SIRS score reflects clinical features of non-acetaminophen-related acute liver failure with hepatic comaYasuhiro Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
Intern Med 51:823-8. 2012
..This study aimed to investigate the impact of SIRS score on clinical features of non-acetaminophen-related ALF...
- Persistent elevation of serum alanine aminotransferase levels leads to poor survival and hepatocellular carcinoma development in type 1 autoimmune hepatitis
Y Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Aliment Pharmacol Ther 24:1197-205. 2006
..Although the prognosis of type 1 autoimmune hepatitis is generally good with immunosuppressive treatment, the disease progresses in some patients despite the treatment. The prognosis may be determined by the clinical course...
- Clinical features of Japanese elderly patients with type 1 autoimmune hepatitis
Yasuhiro Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Intern Med 46:1945-9. 2007
..In this study, we assessed the clinical features of Japanese elderly patients with type 1 autoimmune hepatitis...
- Clinical features of Japanese male patients with type 1 autoimmune hepatitis
Y Miyake
Department of Internal Medicine, Kurashiki Riverside Hospital, Kurashiki, Japan
Aliment Pharmacol Ther 24:519-23. 2006
..Recently, unusual patients with autoimmune hepatitis, such as male patients, have increased...
Meta-analysis: interferon-alpha prevents the recurrence after curative treatment of hepatitis C virus-related hepatocellular carcinomaY Miyake
Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
J Viral Hepat 17:287-92. 2010
....
- Clinical features of autoimmune hepatitis diagnosed based on simplified criteria of the International Autoimmune Hepatitis Group
Yasuhiro Miyake
Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
Dig Liver Dis 42:210-5. 2010
..Recently, simplified diagnostic criteria for autoimmune hepatitis have been proposed...
- Lamivudine treatment improves the prognosis of fulminant hepatitis B
Yasuhiro Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Intern Med 47:1293-9. 2008
..The aim of this study was to clarify the prognostic factors and the efficacy of lamivudine for fulminant hepatitis B in Japan, where the main infection genotype is B...
- A homosexual Japanese man with acute hepatitis due to hepatitis B virus genotype ae, concurrent with amebic colitis
Yasuhiro Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
Acta Med Okayama 61:35-9. 2007
..Furthermore, education of homosexual men regarding hepatitis B virus, hepatitis B virus vaccination, and amebiasis is urgently required...
- Peritoneal dissemination of hepatocellular carcinoma treated with a combination therapy of interferon-alpha-2b and oral tegafur/uracil
Yasuhiro Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Intern Med 46:565-9. 2007
..A combination therapy of interferon-alpha-2b and oral tegafur/uracil is facile and may be effective for extrahepatic metastasis of hepatocellular carcinoma...
- Meta-analysis: reduced incidence of hepatocellular carcinoma in patients not responding to interferon therapy of chronic hepatitis C
Yasuhiro Miyake
Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
Int J Cancer 127:989-96. 2010
..Even if sustained virological response is not achieved, interferon may be worth administering in order to reduce HCC incidence in patients with chronic hepatitis C...
- Clinical characteristics of fulminant-type autoimmune hepatitis: an analysis of eleven cases
Y Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Aliment Pharmacol Ther 23:1347-53. 2006
..Although a few adult cases of fulminant-type autoimmune hepatitis have been reported, their clinical features and prognosis have remained uncertain...
- Meta-analysis: the effect of interferon on development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
Yasuhiro Miyake
Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
J Gastroenterol 44:470-5. 2009
..However, discussion about the effect of interferon on the development of hepatocellular carcinoma (HCC) has been controversial...
- Autoimmune hepatitis with acute presentation in Japan
Y Miyake
Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Dig Liver Dis 42:51-4. 2010
..In Caucasians with autoimmune hepatitis, patients with acute presentation have autoimmune thyroiditis and histological zone 3 necrosis more frequently...
- Persistent normalization of serum alanine aminotransferase levels improves the prognosis of type 1 autoimmune hepatitis
Yasuhiro Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1, Shikata cho, Okayama 700 8558, Japan
J Hepatol 43:951-7. 2005
..The present study was conducted in order to analyze the factors contributing to the outcomes of patients with type 1 autoimmune hepatitis...
- New prognostic scoring model for liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure
Yasuhiro Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
Transplantation 80:930-6. 2005
....
- Prognostic factors for fatal outcomes prior to receiving liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure
Yasuhiro Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
J Gastroenterol Hepatol 22:855-61. 2007
..Many patients continue to die due to the rapid development of cerebral edema and/or multiple organ failure prior to receiving a liver transplantation...
