Victor V Monakhov

Summary

Publications

  1. pmc Ontogenetic variation of the human genome
    Y B Yurov
    Institute of Pediatrics and Children Surgery, Rosmedtechnologii
    Curr Genomics 11:420-5. 2010
  2. pmc An interstitial 20q11.21 microdeletion causing mild intellectual disability and facial dysmorphisms
    Ivan Y Iourov
    Mental Health Research Center, Russian Academy of Medical Sciences, Moscow 119152, Russia Institute of Pediatrics and Children Surgery, Ministry of Health of the Russian Federation, Moscow 125412, Russia
    Case Rep Genet 2013:353028. 2013
  3. pmc Somatic genome variations in health and disease
    I Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences
    Curr Genomics 11:387-96. 2010
  4. doi request reprint Cytogenetic, molecular-cytogenetic, and clinical-genealogical studies of the mothers of children with autism: a search for familial genetic markers for autistic disorders
    S G Vorsanova
    Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia
    Neurosci Behav Physiol 40:745-56. 2010
  5. pmc Molecular cytogenetics and cytogenomics of brain diseases
    I Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences
    Curr Genomics 9:452-65. 2008
  6. ncbi request reprint Cytogenetic and molecular-cytogenetic studies of Rett syndrome (RTT): a retrospective analysis of a Russian cohort of RTT patients (the investigation of 57 girls and three boys)
    S G Vorsanova
    Institute of Pediatrics and Children Surgery, Russian Ministry of Health, 127412, Taldomskaya str. 2, Moscow, Russia
    Brain Dev 23:S196-201. 2001
  7. pmc Reviewer acknowledgement 2013
    Thomas Liehr
    Jena University Hospital, Institute of Human Genetics, Jena, Germany
    Mol Cytogenet 6:9. 2013
  8. pmc Molecular karyotyping by array CGH in a Russian cohort of children with intellectual disability, autism, epilepsy and congenital anomalies
    Ivan Y Iourov
    Mental Health Research Center, Russian Academy of Medical Sciences, 119152, Moscow, Russia
    Mol Cytogenet 5:46. 2012
  9. pmc Chromosomal mosaicism goes global
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, 119152, Russia
    Mol Cytogenet 1:26. 2008
  10. pmc Human interphase chromosomes: a review of available molecular cytogenetic technologies
    Svetlana G Vorsanova
    Institute of Pediatrics and Children Surgery, Rosmedtechnologii, Moscow, 127412, Russia
    Mol Cytogenet 3:1. 2010

Collaborators

  • Ilia V Soloviev
  • Ivan Y Iourov
  • Thomas Liehr
  • Franck Pellestor
  • Y B Yurov
  • Svetlana G Vorsanova
  • S G Vorsanova
  • Valery A Shepelev
  • Alexei D Kolotii
  • I A Demidova
  • I Yu Yurov
  • O S Kurinnaya
  • V Yu Voinova
  • Ivan A Alexandrov
  • Alexander A Alexandrov
  • Petr V Novikov
  • Victoria Y Voinova-Ulas
  • Anja Weise
  • Elena A Kirillova
  • V Y Ulas
  • N L Gorbatchevskaia
  • A D Kolotii
  • V O Sharonin
  • A K Beresheva

