Chi Chiu Mok

Summary

Publications

  1. ncbi request reprint Prognostic factors in lupus nephritis
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, SAR, China
    Lupus 14:39-44. 2005
  2. ncbi request reprint Behçet's disease in southern Chinese patients
    Chi Chiu Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, New Territories, Hong Kong, SAR, China
    J Rheumatol 29:1689-93. 2002
  3. ncbi request reprint Tacrolimus for induction therapy of diffuse proliferative lupus nephritis: an open-labeled pilot study
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong SAR, China
    Kidney Int 68:813-7. 2005
  4. ncbi request reprint Clinical outcomes of systemic lupus erythematosus patients undergoing continuous ambulatory peritoneal dialysis
    Yui Pong Siu
    Department of Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong, China
    Nephrol Dial Transplant 20:2797-802. 2005
  5. doi request reprint Hormone replacement therapy in systemic lupus erythematosus
    Chi Chiu Mok
    Center for Assessment and Treatment of Rheumatic Diseases, Tuen Mun and Pok Oi Hospital, Hong Kong, China
    Nat Clin Pract Rheumatol 4:60-1. 2008
  6. doi request reprint Suicidal ideation in patients with systemic lupus erythematosus: incidence and risk factors
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, China
    Rheumatology (Oxford) 53:714-21. 2014
  7. doi request reprint Drug levels, anti-drug antibodies, and clinical efficacy of the anti-TNFα biologics in rheumatic diseases
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, SAR, China
    Clin Rheumatol 32:1429-35. 2013
  8. doi request reprint Effect of renal disease on the standardized mortality ratio and life expectancy of patients with systemic lupus erythematosus
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, China
    Arthritis Rheum 65:2154-60. 2013
  9. doi request reprint Prevalence of the antiphospholipid syndrome and its effect on survival in 679 Chinese patients with systemic lupus erythematosus: a cohort study
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Medicine (Baltimore) 92:217-22. 2013
  10. pmc Improved health outcomes with etanercept versus usual DMARD therapy in an Asian population with established rheumatoid arthritis
    Sang Cheol Bae
    Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133 792, Korea
    BMC Musculoskelet Disord 14:13. 2013

Detail Information

Publications94

  1. ncbi request reprint Prognostic factors in lupus nephritis
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, SAR, China
    Lupus 14:39-44. 2005
    ..This article reviews the important prognostic factors that have been reported in literature. The management strategy of lupus nephritis should be individualized and based on a composite of these parameters...
  2. ncbi request reprint Behçet's disease in southern Chinese patients
    Chi Chiu Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, New Territories, Hong Kong, SAR, China
    J Rheumatol 29:1689-93. 2002
    ..To describe the clinical characteristics of Behçet's disease (BD) in a southern Chinese population and compare them with those reported in other ethnic groups...
  3. ncbi request reprint Tacrolimus for induction therapy of diffuse proliferative lupus nephritis: an open-labeled pilot study
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong SAR, China
    Kidney Int 68:813-7. 2005
    ..The objective of the current work is to report our preliminary experience with tacrolimus in the treatment of diffuse proliferative glomerulonephritis in systemic lupus erythematosus (SLE)...
  4. ncbi request reprint Clinical outcomes of systemic lupus erythematosus patients undergoing continuous ambulatory peritoneal dialysis
    Yui Pong Siu
    Department of Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong, China
    Nephrol Dial Transplant 20:2797-802. 2005
    ..The purpose of this study was to evaluate the outcome of systemic lupus erythematosus (SLE) patients on continuous ambulatory peritoneal dialysis (CAPD)...
  5. doi request reprint Hormone replacement therapy in systemic lupus erythematosus
    Chi Chiu Mok
    Center for Assessment and Treatment of Rheumatic Diseases, Tuen Mun and Pok Oi Hospital, Hong Kong, China
    Nat Clin Pract Rheumatol 4:60-1. 2008
  6. doi request reprint Suicidal ideation in patients with systemic lupus erythematosus: incidence and risk factors
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, China
    Rheumatology (Oxford) 53:714-21. 2014
    ..01) and cardiovascular SDI score (β = 0.27, P < 0.001). Conclusion. Suicidal ideation is common in SLE and is more intense in patients with depressive symptoms, cardiovascular damage, recent life events and previous suicide attempts. ..
