H Miyake

Summary

Publications

  1. ncbi request reprint Clinicopathological features of patients with biochemical recurrence after radical prostatectomy without progressive rise in serum prostate-specific antigen
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Urol Int 77:200-4. 2006
  2. ncbi request reprint Significance of routine transition zone biopsies in Japanese men undergoing transrectal ultrasound-guided prostate biopsies
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 12:964-8. 2005
  3. ncbi request reprint Is a limited lymphadenectomy targeting obturator nodes alone an adequate procedure for Japanese men undergoing radical prostatectomy?
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 12:739-44. 2005
  4. ncbi request reprint Clinicopathological features of recurrence after radical surgery for nonmetastatic renal cell carcinoma
    Takeshi Ishimura
    Department of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi 673 8558, Japan
    Int J Clin Oncol 9:369-72. 2004
  5. ncbi request reprint Health-related quality of life after chemotherapy for advanced germ cell tumors: a comparison of standard-dose and high-dose chemotherapy
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Kitaohji cho, Akashi, Japan
    Int J Urol 11:542-6. 2004
  6. ncbi request reprint Assessment of efficacy, safety and quality of life of 55 patients with metastatic renal cell carcinoma treated with temsirolimus: a single-center experience in Japan
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Int J Clin Oncol 19:679-85. 2014
  7. ncbi request reprint Significance of circulating matrix metalloproteinase-9 to tissue inhibitor of metalloproteinases-2 ratio as a predictor of disease progression in patients with metastatic renal cell carcinoma receiving sunitinib
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan Electronic address
    Urol Oncol 32:584-8. 2014
  8. ncbi request reprint Assessment of efficacy, safety and quality of life of 110 patients treated with sunitinib as first-line therapy for metastatic renal cell carcinoma: experience in real-world clinical practice in Japan
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Med Oncol 31:978. 2014
  9. pmc Enhanced sensitivity to androgen withdrawal due to overexpression of interleukin-6 in androgen-dependent human prostate cancer LNCaP cells
    T Terakawa
    Division of Urology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Br J Cancer 101:1731-9. 2009
  10. pmc Enhanced progression of human prostate cancer PC3 cells induced by the microenvironment of the seminal vesicle
    M Kumano
    Department of Surgery, Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Br J Cancer 98:356-62. 2008

Collaborators

Detail Information

Publications137 found, 100 shown here

  1. ncbi request reprint Clinicopathological features of patients with biochemical recurrence after radical prostatectomy without progressive rise in serum prostate-specific antigen
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Urol Int 77:200-4. 2006
    ....
  2. ncbi request reprint Significance of routine transition zone biopsies in Japanese men undergoing transrectal ultrasound-guided prostate biopsies
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 12:964-8. 2005
    ..The objective of this study was to evaluate the clinical significance of additional routine transition zone (TZ) biopsies in Japanese men undergoing transrectal ultrasound (TRUS)-guided systematic 8-core peripheral zone (PZ) biopsies...
  3. ncbi request reprint Is a limited lymphadenectomy targeting obturator nodes alone an adequate procedure for Japanese men undergoing radical prostatectomy?
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 12:739-44. 2005
    ..The objective of the present study was to investigate the significance of pelvic lymphadenectomy during radical prostatectomy in Japanese men with prostate cancer...
  4. ncbi request reprint Clinicopathological features of recurrence after radical surgery for nonmetastatic renal cell carcinoma
    Takeshi Ishimura
    Department of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi 673 8558, Japan
    Int J Clin Oncol 9:369-72. 2004
    ..The objective of this study was to clarify the clinicopathological features of recurrent renal cell carcinoma (RCC) in patients who had undergone curative surgical resection of primary disease...
  5. ncbi request reprint Health-related quality of life after chemotherapy for advanced germ cell tumors: a comparison of standard-dose and high-dose chemotherapy
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Kitaohji cho, Akashi, Japan
    Int J Urol 11:542-6. 2004
    ....
  6. ncbi request reprint Assessment of efficacy, safety and quality of life of 55 patients with metastatic renal cell carcinoma treated with temsirolimus: a single-center experience in Japan
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Int J Clin Oncol 19:679-85. 2014
    ..To evaluate experience of the use of temsirolimus for metastatic renal cell carcinoma (mRCC) in a single center in Japan...
