Lyn M Moir

Summary

Publications

  1. pmc TSC2 modulates cell adhesion and migration via integrin-α1β1
    Lyn M Moir
    Cell Biology, Woolcock Institute of Medical Research, PO Box M77, Missenden Rd, NSW, 2050, Australia
    Am J Physiol Lung Cell Mol Physiol 303:L703-10. 2012
  2. doi Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function
    Lyn M Moir
    Woolcock Institute of Medical Research, Sydney, Australia
    J Pharmacol Exp Ther 337:557-66. 2011
  3. pmc Doxycycline inhibits matrix metalloproteinase-2 secretion from TSC2-null mouse embryonic fibroblasts and lymphangioleiomyomatosis cells
    L M Moir
    Woolcock Institute of Medical Research, Sydney, NSW, Australia
    Br J Pharmacol 164:83-92. 2011
  4. doi The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle
    Qi Ge
    Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 227:3044-52. 2012
  5. doi β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers
    Kyoko Niimi
    Cell Biology Group, Woolcock Institute of Medical Research, School of Medical Sciences, The Univ of Sydney, Sydney, NSW, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L334-42. 2012
  6. doi TGFβ1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells: the role of Smad2/3
    Qi Ge
    Respiratory Research Group, Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 225:846-54. 2010
  7. pmc Fibulin-1 is increased in asthma--a novel mediator of airway remodeling?
    Justine Y Lau
    Cooperative Research Centre for Asthma and Airways, Sydney, New South Wales, Australia
    PLoS ONE 5:e13360. 2010
  8. pmc β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D
    Thomas Trian
    Cell Biology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    PLoS ONE 6:e20000. 2011
  9. doi Transforming growth factor beta 1 increases fibronectin deposition through integrin receptor alpha 5 beta 1 on human airway smooth muscle
    Lyn M Moir
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    J Allergy Clin Immunol 121:1034-9.e4. 2008
  10. doi Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness
    Janette K Burgess
    Respiratory Research Group, Discipline of Pharmacology, Bosch Building, D05, University of Sydney, Sydney, NSW, Australia 2006
    Am J Respir Crit Care Med 181:106-15. 2010