  7. doi request reprint Drug levels, anti-drug antibodies, and clinical efficacy of the anti-TNFα biologics in rheumatic diseases
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, SAR, China
    Clin Rheumatol 32:1429-35. 2013
    ..40 ± 1.67 to 3.23 ± 1.40; p = 0.73). We concluded that the presence of neutralizing antibodies is associated with lower serum levels of the anti-TNFα biologics, leading to lower efficacy and higher withdrawal rate...
  8. doi request reprint Effect of renal disease on the standardized mortality ratio and life expectancy of patients with systemic lupus erythematosus
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, China
    Arthritis Rheum 65:2154-60. 2013
    ..To study the effect of renal disease on the standardized mortality ratio (SMR) and life expectancy of patients with systemic lupus erythematosus (SLE)...
  9. doi request reprint Prevalence of the antiphospholipid syndrome and its effect on survival in 679 Chinese patients with systemic lupus erythematosus: a cohort study
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Medicine (Baltimore) 92:217-22. 2013
    ..2) Arterial thrombosis is a more common manifestation of APS than venous thrombosis in Chinese SLE patients. 3) APS related to arterial thrombosis is associated with increased mortality in Chinese patients with SLE. ..
  10. pmc Improved health outcomes with etanercept versus usual DMARD therapy in an Asian population with established rheumatoid arthritis
    Sang Cheol Bae
    Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133 792, Korea
    BMC Musculoskelet Disord 14:13. 2013
    ..Patients with established moderate to severe rheumatoid arthritis who had an inadequate response to methotrexate were studied...
  11. doi request reprint Vitamin D and systemic lupus erythematosus: an update
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, China
    Expert Rev Clin Immunol 9:453-63. 2013
    ..This review updates the recent evidence on the relationship between vitamin D status and the onset, activity and complications of SLE, and summarizes the recommendations for vitamin D supplementation...
  12. doi request reprint Immunogenicity and safety of a quadrivalent human papillomavirus vaccine in patients with systemic lupus erythematosus: a case-control study
    Chi Chiu Mok
    Department of Medicine, Tuen Mun and Pok Oi Hospital, New Territories, Hong Kong, SAR China
    Ann Rheum Dis 72:659-64. 2013
    ..To evaluate the immunogenicity and safety of GARDASIL, a quadrivalent human papillomavirus (HPV) vaccine, in patients with systemic lupus erythematosus (SLE)...
  13. pmc High-sensitivity C-reactive protein, disease activity, and cardiovascular risk factors in systemic lupus erythematosus
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, China
    Arthritis Care Res (Hoboken) 65:441-7. 2013
    ..To study the level of high-sensitivity C-reactive protein (hsCRP) and its relationship with disease activity, damage, and cardiovascular risk factors in patients with systemic lupus erythematosus (SLE)...
  14. doi request reprint Prevalence and risk factors of low bone mineral density in Chinese patients with systemic sclerosis: a case-control study
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, SAR China
    Rheumatology (Oxford) 52:296-303. 2013
    ..To study the prevalence and risk factors of low BMD in patients with SSc...
  15. doi request reprint Anti-müllerian hormone and ovarian reserve in systemic lupus erythematosus
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Arthritis Rheum 65:206-10. 2013
    ..To study the level of anti-müllerian hormone (AMH) and its relationship to age and previous exposure to cyclophosphamide (CYC) in patients with systemic lupus erythematosus (SLE)...
  16. doi request reprint Abatacept for systemic lupus erythematosus: the outlook
    Chi Chiu Mok
    Tuen Mun Hospital, Department of Medicine, New Territories, Tsing Chung Koon Road, Hong Kong, SAR, China 852 2468 5389 852 2456 9100
    Expert Opin Biol Ther 12:1559-61. 2012
    ....
  17. doi request reprint Concurrent psychiatric disorders are associated with significantly poorer quality of life in patients with rheumatoid arthritis
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Scand J Rheumatol 41:253-9. 2012
    ..To study the effect of concurrent psychiatric disorders on health-related quality of life (HRQOL) in patients with rheumatoid arthritis (RA)...
  18. doi request reprint Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, SAR, China
    Rheumatology (Oxford) 51:644-52. 2012
    ..To study the relationship of 25(OH)D(3) level with disease activity, vascular risk factors and atherosclerosis in SLE...
