TSC2 modulates cell adhesion and migration via integrin-α1β1Lyn M Moir
Cell Biology, Woolcock Institute of Medical Research, PO Box M77, Missenden Rd, NSW, 2050, Australia
Am J Physiol Lung Cell Mol Physiol 303:L703-10. 2012
..Together, these data demonstrate that TSC2 controls cell migration, attachment, and spreading through the α1β1-integrin receptor and thus suggest a potential therapeutic target for the treatment of increased cell invasiveness in LAM...
- Doxycycline inhibits matrix metalloproteinase-2 secretion from TSC2-null mouse embryonic fibroblasts and lymphangioleiomyomatosis cells
L M Moir
Woolcock Institute of Medical Research, Sydney, NSW, Australia
Br J Pharmacol 164:83-92. 2011
..The aim of this study was to determine whether doxycycline, a known MMP inhibitor, can inhibit LAM cell proliferation or mitochondrial function and/or modulate MMPs and their tissue inhibitors (TIMPs)...
Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell functionLyn M Moir
Woolcock Institute of Medical Research, Sydney, Australia
J Pharmacol Exp Ther 337:557-66. 2011
..In addition, PIK75 decreased cell survival in TGFβ-stimulated asthmatic, but not nonasthmatic, ASM cells. In conclusion, specific PI3K isoforms may play a role in pathophysiological events relevant to airway wall remodeling...
- The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle
Qi Ge
Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia
J Cell Physiol 227:3044-52. 2012
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- β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers
Kyoko Niimi
Cell Biology Group, Woolcock Institute of Medical Research, School of Medical Sciences, The Univ of Sydney, Sydney, NSW, Australia
Am J Physiol Lung Cell Mol Physiol 302:L334-42. 2012
..This leads us to speculate that continual therapy with β2AR agonists is unlikely to cause PDE4-mediated tachyphylaxis...
- TGFβ1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells: the role of Smad2/3
Qi Ge
Respiratory Research Group, Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
J Cell Physiol 225:846-54. 2010
..Understanding the mechanism of aberrant pro-inflammatory cytokine production in asthmatic airways will allow the development of alternative ways to control airway inflammation...
- Fibulin-1 is increased in asthma--a novel mediator of airway remodeling?
Justine Y Lau
Cooperative Research Centre for Asthma and Airways, Sydney, New South Wales, Australia
PLoS ONE 5:e13360. 2010
..There are four isoforms in humans (A-D) of which fibulin-1C and 1D predominate. The objective of this study was to study the expression of fibulin-1 in volunteers with and without asthma, and to examine its function in vitro...
- β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D
Thomas Trian
Cell Biology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
PLoS ONE 6:e20000. 2011
..In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asthmatics, but the mechanism is not known...
- Transforming growth factor beta 1 increases fibronectin deposition through integrin receptor alpha 5 beta 1 on human airway smooth muscle
Lyn M Moir
Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
J Allergy Clin Immunol 121:1034-9.e4. 2008
..Altered expression of the integrin receptors, such as the fibronectin receptor alpha(5)beta(1), might be implicated in extracellular matrix accumulation in airway remodeling in asthma...
- Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness
Janette K Burgess
Respiratory Research Group, Discipline of Pharmacology, Bosch Building, D05, University of Sydney, Sydney, NSW, Australia 2006
Am J Respir Crit Care Med 181:106-15. 2010
..Collagen IV is decreased in the airway basement membrane in asthma. It has six alpha chains, of which the noncollagenous domain-1 domains have endogenous antiangiogenic properties...
- Rhinovirus-induced exacerbations of asthma: How is the {beta}2-adrenoceptor implicated?
Thomas Trian
The University of Sydney, NSW, Australia
Am J Respir Cell Mol Biol 43:227-33. 2010
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- Tissue and matrix influences on airway smooth muscle function
Janette K Burgess
Discipline of Pharmacology, Bosch Institute, University of Sydney, Sydney, Australia
Pulm Pharmacol Ther 22:379-87. 2009
..This review summarises our current understanding of the influence of the ECM on ASM function...
A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitroJanette K Burgess
Department of Pharmacology, University of Sydney, NSW, Australia
J Allergy Clin Immunol 118:649-57. 2006
..Airway smooth muscle (ASM) cells may contribute to airway remodeling through the release of growth factors, cytokines, and extracellular matrix (ECM) proteins. The effect of current asthma therapies on this release is not known...
- Differential expression of peroxisome proliferator activated receptor gamma and cyclin D1 does not affect proliferation of asthma- and non-asthma-derived airway smooth muscle cells
Justine Y Lau
Cooperative Research Centre for Asthma and Airways, The University of Sydney, Sydney, New South Wales, Australia
Respirology 15:303-12. 2010
..In the presence of FBS, PPARgamma levels were higher in subconfluent asthma-derived cells but lower in confluent cells compared with non-asthma-derived. However, PPARgamma activation did not alter cell proliferation...
- Combined Beta-agonists and corticosteroids do not inhibit extracellular matrix protein production in vitro
Qi Ge
Division of Cell Biology, Woolcock Institute of Medical Research, Sydney, P O Box M77, Missenden Road, NSW 2050, Australia
J Allergy (Cairo) 2012:403059. 2012
..TGFβ1-induced IL-6 release was inhibited by the combination of drugs. Conclusion. Current combination asthma therapies are unable to prevent or reverse remodeling events regulated by ASM cells...
- Effects of β(2) Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts
David Van Ly
Respiratory Research Group, Discipline of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
J Allergy (Cairo) 2011:457169. 2011
..Dimethylfumarate increased RV replication whilst other drugs did not alter RV replication. These data suggest that inhibition of NF-κB alone is unlikely to be an effective treatment compared to current asthma therapeutics...
- Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle
Alaina J Ammit
Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
Am J Physiol Lung Cell Mol Physiol 292:L199-206. 2007
..As levels of sIL-6Ralpha are increased in asthma, this demonstration of IL-6 trans-signaling in ASM has relevance to the development of airway remodeling...