- Therapeutic effects of azathioprine in combination with low-dose prednisolone in patients with intractable autoimmune hepatitis type 1
T Takenami
Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, Japan
Acta Med Okayama 55:341-7. 2001
....
- Development of hepatocellular carcinoma in a woman with HBV- and HCV-negative autoimmune hepatitis with unsatisfactory response to Corticosteroid
Yasuhiro Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
Intern Med 44:949-53. 2005
..Nine years later, hepatocellular carcinoma 20 mm in diameter was detected. This case suggests that hepatocellular carcinoma develops even if serum alanine aminotransferase levels are maintained at less than twice the upper normal limit...
- Laparoscopic features of primary biliary cirrhosis in AMA-positive and AMA-negative patients
S Fujioka
First Department of Internal Medicine, Okayama University Medical School, Okayama, Japan
Endoscopy 34:318-21. 2002
..30 +/- 0.5 in autoimmune hepatitis. CONCLUSION: The laparoscopic findings in AMA-negative PBC did not differ from those of AMA-positive PBC. A laparoscopic scoring system may be helpful in the diagnosis of AMA-negative PBC...
- Evolution of prognostic factors in hepatocellular carcinoma in Japan
K Nouso
Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan
Aliment Pharmacol Ther 31:407-14. 2010
..The surveillance of hepatocellular carcinoma (HCC) has become prevalent, and the modalities for its treatment have improved...
- Surface ultrastructure of collagen fibrils and their association with proteoglycans in human cornea and sclera by atomic force microscopy and energy-filtering transmission electron microscopy
A Miyagawa
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Cornea 20:651-6. 2001
..We aimed to investigate the possible association of proteoglycans with D-periodic collagen fibrils in the human cornea and sclera, using energy-filtering transmission electron microscopy (EF-TEM) and atomic force microscopy (AFM)...
- Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size
Shinichiro Nakamura
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
Am J Gastroenterol 101:2038-43. 2006
..0001). CONCLUSIONS: The utility of DCP for the diagnosis of HCC was lower than that of AFP for small tumors, but higher than that of AFP for large tumors...
- Time-dependent analysis of predisposing factors for the recurrence of hepatocellular carcinoma
Shouta Iwadou
Department of Internal Medicine, Hiroshima City Hospital, Hiroshima, Japan
Liver Int 30:1027-32. 2010
..The aim of this study is to evaluate the predisposing factors after treatments...
- Current status of autoimmune hepatitis in Japan
Yasuhiro Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Acta Med Okayama 62:217-26. 2008
..To improve the prognosis of these patients, persistent normalization of transaminase is required...
- Mortality rate of patients with asymptomatic primary biliary cirrhosis diagnosed at age 55 years or older is similar to that of the general population
Junichi Kubota
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1, Shikata cho, Okayama, 700 8558, Japan
J Gastroenterol 44:1000-6. 2009
..This study investigated the prognosis of asymptomatic PBC patients, focusing on age difference, to clarify its effect on the prognosis of PBC patients...
A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis BKazuyuki Matsumoto
Department of Internal Medicine, Mitoyo General Hospital, Kanonji, Japan
World J Gastroenterol 15:1650-2. 2009
..A combination of entecavir and early-phase corticosteroid may be a useful treatment in severe exacerbation of chronic hepatitis B...
- Short-term high-dose followed by long-term low-dose hepatitis B immunoglobulin and lamivudine therapy prevented recurrent hepatitis B after liver transplantation
Akinobu Takaki
Department of Gastroenterology, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Japan
Transplantation 83:231-3. 2007
..This method allows reliable and cost-effective control of hepatitis B recurrence...
- High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double-deficient mice
T Beppu
Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
J Thromb Haemost 8:2514-22. 2010
..The apolipoprotein-E (ApoE) genotype has been associated with carcinogenesis...
- [A fulminant case of autoimmune hepatitis, who received living-related liver transplantation]
Tamiya Morikawa
Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama
Nippon Naika Gakkai Zasshi 91:2469-72. 2002
- [Case of primary malignant lymphoma of the liver treated by R-CHOP therapy]
Akinori Asagi
Department of Internal Medicine, Mitoyo General Hospital, Japan
Nihon Shokakibyo Gakkai Zasshi 106:389-96. 2009
..After 8 courses of therapy the FDG-PET results were negative and we considered complete remission. We describe a case of primary malignant lymphoma of the liver treated successfully by R-CHOP therapy...
