Thomas J Montine

Summary

Publications

  1. pmc Adult Changes in Thought study: dementia is an individually varying convergent syndrome with prevalent clinically silent diseases that may be modified by some commonly used therapeutics
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Curr Alzheimer Res 9:718-23. 2012
  2. pmc Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e9340. 2010
  3. pmc Prevalence estimates for latent neurodegenerative disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Toxicol Pathol 39:99-102. 2011
  4. pmc National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach
    Thomas J Montine
    Department of Pathology, University of Washington School of Medicine, Box 359791, Seattle, WA 98104, USA
    Acta Neuropathol 123:1-11. 2012
  5. pmc Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease
    Jake G Hoekstra
    Department of Pathology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA
    Alzheimers Res Ther 3:21. 2011
  6. pmc Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, 98104, USA
    Ann Neurol 69:570-80. 2011
  7. ncbi request reprint Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity
    Feng Shiun Shie
    Department of Pathology, University of Washington, Seattle, Washington, USA
    Glia 52:70-7. 2005
  8. pmc Different patterns of cerebral injury in dementia with or without diabetes
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Arch Neurol 66:315-22. 2009
  9. ncbi request reprint Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease
    Randall L Woltjer
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA
    FASEB J 19:1923-5. 2005
  10. ncbi request reprint Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity
    Randall L Woltjer
    Department of Pathology, University of Washington, Seattle, 98104, USA
    J Neurochem 93:1047-56. 2005

Collaborators

Detail Information

Publications96

  1. pmc Adult Changes in Thought study: dementia is an individually varying convergent syndrome with prevalent clinically silent diseases that may be modified by some commonly used therapeutics
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Curr Alzheimer Res 9:718-23. 2012
    ....
  2. pmc Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e9340. 2010
    ....
  3. pmc Prevalence estimates for latent neurodegenerative disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Toxicol Pathol 39:99-102. 2011
    ..The latent stage of diseases that commonly cause dementia is highly prevalent in the adult population, highlighting the need for prevention strategies and longitudinal studies...
  4. pmc National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach
    Thomas J Montine
    Department of Pathology, University of Washington School of Medicine, Box 359791, Seattle, WA 98104, USA
    Acta Neuropathol 123:1-11. 2012
    ..Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations...
  5. pmc Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease
    Jake G Hoekstra
    Department of Pathology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA
    Alzheimers Res Ther 3:21. 2011
    ..Recent discoveries pertaining to mitochondrial dynamics reveal that regulation of mitochondrial fission and fusion may play a key role in the pathogenesis of these diseases and consequently could be novel future therapeutic targets...
  6. pmc Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, 98104, USA
    Ann Neurol 69:570-80. 2011
    ..We and others have demonstrated that a decrease in DJ-1 and/or α-synuclein in the cerebrospinal fluid (CSF) is a potential index for Parkinson disease diagnosis, but not for PD severity...
  7. ncbi request reprint Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity
    Feng Shiun Shie
    Department of Pathology, University of Washington, Seattle, Washington, USA
    Glia 52:70-7. 2005
    ..EP2 should be considered as a therapeutic target for suppression of microglial innate immunity-mediated damage in neurodegenerative diseases...
  8. pmc Different patterns of cerebral injury in dementia with or without diabetes
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Arch Neurol 66:315-22. 2009
    ..Diabetes mellitus (DM) increases the risk of dementia in the elderly. However, its underlying mechanisms, its connection with Alzheimer disease and vascular cognitive impairment, and effects of therapy remain unclear...
  9. ncbi request reprint Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease
    Randall L Woltjer
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA
    FASEB J 19:1923-5. 2005
    ..These results are consistent with the amyloid hypothesis of AD and extend it to include widespread protein insolubility, not exclusively Abeta insolubility, early in AD pathogenesis even before the onset of clinical dementia...
  10. ncbi request reprint Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity
    Randall L Woltjer
    Department of Pathology, University of Washington, Seattle, 98104, USA
    J Neurochem 93:1047-56. 2005
    ..These data suggest that antioxidants may serve as 'Abeta targeting' therapies that suppress toxic protein aggregation rather than simply acting as downstream radical scavengers...