Detail Information

Publications18

  1. pmc TSC2 modulates cell adhesion and migration via integrin-α1β1
    Lyn M Moir
    Cell Biology, Woolcock Institute of Medical Research, PO Box M77, Missenden Rd, NSW, 2050, Australia
    Am J Physiol Lung Cell Mol Physiol 303:L703-10. 2012
    ..Together, these data demonstrate that TSC2 controls cell migration, attachment, and spreading through the α1β1-integrin receptor and thus suggest a potential therapeutic target for the treatment of increased cell invasiveness in LAM...
  2. doi Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function
    Lyn M Moir
    Woolcock Institute of Medical Research, Sydney, Australia
    J Pharmacol Exp Ther 337:557-66. 2011
    ..In addition, PIK75 decreased cell survival in TGFβ-stimulated asthmatic, but not nonasthmatic, ASM cells. In conclusion, specific PI3K isoforms may play a role in pathophysiological events relevant to airway wall remodeling...
  3. pmc Doxycycline inhibits matrix metalloproteinase-2 secretion from TSC2-null mouse embryonic fibroblasts and lymphangioleiomyomatosis cells
    L M Moir
    Woolcock Institute of Medical Research, Sydney, NSW, Australia
    Br J Pharmacol 164:83-92. 2011
    ..The aim of this study was to determine whether doxycycline, a known MMP inhibitor, can inhibit LAM cell proliferation or mitochondrial function and/or modulate MMPs and their tissue inhibitors (TIMPs)...
  4. doi The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle
    Qi Ge
    Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 227:3044-52. 2012
    ....
  5. doi β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers
    Kyoko Niimi
    Cell Biology Group, Woolcock Institute of Medical Research, School of Medical Sciences, The Univ of Sydney, Sydney, NSW, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L334-42. 2012
    ..This leads us to speculate that continual therapy with β2AR agonists is unlikely to cause PDE4-mediated tachyphylaxis...
  6. doi TGFβ1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells: the role of Smad2/3
    Qi Ge
    Respiratory Research Group, Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 225:846-54. 2010
    ..Understanding the mechanism of aberrant pro-inflammatory cytokine production in asthmatic airways will allow the development of alternative ways to control airway inflammation...
  7. pmc Fibulin-1 is increased in asthma--a novel mediator of airway remodeling?
    Justine Y Lau
    Cooperative Research Centre for Asthma and Airways, Sydney, New South Wales, Australia
    PLoS ONE 5:e13360. 2010
    ..There are four isoforms in humans (A-D) of which fibulin-1C and 1D predominate. The objective of this study was to study the expression of fibulin-1 in volunteers with and without asthma, and to examine its function in vitro...
  8. pmc β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D
    Thomas Trian
    Cell Biology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    PLoS ONE 6:e20000. 2011
    ..In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asthmatics, but the mechanism is not known...
  9. doi Transforming growth factor beta 1 increases fibronectin deposition through integrin receptor alpha 5 beta 1 on human airway smooth muscle
    Lyn M Moir
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    J Allergy Clin Immunol 121:1034-9.e4. 2008
    ..Altered expression of the integrin receptors, such as the fibronectin receptor alpha(5)beta(1), might be implicated in extracellular matrix accumulation in airway remodeling in asthma...
  10. doi Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness
    Janette K Burgess
    Respiratory Research Group, Discipline of Pharmacology, Bosch Building, D05, University of Sydney, Sydney, NSW, Australia 2006
    Am J Respir Crit Care Med 181:106-15. 2010
    ..Collagen IV is decreased in the airway basement membrane in asthma. It has six alpha chains, of which the noncollagenous domain-1 domains have endogenous antiangiogenic properties...
  11. ncbi Rhinovirus-induced exacerbations of asthma: How is the {beta}2-adrenoceptor implicated?
    Thomas Trian
    The University of Sydney, NSW, Australia
    Am J Respir Cell Mol Biol 43:227-33. 2010
    ....
  12. doi Tissue and matrix influences on airway smooth muscle function
    Janette K Burgess
    Discipline of Pharmacology, Bosch Institute, University of Sydney, Sydney, Australia
    Pulm Pharmacol Ther 22:379-87. 2009
    ..This review summarises our current understanding of the influence of the ECM on ASM function...
  13. ncbi A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro
    Janette K Burgess
    Department of Pharmacology, University of Sydney, NSW, Australia
    J Allergy Clin Immunol 118:649-57. 2006
    ..Airway smooth muscle (ASM) cells may contribute to airway remodeling through the release of growth factors, cytokines, and extracellular matrix (ECM) proteins. The effect of current asthma therapies on this release is not known...
  14. doi Differential expression of peroxisome proliferator activated receptor gamma and cyclin D1 does not affect proliferation of asthma- and non-asthma-derived airway smooth muscle cells
    Justine Y Lau
    Cooperative Research Centre for Asthma and Airways, The University of Sydney, Sydney, New South Wales, Australia
    Respirology 15:303-12. 2010
    ..In the presence of FBS, PPARgamma levels were higher in subconfluent asthma-derived cells but lower in confluent cells compared with non-asthma-derived. However, PPARgamma activation did not alter cell proliferation...
  15. doi LF-15 & T7, synthetic peptides derived from tumstatin, attenuate aspects of airway remodelling in a murine model of chronic OVA-induced allergic airway disease
    Karryn T Grafton
    Woolcock Institute of Medical Research, Sydney, New South Wales, Australia Discipline of Pharmacology, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 9:e85655. 2014
    ..This study assessed the anti-angiogenic properties of smaller peptides derived from tumstatin, which contain the interface tumstatin uses to interact with the αVβ3 integrin...
  16. pmc Combined Beta-agonists and corticosteroids do not inhibit extracellular matrix protein production in vitro
    Qi Ge
    Division of Cell Biology, Woolcock Institute of Medical Research, Sydney, P O Box M77, Missenden Road, NSW 2050, Australia
    J Allergy (Cairo) 2012:403059. 2012
    ..TGFβ1-induced IL-6 release was inhibited by the combination of drugs. Conclusion. Current combination asthma therapies are unable to prevent or reverse remodeling events regulated by ASM cells...
  17. pmc Effects of β(2) Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts
    David Van Ly
    Respiratory Research Group, Discipline of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
    J Allergy (Cairo) 2011:457169. 2011
    ..Dimethylfumarate increased RV replication whilst other drugs did not alter RV replication. These data suggest that inhibition of NF-κB alone is unlikely to be an effective treatment compared to current asthma therapeutics...
  18. ncbi Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle
    Alaina J Ammit
    Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
    Am J Physiol Lung Cell Mol Physiol 292:L199-206. 2007
    ..As levels of sIL-6Ralpha are increased in asthma, this demonstration of IL-6 trans-signaling in ASM has relevance to the development of airway remodeling...