- Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse
Thomas R Moench
ReProtect, Inc, Baltimore, MD 21286 USA
BMC Infect Dis 10:331. 2010
..However, excipients have not previously been tested in susceptibility models...
- An acceptability and safety study of the Duet cervical barrier and gel delivery system in Zimbabwe
Elizabeth T Montgomery
Women s Global Health Imperative, RTI International, San Francisco Project Office, San Francisco, CA, USA
J Int AIDS Soc 13:30. 2010
..We assessed the acceptability and safety of precoital and continuous use of the Duet, a cervical barrier and gel delivery system, in Zimbabwean women...
- Sensitive methods to detect epithelial disruption: tests for microhemorrhage in cervicovaginal lavages
ReProtect, Inc, 703 Stags Head Road, Baltimore, MD, USA
J Acquir Immune Defic Syndr 37:S194-200. 2004
..We propose that these new methods may be used for the safety assessment of microbicides by detecting and quantifying microhemorrhage in cervicovaginal secretions before and after exposure to microbicide...
- Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission
Richard A Cone
Mucosal Protection Laboratory, Dept of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Infect Dis 6:90. 2006
- Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse model
Stuart S Olmsted
Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Infect Dis 5:79. 2005
- Human monoclonal antibody stability and activity at vaginal pH
Philip E Castle
Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
J Reprod Immunol 56:61-76. 2002
..Taken together, our data and empirical calculations suggest that vaginally applied human MAbs are likely to remain stable and active throughout the duration they are likely to reside in the vagina...
- Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent
Kristen V Khanna
Johns Hopkins School of Hygiene and Public Health, Department of Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Clin Invest 109:205-11. 2002
- In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials
Biosyn, Inc, Huntingdon Valley, PA 19006, USA
AIDS Res Hum Retroviruses 21:845-53. 2005
- Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli
Deirdre E O'Hanlon
Mucosal Protection Laboratory, Thomas C, Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Infect Dis 10:120. 2010
..However, cervicovaginal fluid (CVF) and semen have significant H2O2-blocking activity...
- In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide
Deirdre E O'Hanlon
Mucosal Protection Laboratory, Thomas C Jenkins Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
BMC Infect Dis 11:200. 2011
..Here we used conditions more like those in vivo to compare the effects of physiologically plausible concentrations of H2O2 and lactic acid on a broad range of BV-associated bacteria and vaginal lactobacilli...
- Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatis
Sharon L Achilles
The Johns Hopkins University, Baltimore, Maryland, USA
Sex Transm Dis 29:655-64. 2002
..Microbicides are being developed for woman-controlled protection against sexually transmitted diseases (STDs)...
- Evaluation of microbicide gel adherence monitoring methods
Thomas R Moench
ReProtect, Inc, Baltimore, MD, USA
Sex Transm Dis 39:335-40. 2012
- A self-sampling method to obtain large volumes of undiluted cervicovaginal secretions
Elizabeth R Boskey
Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA
Sex Transm Dis 30:107-9. 2003
..A convenient method for self-sampling these secretions outside a clinical setting can facilitate such studies of reproductive health...
- Contraceptive efficacy of a novel spermicidal microbicide used with a diaphragm: a randomized controlled trial
Kurt T Barnhart
University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Obstet Gynecol 110:577-86. 2007
..The objective of this study was to assess the gel's contraceptive effects, safety, and acceptability...