  7. ncbi request reprint Significance of circulating matrix metalloproteinase-9 to tissue inhibitor of metalloproteinases-2 ratio as a predictor of disease progression in patients with metastatic renal cell carcinoma receiving sunitinib
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan Electronic address
    Urol Oncol 32:584-8. 2014
    ..To assess the significance of circulating matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) as predictors of disease progression in patients with metastatic renal cell carcinoma (mRCC) receiving sunitinib...
  8. ncbi request reprint Assessment of efficacy, safety and quality of life of 110 patients treated with sunitinib as first-line therapy for metastatic renal cell carcinoma: experience in real-world clinical practice in Japan
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Med Oncol 31:978. 2014
    ....
  9. pmc Enhanced sensitivity to androgen withdrawal due to overexpression of interleukin-6 in androgen-dependent human prostate cancer LNCaP cells
    T Terakawa
    Division of Urology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Br J Cancer 101:1731-9. 2009
    ..The objective of this study was to investigate the effects of interleukin-6 (IL-6) overexpression in androgen-dependent prostate cancer LNCaP cells on their phenotype under an androgen-deprived condition...
  10. pmc Enhanced progression of human prostate cancer PC3 cells induced by the microenvironment of the seminal vesicle
    M Kumano
    Department of Surgery, Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Br J Cancer 98:356-62. 2008
    ....
  11. ncbi request reprint Efficacy and safety of temsirolimus in Japanese patients with metastatic renal cell carcinoma on hemodialysis
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Int J Clin Oncol 18:1054-9. 2013
    ..We retrospectively investigated the efficacy and safety of temsirolimus, an inhibitor of the mammalian target of rapamycin, in patients with metastatic renal cell carcinoma (mRCC) on hemodialysis (HD)...
  12. doi request reprint Orthotopic sigmoid vs. ileal neobladders in Japanese patients: a comparative assessment of complications, functional outcomes, and quality of life
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan Electronic address
    Urol Oncol 31:1155-60. 2013
    ..To compare the clinical outcomes of sigmoid and ileal neobladders (NBs) created following radical cystectomy...
  13. ncbi request reprint Prognostic significance of primary Gleason pattern in Japanese men with Gleason score 7 prostate cancer treated with radical prostatectomy
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan Electronic address
    Urol Oncol 31:1511-6. 2013
    ..To evaluate the significance of the primary Gleason pattern in patients with Gleason score (GS) 7 prostate cancer treated with radical prostatectomy...
  14. doi request reprint Oncological outcome of docetaxel-based chemotherapy for Japanese men with metastatic castration-resistant prostate cancer
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    Urol Oncol 31:733-8. 2013
    ..To retrospectively review the oncologic outcomes of docetaxel-based chemotherapy in Japanese men with metastatic castration-resistant prostate cancer (mCRPC)...
  15. doi request reprint Health-related quality of life in Japanese patients with metastatic renal cell carcinoma treated with sunitinib
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Int J Clin Oncol 18:220-5. 2013
    ..To analyze the impact of sunitinib treatment on health-related quality of life (HRQOL) in Japanese patients with metastatic renal cell carcinoma (mRCC)...
  16. doi request reprint Prognostic prediction following radical prostatectomy for prostate cancer using conventional as well as molecular biological approaches
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Urol 20:301-11. 2013
    ....
  17. ncbi request reprint Third-line sunitinib following sequential use of cytokine therapy and sorafenib in Japanese patients with metastatic renal cell carcinoma
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Int J Clin Oncol 18:81-6. 2013
    ..The aim of this study was to evaluate the use of sunitinib as third-line therapy for metastatic renal cell carcinoma (mRCC)...
  18. doi request reprint Significance of docetaxel-based chemotherapy as treatment for metastatic castration-resistant prostate cancer in Japanese men over 75 years old
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Int Urol Nephrol 44:1697-703. 2012
    ..The objective of this study was to evaluate the significance of docetaxel-based chemotherapy in elderly Japanese men with metastatic castration-resistant prostate cancer (CRPC)...
  19. doi request reprint Health related quality of life after radical cystectomy: comparative study between orthotopic sigmoid versus ileal neobladders
    H Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Eur J Surg Oncol 38:1089-94. 2012
    ..To comparatively assess the health-related quality of life (HRQOL) between patients with sigmoid and ileal neobladders (NBs) following radical cystectomy...
