Igor Mokrousov

Summary

Publications

  1. ncbi request reprint Multicenter evaluation of reverse line blot assay for detection of drug resistance in Mycobacterium tuberculosis clinical isolates
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 14 Mira Street, St Petersburg 197101, Russia
    J Microbiol Methods 57:323-35. 2004
  2. pmc Analysis of the allelic diversity of the mycobacterial interspersed repetitive units in Mycobacterium tuberculosis strains of the Beijing family: practical implications and evolutionary considerations
    Igor Mokrousov
    Pasteur Institute, 14, Mira St, St Petersburg 197101, Russia
    J Clin Microbiol 42:2438-44. 2004
  3. pmc Mycobacterium tuberculosis Beijing genotype and mycobacterial interspersed repetitive unit typing
    Igor Mokrousov
    J Clin Microbiol 44:1614; author reply 1614-5. 2006
  4. doi request reprint Molecular snapshot of drug-resistant and drug-susceptible Mycobacterium tuberculosis strains circulating in Bulgaria
    Violeta Valcheva
    Department of Pathogenic Bacteria, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria
    Infect Genet Evol 8:657-63. 2008
  5. pmc Multiple rpoB mutants of Mycobacterium tuberculosis and second-order selection
    Igor Mokrousov
    Emerg Infect Dis 10:1337-8. 2004
  6. pmc Insights into the origin, emergence, and current spread of a successful Russian clone of Mycobacterium tuberculosis
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia
    Clin Microbiol Rev 26:342-60. 2013
  7. pmc Russian "successful" clone B0/W148 of Mycobacterium tuberculosis Beijing genotype: a multiplex PCR assay for rapid detection and global screening
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia
    J Clin Microbiol 50:3757-9. 2012
  8. pmc Rapid detection of the Mycobacterium tuberculosis Beijing genotype and its ancient and modern sublineages by IS6110-based inverse PCR
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 197101 St Petersburg, Russia
    J Clin Microbiol 44:2851-6. 2006
  9. pmc Molecular characterization of ofloxacin-resistant Mycobacterium tuberculosis strains from Russia
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 197101 St Petersburg, Russia
    Antimicrob Agents Chemother 52:2937-9. 2008
  10. pmc Mycobacterium tuberculosis Beijing genotype in Russia: in search of informative variable-number tandem-repeat loci
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg 197101, Russia
    J Clin Microbiol 46:3576-84. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Multicenter evaluation of reverse line blot assay for detection of drug resistance in Mycobacterium tuberculosis clinical isolates
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 14 Mira Street, St Petersburg 197101, Russia
    J Microbiol Methods 57:323-35. 2004
    ..It is open to further development as it allows easy incorporation of new probes for detection of mutations in other genes associated with resistance to second-line (e.g., fluoroquinolones) and new antituberculosis compounds...
  2. pmc Analysis of the allelic diversity of the mycobacterial interspersed repetitive units in Mycobacterium tuberculosis strains of the Beijing family: practical implications and evolutionary considerations
    Igor Mokrousov
    Pasteur Institute, 14, Mira St, St Petersburg 197101, Russia
    J Clin Microbiol 42:2438-44. 2004
    ..08 versus 0.17). To conclude, we suggest to use a limited number of MIRUs for preliminary subdivision of Beijing strains in Russian (loci 26 + 31), South African (10 + 26 + 39), and global settings (10 + 26 + 39)...
  3. pmc Mycobacterium tuberculosis Beijing genotype and mycobacterial interspersed repetitive unit typing
    Igor Mokrousov
    J Clin Microbiol 44:1614; author reply 1614-5. 2006
  4. doi request reprint Molecular snapshot of drug-resistant and drug-susceptible Mycobacterium tuberculosis strains circulating in Bulgaria
    Violeta Valcheva
    Department of Pathogenic Bacteria, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria
    Infect Genet Evol 8:657-63. 2008
    ..Comparison with spoligotyping and 24-VNTR locus typing data suggested that emergence and spread of drug-resistant and MDR-TB in Bulgaria are not associated with any specific spoligotype or MIRU-VNTR genotype...