- Surveillance of hepatocellular carcinoma in patients with hepatitis C virus infection may improve patient survival
Hironori Tanaka
Department of Gastroenterology, Hepatology, and Infectious Disease, Okayama University School of Medicine, Okayama, Japan
Liver Int 26:543-51. 2006
..The benefit of surveillance of hepatocellular carcinoma (HCC) for patients with hepatitis C virus (HCV) infection, in terms of long-term survival, has not yet been established...
- Large waist circumference is a risk factor for reflux esophagitis in Japanese males
Hisae Yasuhara
Department of Internal Medicine, Mitoyo General Hospital, Kanonji, Japan
Digestion 81:181-7. 2010
..The prevalence of reflux esophagitis, which might lead to development of Barrett's esophagus and esophageal adenocarcinoma, has been increasing. The aim of this study was to assess risk factors for reflux esophagitis...
- Systemic inflammatory response syndrome strongly affects the prognosis of patients with fulminant hepatitis B
Yasuhiro Miyake
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
J Gastroenterol 42:485-92. 2007
..However, prognostic factors for fulminant hepatitis B have not been fully examined. In this study, we analyzed prognostic factors for fulminant hepatitis B in order to accurately identify patients with fatal outcomes...
- A case of hepatic angiomyolipoma difficult to distinguish from hepatocellular carcinoma
Masahiro Takahara
Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
World J Gastroenterol 15:2930-2. 2009
..In cases with uncommon features of angiomyolipoma, it is quite difficult to distinguish angiomyolipoma from hepatocellular carcinoma...
- [A long term survival case of advanced colon cancer with adjacent organ involvement and multiple liver metastases]
Rio Handa
Dept. of Surgery, Minoh City Hospital Gastrointestinal Center, Research Center
Gan To Kagaku Ryoho 33:1795-7. 2006
..Even thougn a few patients with Stage IV colorectal cancer can be a long-term survivor after multiple operations, we need to consider carefully the indication of the operation and QOL for a Stage IV colorectal cancer patient...
- [Three successful cases with CPT-11 + CDDP chemotherapy where S-1 failed to respond to recurrent gastric cancer]
Rio Handa
Dept of Surgery, Minoh City Hospital Gastrointestinal Research Center
Gan To Kagaku Ryoho 34:2108-10. 2007
..We treated this patient with S-1 + paclitaxel (PTX) chemotherapy. No reductions were noted after 2 courses. We next treated this patient with CPT-11 + CDDP. An abdominal CT revealed a CR after 8 courses...
- Hepatic expression of ANG2 RNA in metastatic colorectal cancer
Minoru Ogawa
Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan
Hepatology 39:528-39. 2004
..In conclusion, the current study suggests that Ang-2 and VEGF may cooperate to enhance the formation of new blood vessels in metastases of CRC to the liver...
- Comparative detection of lymph node micrometastases of stage II colorectal cancer by reverse transcriptase polymerase chain reaction and immunohistochemistry
Shingo Noura
Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Japan
J Clin Oncol 20:4232-41. 2002
..CONCLUSION: Micrometastases detected by RT-PCR, but not IHC, may be of clinical value in identifying patients who may be at high risk for recurrence of CRC and who are therefore likely to benefit from systemic adjuvant therapy...
- [A clinical significance of direct invasion to adjacent organs in stage IV colorectal cancer]
Takeshi Kato
Dept. of Surgery, Minoh City Hospital Gastrointestinal Research Center
Gan To Kagaku Ryoho 33:1827-9. 2006
..The optimum resection for adjacent organs may prolong survival. But an extended resection is a possibility in shortening survival time...
- [A clinical significance of peritoneal carcinomatosis to recurrent colorectal cancer with ileus]
Takeshi Kato
Dept of Surgery, Minoh City Hospital Gastrointestinal Research Center
Gan To Kagaku Ryoho 34:1949-51. 2007
..The 3 patients in the surgical treatment were aggravated. An optimum resection may prolong a survival time and patient's QOL could be improved. On the other hand, an extended resection may contribute to shorting a survival time...
- [A case of ascending colon carcinoma metastasized to an inguinal hernia sac]
Yasuhiro Miyake
Dept of Surgery, Minoh City Hospital Gastrointestinal Research Center
Gan To Kagaku Ryoho 34:2016-8. 2007
..Examination of the entire body showed no other metastasis. As for the advanced colon cancer, we need to mention the possibility of metastatic saccular tumor...
- [A case of metastatic rectal cancer from serous adenocarcinoma of the ovary]
Yasuhiro Miyake
Dept of Surgery Gynecology, Minoh City Hospital
Gan To Kagaku Ryoho 34:2317-9. 2007
..No viable cancer tissue could be found. After the second operation, she has been doing well without any recurrence for 1 year and half...
