K Mokbel

Summary

Publications

  1. ncbi request reprint Towards optimal management of ductal carcinoma in situ of the breast
    Kefah Mokbel
    Brunel Institute of Cancer Genetics, London, SW17 0QT, UK
    Eur J Surg Oncol 29:191-7. 2003
  2. ncbi request reprint Is there a link between breast cancer and abortion: a review of the literature
    A J Kitchen
    Department of Breast Surgery, St George s Hospital London, UK
    Int J Fertil Womens Med 50:267-71. 2005
  3. ncbi request reprint Dairy products and breast cancer risk: a review of the literature
    W Al Sarakbi
    St George s and The Princess Grace Hospitals, London, UK
    Int J Fertil Womens Med 50:244-9. 2005
  4. ncbi request reprint COX-2 inhibitors and breast cancer
    Gurpreet Singh Ranger
    Breast Cancer Unit, St George s Hospital and Medical School, London, UK
    ANZ J Surg 73:565-6. 2003
  5. ncbi request reprint hTERT mRNA expression correlates with telomerase activity in human breast cancer
    K L Kirkpatrick
    Academic Division of Breast Surgery, St George s Hospital, University of London, UK
    Eur J Surg Oncol 29:321-6. 2003
  6. pmc Ductal carcinoma in situ: recent advances and future prospects
    Kelly Lambert
    The Breast Unit, University Hospitals Leicester, Leicester LE3 9QP, UK
    Int J Surg Oncol 2012:347385. 2012
  7. pmc Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer
    Neill Patani
    Department of Breast Surgery, The London Breast Institute, The Princess Grace Hospital, London
    J Carcinog 9:9. 2010
  8. ncbi request reprint The interaction between DAP1 and autophagy in the context of human carcinogenesis
    Umar Wazir
    London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, U K
    Anticancer Res 34:1-8. 2014
  9. ncbi request reprint P14ARF is down-regulated during tumour progression and predicts the clinical outcome in human breast cancer
    Umar Wazir
    London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, UK
    Anticancer Res 33:2185-9. 2013
  10. ncbi request reprint The mRNA expression of inhibitors of DNA binding-1 and -2 is associated with advanced tumour stage and adverse clinical outcome in human breast cancer
    Umar Wazir
    London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, UK
    Anticancer Res 33:2179-83. 2013

Collaborators

Detail Information

Publications125 found, 100 shown here

  1. ncbi request reprint Towards optimal management of ductal carcinoma in situ of the breast
    Kefah Mokbel
    Brunel Institute of Cancer Genetics, London, SW17 0QT, UK
    Eur J Surg Oncol 29:191-7. 2003
    ..Future research will focus on the relevance of gene expression profiling, proteomics, Laser therapy and mammary ductoscopy to the management of DCIS...
  2. ncbi request reprint Is there a link between breast cancer and abortion: a review of the literature
    A J Kitchen
    Department of Breast Surgery, St George s Hospital London, UK
    Int J Fertil Womens Med 50:267-71. 2005
    ..Absence of a link with induced abortion is less clear, and further research should concentrate on investigating any relationship. We suggest that prospective research is used, with point of entry at first termination...
  3. ncbi request reprint Dairy products and breast cancer risk: a review of the literature
    W Al Sarakbi
    St George s and The Princess Grace Hospitals, London, UK
    Int J Fertil Womens Med 50:244-9. 2005
    ..We aim to review the current epidemiological literature on the relationship between the intake of dairy products and breast cancer risk...
  4. ncbi request reprint COX-2 inhibitors and breast cancer
    Gurpreet Singh Ranger
    Breast Cancer Unit, St George s Hospital and Medical School, London, UK
    ANZ J Surg 73:565-6. 2003
  5. ncbi request reprint hTERT mRNA expression correlates with telomerase activity in human breast cancer
    K L Kirkpatrick
    Academic Division of Breast Surgery, St George s Hospital, University of London, UK
    Eur J Surg Oncol 29:321-6. 2003
    ..Furthermore the associations with other parameters including estrogen receptor (ER) and progesterone receptor (PgR) status, DNA ploidy, and S-phase fraction (SPF) are also examined...
  6. pmc Ductal carcinoma in situ: recent advances and future prospects
    Kelly Lambert
    The Breast Unit, University Hospitals Leicester, Leicester LE3 9QP, UK
    Int J Surg Oncol 2012:347385. 2012
    ..Biological profiling and molecular analysis represent an opportunity to improve our understanding of tumour biology in DCIS to rationalise treatment. Reliable identification of low-risk lesions could allow treatment to be less radical...
  7. pmc Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer
    Neill Patani
    Department of Breast Surgery, The London Breast Institute, The Princess Grace Hospital, London
    J Carcinog 9:9. 2010
    ..However, paradoxical roles are reported. In this study, the level of mRNA expression of CHIP and LOX were assessed in normal and malignant breast tissue and correlated with clinico-pathological parameters...