  11. ncbi request reprint Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent
    Thomas J Montine
    Department of Pathology, Vanderbilt University, Nashville, Tennessee, USA
    J Neurochem 83:463-70. 2002
    ..These results suggest the EP2 receptor as a therapeutic target to limit oxidative damage from activation of innate immunity in cerebrum...
  12. pmc APOE3, but not APOE4, bone marrow transplantation mitigates behavioral and pathological changes in a mouse model of Alzheimer disease
    Yue Yang
    Department of Pathology, University of Washington, Seattle, Washington, USA
    Am J Pathol 183:905-17. 2013
    ..Together, these findings suggest that BMT-derived APOE3-expressing cells are superior to those that express APOE4 in their ability to mitigate the behavioral and neuropathological changes in experimental Alzheimer disease. ..
  13. pmc Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial
    Angela J Hanson
    Geriatric Research, Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Washington, USA
    JAMA Neurol 70:972-80. 2013
    ..Lipid-depleted (LD) apolipoproteins are less effective at binding and clearing Aβ, and LD Aβ peptides are more toxic to neurons. However, not much is known about the lipid states of these proteins in human cerebrospinal fluid...
  14. pmc Neuropathology in the adult changes in thought study: a review
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 18:703-11. 2009
    ..This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease...
  15. pmc Blood pressure and brain injury in older adults: findings from a community-based autopsy study
    Lucy Y Wang
    Mental Illness Research and Education Clinical Center, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington 98108, USA
    J Am Geriatr Soc 57:1975-81. 2009
    ..To examine correlations between blood pressure (BP) and dementia-related pathological brain changes in a community-based autopsy sample...
  16. pmc Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 4:e5424. 2009
    ..We tested hypothesis that reduced CSF BDNF is associated with age-related cognitive decline...
  17. pmc Detergent-insoluble EAAC1/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer's disease patients
    Kevin Duerson
    Geriatric Research Education and Clinical Center, VA Medical Center, 1660 S Columbian Way, Seattle, WA 98108, USA
    Brain Pathol 19:267-78. 2009
    ....
  18. ncbi request reprint Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment
    Randall L Woltjer
    Department of Pathology, University of Washington, Box 359645, Harborview Medical Center, 300 Ninth Avenue, Seattle, WA 98104, USA
    Neurobiol Dis 25:427-37. 2007
    ..These results suggest that protein misfolding associated with overexpression of APP CTFs promotes oxidative stress and cytotoxicity and contributes to formation of detergent-insoluble species that appear unrelated to cytotoxicity...
  19. pmc ADAM10 expression and promoter haplotype in Alzheimer's disease
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 33:2229.e1-2229.e9. 2012
    ..Taken together, these findings suggest that ADAM10 expression is modulated according to a promoter haplotype that is influenced in a brain region- and cell type-specific manner...
  20. ncbi request reprint Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease
    Jing Zhang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    J Alzheimers Dis 7:125-33; discussion 173-80. 2005
    ....
  21. pmc Complement 3 and factor h in human cerebrospinal fluid in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy
    Yu Wang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Am J Pathol 178:1509-16. 2011
    ..Both C3 and FH correlated with the severity of impairment in AD as indicated using Mini-Mental State Examination scores...
  22. pmc Cerebrospinal fluid biomarkers and cognitive performance in non-demented patients with Parkinson's disease
    James B Leverenz
    Mental Illness Research, Education, and Clinical Center of Veterans Administration, Seattle, WA, USA
    Parkinsonism Relat Disord 17:61-4. 2011
    ....
  23. pmc High-intensity physical activity modulates diet effects on cerebrospinal amyloid-β levels in normal aging and mild cognitive impairment
    Laura D Baker
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 28:137-46. 2012
    ..Exercise may thus interact with diet to alter pathological processes that ultimately modify risk of Alzheimer's disease...