  20. ncbi request reprint Prognostic significance of tumor extension into venous system in patients undergoing surgical treatment for renal cell carcinoma with venous tumor thrombus
    H Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Eur J Surg Oncol 38:630-6. 2012
    ..The objective of this study was to evaluate the prognostic significance of the extent of a tumor thrombus in renal cell carcinoma (RCC) involving the venous system...
  21. doi request reprint Orthotopic bladder substitution following radical cystectomy in women: comparative study between sigmoid and ileal neobladders
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    Urol Oncol 30:38-43. 2012
    ..These findings suggest that it might be preferable to create sigmoid rather than ileal NB in women following radical cystectomy considering the favorable voiding function and QOL in SNBG...
  22. ncbi request reprint The potential of clusterin inhibiting antisense oligodeoxynucleotide therapy for prostate cancer
    Hideaki Miyake
    Hyogo Medical Center for Adults, Department of Urology, 13 70 Kitaohji cho, Akashi 673 8558, Japan
    Expert Opin Investig Drugs 15:507-17. 2006
    ..There have been four kinds of Phase II studies that have begun to further evaluate the efficacy of OGX-011 in patients with prostate, breast and lung cancers...
  23. ncbi request reprint Enhanced expression of the secreted form of clusterin following neoadjuvant hormonal therapy as a prognostic predictor in patients undergoing radical prostatectomy for prostate cancer
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi 673 8558, Japan
    Oncol Rep 14:1371-5. 2005
    ....
  24. ncbi request reprint Clinical outcome of combined immunotherapy with low-dose interleukin-2 and interferon-alpha for Japanese patients with metastatic renal cell carcinoma who had undergone radical nephrectomy: a preliminary report
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi 673 8558, Japan
    Int J Clin Oncol 10:338-41. 2005
    ....
  25. ncbi request reprint Increased detection of clinically significant prostate cancer by additional sampling from the anterior lateral horns of the peripheral zone in combination with the standard sextant biopsy
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 11:402-6. 2004
    ....
  26. ncbi request reprint Significance of renal function in changes in acid-base metabolism after orthotopic bladder replacement: colon neobladder compared with ileal neobladder
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 11:83-7. 2004
    ..The objective of this study was to determine whether renal function influences the acid-base metabolism in patients undergoing orthotopic bladder replacement using intestinal segment...
  27. ncbi request reprint Long-term results of adjuvant hormonal therapy plus radiotherapy following radical prostatectomy for patients with pT3N0 or pT3N1 prostate cancer
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 11:397-401. 2004
    ..The objective of the present study was to evaluate the efficacy of adjuvant androgen suppression in conjunction with external beam irradiation after radical prostatectomy in patients with pathologically confirmed extraprostatic disease...
  28. ncbi request reprint Antisense oligodeoxynucleotide therapy for bladder cancer: recent advances and future prospects
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi 673 8558, Japan
    Expert Rev Anticancer Ther 5:1001-9. 2005
    ..These findings may help clarify the significance of antisense oligodeoxynucleotide therapy as an attractive alternative to conventional strategies...
  29. ncbi request reprint Enhanced expression of heat shock protein 27 following neoadjuvant hormonal therapy is associated with poor clinical outcome in patients undergoing radical prostatectomy for prostate cancer
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi, Japan
    Anticancer Res 26:1583-7. 2006
    ....
  30. ncbi request reprint Limited significance of routine excretory urography in the follow-up of patients with superficial bladder cancer after transurethral resection
    Hideaki Miyake
    Departments of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi 673 8558, Japan
    BJU Int 97:720-3. 2006
    ..To evaluate the utility of routine excretory intravenous urography (IVU) for detecting subsequent upper urinary tract cancer (UUTC) during the follow-up of patients with superficial bladder cancer...
  31. ncbi request reprint Significance of cancer detection in the anterior lateral horn on systematic prostate biopsy: the effect on pathological findings of radical prostatectomy specimens
    H Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    BJU Int 93:57-9; discussion 59. 2004
    ..To clarify the significance of cancer detection in the anterior lateral horn (ALH) on systematic prostate biopsy in relation to its effect on the pathological findings from retropubic radical prostatectomy (RRP) specimens...
  32. ncbi request reprint Antisense oligodeoxynucleotide therapy targeting clusterin gene for prostate cancer: Vancouver experience from discovery to clinic
    Hideaki Miyake
    The Prostate Center, Vancouver General Hospital, Vancouver, Canada
    Int J Urol 12:785-94. 2005
    ..The objective of this study was to review our experience in the development of antisense (AS) oligodeoxynucleotide (ODN) therapy for prostate cancer targeting antiapoptotic gene, clusterin...