  19. doi request reprint Childhood-onset disease carries a higher risk of low bone mineral density in an adult population of systemic lupus erythematosus
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, SAR, China
    Rheumatology (Oxford) 51:468-75. 2012
    ..To study the BMD of patients with SLE according to the age of disease onset...
  20. ncbi request reprint Rituximab for refractory polymyositis: an open-label prospective study
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    J Rheumatol 34:1864-8. 2007
    ..To report the efficacy and toxicity of rituximab in the treatment of refractory polymyositis...
  21. doi request reprint Membranous nephropathy in systemic lupus erythematosus: a therapeutic enigma
    Chi Chiu Mok
    Division of Rheumatology, Department of Medicine, Tuen Mun Hospital, Center for Assessment and Treatment of Rheumatic Diseases, Pok Oi Hospital, Hong Kong
    Nat Rev Nephrol 5:212-20. 2009
    ..Controlled trials to compare existing immunosuppressive agents and experimental modalities such as sirolimus, rituximab and infliximab should be undertaken in the future...
  22. doi request reprint Risk and predictors of work disability in Chinese patients with systemic lupus erythematosus
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, SAR, China
    Lupus 17:1103-7. 2008
    ..More than 50% of these patients developed work disability within the first 2 years of SLE diagnosis. Older age, fatigue and more active disease were independent predictors of work disability...
  23. doi request reprint Effect of disease activity and damage on quality of life in patients with systemic lupus erythematosus: a 2-year prospective study
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR China
    Scand J Rheumatol 38:121-7. 2009
    ..To examine the effect of disease activity and damage on health-related quality of life (HRQoL) in patients with systemic lupus erythematosus (SLE)...
  24. doi request reprint Changes in body composition after glucocorticoid therapy in patients with systemic lupus erythematosus
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR China
    Lupus 17:1018-22. 2008
    ..In SLE patients, high-dose glucocorticoids lead to an early and rapid drop in bone mass, which is more serious in older patients and correlates with an increase in body fat...
  25. ncbi request reprint Incidence and mortality of systemic lupus erythematosus in a southern Chinese population, 2000-2006
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, SAR China
    J Rheumatol 35:1978-82. 2008
    ..To study the annual incidence and standardized mortality ratio (SMR) of a longitudinal cohort of Chinese patients with systemic lupus erythematosus (SLE)...
  26. doi request reprint Bone mineral density and body composition in men with systemic lupus erythematosus: a case control study
    Chi Chiu Mok
    Department of Medicine and Nuclear Medicine, Tuen Mun Hospital, Hong Kong, China
    Bone 43:327-31. 2008
    ..To study the bone mineral density (BMD) and body composition in men with systemic lupus erythematosus (SLE)...
  27. ncbi request reprint Who should treat lupus nephritis: rheumatologists or nephrologists?
    Chi Chiu Mok
    Division of Rheumatology, Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, Hong Kong, China
    Nat Clin Pract Nephrol 4:E1. 2008
  28. ncbi request reprint Immunoablative cyclophosphamide for refractory lupus-related neuromyelitis optica
    Chi Chiu Mok
    Department of Medicine and Radiology, Tuen Mun Hospital, Hong Kong SAR
    J Rheumatol 35:172-4. 2008
    ....
  29. ncbi request reprint Risedronate for prevention of bone mineral density loss in patients receiving high-dose glucocorticoids: a randomized double-blind placebo-controlled trial
    C C Mok
    Department of Medicine and Nuclear Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong, SAR, China
    Osteoporos Int 19:357-64. 2008
    ..This 6-month randomized double-blind placebo-controlled trial shows that risedronate is well tolerated and effective in improving lumbar spine BMD and reducing loss of BMD at the hips in patients receiving high-dose prednisolone...
  30. ncbi request reprint Risk and predictors of arterial thrombosis in lupus and non-lupus primary glomerulonephritis: a comparative study
    Chi Chiu Mok
    Division of Rheumatology, Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR, China
    Medicine (Baltimore) 86:203-9. 2007
    ..67; p = 0.04). We concluded that in immune-mediated glomerulonephritis, having systemic lupus increased the risk of arterial thromboembolism after adjustment for age, renal insufficiency, and other traditional risk factors...