  8. ncbi request reprint The interaction between DAP1 and autophagy in the context of human carcinogenesis
    Umar Wazir
    London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, U K
    Anticancer Res 34:1-8. 2014
    ..We discuss the current understanding of these mechanisms, including recent research regarding the role of death-associated protein-1 in autophagy and apoptosis. ..
  9. ncbi request reprint P14ARF is down-regulated during tumour progression and predicts the clinical outcome in human breast cancer
    Umar Wazir
    London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, UK
    Anticancer Res 33:2185-9. 2013
    ..The objective of this study was to determine the mRNA expression for p14 and p16 in a cohort of women with breast cancer...
  10. ncbi request reprint The mRNA expression of inhibitors of DNA binding-1 and -2 is associated with advanced tumour stage and adverse clinical outcome in human breast cancer
    Umar Wazir
    London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, UK
    Anticancer Res 33:2179-83. 2013
    ..Inhibitors of DNA binding (ID) are known to have a role in embryogenesis and oncogenesis. In this study, we analyzed the role of ID1 and ID2 in breast cancer, by assessing associations of mRNA expression with clinicopathological parameters...
  11. ncbi request reprint Guanine nucleotide binding protein β 1: a novel transduction protein with a possible role in human breast cancer
    Umar Wazir
    Department of Breast Surgery, St George s Hospital and Medical School, University of London, London, UK
    Cancer Genomics Proteomics 10:69-73. 2013
    ..Furthermore, the correlations between GNB1, Rictor and the mammalian target of rapamycin (mTOR) were also investigated...
  12. ncbi request reprint Evidence of an autocrine role for leptin and leptin receptor in human breast cancer
    Umar Wazir
    The London Breast Institute, Princess Grace Hospital, and Medical School, University of London, London, UK
    Cancer Genomics Proteomics 9:383-7. 2012
    ..associations between the expression of leptin, leptin receptor (LEPR) and clinicopathological parameters of breast cancer, and the correlation of leptin with human telomerase reverse transcriptase (hTERT) and cyclooxygenase 2 (COX2)..
  13. pmc Is telomerase reactivation associated with the down-regulation of TGF beta receptor-II expression in human breast cancer?
    Abd E Elkak
    St George s Hospital and Medical School, London, UK
    Cancer Cell Int 3:9. 2003
    ..0). CONCLUSION: The results of this pilot study suggest that there is no significant association between telomerase reactivation and TGF-beta RII down-regulation in human breast cancer...
  14. pmc Lymphangiogenesis and lymph node metastasis in breast cancer
    Giles H Cunnick
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, CF14 4XN, Wales, UK
    Mol Cancer 7:23. 2008
    ..The cDNA from 153 frozen archived breast samples were analysed with Q-PCR for all seven lymphangiogenic markers. This was correlated with various prognostic factors as well as patient survival...
  15. pmc Paraneoplastic cerebellar degeneration as a presentation of breast cancer - a case report and review of the literature
    Alia Noorani
    Breast Surgery Unit, St George s Hospital NHS Trust, London, UK
    Int Semin Surg Oncol 5:8. 2008
    ..The presence of onconeural antibodies and PET scanning help in the challenging diagnosis of these conditions but despite the treatment of the primary cancer, the prognosis for the neurological symptoms is poor...
  16. pmc The role of Herceptin in early breast cancer
    Ashok Subramanian
    St Georges Hospital, Blackshaw Road, Tooting, SW17 0QT, UK
    Int Semin Surg Oncol 5:9. 2008
    ..This review will focus on the nature of the Her2 overexpression and the role of herceptin in the treatment of early breast cancer...
  17. pmc Risk-reducing strategies for women carrying BRCA1/2 mutations with a focus on prophylactic surgery
    Mohamed Salhab
    London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, UK
    BMC Womens Health 10:28. 2010
    ..The aim of this review is to provide an up-to-date analysis and to subsequently summarise the available literature in relation to risk-reducing strategies, with a keen focus on prophylactic surgery...
  18. pmc Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer
    Walid Sasi
    St George s University of London, London, UK
    BMC Cancer 10:178. 2010
    ..In this study, we examined the expression of SOCS1-7 genes in normal and breast cancer tissue and correlated this with several clinico-pathological and prognostic factors...
  19. pmc Oncological outcome and patient satisfaction with skin-sparing mastectomy and immediate breast reconstruction: a prospective observational study
    Sara Reefy
    The London Breast Institute, The Princess Grace Hospital, London, UK
    BMC Cancer 10:171. 2010
    ..In this study, the oncological outcome, post-operative morbidity and patients' satisfaction with SSM and IBR using the latissimus dorsi (LD) myocutaneous flap and/or breast prosthesis is evaluated...
  20. pmc The mRNA expression of SATB1 and SATB2 in human breast cancer
    Neill Patani
    Department of Breast Surgery, St, George s University of London, London, UK
    Cancer Cell Int 9:18. 2009
    ..SATB2 mRNA expression is significantly associated with increasing tumour grade and poorer OS. These results are consistent with the notion that SATB1 acts as a 'master genome organizer' in human breast carcinogenesis...