  5. pmc Multiple rpoB mutants of Mycobacterium tuberculosis and second-order selection
    Igor Mokrousov
    Emerg Infect Dis 10:1337-8. 2004
  6. pmc Insights into the origin, emergence, and current spread of a successful Russian clone of Mycobacterium tuberculosis
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia
    Clin Microbiol Rev 26:342-60. 2013
    ..In contrast, there is some indication, but not yet systematic proof, of an enhanced virulence of this strain...
  7. pmc Russian "successful" clone B0/W148 of Mycobacterium tuberculosis Beijing genotype: a multiplex PCR assay for rapid detection and global screening
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia
    J Clin Microbiol 50:3757-9. 2012
    ..tuberculosis isolates of different genotypes and origins. This assay may be used for accurate and simple detection and surveillance of this clinically and epidemiologically important variant of M. tuberculosis...
  8. pmc Rapid detection of the Mycobacterium tuberculosis Beijing genotype and its ancient and modern sublineages by IS6110-based inverse PCR
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 197101 St Petersburg, Russia
    J Clin Microbiol 44:2851-6. 2006
    ..The method is fast and inexpensive and does not require additional experiments but instead is implemented in the routine typing method of M. tuberculosis...
  9. pmc Molecular characterization of ofloxacin-resistant Mycobacterium tuberculosis strains from Russia
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 197101 St Petersburg, Russia
    Antimicrob Agents Chemother 52:2937-9. 2008
    ..tuberculosis...
  10. pmc Mycobacterium tuberculosis Beijing genotype in Russia: in search of informative variable-number tandem-repeat loci
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg 197101, Russia
    J Clin Microbiol 46:3576-84. 2008
    ..tuberculosis Beijing genotype strains circulating in or imported from Russia...
  11. pmc Evolution of drug resistance in different sublineages of Mycobacterium tuberculosis Beijing genotype
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 14 Mira Street, 197101 St Petersburg, Russia
    Antimicrob Agents Chemother 50:2820-3. 2006
    ....
  12. pmc Detection of isoniazid-resistant Mycobacterium tuberculosis strains by a multiplex allele-specific PCR assay targeting katG codon 315 variation
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 197101 St Petersburg, Russia
    J Clin Microbiol 40:2509-12. 2002
    ..The MAS-PCR assay can be used for the detection of resistance to INH in clinical laboratories in regions with a high prevalence of MDR M. tuberculosis strains...
  13. doi request reprint At Baltic crossroads: a molecular snapshot of Mycobacterium tuberculosis population diversity in Kaliningrad, Russia
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia
    FEMS Immunol Med Microbiol 55:13-22. 2009
    ..Comparison of the genotyping and drug resistance data emphasized that the high prevalence of the MDR Beijing genotype strains is a major cause of the adverse epidemiological situation of MDR-tuberculosis in the Kaliningrad region...
  14. pmc High prevalence of KatG Ser315Thr substitution among isoniazid-resistant Mycobacterium tuberculosis clinical isolates from northwestern Russia, 1996 to 2001
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia
    Antimicrob Agents Chemother 46:1417-24. 2002
    ..The simplicity of the assay permits its implementation into routine practice in clinical microbiology laboratories in regions with a high incidence of TB where this mutation is predominant, including northwestern Russia...
  15. pmc Detection of embB306 mutations in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis from Northwestern Russia: implications for genotypic resistance testing
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 197101 St Petersburg, Russia
    J Clin Microbiol 40:3810-3. 2002
    ..Comparison with DNA fingerprinting data showed that, irrespectively of the phenotypic susceptibility profiles, 46 (50.6%) of 91 Beijing family strains and 16 (17.4%) of 92 strains of other genotypes had a mutation in embB306...