  24. pmc Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Ann Neurol 65:226-9. 2009
    ....
  25. pmc CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases
    Jing Zhang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Am J Clin Pathol 129:526-9. 2008
    ..This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD...
  26. pmc CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment
    Thomas J Montine
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mov Disord 25:2682-5. 2010
    ..01), whereas average CSF T-tau and P181-tau were unchanged or decreased. One-third of PD-CIND and one-half of PD-D patients had the biomarker signature of AD. Abnormal metabolism of Aβ(42) may be a common feature of PD-CIND and PD-D...
  27. pmc Association between lifetime cigarette smoking and lewy body accumulation
    Debby Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 20:412-8. 2010
    ..Although cigarette smoking is too toxic to suggest as a treatment, if confirmed, these findings may guide future therapeutic strategies that attempt to suppress LRP in human brain by other means...
  28. pmc DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    Zhen Hong
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
    Brain 133:713-26. 2010
    ..We have demonstrated that total DJ-1 and alpha-synuclein in human cerebrospinal fluid are helpful diagnostic markers for Parkinson's disease, if variables such as blood contamination and age are taken into consideration...
  29. ncbi request reprint Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid
    Robert G Riekse
    Department of Medicine, Division of Geriatric Medicine, University of Washington School of Medicine, and VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 10:399-406. 2006
    ..Putative neuroprotective effects of statins may vary in relation to their ability to penetrate into the central nervous system (CNS)...
  30. pmc Glucose levels and risk of dementia
    Paul K Crane
    Department of Medicine, University of Washington, Seattle, WA, USA
    N Engl J Med 369:540-8. 2013
    ..Diabetes is a risk factor for dementia. It is unknown whether higher glucose levels increase the risk of dementia in people without diabetes...
  31. pmc APOE ε4 increases risk for dementia in pure synucleinopathies
    Debby Tsuang
    Veterans Affairs Puget Sound Health Care System, Seattle, WA98108, USA
    JAMA Neurol 70:223-8. 2013
    ..To test for an association between the apolipoprotein E (APOE) ϵ4 allele and dementias with synucleinopathy...
  32. pmc Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation
    Eiron Cudaback
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Neuroinflammation 9:192. 2012
    ..Here we tested the hypothesis that APOE-genotype dependent innate immunomodulation may be mediated in part by apoC-I...
  33. ncbi request reprint Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein
    Qin Wang
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, Washington 98105, USA
    FASEB J 19:869-71. 2005
    ....
  34. ncbi request reprint Proteomic identification of novel proteins in cortical lewy bodies
    James B Leverenz
    Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 17:139-45. 2007
    ..Further investigation of these novel candidates is also necessary to ensure that the potential proteins in cortical LBs are not identified incorrectly because of incomplete current human protein database...
  35. pmc The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 67:161-70. 2010
    ..However, it is unclear whether some rare FTD-related GRN variants are pathogenic and whether neurodegenerative disorders other than FTD can also be caused by GRN mutations...
  36. ncbi request reprint Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK
    Izumi Maezawa
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    FASEB J 20:797-9. 2006
    ..These findings suggest a new mechanism by which inheritance of different APOE alleles may influence the outcome of neurodegenerative diseases associated with microglial innate immune response...
  37. pmc Pacific Northwest Udall Center of excellence clinical consortium: study design and baseline cohort characteristics
    Brenna A Cholerton
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98493, USA
    J Parkinsons Dis 3:205-14. 2013
    ....
  38. pmc Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    J Neuroinflammation 4:2. 2007
    ..It has been demonstrated that aggregated alpha-synuclein potently activates microglia and causes neurotoxicity. However, the mechanisms by which aggregated alpha-synuclein activates microglia are not understood fully...
  39. pmc Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, S 182, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 69:29-38. 2012
    ..To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD)...
