Raju Mohan

Summary

Publications

  1. ncbi request reprint Orphan nuclear receptor modulators
    Raju Mohan
    X Ceptor Therapeutics, San Diego, CA 92121, USA
    Curr Top Med Chem 3:1637-47. 2003
  2. ncbi request reprint Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha
    Brett B Busch
    Department of Medicinal Chemistry, X Ceptor Therapeutics, Inc, 4757 Nexus Center Drive, San Diego, California 92121, USA
    J Med Chem 47:5593-6. 2004
  3. pmc Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand
    Patricia J Willy
    Department of Biology, X Ceptor Therapeutics, Inc, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 101:8912-7. 2004
  4. doi request reprint Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR)
    Brenton Flatt
    Department of Medicinal Chemistry, Exelixis Inc, 4757 Nexus Centre Drive, San Diego, California 92121, USA
    J Med Chem 52:904-7. 2009
  5. ncbi request reprint 1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation
    Robert G Wei
    Department of Medicinal Chemistry, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
    Bioorg Med Chem Lett 17:2499-504. 2007

Collaborators

  • Ira G Schulman
  • Peter Ordentlich
  • Jay Wrobel
  • Richard Martin
  • Brett B Busch
  • Brenton Flatt
  • Robert G Wei
  • Patricia J Willy
  • Robert A Horlick
  • Douglas W Sapp
  • Sihong Zhou
  • William C Stevens
  • Tie Lin Wang
  • Stefan Westin
  • Mary Petrowski
  • Eric Bischoff
  • Paul Foster
  • Brett Murphy
  • Parinaz Pircher
  • Chris Daige
  • Grace Yan
  • Paige Mahaney
  • Xiao Hui Gu
  • Jiali Li
  • Marc Adler
  • Mark Polokoff
  • Jih Lie Tseng
  • Wei Xu
  • Marc Whitlow
  • Elena Ho
  • David Davey
  • Gary Phillips
  • Shendong Yuan
  • Jing Qian
  • Richard A Heyman
  • Ping Wei
  • Ian R Murray

Detail Information

Publications5

  1. ncbi request reprint Orphan nuclear receptor modulators
    Raju Mohan
    X Ceptor Therapeutics, San Diego, CA 92121, USA
    Curr Top Med Chem 3:1637-47. 2003
    ..These targets offer multiple opportunities for therapeutic intervention with small-molecule drugs, in diseases related to neuronal function, inflammation, lipid homeostasis, metabolic function and cancer...
  2. ncbi request reprint Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha
    Brett B Busch
    Department of Medicinal Chemistry, X Ceptor Therapeutics, Inc, 4757 Nexus Center Drive, San Diego, California 92121, USA
    J Med Chem 47:5593-6. 2004
    ..Through in vitro and in vivo studies, these ligands will elucidate the endocrine signaling pathways mediated by ERRalpha including association with human disease states...
  3. pmc Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand
    Patricia J Willy
    Department of Biology, X Ceptor Therapeutics, Inc, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 101:8912-7. 2004
    ..These findings validate ERRalpha as a promising therapeutic target in the treatment of metabolic disorders, including diabetes and obesity...
  4. doi request reprint Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR)
    Brenton Flatt
    Department of Medicinal Chemistry, Exelixis Inc, 4757 Nexus Centre Drive, San Diego, California 92121, USA
    J Med Chem 52:904-7. 2009
    ..Oral administration of 6m to LDLR(-/-) mice results in lowering of cholesterol and triglycerides. Chronic administration in an atherosclerosis model results in significant reduction in aortic arch lesions...
  5. ncbi request reprint 1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation
    Robert G Wei
    Department of Medicinal Chemistry, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
    Bioorg Med Chem Lett 17:2499-504. 2007
    ..Compound 12S showed high potency and high iNOS selectivity versus nNOS and eNOS...