  21. ncbi request reprint Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer
    Neill Patani
    Department of Breast Surgery, The London Breast Institute, The Princess Grace Hospital, London, UK
    Anticancer Res 31:4115-25. 2011
    ....
  22. ncbi request reprint Recent advances in breast cancer: the 27th ESMO Congress 2002
    Kefah Mokbel
    Brunel Institute of Cancer Genetics, Brunel University, Uxbridge, UK
    Curr Med Res Opin 19:141-2. 2003
    ..VEGF was found to be an independent prognostic factor in patients with node-negative breast cancer. The implications and limitations of these findings are discussed...
  23. ncbi request reprint Recent advances in breast cancer: the 25th Annual San Antonio Breast Cancer Symposium
    Kefah Mokbel
    Brunel Institute of Cancer Genetics, Brunel University, Uxbridge, UK
    Curr Med Res Opin 19:143-6. 2003
    ..These include an updated analysis of the ATAC trial, new data demonstrating the superiority of dose-dense adjuvant chemotherapy over conventional scheduling, and recent developments in the field of proteomics...
  24. ncbi request reprint Focus on anastrozole and breast cancer
    K Mokbel
    St George s Hospital and Medical School, London, UK
    Curr Med Res Opin 19:683-8. 2003
    ..The potential role of anastrozole in the neoadjuvant setting, the management of DCIS, premenopausal breast cancer and breast cancer prevention is currently being investigated...
  25. ncbi request reprint Contemporary treatment of ductal carcinoma in situ of the breast
    Kefah Mokbel
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Breast and Endocrine Surgeon at St George s and The Princess Grace Hospitals, London, United Kingdom
    Med Sci Monit 11:RA86-93. 2005
    ..Tamoxifen can be considered in high-risk young women (USC/VNPI score =9-12) treated by BCS for ER+ DCIS as long as the potential benefits and adverse effects are explained to the patient...
  26. ncbi request reprint The evolving role of telomerase inhibitors in the treatment of cancer
    Kefah Mokbel
    Institute of Cancer Genetics and Pharmacogenomics, Brunel University, and St George s and the Princess Grace Hospitals, London, UK
    Curr Med Res Opin 19:470-2. 2003
    ..Alternative lengthening of telomeres (ALT) and efficacy delay remain important limitations to anti-telomerase therapy...
  27. pmc Tumour suppressor function of MDA-7/IL-24 in human breast cancer
    Neill Patani
    Department of Breast Surgery, The London Breast Institute, The Princess Grace Hospital, 42 52 Nottingham Place, W1U 5NY, London, UK
    Cancer Cell Int 10:29. 2010
    ..Furthermore, mRNA expression of MDA-7 is assessed in a cohort of women with BC and correlated with established pathological parameters and clinical outcome...
  28. pmc Brain-derived neurotrophic factor expression predicts adverse pathological & clinical outcomes in human breast cancer
    Neill Patani
    Department of Breast Surgery, The London Breast Institute, The Princess Grace Hospital, 42 52 Nottingham Place, W1U 5NY, London, England, UK
    Cancer Cell Int 11:23. 2011
    ..abstract:..
  29. ncbi request reprint Current management of ductal carcinoma in situ of the breast
    Kefah Mokbel
    St George s Hospital, London, SW17 0QT, UK
    Int J Clin Oncol 8:18-22. 2003
    ....
  30. ncbi request reprint The evolving role of aromatase inhibitors in breast cancer
    Kefah Mokbel
    St George s Hospital and Medical School, London SW17 0QT, UK
    Int J Clin Oncol 7:279-83. 2002
    ..The potential role of these drugs in the management of ductal carcinoma in situ (DCIS), premenopausal breast cancer, and breast cancer prevention is worth investigating...
  31. ncbi request reprint The evolving role of mammary ductoscopy
    Kefah Mokbel
    The Breast Cancer Centre, St George s Hospital and Medical School, London, UK
    Curr Med Res Opin 18:30-2. 2002
    ..Furthermore, the addition of molecular and genetic analysis of cells obtained by MD and the emergence of newer generations of microendoscopes are likely to enhance the use of this technique...
  32. ncbi request reprint Mammary ductoscopy: current status and future prospects
    Kefah Mokbel
    St George s Hospital, Blackshaw Road, London SW17 0QT, UK
    Eur J Surg Oncol 31:3-8. 2005
    ..MD can be performed under local anaesthesia in the office setting. This article reviews the evolving role of MD in the diagnosis and treatment of intraductal breast disease...
  33. ncbi request reprint Breast cancer chemoprevention--an update
    K Mokbel
    Academic Division of Breast Surgery, St George s Hospital and Medical School, London, UK
    Curr Med Res Opin 18:329-31. 2002
    ..The prevention of ER-negative disease requires further research, and is likely to be challenging...