Detail Information

Publications30

  1. pmc Ontogenetic variation of the human genome
    Y B Yurov
    Institute of Pediatrics and Children Surgery, Rosmedtechnologii
    Curr Genomics 11:420-5. 2010
    ..Here, a review of these ontogenetic variations is given to propose a new "dynamic genome" model for pathological and natural genomic changes throughout life that mimic those of phylogenetic diversity...
  2. pmc An interstitial 20q11.21 microdeletion causing mild intellectual disability and facial dysmorphisms
    Ivan Y Iourov
    Mental Health Research Center, Russian Academy of Medical Sciences, Moscow 119152, Russia Institute of Pediatrics and Children Surgery, Ministry of Health of the Russian Federation, Moscow 125412, Russia
    Case Rep Genet 2013:353028. 2013
    ..As a result, it was suggested that loss is likely to be the main cause of the phenotypic manifestations. The present case report indicates that a loss of the disease-causing gene can produce a milder phenotype of a single gene condition...
  3. pmc Somatic genome variations in health and disease
    I Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences
    Curr Genomics 11:387-96. 2010
    ..Together, we suggest that detection and characterization of somatic genome behavior and variations can provide new opportunities for human genome research and genetics...
  4. doi request reprint Cytogenetic, molecular-cytogenetic, and clinical-genealogical studies of the mothers of children with autism: a search for familial genetic markers for autistic disorders
    S G Vorsanova
    Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia
    Neurosci Behav Physiol 40:745-56. 2010
    ....
  5. pmc Molecular cytogenetics and cytogenomics of brain diseases
    I Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences
    Curr Genomics 9:452-65. 2008
    ..In this light, the present review considers perspectives of this dynamically developing field of neurogenetics and genomics...
  6. ncbi request reprint Cytogenetic and molecular-cytogenetic studies of Rett syndrome (RTT): a retrospective analysis of a Russian cohort of RTT patients (the investigation of 57 girls and three boys)
    S G Vorsanova
    Institute of Pediatrics and Children Surgery, Russian Ministry of Health, 127412, Taldomskaya str. 2, Moscow, Russia
    Brain Dev 23:S196-201. 2001
    ..We believe that the phenomenon of altered chromatin conformation in inactive chromosome X could be used as a laboratory test for preclinical diagnosis of the RTT...
  7. pmc Reviewer acknowledgement 2013
    Thomas Liehr
    Jena University Hospital, Institute of Human Genetics, Jena, Germany
    Mol Cytogenet 6:9. 2013
    ..CONTRIBUTING REVIEWERS: The editors of Molecular Cytogenetics would like to thank all our reviewers who have contributed to the journal in volume 5 (2012)...
  8. pmc Molecular karyotyping by array CGH in a Russian cohort of children with intellectual disability, autism, epilepsy and congenital anomalies
    Ivan Y Iourov
    Mental Health Research Center, Russian Academy of Medical Sciences, 119152, Moscow, Russia
    Mol Cytogenet 5:46. 2012
    ..abstract:..
  9. pmc Chromosomal mosaicism goes global
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, 119152, Russia
    Mol Cytogenet 1:26. 2008
    ....
  10. pmc Human interphase chromosomes: a review of available molecular cytogenetic technologies
    Svetlana G Vorsanova
    Institute of Pediatrics and Children Surgery, Rosmedtechnologii, Moscow, 127412, Russia
    Mol Cytogenet 3:1. 2010
    ....
  11. pmc Partial monosomy 7q34-qter and 21pter-q22.13 due to cryptic unbalanced translocation t(7;21) but not monosomy of the whole chromosome 21: a case report plus review of the literature
    Svetlana G Vorsanova
    Institute of Human Genetics and Anthropology, Friedrich Schiller University, Jena, Germany
    Mol Cytogenet 1:13. 2008
    ..Here, we report a cytogenetically similar case associated with congenital malformation including mental retardation, motor development delay, craniofacial dysmorphism and skeletal abnormalities...
  12. ncbi request reprint The schizophrenia brain exhibits low-level aneuploidy involving chromosome 1
    Yuri B Yurov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow 119152, Russian Federation
    Schizophr Res 98:139-47. 2008
    ..To gain further insights into the relationship between aneuploidy in the brain and schizophrenia pathogenesis, a molecular-cytogenetic study of chromosome 1 aneuploidy was performed...
  13. pmc Aneuploidy and confined chromosomal mosaicism in the developing human brain
    Yuri B Yurov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia Institute of Pediatrics and Children Surgery, Roszdrav, Moscow, Russia
    PLoS ONE 2:e558. 2007
    ..However, the incidence of aneuploidy in the developing human brain and its impact on the brain development and function are obscure...
  14. ncbi request reprint The variation of aneuploidy frequency in the developing and adult human brain revealed by an interphase FISH study
    Yuri B Yurov