  31. ncbi request reprint Mycophenolate mofetil for non-renal manifestations of systemic lupus erythematosus: a systematic review
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR China
    Scand J Rheumatol 36:329-37. 2007
    ..To summarize the evidence for the use of mycophenolate mofetil (MMF) in non-renal manifestations of systemic lupus erythematosus (SLE)...
  32. doi request reprint Very long-term outcome of pure lupus membranous nephropathy treated with glucocorticoid and azathioprine
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR China
    Lupus 18:1091-5. 2009
    ..Treatment with high-dose prednisolone and AZA is effective, inexpensive and well-tolerated. Prolonged observation shows that one of three patients develop renal flares, which are often proteinuric and responsive to reinduction therapy...
  33. doi request reprint Venous thromboembolism in southern Chinese patients with systemic lupus erythematosus
    Chi Chiu Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, Special Administrative Region, China
    Clin Rheumatol 29:599-604. 2010
    ..36 [1.67-11.4]; p = 0.003). Although venous thrombosis is uncommon in Chinese, Chinese patients with SLE are 12 times more prone to VTE than the general population...
  34. doi request reprint Metabolic syndrome, endothelial injury, and subclinical atherosclerosis in patients with systemic lupus erythematosus
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR China
    Scand J Rheumatol 39:42-9. 2010
    ..To study the link between metabolic syndrome (MetS), endothelial injury, and atherosclerosis in patients with systemic lupus erythematosus (SLE)...
  35. doi request reprint Vitamin D deficiency as marker for disease activity and damage in systemic lupus erythematosus: a comparison with anti-dsDNA and anti-C1q
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Lupus 21:36-42. 2012
    ..To study the sensitivity and specificity of vitamin D deficiency for predicting disease activity and damage of systemic lupus erythematosus (SLE) in comparison with anti-dsDNA and anti-C1q...
  36. doi request reprint Life expectancy, standardized mortality ratios, and causes of death in six rheumatic diseases in Hong Kong, China
    C C Mok
    Tuen Mun Hospital, Hong Kong, China
    Arthritis Rheum 63:1182-9. 2011
    ..To examine the life expectancy, standardized mortality ratios (SMRs), and causes of death in 6 groups of patients from Hong Kong with different rheumatic diseases...
  37. doi request reprint Raloxifene for prevention of glucocorticoid-induced bone loss: a 12-month randomised double-blinded placebo-controlled trial
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, SAR China
    Ann Rheum Dis 70:778-84. 2011
    ..To study the efficacy of raloxifene in preventing bone mineral density (BMD) loss in women receiving long-term glucocorticoids (GC). The study took the form of a parallel-group randomised double-blinded placebo-controlled trial...
  38. doi request reprint Epidemiology and survival of systemic lupus erythematosus in Hong Kong Chinese
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Lupus 20:767-71. 2011
    ..With the availability of novel therapeutics and an increased awareness of complication prevention in SLE, it is expected that our patients will live longer with a better quality of life in the next decade...
  39. doi request reprint Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, SAR China
    Transl Res 156:320-5. 2010
    ..The anti-C1q antibody, however, is more specific than anti-dsDNA for both active renal and extrarenal lupus. The absence of both anti-dsDNA and anti-C1q has a high NPV for renal activity...
  40. pmc Management of rheumatoid arthritis: consensus recommendations from the Hong Kong Society of Rheumatology
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong
    Clin Rheumatol 30:303-12. 2011
    ....
  41. doi request reprint Effects of rosuvastatin on vascular biomarkers and carotid atherosclerosis in lupus: a randomized, double-blind, placebo-controlled trial
    Chi Chiu Mok
    Tuen Mun Hospital, Hong Kong, China
    Arthritis Care Res (Hoboken) 63:875-83. 2011
    ..To study the effect of rosuvastatin on vascular biomarkers and carotid intima-media thickness (IMT) in systemic lupus erythematosus (SLE)...
  42. doi request reprint Prevalence and determinants of psychiatric disorders in patients with rheumatoid arthritis
    Eugenia Yung Ching Lok
    correspondence and M D, FRCP, Chief of Rheumatology, Dept of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, SAR, China
    Psychosomatics 51:338-338.e8. 2010
    ..33%-0.35%. The resulting chronic pain, disability, social stress, and isolation contribute to the development of psychiatric symptoms...