  40. pmc Antagonism of neuronal prostaglandin E(2) receptor subtype 1 mitigates amyloid β neurotoxicity in vitro
    Xianwu Li
    Department of Pathology, University of Washington, Box 359645, Seattle, WA 98104, USA
    J Neuroimmune Pharmacol 8:87-93. 2013
    ..Based on these data, we conclude that suppressing neuronal EP1 signaling may represent a promising therapeutic approach to ameliorate Aβ peptide neurotoxicity...
  41. pmc Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease
    Patrick J Cimino
    Department of Pathology, University of Washington, Seattle, WA 63110 1093, USA
    Exp Mol Pathol 94:366-71. 2013
    ..In combination with earlier cell culture results, our in vivo results presented here suggest DOCK2 contributes to Aβ plaque burden via regulation of microglial innate immune function and may represent a novel therapeutic target for AD...
  42. pmc DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease
    Xiangmin Lin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Sci Rep 2:954. 2012
    ....
  43. pmc Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults
    Nadia Postupna
    Department of Pathology, University of Washington, Seattle, USA
    Brain Pathol 22:472-84. 2012
    ....
  44. ncbi request reprint Suppression of murine cerebral F2-isoprostanes and F4-neuroprostanes from excitotoxicity and innate immune response in vivo by alpha- or gamma-tocopherol
    Dejan Milatovic
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 827:88-93. 2005
    ..These data imply that AT may be more broadly protective of cerebrum from oxidative damage in different disease contexts...
  45. pmc Apolipoprotein E isoform-dependent microglia migration
    Eiron Cudaback
    Department of Pathology, Neuropathology Division, University of Washington, Seattle, Washington, USA
    FASEB J 25:2082-91. 2011
    ..This study, for the first time, demonstrates apoE dependence and apoE isoform-specific modulation of microglial migration in response to distinct chemotactic stimuli commonly associated with neurodegenerative disease...
  46. pmc Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype
    Suman Jayadev
    Department of Neurology, University of Washington, Seattle, WA, USA
    Ann Neurol 69:712-20. 2011
    ..To describe the Alzheimer disease (AD)-like clinical and pathological features, including marked neurofibrillary tangle (NFT) pathology, of a familial prion disease due to a rare nonsense mutation of the prion gene (PRNP)...
  47. ncbi request reprint Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Alzheimers Dis 8:359-67. 2005
    ..In addition, measurement of CSF F2-IsoPs can increase the accuracy of laboratory-based classification of geriatric dementias, and have been used to assess objectively the response to anti-oxidant interventions in AD...
  48. ncbi request reprint Microglial EP2 as a new target to increase amyloid beta phagocytosis and decrease amyloid beta-induced damage to neurons
    Feng Shiun Shie
    Department of Pathology, University of Washington, Seattle 98104, USA
    Brain Pathol 15:134-8. 2005
    ..These data point to microglial EP2 as a more focused target within the PG pathway for therapy in AD...
  49. ncbi request reprint Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid
    Jing Zhang
    Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
    Neurobiol Aging 26:207-27. 2005
    ..These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases...
  50. ncbi request reprint F2-isoprostanes in Alzheimer and other neurodegenerative diseases
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Antioxid Redox Signal 7:269-75. 2005
    ..These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD, and that CSF F2-IsoPs may aid in the assessment of antioxidant experimental therapeutics and laboratory diagnosis of AD...
  51. pmc Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease
    Randall L Woltjer
    Department of Pathology, Oregon Health and Sciences Univ, Portland, Oregon, USA
    J Neuropathol Exp Neurol 69:667-76. 2010
    ..These findings lend further support to the idea that dysregulation of the glutamatergic system may play a significant role in AD pathogenesis...
  52. pmc Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice
    Jamil A Haque
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Lab Invest 90:1704-17. 2010
    ..Thus, metabolic adaptations resulting from severe GSH deficiency seem to protect against the development of steatohepatitis...
  53. pmc Ecology of the aging human brain
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, 98104, USA
    Arch Neurol 68:1049-56. 2011
    ..Alzheimer disease, cerebral vascular brain injury, and isocortical Lewy body disease (LBD) are the major contributors to dementia in community- and population-based studies...