  33. pmc Therapeutic efficacy of adenoviral-mediated p53 gene transfer is synergistically enhanced by combined use of antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi 673 8558, Japan
    Neoplasia 7:171-9. 2005
    ....
  34. ncbi request reprint Preoperative prediction of final pathological features is not improved by the free-to-total prostate-specific antigen ratio in Japanese men with clinically localized prostate cancer
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 12:182-6. 2005
    ....
  35. ncbi request reprint Clinicopathological features of prostate cancer in Japanese men diagnosed on repeat transrectal ultrasound-guided biopsy
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi, 673 8558, Japan
    Int J Clin Oncol 10:30-4. 2005
    ..The objective of this study was to analyze the clinicopathological features of prostate cancer detected on repeat transrectal ultrasound-guided random biopsy in comparison with those detected on initial biopsy...
  36. ncbi request reprint Prognostic significance of insulin-like growth factor (IGF) binding protein-2 to IGF-binding protein-3 ratio in patients undergoing radical cystectomy for invasive transitional cell carcinoma of the bladder
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    BJU Int 95:987-91. 2005
    ..To analyse the prognostic significance of insulin-like growth factor binding protein-2 (IGFBP-2) and IGFBP-3 in patients having a radical cystectomy for invasive bladder cancer...
  37. ncbi request reprint Prognostic significance of the tumor volume in radical prostatectomy specimens after neoadjuvant hormonal therapy
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Urol Int 74:27-31. 2005
    ..The objective of this study was to determine whether the tumor volume in radical prostatectomy specimens of patients with prostate cancer who underwent neoadjuvant hormonal therapy (NHT) could be used as a prognostic predictor...
  38. ncbi request reprint Introduction of insulin-like growth factor binding protein-2 gene into human bladder cancer cells enhances their metastatic potential
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi 673 8558, Japan
    Oncol Rep 13:341-5. 2005
    ..These findings suggest that overexpression of IGFBP-2 induces an increase in MMP-2 production, resulting in the enhanced metastatic potential of bladder cancer...
  39. ncbi request reprint Clinical outcome of oral uracil/tegafur (UFT) therapy for patients with hormone refractory prostate cancer
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi 673 8558, Japan
    Oncol Rep 14:673-6. 2005
    ....
  40. ncbi request reprint Global analysis of gene expression profiles in ileum in a rat bladder augmentation model using cDNA microarrays
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 11:1009-12. 2004
    ..The objective of the present study was to globally characterize the changes in the gene expression profile in the ileum after long-term urine exposure in a rat ileal augmented bladder model using cDNA microarrays...
  41. ncbi request reprint Urinary levels of vascular endothelial growth factor in patients with prostate cancer as a predictor of disease progression
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi, Japan
    Anticancer Res 25:3645-9. 2005
    ....
  42. ncbi request reprint Clinical outcome of maximum androgen blockade using flutamide as second-line hormonal therapy for hormone-refractory prostate cancer
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    BJU Int 96:791-5. 2005
    ..To investigate the efficacy of maximum androgen blockade (MAB) using flutamide as second-line hormonal therapy for advanced hormone-refractory prostate cancer (HRPC)...
  43. ncbi request reprint Health-related quality of life in patients with testicular cancer: a comparative analysis according to therapeutic modalities
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi 673 8558, Japan
    Oncol Rep 12:867-70. 2004
    ..Therefore, the overall HRQoL in patients with testicular cancer may be generally favorable and not affected by differences in treatment type...
  44. ncbi request reprint Prediction of potentially insignificant prostate cancer in men undergoing radical prostatectomy for clinically organ-confined disease
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 12:270-4. 2005
    ....
  45. ncbi request reprint The limited significance of a longer duration of neoadjuvant hormonal therapy prior to radical prostatectomy for high-risk prostate cancer in Japanese men
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Urol Int 77:122-6. 2006
    ..The objective of this study was to evaluate the therapeutic significance of a longer duration of neoadjuvant hormonal therapy (NHT) followed by radical prostatectomy (RP) in Japanese men with high-risk prostate cancer...