  34. ncbi request reprint From HER2 to herceptin
    K Mokbel
    St George s Hospital, Blackshaw Road, London SW17 0QT, UK
    Curr Med Res Opin 17:51-9. 2001
    ..The main risk factors for cardiotoxicity are concurrent or previous anthracycline exposure. The potential role of Herceptin in the adjuvant setting is currently being evaluated...
  35. ncbi request reprint Predictors of positive margins after local excision of ductal carcinoma in situ
    K Mokbel
    Breast Cancer Centre, St George s Hospital, London, United Kingdom
    Am J Surg 181:91-5. 2001
    ..This study aimed to examine the association between clinicopathologic parameters and positive margins in women with ductal carcinoma in situ (DCIS) treated by breast-conserving surgery (BCS)...
  36. ncbi request reprint The Twenty-third Annual San Antonio Breast Cancer Symposium
    K Mokbel
    St George s Hospital, Blackshaw Road, London SW17 0QT, UK
    Curr Med Res Opin 16:276-84. 2001
    ..The role of new diagnostic tools, such as fibre-optic ductoscopy (FDS) and microcatheters to obtain ductal cells, was discussed. Finally, the worldwide overview was presented...
  37. ncbi request reprint Recent advances in breast cancer (the 37th ASCO meeting, May 2001)
    K Mokbel
    St George s Breast Cancer Centre, St George s Hospital, London SW17 0QT, UK
    Curr Med Res Opin 17:116-22. 2001
    ..Biological therapy using inhibitors/antagonists of angiogenesis and EGFR seems to be safe and well tolerated. Although the response rates are currently unimpressive, further research using survival as an endpoint is required...
  38. ncbi request reprint Radiotherapy and tamoxifen after breast-conserving surgery for DCIS
    G H Cunnick
    Department of Breast Surgery, St George s Hospital, London, UK
    Int J Fertil Womens Med 49:237-8. 2004
    ..The effect of tamoxifen was greater in both trials for women under 50 years...
  39. ncbi request reprint Evidence of a tumour suppressor function for DLEC1 in human breast cancer
    W Al Sarakbi
    St George s University of London, Tooting, London, UK
    Anticancer Res 30:1079-82. 2010
    ..3, is a candidate tumour suppressor gene in lung, esophageal, and renal cancer. The aim of this study was determine whether the mRNA expression levels of DLEC1 were consistent with a tumour suppressive function...
  40. ncbi request reprint Advances in breast oncology: the 2002 ASCO meeting
    G Singh-Ranger
    St George s Hospital and Medical School, Blackshaw Road, London SW17 0QT, UK
    Curr Med Res Opin 18:401-6. 2002
    ....
  41. ncbi request reprint Cyclooxygenase-2 mRNA expression correlates with aromatase expression in human breast cancer
    M Salhab
    St George s University of London, Tooting, London, United Kingdom
    J Surg Oncol 96:424-8. 2007
    ..Increasing evidence supports a role for COX-2 in upregulation of aromatase activity. The aim of this study was to examine the relationship between COX-2 and aromatase mRNA expression in human breast cancer...
  42. doi request reprint The impact of digital mammography on screening a young cohort of women for breast cancer in an urban specialist breast unit
    Nicholas M Perry
    The London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, UK
    Eur Radiol 21:676-82. 2011
    ..To compare the diagnostic performance of full-field digital mammography (FFDM) with screen-film mammography (SFM) in a corporate screening programme including younger women...
  43. ncbi request reprint The role of STS and OATP-B mRNA expression in predicting the clinical outcome in human breast cancer
    W Al Sarakbi
    St George s Hospital, Blackshaw Road, Tooting, London, UK
    Anticancer Res 26:4985-90. 2006
    ..This is the first study in the literature to examine the relationship between STS and OATP-B in human breast cancer and to investigate the potential prognostic value of OATP-B...
  44. ncbi request reprint Cyclo-oxygenase-2 (COX-2) mRNA expression correlates with progesterone receptor positivity in human breast cancer
    G Singh-Ranger
    The Breast Unit, St George s Hospital, London, UK
    Curr Med Res Opin 19:131-4. 2003
    ..The present study aims to compare COX-2 mRNA expression with hormone receptor status, S-phase fraction, telomerase activity, and DNA ploidy in human breast cancer...
  45. ncbi request reprint The role of aromatase and 17-beta-hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer
    M Salhab
    St George s Hospital, Blackshaw Road, London, Tooting, UK
    Breast Cancer Res Treat 99:155-62. 2006
    ..The aim of this study is to investigate the relationship between CYP19 and 17-beta-HSD type 1A mRNA expression and clinico-pathological parameters of human breast cancer...
  46. ncbi request reprint Evidence of a tumour suppressive function of E2F1 gene in human breast cancer
    D Worku
    Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, Middlesex, UK
    Anticancer Res 28:2135-9. 2008
    ..This study aimed to examine the level of mRNA expression of E2F1 gene in normal and malignant breast tissue and correlate the level of expression to tumour stage...
  47. ncbi request reprint The prevention of breast cancer: an overview
    C Leris
    South East Thames Training Programme, London, UK
    Curr Med Res Opin 16:252-7. 2001
    ..Bilateral prophylactic mastectomy reduces the risk of breast cancer by 90% in high risk women...