  16. pmc Novel IS6110 insertion sites in the direct repeat locus of Mycobacterium tuberculosis clinical strains from the St. Petersburg area of Russia and evolutionary and epidemiological considerations
    Igor Mokrousov
    Laboratory of Molecular Microbiology, Pasteur Institute, St Petersburg 197101, Russia
    J Clin Microbiol 40:1504-7. 2002
    ..Asymmetrical insertions prevented detection of the adjacent spacer by standard spoligotyping. This, therefore, should be taken into consideration when similar spoligoprofiles that differ only in signals 37 and 38 are interpreted...
  17. pmc Origin and primary dispersal of the Mycobacterium tuberculosis Beijing genotype: clues from human phylogeography
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, 197101, Russia
    Genome Res 15:1357-64. 2005
    ....
  18. ncbi request reprint Phylogenetic reconstruction within Mycobacterium tuberculosis Beijing genotype in northwestern Russia
    Igor Mokrousov
    Laboratory of Molecular Microbiology Pasteur Institute, St Petersburg, 197101, Russia
    Res Microbiol 153:629-37. 2002
    ..The atypical Beijing strains (4%) are evolutionary older; they probably had a common (unknown) ancestor with typical Beijing strains...
  19. doi request reprint Genetic geography of Mycobacterium tuberculosis Beijing genotype: a multifacet mirror of human history?
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 14 Mira Street, St Petersburg 197101, Russia
    Infect Genet Evol 8:777-85. 2008
    ..At the same time, less expected affinities observed between distant populations of M. tuberculosis may reflect hidden patterns of human migrations or yet unknown epidemiological links between distant regions...
  20. pmc Allele-specific rpoB PCR assays for detection of rifampin-resistant Mycobacterium tuberculosis in sputum smears
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 197101 St Petersburg, Russia
    Antimicrob Agents Chemother 47:2231-5. 2003
    ..The developed rpoB-PCR assay can be used in clinical laboratories to detect RIF-resistant and hence MDR M. tuberculosis in the regions with high burdens of the MDR-TB...
  21. doi request reprint Corynebacterium diphtheriae: genome diversity, population structure and genotyping perspectives
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia
    Infect Genet Evol 9:1-15. 2009
    ..diphtheriae are still needed. In this view, CRISPRs and minisatellites are promising genomic markers for development of high-resolution typing schemes and databasing of C. diphtheriae...
  22. pmc Mycobacterium tuberculosis population in northwestern Russia: an update from Russian-EU/Latvian border region
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia
    PLoS ONE 7:e41318. 2012
    ..3% versus 44.4% in LAM), these findings suggest the critical impact of the Beijing genotype on the current situation with MDR-TB in the Pskov region in northwestern Russia...
  23. pmc Efficient discrimination within a Corynebacterium diphtheriae epidemic clonal group by a novel macroarray-based method
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, 14, Mira St, St Petersburg 197101, Russia corrected
    J Clin Microbiol 43:1662-8. 2005
    ..The results are easy to interpret and can be presented and stored in a user-friendly digital database (Excel file), allowing rapid type determination of new strains...
  24. pmc Detection of ethambutol-resistant Mycobacterium tuberculosis strains by multiplex allele-specific PCR assay targeting embB306 mutations
    Igor Mokrousov
    Laboratory of Molecular Microbiology, Pasteur Institute, 14, Mira Street, St Petersburg 197101, Russia
    J Clin Microbiol 40:1617-20. 2002
    ....
  25. ncbi request reprint Corynebacterium diphtheriae spoligotyping based on combined use of two CRISPR loci
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia
    Biotechnol J 2:901-6. 2007
    ..diphtheriae...
  26. ncbi request reprint Towards a quantitative perception of human-microbial co-evolution
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia
    Front Biosci 12:4818-25. 2007
    ..The proposed approach may be helpful for a quantitative understanding of human-microbial interactions that constitute an integral part of the global history...
  27. doi request reprint Mycobacterium tuberculosis co-existence with humans: making an imprint on the macrophage P2X(7) receptor gene?
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg 197101, Russia
    J Med Microbiol 57:581-4. 2008
    ....
  28. doi request reprint The quiet and controversial: Ural family of Mycobacterium tuberculosis
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia
    Infect Genet Evol 12:619-29. 2012
    ....