  46. doi request reprint Prediction of response to combined immunotherapy with interferon-alpha and low-dose interleukin-2 in metastatic renal cell carcinoma: expression patterns of potential molecular markers in radical nephrectomy specimens
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    Int J Urol 16:465-71. 2009
    ....
  47. doi request reprint Serum level of clusterin and its density in men with prostate cancer as novel biomarkers reflecting disease extension
    Hideaki Miyake
    Division of Urology, Kobe University, Graduate School of Medicine, Kobe, Japan
    Urology 75:454-9. 2010
    ..To assess whether the serum level of clusterin and its density could be used as novel biomarkers of prostate cancer...
  48. ncbi request reprint Orthotopic sigmoid neobladder after radical cystectomy: assessment of complications, functional outcomes and quality of life in 82 Japanese patients
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    BJU Int 106:412-6. 2010
    ..To retrospectively review our clinical experience with sigmoid neobladder reconstruction...
  49. doi request reprint Development of "extended radical retropubic prostatectomy": a surgical technique for improving margin positive rates in prostate cancer
    H Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Eur J Surg Oncol 36:281-6. 2010
    ..The objective of this study was to introduce a surgical approach called "extended radical retropubic prostatectomy (ERRP)" developed to reduce positive surgical margin rates in prostate cancer...
  50. ncbi request reprint Abnormalities of thyroid function in Japanese patients with metastatic renal cell carcinoma treated with sorafenib: a prospective evaluation
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    Urol Oncol 28:515-9. 2010
    ..Accordingly, regular surveillance of thyroid function by the measurement of TSH, free T3, and T4 is warranted during sorafenib treatment in Japanese RCC patients...
  51. doi request reprint Experience with various types of orthotopic neobladder in Japanese men: long-term follow-up
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Urol Int 84:34-9. 2010
    ..The objective of this study was to review the long-term outcomes of orthotopic neobladder (NB) creation...
  52. ncbi request reprint Impact of sorafenib on health-related quality of life in Japanese patients with metastatic renal cell carcinoma: a prospective evaluation
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    BJU Int 106:1643-7. 2010
    ..To characterize the impact of sorafenib treatment on health-related quality of life (HRQL) in Japanese patients with mRCC...
  53. doi request reprint Metastatic collecting duct carcinoma of the kidney responded to sunitinib
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Int J Clin Oncol 16:153-5. 2011
    ..Considering these findings, it would be worthwhile prospectively investigating the role of multiple tyrosine kinase inhibitors, particularly sunitinib, in the management of metastatic CDC...
  54. ncbi request reprint Clinical outcome of bacillus Calmette-Guérin perfusion therapy for carcinoma in situ of the upper urinary tract
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 9:677-80. 2002
    ..The objective of this study was to evaluate the efficacy of intrarenal bacillus Calmette-Guérin (BCG) instillation for the treatment of carcinoma in situ (CIS) of the upper urinary tract...
  55. ncbi request reprint Novel therapeutic strategy for advanced prostate cancer using antisense oligodeoxynucleotides targeting anti-apoptotic genes upregulated after androgen withdrawal to delay androgen-independent progression and enhance chemosensitivity
    H Miyake
    The Prostate Center, Vancouver General Hospital, Vancouver, Canada
    Int J Urol 8:337-49. 2001
    ..These findings provide a basic significance for the design of clinical studies using antisense ODN either alone or in combination with chemotherapeutic agents in patients with advanced prostate cancer...
  56. doi request reprint Expression of potential molecular markers in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    Urol Oncol 28:145-51. 2010
    ....
  57. ncbi request reprint Clinical outcome of combined immunotherapy with interferon-alpha and low-dose interleukine-2 for Japanese patients with metastatic renal cell carcinoma
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    Urol Oncol 27:598-603. 2009
    ....
  58. ncbi request reprint Pathological findings of radical prostatectomy specimens in Japanese men diagnosed on single core positive prostate biopsy in eight with a Gleason score less than 4
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 10:383-6. 2003
    ....
  59. ncbi request reprint Increased urinary 8-hydroxy-2'-deoxyguanosine excretion after ileal neobladder replacement
    H Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    BJU Int 91:657-60. 2003
    ....
  60. ncbi request reprint Prediction of the extent of prostate cancer by the combined use of systematic biopsy and serum level of cathepsin D
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi 673 8558, Japan
    Int J Urol 10:196-200. 2003
    ..The objective of this study was to assess the usefulness of combined systematic prostate biopsy with the serum level of cathepsin D, which has recently been shown to be a useful marker for prostate cancer, to predict the disease extension...