  48. ncbi request reprint hTERT expression in human breast cancer and non-cancerous breast tissue: correlation with tumour stage and c-Myc expression
    K L Kirkpatrick
    Academic Division of Breast Surgery, St George s Hospital, London, UK
    Breast Cancer Res Treat 77:277-84. 2003
    ..The hTERT mRNA levels in tumour do not seem to be associated with the patient's age or advanced tumour stage. Furthermore, hTERT mRNA expression does not correlate with c-Myc mRNA expression in breast cancer...
  49. ncbi request reprint The mRNA expression of DAP3 in human breast cancer: correlation with clinicopathological parameters
    U Wazir
    MS FRCS, London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London, W1U 5NY, UK
    Anticancer Res 32:671-4. 2012
    ..This pilot study is the first to focus on the potential role for death-associated protein 3 (DAP3) in human breast cancer...
  50. ncbi request reprint Evidence for a tumour suppressive function of IGF1-binding proteins in human breast cancer
    A Subramanian
    St George s University of London, Blackshaw Road, Tooting, London, UK
    Anticancer Res 27:3513-8. 2007
    ....
  51. ncbi request reprint Evidence for a tumour suppressive function of APRG1 in breast cancer
    A C A Leris
    St George s Hospital, London, UK
    Breast Cancer Res Treat 93:97-100. 2005
    ..This gene codes for a protein, which has been implicated in cell membrane interactions. The aim was to determine using quantitative PCR whether the levels of this gene were negatively correlated with clinical outcome in breast cancer...
  52. doi request reprint Herceptin and breast cancer: an overview for surgeons
    N Patani
    The London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, UK
    Surg Oncol 19:e11-21. 2010
    ..This article reviews the established and emerging roles of TZ in the management of breast cancer (BC)...
  53. ncbi request reprint Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis
    R F Newbold
    The Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    Anticancer Res 30:3309-11. 2010
    ..A hypothesis is proposed that explains the mode of action of SETD2 as a tumour suppressor gene...
  54. doi request reprint Prognostic and therapeutic implications of mTORC1 and Rictor expression in human breast cancer
    U Wazir
    The London Breast Institute, Princess Grace Hospital, London, UK
    Oncol Rep 29:1969-74. 2013
    ..Our findings support the hypothesis that mTORC1 is an important upregulator of telomerase in breast cancer...
  55. ncbi request reprint The accuracy of intraoperative frozen section analysis of the sentinel lymph nodes during breast cancer surgery
    K Khalifa
    St George s Hospital, London, UK
    Int J Fertil Womens Med 49:208-11. 2004
    ..The aim of this study is to determine the accuracy and the limitations of intraoperative frozen section (IFS) analysis of SLNs during breast cancer surgery...
  56. pmc The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters
    W Al Sarakbi
    St George s University of London, London, UK
    BMC Cancer 9:290. 2009
    ..This is the first study in the literature to examine the direct relationship between SETD2 and breast cancer...
  57. ncbi request reprint HTERT mRNA expression correlates with matrix metalloproteinase-1 and vascular endothelial growth factor expression in human breast cancer: a correlative study using RT-PCR
    L Mansfield
    The Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, London, UK
    Anticancer Res 27:2265-8. 2007
    ..This study aims to examine the association between hTERT transcription and that of VEGF-D, VEGF-C, MMP-1, PAR1a and PAR1b through a correlative analysis of the mRNA transcripts of these genes in human breast cancer...
  58. ncbi request reprint The significance of human telomerase reverse transcriptase (hTERT) in cancer
    K L Kirkpatrick
    Barts Hospital, NHS Trust, London, UK
    Eur J Surg Oncol 27:754-60. 2001
    ..The aim of this article is to review the current evidence for the function and activity of hTERT in malignant conditions, and to discuss the future possibilities in terms of cancer diagnosis and treatment...
  59. ncbi request reprint The potential clinical applications of insulin-like growth factor-1 ligand in human breast cancer
    Y M Chong
    Department of Breast and Endocrine Surgery, St George s Hospital, Tooting, London, UK
    Anticancer Res 27:1617-24. 2007
    ..The role of IGF-1 expression in breast cancer tissue as a prognostic marker is not clearly established. Identifying the IGF-1 gene polymorphism can potentially be used in predicting breast cancer risk...
  60. ncbi request reprint Aromatase inhibitors
    G H Cunnick
    St George's Breast Cancer Centre, St George's Hospital, London, UK
    Curr Med Res Opin 17:217-22. 2001
    ..Studies comparing these drugs head-to-head and with adjuvant tamoxifen are currently in progress. The potential role of these drugs in breast cancer prevention is worth investigating...
  61. ncbi request reprint The role of mammary ductoscopy in the assessment of breast disease
    Clare Leris
    St George s Hospital, London, UK
    Int J Fertil Womens Med 49:200-2. 2004
    ....