  54. pmc Increased cerebrospinal fluid F2-isoprostanes are associated with aging and latent Alzheimer's disease as identified by biomarkers
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA, USA
    Neuromolecular Med 13:37-43. 2011
    ..01). These results show that CSF F(2)-IsoPs increased across the human lifespan and that this age-related increase in free radical injury to brain persisted after culling those with laboratory evidence of latent AD...
  55. pmc Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy
    Wan Yang
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 171:993-1002. 2007
    ..These results show that frontal and temporal cortex in PDC is distinguished from AD and PSP by its accumulation of abnormal SNCA and suggest that PDC be considered a synucleinopathy as well as a tauopathy...
  56. ncbi request reprint Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum
    Dejan Milatovic
    Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    J Neurochem 87:1518-26. 2003
    ....
  57. pmc MicroRNA in Alzheimer's disease: an exploratory study in brain, cerebrospinal fluid and plasma
    Lynn M Bekris
    Department of Geriatric GRECC, Research, Education, and Clinical Centers, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Biomarkers 18:455-66. 2013
    ..Plasma miR-15a was found to be associated with plaque score in the independent sample. In conclusion, miRNA present in human biofluids may offer utility as biomarkers of AD...
  58. ncbi request reprint Pathological correlates of dementia in a longitudinal, population-based sample of aging
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA, USA
    Ann Neurol 62:406-13. 2007
    ..Our goal was to determine the independent pathological correlates associated with dementia in a typical US population...
  59. ncbi request reprint Characterization of proteome of human cerebrospinal fluid
    Jing Xu
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Int Rev Neurobiol 73:29-98. 2006
  60. pmc Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2
    C Dirk Keene
    Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 174:2300-9. 2009
    ....
  61. pmc APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure
    Lynn M Bekris
    Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Med Genet B Neuropsychiatr Genet 153:409-17. 2010
    ....
  62. ncbi request reprint Analysis of alpha-synuclein-associated proteins by quantitative proteomics
    Yong Zhou
    Department of Pathology and Medicinal Chemistry, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Biol Chem 279:39155-64. 2004
    ..Furthermore, the protection afforded by hsp70 transfection appeared to be related to suppression of rotenone-induced oxidative stress as well as mitochondrial and proteasomal dysfunction...
  63. pmc Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment
    Jennifer L Bayer-Carter
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 68:743-52. 2011
    ....
  64. pmc Proteomics of human neurodegenerative diseases
    Jing Zhang
    Department of Pathology, University of Washington, Harborview Medical Centre, Seattle, Washington 98104, USA
    J Neuropathol Exp Neurol 67:923-32. 2008
    ..Here, we review the fundamentals of commonly used proteomic approaches and the outcomes of these investigations with autopsy and cerebrospinal fluid samples from patients with neurodegenerative diseases...
  65. ncbi request reprint Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases
    Kathleen S Montine
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, 325 9th Ave, Seattle, WA 98104, USA
    Chem Phys Lipids 128:117-24. 2004
    ..These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD and HD, that CSF IsoPs may aid in the assessment of anti-oxidant experimental therapeutics and laboratory diagnosis of AD...
  66. ncbi request reprint Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity
    Izumi Maezawa
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Neurochem 91:1312-21. 2004
    ....
  67. pmc Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease
    C Dirk Keene
    Department of Pathology, University of Washington, Seattle, WA, United States
    Curr Opin Neurobiol 21:920-8. 2011
    ....
  68. pmc Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity
    Feng Shiun Shie
    Department of Pathology, University of Washington, Box 359645, Harborview Medical Center, 325 9th Ave, Seattle, WA 98104, USA
    Am J Pathol 166:1163-72. 2005
    ..These data demonstrate that blockade of microglial EP2 is a highly desirable mechanism for AD therapy that can maximize neuroprotective actions while minimizing bystander damage to neurons...
  69. ncbi request reprint Lewy body pathology in late-onset familial Alzheimer's disease: a clinicopathological case series
    Debby W Tsuang
    Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 9:235-42. 2006
    ..Lewy body pathology (LBP) is a common finding in Alzheimer's disease (AD), but the pathophysiology for this coexistent pathology remains unclear...