  61. ncbi request reprint Expression of clusterin in prostate cancer correlates with Gleason score but not with prognosis in patients undergoing radical prostatectomy without neoadjuvant hormonal therapy
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Urology 68:609-14. 2006
    ..To determine whether the expression level of clusterin in prostate cancer could be used as a prognostic predictor in patients who have undergone radical prostatectomy (RP)...
  62. ncbi request reprint Resistance to cytotoxic chemotherapy-induced apoptosis in human prostate cancer cells is associated with intracellular clusterin expression
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi 673 8558, Japan
    Oncol Rep 10:469-73. 2003
    ..These findings suggest that the sensitivity of PC3 cells to paclitaxel-induced cytotoxicity may be regulated by the intracellular rather than extracellular level of clusterin...
  63. ncbi request reprint Significance of micrometastases in pelvic lymph nodes detected by real-time reverse transcriptase polymerase chain reaction in patients with clinically localized prostate cancer undergoing radical prostatectomy after neoadjuvant hormonal therapy
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    BJU Int 99:315-20. 2007
    ..To clarify the significance of micrometastases in pelvic lymph nodes in patients treated by radical prostatectomy (RP) for prostate cancer after neoadjuvant hormonal therapy (NHT)...
  64. ncbi request reprint Quantitative detection of micrometastases in pelvic lymph nodes in patients with clinically localized prostate cancer by real-time reverse transcriptase-PCR
    Hideaki Miyake
    Department of Urology, Kobe University School of Medicine, Kobe, Japan
    Clin Cancer Res 13:1192-7. 2007
    ..The objective of this study was to clarify the significance of micrometastases in pelvic lymph nodes in patients who underwent radical prostatectomy for prostate cancer...
  65. ncbi request reprint Additional sampling of dorsal apex on systematic prostate biopsy: impact on early detection of prostate cancer
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    Urology 69:738-42. 2007
    ..To evaluate the significance of additional routine biopsies targeting the dorsal apex (DA) in men undergoing transrectal ultrasound (TRUS)-guided biopsies...
  66. ncbi request reprint Improved accuracy for predicting the Gleason score of prostate cancer by increasing the number of transrectal biopsy cores
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    Urol Int 79:302-6. 2007
    ..The objective of this study was to determine whether an increased number of transrectal biopsy cores improves the accuracy of the biopsy Gleason score...
  67. ncbi request reprint Impact of body mass index on perioperative outcomes of laparoscopic radical nephrectomy in Japanese patients with clinically localized renal cell carcinoma
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    Int J Urol 17:522-6. 2010
    ..The aim of this study was to review the association between body mass index (BMI) and perioperative outcomes of laparoscopic radical nephrectomy (LRN) in Japanese patients with renal cell carcinoma (RCC)...
  68. ncbi request reprint Synergistic antitumor effect of ionomycin and cisplatin against renal cell carcinoma in vitro and in vivo
    M Okamoto
    Department of Urology, Kobe University School of Medicine, Kobe, Japan
    Urology 57:188-92. 2001
    ..Conclusions. The synergistic antitumor effects suggest that ionomycin-based therapy could be a novel therapeutic strategy with which to treat advanced renal cell carcinoma...
  69. ncbi request reprint Bcl-2 modulates Fas-mediated apoptosis in human renal cell carcinoma cell lines
    I Hara
    Department of Urology, Kobe University School of Medicine, Kobe 650 0017, Japan
    Int J Oncol 18:1181-5. 2001
    ....
  70. pmc Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gene clusterin
    T Zellweger
    The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada V6H 3Z6
    Neoplasia 3:360-7. 2001
    ..CONCLUSION: These findings confirm that the use of clusterin ASO may be a feasible strategy to enhance chemosensitivity for patients with advanced RCC...
  71. ncbi request reprint Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model
    S Leung
    The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Int J Cancer 91:846-50. 2001
    ....
  72. pmc Overexpression of Bcl-2 enhances metastatic potential of human bladder cancer cells
    H Miyake
    Department of Urology, Kobe University School of Medicine, Japan
    Br J Cancer 79:1651-6. 1999
    ..These findings suggest that, if it is overexpressed, Bcl-2 prolongs cell survival under unfavourable conditions encountered in the metastatic process, resulting in the enhanced metastatic potential of bladder cancer...