  43. ncbi request reprint Management of systemic lupus erythematosus in Chinese patients
    Chi Chiu Mok
    Tuen Mun Hospital, Department of Medicine and Geriatrics, New Territories, Hong Kong, China
    Expert Rev Clin Immunol 3:925-35. 2007
    ..This review summarizes the management strategies and novel therapeutic modalities in SLE...
  44. pmc Biomarkers for lupus nephritis: a critical appraisal
    Chi Chiu Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital and Center for Assessment and Treatment of Rheumatic Diseases, Pok Oi Hospital, Hong Kong
    J Biomed Biotechnol 2010:638413. 2010
    ..This paper reviews promising biomarkers that have recently been evaluated in longitudinal studies of lupus nephritis...
  45. doi request reprint Minimal mesangial lupus nephritis: a systematic review
    C C Mok
    Department of Medicine, Tuen Mun Hospital and Centre for Assessment and Treatment of Rheumatic Diseases, Pok Oi Hospital, Hong Kong, China
    Scand J Rheumatol 39:181-9. 2010
    ..To summarize the clinical presentation, histological features, treatment, and outcome of minimal change nephropathy (MCN) in patients with systemic lupus erythematosus (SLE)...
  46. doi request reprint Update on emerging drug therapies for systemic lupus erythematosus
    Chi Chiu Mok
    Tuen Mun Hospital, Department of Medicine and Geriatrics, New Territories, Hong Kong, Japan
    Expert Opin Emerg Drugs 15:53-70. 2010
    ..More effective but less toxic therapies through modification of existing regimens, combination strategies or more specific targeting at the immunopathogenetic pathways are necessary...
  47. doi request reprint Prevalence of atherosclerotic risk factors and the metabolic syndrome in patients with chronic inflammatory arthritis
    Chi Chiu Mok
    Tuen Mun Hospital, Chinese University of Hong Kong, Hong Kong, China
    Arthritis Care Res (Hoboken) 63:195-202. 2011
    ..To evaluate the prevalence of the metabolic syndrome in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)...
  48. ncbi request reprint Emerging drug therapies for systemic lupus erythematosus
    Chi Chiu Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, New Territories, Hong Kong, China
    Expert Opin Emerg Drugs 11:597-608. 2006
    ..This article reviews the emerging therapeutic modalities that have been used or are being tried in patients with SLE...
  49. ncbi request reprint Incidence and risk factors of thromboembolism in systemic lupus erythematosus: a comparison of three ethnic groups
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, China
    Arthritis Rheum 52:2774-82. 2005
    ..To compare the incidence and risk factors for thromboembolic events in systemic lupus erythematosus (SLE) patients of different ethnic backgrounds...
  50. ncbi request reprint Diffuse skeletal hyperostosis and pseudohypoparathyroidism
    A Mak
    Rheumatology (Oxford) 44:182. 2005
  51. ncbi request reprint Bone mineral density in postmenopausal Chinese patients with systemic lupus erythematosus
    C C Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, SAR, China
    Lupus 14:106-12. 2005
    ..Active intervention should be considered. The protective role of HCQ has to be confirmed with further studies...
  52. ncbi request reprint Long-term survival of southern Chinese patients with systemic lupus erythematosus: a prospective study of all age-groups
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong
    Medicine (Baltimore) 84:218-24. 2005
    ..Long-term survival of Chinese SLE patients is comparable to that reported for white patients in the 1990s. Late-onset SLE patients have the worst prognosis. Early damage predicts mortality...
  53. ncbi request reprint Incidence and predictors of renal disease in Chinese patients with systemic lupus erythematosus
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, Special Administrative Region, China
    Am J Med 117:791-5. 2004
  54. ncbi request reprint Investigations and management of gastrointestinal and hepatic manifestations of systemic lupus erythematosus
    C C Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, New Territories, Hong Kong, China
    Best Pract Res Clin Rheumatol 19:741-66. 2005
    ..Surgical intervention should be instituted without delay if conservative management fails or when there is clinical or radiological suspicion of visceral perforation or intra-abdominal collections...