  62. ncbi request reprint Treatment of ductal carcinoma in situ of the breast: review of recent advances and future prospects
    Kefah Mokbel
    Brunel Institute of Cancer Genetics, and Breast and Endocrine Surgeon, St George s Hospital, London, UK
    Int J Fertil Womens Med 48:217-25. 2003
    ....
  63. doi request reprint Does post-mastectomy radiotherapy represent a contraindication to skin-sparing mastectomy and immediate reconstruction: an update
    K Lambert
    The Breast Unit, University Hospitals Leicester, 56 Stretton Road, Leicester, UK
    Surg Oncol 21:e67-74. 2012
    ..This article summarises the above evidence and highlights a reconstructive algorithm that may be used to mitigate the possible deleterious effects of PMRT on results...
  64. ncbi request reprint The mRNA expression of DAP1 in human breast cancer: correlation with clinicopathological parameters
    U Wazir
    Department of Breast Surgery, St George s Hospital and Medical School, University of London, London, U K
    Cancer Genomics Proteomics 9:199-201. 2012
    ..This pilot study is the first to focus on the potential role of death-associated protein 1 (DAP1) in human breast cancer...
  65. ncbi request reprint British women's choice between sentinel node biopsy and axillary node clearance for breast cancer
    M Asaad
    The Princess Grace Hospital, London, UK
    Curr Med Res Opin 19:570-4. 2003
    ..The aim of this study is to determine the proportion of female patients attending a breast unit who would choose the SNB in preference to ANC...
  66. doi request reprint The utility of MRI for the screening and staging of breast cancer
    N Patani
    The London Breast Institute, The Princess Grace Hospital, London, UK
    Int J Clin Pract 62:450-3. 2008
    ..Controversies are discussed in the context of the tumour biology and natural history of breast cancer...
  67. ncbi request reprint Surgical excision for B3 breast lesions diagnosed by vacuum-assisted core biopsy
    S Reefy
    London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, UK
    Anticancer Res 30:2287-90. 2010
    ..The aim of this retrospective study was to assess whether open surgical excision is required following a B3 diagnosis on 11-gauge vacuum-assisted core biopsy (VACB) of radiologically indeterminate breast lesions...
  68. ncbi request reprint Re: Poremba et al Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR. J Pathol 2002; 198: 181-189
    K Mokbel
    Brunel Institute of Cancer Genetics, Brunel University and St George s Hospital and Medical School, London, UK
    J Pathol 199:542. 2003
  69. ncbi request reprint The evolving role of sentinel lymph node biopsy for breast cancer
    G Singh Ranger
    St George s Hospital and Medical School, Blackshaw Road, London SW17 0QT, UK
    Eur J Surg Oncol 29:423-5. 2003
    ....
  70. ncbi request reprint Pure antiestrogens and breast cancer
    A E Elkak
    The Breast Cancer Centre, St George's Hospital and Medical School, London, UK
    Curr Med Res Opin 17:282-9. 2001
    ..They have no stimulatory effects on the uterus or vagina. It seems reasonable to expect that pure antiestrogens will be good alternatives to tamoxifen and aromatase inhibitors in the treatment of breast cancer...
  71. ncbi request reprint The sentinel node biopsy is a new standard of care for patients with early breast cancer
    Gurpreet Singh-Ranger
    Department of Breast Surgery, St George s Hospital, London, UK
    Int J Fertil Womens Med 49:225-7. 2004
    ..The SLNB is emerging as a new standard of care in patients with early breast cancer. However, certain criteria should be fulfilled for its safe application...
  72. ncbi request reprint Oncological safety and patient satisfaction with skin-sparing mastectomy and immediate breast reconstruction
    N Patani
    The London Breast Institute, The Princess Grace Hospital, London, UK
    Surg Oncol 17:97-105. 2008
    ..The purpose of this study is to evaluate the oncological safety, post-operative morbidity and patients' satisfaction with SSM and IBR using the latissimus dorsi (LD) myocutaneous flap and/or breast prosthesis...
  73. ncbi request reprint WNT5A expression in human breast cancer
    A C A Leris
    St George s Hospital, Blackshaw Road, Tooting, London SW17 OQT, UK
    Anticancer Res 25:731-4. 2005
    ..Therefore the observed function of Wnt5a is entirely dependent upon its context, hence the confusion over its role in tumorigenesis. This study examines Wnt5a mRNA expression using RT-PCR in human breast cancer...
  74. ncbi request reprint Insulin-like growth factor 1 (IGF-1) and its receptor mRNA levels in breast cancer and adjacent non-neoplastic tissue
    Y M Chong
    Department of Breast Surgery, St George s Hospital and Medical School, University of London, London SW17 0RE, UK
    Anticancer Res 26:167-73. 2006
    ..The IGF-1 and IGF-1R expression in pairs of breast cancer tissue and ANCT were investigated using RT-PCR and immunohistochemistry. The results of both methods were compared...