  70. pmc Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor subtype 2-null bone marrow
    C Dirk Keene
    Harborview Medical Center, Box 359645, 325 Ninth Ave, Seattle, WA 98104, USA
    Am J Pathol 177:346-54. 2010
    ..Our results provide a foundation for an adult stem cell-based therapy to suppress soluble Abeta peptide and plaque accumulation in the cerebrum of patients with AD...
  71. pmc Liquid chromatography with tandem mass spectrometry-based proteomic discovery in aging and Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    NeuroRx 3:336-43. 2006
    ..As protocols and methods for improved quantitative high-throughput proteomics constantly improve, this approach will likely continue to provide deeper insight into human brain aging and neurodegenerative diseases...
  72. pmc Biomarkers for cognitive impairment and dementia in elderly people
    Joshua A Sonnen
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104, USA
    Lancet Neurol 7:704-14. 2008
    ..An approach that efficiently combines independent information from risk-factor assessment, neuroimaging measures, and biomarkers might soon guide clinicians in the early diagnosis and management of cognitive impairment in elderly people...
  73. pmc A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesions
    C Dirk Keene
    Department of Pathology, Harborview Medical Center, University of Washington Medical Center, Seattle, 98104, USA
    Acta Neuropathol 117:329-38. 2009
    ..This report, for the first time, highlights the potential for graft overgrowth in a patient receiving fetal neural transplantation...
  74. ncbi request reprint A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectrometry
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Proteomics 7:469-73. 2007
    ..In total, 2594 proteins were identified in well-characterized pooled human CSF samples using stringent proteomics criteria. This report summarizes our efforts to comprehensively characterize the human CSF proteome to date...
  75. pmc Glycoproteomics in neurodegenerative diseases
    Hyejin Hwang
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Mass Spectrom Rev 29:79-125. 2010
    ....
  76. pmc Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progression
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Am J Pathol 175:54-65. 2009
    ..These results have, for the first time, suggested that the levels of glutathione S-transferase Pi may play an important role in modulating the progression of PD...
  77. pmc Parkinson-dementia complex and development of a new stable isotope dilution assay for BMAA detection in tissue
    Laura R Snyder
    Department of Chemistry, University of Washington, Seattle, WA, USA
    Toxicol Appl Pharmacol 240:180-8. 2009
    ..These studies demonstrate the importance of a sensitive and specific assay for tissue BMAA and seriously challenge the proposal that BMAA is accumulating in human brain...
  78. pmc Pathologic correlates of dementia in individuals with Lewy body disease
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 20:654-9. 2010
    ..Diseases contributing to cognitive impairment and dementia in patients with bLBD are heterogeneous, providing diagnostic challenges as well as multiple opportunities for successful intervention in patients with PD...
  79. pmc F2-dihomo-isoprostanes arise from free radical attack on adrenic acid
    Mike VanRollins
    Department of Pathology, University of Washington, Seattle, WA, USA
    J Lipid Res 49:995-1005. 2008
    ..We propose that F2-dihomo-IsoPs may serve as quantitative in vivo biomarkers of free radical damage to myelin from primate white matter...
  80. pmc Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models
    Joshua A Sonnen
    Department of Pathology and of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    Free Radic Biol Med 45:219-30. 2008
    ..Future efforts in preclinical models and ultimately clinical trials are needed to define optimally effective agents and combinations, doses, and timing to suppress safely this facet of AD...
  81. ncbi request reprint Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease
    Thomas J Montine
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Ann Neurol 52:175-9. 2002
    ..These results should guide the organization of clinical trials now being planned for patients with Alzheimer's disease...
  82. ncbi request reprint Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE
    Joseph F Pulliam
    Department of Pathology, University of Kentucky, Lexington, Kentucky 40536, USA
    Am J Med Genet B Neuropsychiatr Genet 119:48-53. 2003
    ....