  29. doi request reprint Molecular snapshot of Mycobacterium tuberculosis population structure and drug-resistance in Kyrgyzstan
    Igor Mokrousov
    Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia WHO Supranational TB Reference Laboratory, Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Abymes Cedex, Guadeloupe, France Electronic address
    Tuberculosis (Edinb) 93:501-7. 2013
    ..In summary, we suggest: (i) a clear shift of the local M. tuberculosis population structure during the last 100 years and (ii) a critical impact of the Beijing genotype on the current situation with drug resistant TB in Kyrgyzstan. ..
  30. pmc Molecular characterization of Mycobacterium tuberculosis isolates from different regions of Bulgaria
    Violeta Valcheva
    Department of Pathogenic Bacteria, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria
    J Clin Microbiol 46:1014-8. 2008
    ..To conclude, this first study of the Bulgarian M. tuberculosis population demonstrated its heterogeneity and predominance of several worldwide-distributed and Balkan-specific spoligotypes...
  31. pmc Snapshot of moving and expanding clones of Mycobacterium tuberculosis and their global distribution assessed by spoligotyping in an international study
    Ingrid Filliol
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Pointe a Pitre, Guadeloupe
    J Clin Microbiol 41:1963-70. 2003
    ..Intercontinental matches of shared types among eight continents and subcontinents (Africa, North America, Central America, South America, Europe, the Middle East and Central Asia, and the Far East) are analyzed and discussed...
  32. ncbi request reprint Molecular characteristics of rifampin and isoniazid resistant Mycobacterium tuberculosis strains from Beijing, China
    Wei Wei Jiao
    Beijing Pediatric Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing 100045, China
    Chin Med J (Engl) 120:814-9. 2007
    ..We studied the molecular characteristics of rifampin (RIF) and isoniazid (INH) resistant Mycobacterium tuberculosis strains from Beijing, China, in order to find out the genetic marker for rapid detection of specific drug resistance...
  33. pmc Designation of major mycobacterial interspersed repetitive-unit types within Mycobacterium tuberculosis Beijing genotype, an important point
    Igor Mokrousov
    J Clin Microbiol 45:4092; author reply 4092-3. 2007
  34. pmc Evaluation of new variable-number tandem-repeat systems for typing Mycobacterium tuberculosis with Beijing genotype isolates from Beijing, China
    Wei Wei Jiao
    Public Central Laboratory, Beijing Pediatric Research Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing 100045, China
    J Clin Microbiol 46:1045-9. 2008
    ..tuberculosis isolates in Beijing, while secondary typing of clustered strains by IS6110-RFLP is still required...
  35. pmc Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
    Karine Brudey
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Guadeloupe
    BMC Microbiol 6:23. 2006
    ....
  36. pmc Global distribution of Mycobacterium tuberculosis spoligotypes
    Ingrid Filliol
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur, Pointe a Pitre, Guadeloupe, French West Indies
    Emerg Infect Dis 8:1347-9. 2002
    ..The 11708 spoligotypes were clustered into 813 shared types. A total of 1300 orphan patterns (clinical isolates showing a unique spoligotype) were also detected...
  37. ncbi request reprint Molecular characterization of multiple-drug-resistant Mycobacterium tuberculosis isolates from northwestern Russia and analysis of rifampin resistance using RNA/RNA mismatch analysis as compared to the line probe assay and sequencing of the rpoB gene
    Igor Mokrousov
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Morne Joliviere, Pointe a Pitre
    Res Microbiol 153:213-9. 2002
    ....
  38. ncbi request reprint Study of Corynebacterium diphtheriae strains isolated in Romania, northwestern Russia and the Republic of Moldova
    Maria Damian
    Molecular Epidemiology Laboratory, Cantacuzino Institute, Bucharest, Romania
    Res Microbiol 153:99-106. 2002
    ..The phenotypic methods associated with molecular typing techniques enabled distinguishing between strains, detecting the epidemic clone, and sustaining the absence of transmission across borders...