  55. ncbi request reprint Outcome of protein-losing gastroenteropathy in systemic lupus erythematosus treated with prednisolone and azathioprine
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, SAR, China
    Rheumatology (Oxford) 45:425-9. 2006
    ..To report the efficacy of prednisolone and azathioprine (AZA) in the treatment of systemic lupus erythematosus (SLE)-related protein-losing gastroenteropathy (PLGE)...
  56. ncbi request reprint Accelerated atherosclerosis, arterial thromboembolism, and preventive strategies in systemic lupus erythematosus
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR China
    Scand J Rheumatol 35:85-95. 2006
    ..Judicious use of corticosteroids, calcineurin inhibitors, hormonal replacement therapy, and the cyclooxygenase 2 inhibitors is equally important...
  57. ncbi request reprint Neuropsychiatric damage in Southern Chinese patients with systemic lupus erythematosus
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong SAR, China
    Medicine (Baltimore) 85:221-8. 2006
    ..Primary prevention for cerebrovascular disease in high-risk patients may reduce NP damage...
  58. ncbi request reprint Therapeutic options for resistant lupus nephritis
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR China
    Semin Arthritis Rheum 36:71-81. 2006
    ..To summarize the therapeutic options for proliferative and membranous lupus nephritis that is resistant to conventional treatment...
  59. ncbi request reprint Long-term outcome of diffuse proliferative lupus glomerulonephritis treated with cyclophosphamide
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, China
    Am J Med 119:355.e25-33. 2006
    ..To report the long-term outcome of diffuse proliferative lupus nephritis (DPLN) treated with cyclophosphamide (CYC) in Chinese patients...
  60. ncbi request reprint Raloxifene for postmenopausal women with systemic lupus erythematosus: a pilot randomized controlled study
    Chi Chiu Mok
    Tuen Mun Hospital, Hong Kong, China
    Arthritis Rheum 52:3997-4002. 2005
    ..To study the effects of raloxifene on disease activity and bone mineral density (BMD) in postmenopausal women with systemic lupus erythematosus (SLE)...
  61. doi request reprint Annual incidence and standardized incidence ratio of cerebrovascular accidents in patients with systemic lupus erythematosus
    C C Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, SAR China
    Scand J Rheumatol 38:362-8. 2009
    ..To study the annual incidence and standardized incidence ratio (SIR) of cerebrovascular accident (CVA) in patients with systemic lupus erythematosus (SLE)...
  62. ncbi request reprint Damage accrual in southern Chinese patients with systemic lupus erythematosus
    Chi Chiu Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, New Territories, Hong Kong
    J Rheumatol 30:1513-9. 2003
    ..To study the predictive factors of damage accrual in a large cohort of southern Chinese patients with systemic lupus erythematosus (SLE)...
  63. ncbi request reprint Predictors and outcome of renal flares after successful cyclophosphamide treatment for diffuse proliferative lupus glomerulonephritis
    Chi Chiu Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, New Territories, Hong Kong, China
    Arthritis Rheum 50:2559-68. 2004
    ..To study the incidence, predictors, and outcome of renal flares after successful cyclophosphamide (CYC) treatment for diffuse proliferative glomerulonephritis (DPGN) in patients with systemic lupus erythematosus (SLE)...
  64. ncbi request reprint Factors predictive of corticosteroid psychosis in patients with systemic lupus erythematosus
    Shuk Yi Chau
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong SAR, China
    Neurology 61:104-7. 2003
    ..After multivariate adjustment, only hypoalbuminemia remained significant...
  65. ncbi request reprint Treatment of lupus psychosis with oral cyclophosphamide followed by azathioprine maintenance: an open-label study
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, China
    Am J Med 115:59-62. 2003
  66. ncbi request reprint Treatment of pure membranous lupus nephropathy with prednisone and azathioprine: an open-label trial
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, SAR, People, s Republic of China
    Am J Kidney Dis 43:269-76. 2004
    ..The aim of this study was to report the outcome of pure membranous lupus nephropathy treated with prednisone and azathioprine (AZA)...
  67. ncbi request reprint Renal damage in systemic lupus erythematosus: a comparative analysis of different age groups
    A Mak
    Department of Medicine and Geriatrics, Tuen Mun Hospital, Tsing Chung Koon Road, Hong Kong SAR
    Lupus 16:28-34. 2007
    ..Late onset SLE patients had accrued more renal damage but age did not correlate with renal damage after adjustment for various clinical parameters...