  83. ncbi request reprint Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults
    Mark A Fishel
    Department of Neurology, University of Washington, Seattle, WA 98108, USA
    Arch Neurol 62:1539-44. 2005
    ..Hyperinsulinemia induces inflammation and is a risk factor for Alzheimer disease. Thus, insulin abnormalities may contribute to Alzheimer disease pathophysiology through effects on the inflammatory network...
  84. pmc DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain
    Patrick J Cimino
    Division of Neuropathology, Department of Pathology, the Neurobiology and Behavior Program, University of Washington, Box 359645, Harborview Medical Center, Seattle, WA 98104, USA
    Am J Pathol 175:1622-30. 2009
    ..Together, these results suggest DOCK2 as a COX2 expression-independent therapeutic target for neurodegenerative diseases such as AD...
  85. ncbi request reprint Biomarkers for Alzheimer's disease
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
    Expert Rev Neurother 7:1021-8. 2007
    ..The next 5 years will see standardization of more established approaches, and the combination of different modalities into the most effective means for assessing different stages of AD...
  86. pmc Cerebrospinal fluid biomarkers in mild cognitive impairment and dementia
    Joshua A Sonnen
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 19:301-9. 2010
    ..A multimodal approach that brings independent information from risk factor assessment, neuroimaging, and biomarkers may soon guide physicians in the early diagnosis and management of cognitive impairment in the elderly...
  87. ncbi request reprint F(2)-isoprostanes as biomarkers of late-onset Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Mol Neurosci 33:114-9. 2007
    ..CSF F(2)-IsoPs may be used to assist in diagnosis and aid in objective assessment of disease progression and response to therapeutics in patients with AD...
  88. ncbi request reprint Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders
    Guangyu Gu
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2561, USA
    J Neuropathol Exp Neurol 61:634-9. 2002
    ..These data suggest that accumulation of total mtDNA deletions/rearrangements is a relatively specific characteristic of PD and may be one of the contributing factors leading to mitochondrial dysfunction and neurodegeneration in PD...
  89. ncbi request reprint Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanes
    Dejan Milatovic
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Neurovirol 8:295-305. 2002
    ....
  90. ncbi request reprint Mouse cerebral prostaglandins, but not oxidative damage, change with age and are responsive to indomethacin treatment
    Kathleen S Montine
    Department of Pathology, Vanderbilt University Medical Center, C3321 A Medical Center North, Nashville, TN 37232, USA
    Brain Res 930:75-82. 2002
    ..These results suggest that indomethacin may influence the initiation of AD by reducing cerebral PG elevation that may occur in middle age, but that it is unlikely to have a direct effect on levels of oxidative damage...
  91. ncbi request reprint Cerebrospinal fluid lipoprotein delivery to human neuronal cells is increased in Alzheimer's disease and is dependent on apoE monomer concentration
    Casey N Bassett
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Alzheimers Dis 4:19-30. 2002
    ....
  92. ncbi request reprint Carbofuran-induced oxidative stress in slow and fast skeletal muscles: prevention by memantine and atropine
    Dejan Milatovic
    University Washington, Seattle, WA, USA
    Toxicology 208:13-24. 2005
    ..MEM and ATS prevent the carbofuran-induced chain of events involved in oxidative stress...
  93. pmc Fatty acid oxidation in the pathogenesis of Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 166:1283-9. 2005
    ..If successful, these interventions are unlikely to cure AD, but may check its explosive growth and hopefully reduce its incidence and prevalence in the elderly...
  94. ncbi request reprint Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Neurology 65:768-9. 2005
    ..In contrast to others, they detected no free BMAA in any of these samples...
  95. pmc Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype
    James B Leverenz
    Parkinson s Disease, Mental Illness Research, Education, and Clinical Centers, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA
    Arch Neurol 63:370-6. 2006
    ..The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood...
  96. ncbi request reprint Advanced glycation endproduct precursor alters intracellular amyloid-beta/A beta PP carboxy-terminal fragment aggregation and cytotoxicity
    Randall L Woltjer
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Alzheimers Dis 5:467-76. 2003
    ....