  75. ncbi request reprint Mammographic breast density by area of residence: possible evidence of higher density in urban areas
    N M Perry
    London Breast Institute, Princess Grace Hospital, 42 52 Nottingham Place, London, UK
    Curr Med Res Opin 24:365-8. 2008
    ..A comparison of mammographic breast densities of women living in London with those of women living in rural and suburban areas...
  76. ncbi request reprint Recent advances in breast cancer (the Twenty-fourth San Antonio Breast Cancer Symposium, December, 2001)
    K Mokbel
    The Breast Unit, St George s Hospital and Medical School, London, UK
    Curr Med Res Opin 18:26-9. 2002
    ..There is no evidence to support the use of IHC of the sentinel node in routine clinical practice. LCIS is currently considered as a non-obligate precursor to breast cancer rather than just a risk factor...
  77. ncbi request reprint Infiltrating fibromatosis of the breast: a potential pitfall
    C Kouriefs
    Breast Unit, St Bartholomew s Hospital, London, UK
    Int J Clin Pract 56:401-2. 2002
    ..It presents a big dilemma for the clinician, because it mimics breast cancer clinically, radiologically and sometimes cytologically. We report a case of fibromatosis of the breast and highlight the diagnostic difficulties and management...
  78. ncbi request reprint The role of cyclooxygenase-2 (COX-2) in breast cancer, and implications of COX-2 inhibition
    G Singh-Ranger
    Breast Cancer Unit, St George s Hospital Medical School, London, SW17 0QT, UK
    Eur J Surg Oncol 28:729-37. 2002
    ..This article reviews the evidence for a relationship between the COX enzyme system and mammary carcinogenesis, and discusses the likely therapeutic roles and potential pitfalls of COX inhibition...
  79. ncbi request reprint Mammary ductoscopy: past, present, and future
    Bernadette Pereira
    St George s Hospital and Medical School, Tooting, London, UK
    Int J Clin Oncol 10:112-6. 2005
    ....
  80. ncbi request reprint The clinical significance of sentinel lymph node micrometastasis in breast cancer
    Neill Patani
    The London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, UK
    Breast Cancer Res Treat 114:393-402. 2009
    ..In this article we review the literature concerning axillary lymph node (ALN) MM, with particular reference to SLNB. The controversies regarding histopathological assessment, clinical relevance and management implications are discussed...
  81. ncbi request reprint Current management of DCIS: a review
    Neill Patani
    The London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London, W1U 5NY, UK
    Breast Cancer Res Treat 111:1-10. 2008
    ..This article reviews the management strategies for DCIS in the context of recent randomized trials, including the role of sentinel lymph node biopsy, adjuvant radiotherapy and tamoxifen...
  82. ncbi request reprint Oncological and aesthetic considerations of skin-sparing mastectomy
    Neill Patani
    London Breast Institute, The Princess Grace Hospital, London, W1U 5NY, UK
    Breast Cancer Res Treat 111:391-403. 2008
    ..Controversies including the impact of radiotherapy (RT) on immediate breast reconstruction (IBR), preservation of the nipple-areola complex (NAC) and the role of endoscopic mastectomy are also considered...
  83. ncbi request reprint Commentary: optimal adjuvant endocrine therapy of postmenopausal breast cancer
    Giles Cunnick
    St George s Hospital, London, United Kingdom
    Int J Fertil Womens Med 50:197-8. 2005
    ..However, further research is required to establish the optimal aromatase inhibitor and whether such a drug should be used as monotherapy or in sequence after 2 to 3 years of tamoxifen...
  84. ncbi request reprint The potential role of breast ductoscopy in breast cancer screening
    W Al Sarakbi
    Department of Breast Surgery, St George s Hospital, London, United Kingdom
    Int J Fertil Womens Med 50:208-11. 2005
    ..This article focuses on the potential of this technique in breast cancer screening and highlights its limitations in this context...
  85. ncbi request reprint Abdominal ganglioneuromas in adults
    C Kouriefs
    Endocrine Surgical Unit, St Bartholomew s Hospital, London, UK
    Urol Int 71:110-3. 2003
    ..We here report 3 cases of ganglioneuromas highlighting important points regarding the radiological assessment, management, decision making and surgical approaches...
  86. ncbi request reprint Skin-sparing mastectomy
    Giles H Cunnick
    Department of Breast Surgery, St George s Hospital, Tooting, London, United Kingdom
    Am J Surg 188:78-84. 2004
    ..It facilitates immediate breast reconstruction using an implant or myocutaneous flap, resulting in excellent cosmesis...
  87. ncbi request reprint Skin-sparing mastectomy and immediate breast reconstruction: patient satisfaction and clinical outcome
    Mohamed Salhab
    The Princess Grace Hospital, 42 52 Nottingham Place, London, W1M 3FD, UK
    Int J Clin Oncol 11:51-4. 2006
    ....
  88. ncbi request reprint Breast cancer risk in flight attendants: an update
    M Salhab
    St George s, University of London, London, United Kingdom
    Int J Fertil Womens Med 51:205-7. 2006
    ..Female flight attendants and women who fly frequently should be informed of this potential increase in risk and be encouraged to participate in appropriate breast cancer screening programs...
