease
Joshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Brain Pathol 20:654-9. 2010
..Diseases contributing to cognitive impairment and dementia in patients with bLBD are heterogeneous, providing diagnostic challenges as well as multiple opportunities for successful intervention in patients with PD...
- Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models
Joshua A Sonnen
Department of Pathology and of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
Free Radic Biol Med 45:219-30. 2008
..Future efforts in preclinical models and ultimately clinical trials are needed to define optimally effective agents and combinations, doses, and timing to suppress safely this facet of AD...
- F2-dihomo-isoprostanes arise from free radical attack on adrenic acid
Mike VanRollins
Department of Pathology, University of Washington, Seattle, WA, USA
J Lipid Res 49:995-1005. 2008
..We propose that F2-dihomo-IsoPs may serve as quantitative in vivo biomarkers of free radical damage to myelin from primate white matter...
- Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease
Thomas J Montine
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Ann Neurol 52:175-9. 2002
..These results should guide the organization of clinical trials now being planned for patients with Alzheimer's disease...
- Biomarkers for Alzheimer's disease
Joshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
Expert Rev Neurother 7:1021-8. 2007
..The next 5 years will see standardization of more established approaches, and the combination of different modalities into the most effective means for assessing different stages of AD...
- Cerebrospinal fluid biomarkers in mild cognitive impairment and dementia
Joshua A Sonnen
Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104 2420, USA
J Alzheimers Dis 19:301-9. 2010
..A multimodal approach that brings independent information from risk factor assessment, neuroimaging, and biomarkers may soon guide physicians in the early diagnosis and management of cognitive impairment in the elderly...
- Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE
Joseph F Pulliam
Department of Pathology, University of Kentucky, Lexington, Kentucky 40536, USA
Am J Med Genet B Neuropsychiatr Genet 119:48-53. 2003
....
- DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain
Patrick J Cimino
Division of Neuropathology, Department of Pathology, the Neurobiology and Behavior Program, University of Washington, Box 359645, Harborview Medical Center, Seattle, WA 98104, USA
Am J Pathol 175:1622-30. 2009
..Together, these results suggest DOCK2 as a COX2 expression-independent therapeutic target for neurodegenerative diseases such as AD...
- Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults
Mark A Fishel
Department of Neurology, University of Washington, Seattle, WA 98108, USA
Arch Neurol 62:1539-44. 2005
..05). CONCLUSION: Moderate hyperinsulinemia can elevate inflammatory markers and Abeta42 in the periphery and the brain, thereby potentially increasing the risk of Alzheimer disease...
- Mouse cerebral prostaglandins, but not oxidative damage, change with age and are responsive to indomethacin treatment
Kathleen S Montine
Department of Pathology, Vanderbilt University Medical Center, C3321 A Medical Center North, Nashville, TN 37232, USA
Brain Res 930:75-82. 2002
..These results suggest that indomethacin may influence the initiation of AD by reducing cerebral PG elevation that may occur in middle age, but that it is unlikely to have a direct effect on levels of oxidative damage...
- Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders
Guangyu Gu
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561, USA
J Neuropathol Exp Neurol 61:634-9. 2002
..These data suggest that accumulation of total mtDNA deletions/rearrangements is a relatively specific characteristic of PD and may be one of the contributing factors leading to mitochondrial dysfunction and neurodegeneration in PD...
- Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanes
Dejan Milatovic
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Neurovirol 8:295-305. 2002
....
- F(2)-isoprostanes as biomarkers of late-onset Alzheimer's disease
Thomas J Montine
Department of Pathology, University of Washington, Seattle, WA 98104, USA
J Mol Neurosci 33:114-9. 2007
..CSF F(2)-IsoPs may be used to assist in diagnosis and aid in objective assessment of disease progression and response to therapeutics in patients with AD...
- Cerebrospinal fluid lipoprotein delivery to human neuronal cells is increased in Alzheimer's disease and is dependent on apoE monomer concentration
Casey N Bassett
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Alzheimers Dis 4:19-30. 2002
....
- Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype
James B Leverenz
Parkinson s Disease, Mental Illness Research, Education, and Clinical Centers, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA
Arch Neurol 63:370-6. 2006
..The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood...
- Fatty acid oxidation in the pathogenesis of Alzheimer's disease
Thomas J Montine
Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104, USA
Am J Pathol 166:1283-9. 2005
..If successful, these interventions are unlikely to cure AD, but may check its explosive growth and hopefully reduce its incidence and prevalence in the elderly...
- Advanced glycation endproduct precursor alters intracellular amyloid-beta/A beta PP carboxy-terminal fragment aggregation and cytotoxicity
Randall L Woltjer
Department of Pathology, University of Washington, Seattle, Washington 98104, USA
J Alzheimers Dis 5:467-76. 2003
....
- Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC
Thomas J Montine
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Neurology 65:768-9. 2005
..In contrast to others, they detected no free BMAA in any of these samples...
- Carbofuran-induced oxidative stress in slow and fast skeletal muscles: prevention by memantine and atropine
Dejan Milatovic
University Washington, Seattle, WA, USA
Toxicology 208:13-24. 2005
..MEM and ATS prevent the carbofuran-induced chain of events involved in oxidative stress...
