Norihito Moniwa

Summary

Publications

  1. pmc Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension
    Norihito Moniwa
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hypertension 61:417-24. 2013
  2. pmc Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats
    Norihito Moniwa
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ther Adv Cardiovasc Dis 6:15-29. 2012
  3. pmc Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University, Winston Salem, NC, USA
    Am J Hypertens 26:583-90. 2013
  4. pmc Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism
    Norihito Moniwa
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina
    Am J Physiol Heart Circ Physiol 305:H644-50. 2013
  5. pmc Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Hypertens 30:1766-74. 2012
  6. pmc Chymase mediates angiotensin-(1-12) metabolism in normal human hearts
    Sarfaraz Ahmad
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Am Soc Hypertens 7:128-36. 2013
  7. pmc Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue
    Sarfaraz Ahmad
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 6:e28501. 2011

Detail Information

Publications7

  1. pmc Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension
    Norihito Moniwa
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hypertension 61:417-24. 2013
    ....
  2. pmc Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats
    Norihito Moniwa
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ther Adv Cardiovasc Dis 6:15-29. 2012
    ..Lewis hypertensive rats, a renin-dependent model of hypertension derived from the backcross of transgenic hypertensive [mRen-2]27 rats with Lewis normotensive ones...
  3. pmc Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University, Winston Salem, NC, USA
    Am J Hypertens 26:583-90. 2013
    ..We investigated whether the antihypertensive actions of the angiotensin II (Ang II) receptor (AT(1)-R) blocker, olmesartan medoxomil, may in part be mediated by increased Ang-(1-7) in the absence of significant changes in plasma Ang II...
  4. pmc Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism
    Norihito Moniwa
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina
    Am J Physiol Heart Circ Physiol 305:H644-50. 2013
    ..We conclude that ACE acts as the primary enzyme for the conversion of ANG-(1-12) to smaller angiotensin peptides in the circulation of WKY and SHR and that chymase may be an ANG-(1-7) degrading enzyme. ..
  5. pmc Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Hypertens 30:1766-74. 2012
    ..This study evaluated the hypothesis that nebivolol reduces salt-induced cardiac remodeling and dysfunction in spontaneous hypertensive rats (SHRs) by suppressing cardiac RAS and oxidative stress...
  6. pmc Chymase mediates angiotensin-(1-12) metabolism in normal human hearts
    Sarfaraz Ahmad
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Am Soc Hypertens 7:128-36. 2013
    ..Chymase accounts for the conversion of Ang-(1-12) and Ang I to Ang II in normal human LV. These novel findings expand knowledge of the alternate mechanism by which Ang-(1-12) contributes to the production of cardiac angiotensin peptides...
  7. pmc Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue
    Sarfaraz Ahmad
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 6:e28501. 2011
    ..In conclusion, we demonstrate for the first time in human cardiac tissue a dominant role of cardiac chymase in the formation of Ang II from Ang-(1-12)...