  68. ncbi request reprint Adrenomedullin--a potential disease activity marker and suppressor of nephritis activity in systemic lupus erythematosus
    A Mak
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China
    Rheumatology (Oxford) 45:1266-72. 2006
    ....
  69. doi request reprint Prognostically distinct clinical patterns of systemic lupus erythematosus identified by cluster analysis
    C H To
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong SAR, China
    Lupus 18:1267-75. 2009
    ..27 (1.1-1.5), p = 0.005] and cluster 1 [standardized mortality ratio 0.95 (0.5-1.7), p = 0.86]. In conclusion, patients with systemic lupus erythematosus could be clustered into prognostically distinct patterns of clinical manifestations...
  70. ncbi request reprint Treatment of diffuse proliferative lupus glomerulonephritis: a comparison of two cyclophosphamide-containing regimens
    C C Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, SAR, China
    Am J Kidney Dis 38:256-64. 2001
    ..Additional randomized trials involving a larger cohort of patients with a longer period of observation are necessary...
  71. ncbi request reprint Serositis related to systemic lupus erythematosus: prevalence and outcome
    B L Man
    Department of Medicine, Tuen Mun Hospital, Hong Kong SAR, China
    Lupus 14:822-6. 2005
    ..The prognosis of lupus serositis is generally good. Relapse or progression to fibrotic disease is uncommon...
  72. ncbi request reprint Treatment for lupus nephritis: a revisit
    Kar Neng Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Nephrology (Carlton) 10:180-8. 2005
    ..The potential of other new therapeutic agents is discussed together with the need for patient recruitment in future trials of lupus nephritis to address the importance of ethnicity as well as histological grading...
  73. ncbi request reprint Clinical characteristics, treatment, and outcome of adult onset Still's disease in southern Chinese
    C C Mok
    Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
    J Rheumatol 25:2345-51. 1998
    ..To study the clinical characteristics, treatment outcome, and complications of patients with adult onset Still's disease (AOSD) in our local Chinese population...
  74. ncbi request reprint Mycophenolate mofetil for refractory haemolytic anemia in systemic lupus erythematosus
    A Mak
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong SAR, China
    Lupus 14:856-8. 2005
    ..The mechanisms of action of MMF are briefly reviewed...
  75. ncbi request reprint Successful treatment of dermatomyositis-related rapidly progressive interstitial pneumonitis with sequential oral cyclophosphamide and azathioprine
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, New Territories, SAR China
    Scand J Rheumatol 32:181-3. 2003
    ..Prompt recognition and early aggressive immunosuppressive therapy may improve the outlook of this condition...
  76. ncbi request reprint Mycophenolate mofetil in lupus glomerulonephritis
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong
    Am J Kidney Dis 40:447-57. 2002
    ..However, the lack of long-term efficacy data and comparative studies with standard CYC regimens is the major deterrent for the first-line use of MMF in high-risk patients at this juncture...
  77. doi request reprint Erythema elevatum diutinum in systemic lupus erythematosus
    Yung Chan
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong
    Rheumatol Int 31:259-62. 2011
    ..Skin biopsy confirmed the diagnosis of EED. Treatment with dapsone resulted in complete resolution of the skin lesions. EED is rarely reported in SLE, and its presentation and treatment is reviewed...
  78. ncbi request reprint Mucormycosis in systemic lupus erythematosus
    Chi Chiu Mok
    Departments of Medicine, Microbiology, Radiology, and Pathology, Tuen Mun Hospital, Hong Kong, China
    Semin Arthritis Rheum 33:115-24. 2003
    ..To describe a case of mucormycosis in systemic lupus erythematosus (SLE) and to review other patients reported in the English literature...
  79. doi request reprint ELF1 is associated with systemic lupus erythematosus in Asian populations
    Jing Yang
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Hum Mol Genet 20:601-7. 2011
    ....
  80. pmc Treatment of severe proliferative lupus nephritis: the current state
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR, China
    Ann Rheum Dis 62:799-804. 2003
  81. ncbi request reprint Lupus in Hong Kong Chinese
    C C Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong Special Administrative Region, China
    Lupus 12:717-22. 2003
    ..More grants and funding are being sought for basic and clinical researches in SLE and subsidising patients to receive newer and less toxic treatment options...
