Thomas R Moench

Summary

Publications

  1. pmc Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse
    Thomas R Moench
    ReProtect, Inc, Baltimore, MD 21286 USA
    BMC Infect Dis 10:331. 2010
  2. pmc An acceptability and safety study of the Duet cervical barrier and gel delivery system in Zimbabwe
    Elizabeth T Montgomery
    Women s Global Health Imperative, RTI International, San Francisco Project Office, San Francisco, CA, USA
    J Int AIDS Soc 13:30. 2010
  3. ncbi request reprint Sensitive methods to detect epithelial disruption: tests for microhemorrhage in cervicovaginal lavages
    Thomas Moench
    ReProtect, Inc, 703 Stags Head Road, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 37:S194-200. 2004
  4. pmc Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission
    Richard A Cone
    Mucosal Protection Laboratory, Dept of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 6:90. 2006
  5. pmc Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse model
    Stuart S Olmsted
    Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 5:79. 2005
  6. ncbi request reprint Human monoclonal antibody stability and activity at vaginal pH
    Philip E Castle
    Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    J Reprod Immunol 56:61-76. 2002
  7. pmc Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent
    Kristen V Khanna
    Johns Hopkins School of Hygiene and Public Health, Department of Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Invest 109:205-11. 2002
  8. ncbi request reprint In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials
    Deborah Tien
    Biosyn, Inc, Huntingdon Valley, PA 19006, USA
    AIDS Res Hum Retroviruses 21:845-53. 2005
  9. pmc Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli
    Deirdre E O'Hanlon
    Mucosal Protection Laboratory, Thomas C, Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 10:120. 2010
  10. pmc In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide
    Deirdre E O'Hanlon
    Mucosal Protection Laboratory, Thomas C Jenkins Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    BMC Infect Dis 11:200. 2011

Collaborators

Detail Information

Publications14

  1. pmc Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse
    Thomas R Moench
    ReProtect, Inc, Baltimore, MD 21286 USA
    BMC Infect Dis 10:331. 2010
    ..However, excipients have not previously been tested in susceptibility models...
  2. pmc An acceptability and safety study of the Duet cervical barrier and gel delivery system in Zimbabwe
    Elizabeth T Montgomery
    Women s Global Health Imperative, RTI International, San Francisco Project Office, San Francisco, CA, USA
    J Int AIDS Soc 13:30. 2010
    ..We assessed the acceptability and safety of precoital and continuous use of the Duet, a cervical barrier and gel delivery system, in Zimbabwean women...
  3. ncbi request reprint Sensitive methods to detect epithelial disruption: tests for microhemorrhage in cervicovaginal lavages
    Thomas Moench
    ReProtect, Inc, 703 Stags Head Road, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 37:S194-200. 2004
    ..We propose that these new methods may be used for the safety assessment of microbicides by detecting and quantifying microhemorrhage in cervicovaginal secretions before and after exposure to microbicide...
  4. pmc Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission
    Richard A Cone
    Mucosal Protection Laboratory, Dept of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 6:90. 2006
    ....
  5. pmc Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse model
    Stuart S Olmsted
    Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 5:79. 2005
    ....
  6. ncbi request reprint Human monoclonal antibody stability and activity at vaginal pH
    Philip E Castle
    Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    J Reprod Immunol 56:61-76. 2002
    ..Taken together, our data and empirical calculations suggest that vaginally applied human MAbs are likely to remain stable and active throughout the duration they are likely to reside in the vagina...
  7. pmc Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent
    Kristen V Khanna
    Johns Hopkins School of Hygiene and Public Health, Department of Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Invest 109:205-11. 2002
    ....
  8. ncbi request reprint In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials
    Deborah Tien
    Biosyn, Inc, Huntingdon Valley, PA 19006, USA
    AIDS Res Hum Retroviruses 21:845-53. 2005
    ....
  9. pmc Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli
    Deirdre E O'Hanlon
    Mucosal Protection Laboratory, Thomas C, Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 10:120. 2010
    ..However, cervicovaginal fluid (CVF) and semen have significant H2O2-blocking activity...
  10. pmc In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide
    Deirdre E O'Hanlon
    Mucosal Protection Laboratory, Thomas C Jenkins Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    BMC Infect Dis 11:200. 2011
    ..Here we used conditions more like those in vivo to compare the effects of physiologically plausible concentrations of H2O2 and lactic acid on a broad range of BV-associated bacteria and vaginal lactobacilli...
  11. ncbi request reprint Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatis
    Sharon L Achilles
    The Johns Hopkins University, Baltimore, Maryland, USA
    Sex Transm Dis 29:655-64. 2002
    ..Microbicides are being developed for woman-controlled protection against sexually transmitted diseases (STDs)...
  12. doi request reprint Evaluation of microbicide gel adherence monitoring methods
    Thomas R Moench
    ReProtect, Inc, Baltimore, MD, USA
    Sex Transm Dis 39:335-40. 2012
    ....
  13. ncbi request reprint A self-sampling method to obtain large volumes of undiluted cervicovaginal secretions
    Elizabeth R Boskey
    Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Sex Transm Dis 30:107-9. 2003
    ..A convenient method for self-sampling these secretions outside a clinical setting can facilitate such studies of reproductive health...
  14. ncbi request reprint Contraceptive efficacy of a novel spermicidal microbicide used with a diaphragm: a randomized controlled trial
    Kurt T Barnhart
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 110:577-86. 2007
    ..The objective of this study was to assess the gel's contraceptive effects, safety, and acceptability...