    National Center of Mental Health, Russian Academy of Medical Sciences, Zagorodnoe sh 2, 119152 Moscow, Russia
    J Histochem Cytochem 53:385-90. 2005
    ..6-3.0% and 0.1-0.8% in uncultured fetal and postmortem adult brain cells, respectively). The data obtained support the hypothesis regarding aneuploidy occurrence in normal developing and adult human brain...
  15. pmc GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny
    Yuri B Yurov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow 119152, Russia
    Mol Cytogenet 2:23. 2009
    ....
  16. ncbi request reprint An approach for quantitative assessment of fluorescence in situ hybridization (FISH) signals for applied human molecular cytogenetics
    Ivan Y Iourov
    National Center of Mental Health, Russian Academy of Medical Sciences, Zagorodnoe sh 2, 119152 Moscow, Russia
    J Histochem Cytochem 53:401-8. 2005
    ..We propose this approach to be efficient and to be considered as a useful tool in addition to visual FISH signal analysis for applied molecular cytogenetic studies...
  17. doi request reprint Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaning
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia
    Neurobiol Dis 34:212-20. 2009
    ..These data indicate neural aneuploidy to be a newly identified feature of neurodegenerative diseases, similar to other devastative disorders hallmarked by aneuploidy such as chromosome syndromes and cancer...
  18. ncbi request reprint Interphase chromosome-specific multicolor banding (ICS-MCB): a new tool for analysis of interphase chromosomes in their integrity
    Ivan Y Iourov
    National Research Center of Mental Health, RAMS, Moscow, Russia
    Biomol Eng 24:415-7. 2007
    ..We introduce a technology using microdissection-based engineering of DNA probes and fluorescence multicolor chromosome banding that allows studying interphase chromosome organization, numbers and rearrangements in somatic cells...
  19. ncbi request reprint Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Zagorodnoe sh 2, Moscow 119152, Russia
    Hum Mol Genet 18:2656-69. 2009
    ..Our data suggest that mosaic instability of somatic genome in cells of the central nervous system is more significant genetic factor predisposing to the brain pathology than previously recognized...
  20. ncbi request reprint Evidence for high frequency of chromosomal mosaicism in spontaneous abortions revealed by interphase FISH analysis
    Svetlana G Vorsanova
    National Center of Mental Health, Russian Academy of Medical Sciences, Zagorodnoe sh 2, 119152 Moscow, Russia
    J Histochem Cytochem 53:375-80. 2005
    ..Chromosomal mosaicism may contribute significantly to both pregnancy complications and spontaneous fetal loss...
  21. ncbi request reprint Brain tissue preparations for chromosomal PRINS labeling
    Ivan Y Iourov
    Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia
    Methods Mol Biol 334:123-32. 2006
    ..Here, we propose the detailed brain tissue processing protocol that could be used for different molecular cytogenetic approaches to study chromosome complement in interphase nuclei...
  22. ncbi request reprint Recent patents on molecular cytogenetics
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, 119152, Russia
    Recent Pat DNA Gene Seq 2:6-15. 2008
    ..Here, we address world-wide patents on DNA sequences used as molecular cytogenetic probes and molecular cytogenetic techniques to define current state and perspectives of this biomedical direction...
  23. ncbi request reprint Chromosomal variation in mammalian neuronal cells: known facts and attractive hypotheses
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Sciences, Moscow, Russia 119152
    Int Rev Cytol 249:143-91. 2006
    ..We propose to cover the term "molecular neurocytogenetics to cover all studies the aim of which is to reveal chromosome variations and organization in the mammalian brain...
  24. pmc The DNA replication stress hypothesis of Alzheimer's disease
    Yuri B Yurov
    Laboratory of Cytogenetics and Genomics of Psychiatric Disorders, Mental Health Research Center, Russian Academy of Medical Sciences, Moscow 119152, Russia
    ScientificWorldJournal 11:2602-12. 2011
    ..Abnormal cell cycle reentry and somatic genome variations can be used for updating the cell cycle theory introducing replication stress as a missing link between cell genetics and neurobiology of AD...
  25. pmc The evolutionary origin of man can be traced in the layers of defunct ancestral alpha satellites flanking the active centromeres of human chromosomes
    Valery A Shepelev
    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia
    PLoS Genet 5:e1000641. 2009
    ..If applicable to other satellites in non-primate taxa, analysis of centromeric layers could become an invaluable tool for phylogenetic studies...
  26. ncbi request reprint First case of del(1)(p36.2p33) in a fetus delivered stillborn
    Ivan Y Iourov
    Prenat Diagn 26:1092-3. 2006
  27. ncbi request reprint Mosaic X chromosome aneuploidy can help to explain the male-to-female ratio in autism
    Ivan Y Iourov
    Med Hypotheses 70:456. 2008