  82. pmc Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese
    Y K Chang
    Li Ka Shing Faculty of Medicine, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Genes Immun 10:414-20. 2009
    ..26 x 10(-3)), but not vice versa (P=0.55). These findings suggest that multiple independent genetic variants may be present within the gene locus, which exert their effects on SLE pathogenesis through different mechanisms...
  83. ncbi request reprint Neuropsychiatric manifestations and their clinical associations in southern Chinese patients with systemic lupus erythematosus
    C C Mok
    Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, China
    J Rheumatol 28:766-71. 2001
    ..Seizure and cerebrovascular disorders were the most common NP features. The presence of antiphospholipid antibodies was significantly associated with NP manifestations, especially cerebrovascular disorders...
  84. ncbi request reprint Lupus nephritis in Southern Chinese patients: clinicopathologic findings and long-term outcome
    C C Mok
    Division of Rheumatology, Queen Mary Hospital, Pokfulam, Hong Kong
    Am J Kidney Dis 34:315-23. 1999
    ..Prospective randomized studies with well-defined treatment protocols are needed to delineate the optimal treatment strategy for LN...
  85. pmc Pregnancy in systemic lupus erythematosus
    C C Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong
    Postgrad Med J 77:157-65. 2001
    ....
  86. pmc Pathogenesis of systemic lupus erythematosus
    C C Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong
    J Clin Pathol 56:481-90. 2003
    ..Finally, certain environmental factors are probably required to trigger the disease...
  87. doi request reprint Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese
    W Yang
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Genes Immun 10:219-26. 2009
    ..36, OR=1.06, 95% confidence interval: 0.93-1.21). Our study indicates that some of the susceptibility genes for this disease may be population specific...
  88. ncbi request reprint Lupus pneumonitis or severe acute respiratory syndrome?
    C C Mok
    Department of Medicine, Tuen Mun Hospital, SAR, China
    Lupus 13:549-53. 2004
    ..One patient was confirmed to have coronavirus pneumonia while the other had active SLE with lung involvement. Our cases illustrate the difficult diagnostic dilemma in the evaluation of febrile SLE patients during the SARS epidemic...
  89. ncbi request reprint Use of exogenous estrogens in systemic lupus erythematosus
    C C Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital and the Department of Medicine, Queen Mary Hospital, Hong Kong
    Semin Arthritis Rheum 30:426-35. 2001
    ..To review the current literature on the safety of using exogenous estrogens in patients with systemic lupus erythematosus (SLE)...
  90. ncbi request reprint Scleroderma renal crisis sine scleroderma during pregnancy
    C C Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, New Territories, Hong Kong, SAR China
    Scand J Rheumatol 32:55-7. 2003
    ..The relationship between pregnancy, scleroderma activity and renal crisis is discussed...
  91. ncbi request reprint Profile of sex hormones in male patients with systemic lupus erythematosus
    C C Mok
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Lupus 9:252-7. 2000
    ..To study the profile of sex hormones in male patients with systemic lupus erythematosus (SLE)...
  92. ncbi request reprint Rheumatoid-like polyarthritis as a presenting feature of metastatic carcinoma: a case presentation and review of the literature
    C C Mok
    Tuen Mun Hospital, New Territories, Hong Kong, SAR China
    Clin Rheumatol 22:353-4. 2003
    ..An underlying malignancy should always be looked for in elderly patients who present with explosive polyarthritis for the first time, particular if unexplained anaemia or constitutional symptoms persist after treatment...
  93. ncbi request reprint Outcome and prognostic indicators of diffuse proliferative lupus glomerulonephritis treated with sequential oral cyclophosphamide and azathioprine
    Chi Chiu Mok
    Queen Mary Hospital, Pokfulam, Hong Kong
    Arthritis Rheum 46:1003-13. 2002
    ..To study the outcome and prognostic indicators of diffuse proliferative glomerulonephritis (DPGN) in patients with systemic lupus erythematosus (SLE) treated with sequential oral cyclophosphamide (CYC) and azathioprine (AZA)...
  94. ncbi request reprint Cyclophosphamide for severe lupus nephritis: where are we now?
    Chi Chiu Mok
    Arthritis Rheum 50:3748-50. 2004