  89. ncbi request reprint Telomerase activity and Bcl-2 expression in human breast cancer
    A E Elkak
    The Breast Cancer Centre, St George s Hospital and Medical School, Blackshaw Road, London, SW17 0QT, UK
    Eur J Surg Oncol 28:14-8. 2002
    ..We hypothesized that telomerase reactivation in human breast cancer was associated with increased immunohistochemical expression of Bcl-2...
  90. ncbi request reprint Risk-reducing strategies for breast cancer--a review of recent literature
    Kefah Mokbel
    Brunel Institute of Cancer Genetics, and The Princess Grace Hospitals, London, UK
    Int J Fertil Womens Med 48:274-7. 2003
    ....
  91. ncbi request reprint Elevated cyclooxygenase-2 expression correlates with distant metastases in breast cancer
    Gurpreet Singh Ranger
    Breast Cancer Unit, St George s Hospital and Medical School, Level 3, St James Wing, Blackshaw Road, Tooting, London, SW17 0QT, UK
    Anticancer Res 24:2349-51. 2004
    ..In this study, we analysed the relationship between COX-2 expression and various clinicopathological factors in human breast cancer...
  92. ncbi request reprint Is it safe to preserve the nipple areola complex during skin-sparing mastectomy for breast cancer?
    Ramia Mokbel
    Department of Breast Surgery, St George s and The Princess Grace Hospitals, London, United Kingdom
    Int J Fertil Womens Med 51:230-2. 2006
    ..Skin-sparing mastectomy (SSM) with nipple areola complex (NAC) preservation appears to be oncologically safe, provided the tumor is not close to the nipple and a frozen section protocol for the retroareolar tissue is followed...
  93. ncbi request reprint Oestrogen producing enzymes and mammary carcinogenesis: a review
    Ashok Subramanian
    St George s Hospital, Blackshaw Road, Tooting, London, UK
    Breast Cancer Res Treat 111:191-202. 2008
    ..Such endocrine therapy is currently being explored and the development of STS inhibitors, combined aromatase/steroid sulfatase inhibitors and 17-beta-HSD type 1 inhibitors is underway with promising initial results...
  94. ncbi request reprint The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome
    Mohamed Salhab
    St George s University of London, Blackshaw Road, and The Princess Grace Hospital, London, SW17 OQT, UK
    Breast Cancer Res Treat 109:35-46. 2008
    ..These proteins include hTR, TRF1, TRF2, TANK1, TANK2, POT1, TIN2, EST1, and TEP. This study represents the first comprehensive investigation of the mRNA expression of key telomere-related genes in human breast cancer...
  95. ncbi request reprint Management of gynaecomastia: an update
    P Gikas
    St George s Hospital, London, UK
    Int J Clin Pract 61:1209-15. 2007
    ..The use of a combination of surgical excision and liposuction through a periareolar incision represents the surgical approach of choice...
  96. ncbi request reprint The evolving role of radiofrequency ablation therapy of breast lesions
    B Soukup
    St George s Hospital University of London, London, UK
    Anticancer Res 30:3693-7. 2010
    ..This non surgical technique potentially provides a non invasive, cosmetically pleasing result that is preferable to surgeon and patient...
  97. ncbi request reprint Evidence for the management of mastalgia
    R Gumm
    Department of Breast Surgery, St George s Hospital, Tooting, London, UK
    Curr Med Res Opin 20:681-4. 2004
    ..Other proven agents include danazol and bromocriptine, but these have a higher side-effect profile and are rarely indicated nowadays. Newer treatments include lisuride maleate and topical non-steroidal anti-inflammatory preparations...
  98. ncbi request reprint Oestrogen-synthesising enzymes and breast cancer
    Myutan Kulendran
    The London Breast Institute, The Princess Grace Hospitals, London, W1M 3FD, UK
    Anticancer Res 29:1095-109. 2009
    ..The over-expression of such enzymes seems to be associated with the development of a more aggressive disease process, a poorer outcome and increased local and distant recurrences...
  99. ncbi request reprint Prognostic utility of glycosyltransferase expression in breast cancer
    Neill Patani
    The London Breast Institute, The Princess Grace Hospital, London, UK
    Cancer Genomics Proteomics 5:333-40. 2008
    ....
  100. ncbi request reprint Heterogeneity of ductal carcinoma in situ and its effects on management
    Kefah Mokbel
    St George s Medical School, London, UK
    Lancet Oncol 7:756-65. 2006
    ....
  101. ncbi request reprint Elevated expression of cyclooxygenase-2 in breast cancer and ductal carcinoma in situ has no correlation with established prognostic markers
    Gurpreet Singh Ranger
    Breast Cancer Unit, St George s Hospital and Medical School, London, United Kingdom
    J Surg Oncol 88:100-3. 2004
    ..We studied COX-2 expression in invasive ductal cancer (IDC) specimens and ductal carcinoma in situ (DCIS) in order to clarify these issues...