  73. ncbi request reprint Use of antisense oligonucleotides targeting the antiapoptotic gene, clusterin/testosterone-repressed prostate message 2, to enhance androgen sensitivity and chemosensitivity in prostate cancer
    M E Gleave
    Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Urology 58:39-49. 2001
    ..Inhibition of clusterin upregulation using clusterin ASOs can enhance cell death after treatment with androgen ablation and chemotherapy...
  74. ncbi request reprint Sodium butyrate induces apoptosis in human renal cell carcinoma cells and synergistically enhances their sensitivity to anti-Fas-mediated cytotoxicity
    I Hara
    Department of Urology, Kobe University School of Medicine, Kobe 650 0017, Japan
    Int J Oncol 17:1213-8. 2000
    ..These findings suggest that NaBt could be a novel attractive approach for patients with RCC, and that the efficacy of NaBt may be enhanced by the combined use of Fas-mediated therapy...
  75. ncbi request reprint Serum matrix metalloproteinase-2 and its density in men with prostate cancer as a new predictor of disease extension
    K Gohji
    Department of Urology, Kobe University School of Medicine, Japan
    Int J Cancer 79:96-101. 1998
    ....
  76. ncbi request reprint Synergistic chemsensitization and inhibition of tumor growth and metastasis by the antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model
    H Miyake
    The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, V6H 3Z6 Canada
    Clin Cancer Res 7:4245-52. 2001
    ....
  77. ncbi request reprint Clinical outcome of high-dose chemotherapy combined with peripheral blood stem cell transplantation for male germ cell tumors
    I Hara
    Department of Urology, Kobe University School of Medicine, Japan
    Anticancer Drugs 10:711-8. 1999
    ..3%) remain disease free at 18 months of median follow up time (range 12-60). We conclude that high-dose chemotherapy is a safe and effective means of treating advanced or refractory germ cell tumors in male patients...
  78. ncbi request reprint Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-O-(2-methoxy)ethyl chemistry
    T Zellweger
    The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada
    J Pharmacol Exp Ther 298:934-40. 2001
    ..These results support the use of 2'-MOE-modified ASO over conventional P=S ASO by potentially increasing potency and allowing longer dosing intervals in clinical trials...
  79. ncbi request reprint Introduction of clusterin gene into human renal cell carcinoma cells enhances their resistance to cytotoxic chemotherapy through inhibition of apoptosis both in vitro and in vivo
    I Hara
    Department of Urology, Kobe University School of Medicine, Chuo Ku, Kobe 650 0017
    Jpn J Cancer Res 92:1220-4. 2001
    ..These findings suggest that clusterin overexpression helps confer a chemoresistant phenotype through inhibition of apoptosis in human RCC cells...
  80. ncbi request reprint Neoadjuvant androgen withdrawal prior to external radiotherapy for locally advanced adenocarcinoma of the prostate
    Isao Hara
    Department of Urology, Kobe University School of Medicine, Japan
    Int J Urol 9:322-8; discussion 328. 2002
    ..The present study aimed to clarify the significance of neoadjuvant androgen ablation prior to external radiotherapy in a human prostate LNCaP tumor model and in patients with locally advanced prostate cancer...
  81. ncbi request reprint A novel antisense oligonucleotide inhibiting several antiapoptotic Bcl-2 family members induces apoptosis and enhances chemosensitivity in androgen-independent human prostate cancer PC3 cells
    Kazuki Yamanaka
    The Prostate Centre, Vancouver General Hospital, British Columbia, Canada
    Mol Cancer Ther 4:1689-98. 2005
    ....
  82. ncbi request reprint Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression
    Isao Hara
    Department of Urology, Kobe University School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Oncol Rep 9:1379-83. 2002
    ..These findings suggest that the elevation of CatD or CatD-D could be used as new predictors of disease progression, but not prognosis, in patients with prostate cancer...
  83. ncbi request reprint Alternative nonsteroidal antiandrogen therapy for advanced prostate cancer that relapsed after initial maximum androgen blockade
    Hiroyoshi Suzuki
    Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Urol 180:921-7. 2008
    ....
  84. ncbi request reprint Synergistic antitumor effect of combined use of adenoviral-mediated p53 gene transfer and antisense oligodeoxynucleotide targeting clusterin gene in an androgen-independent human prostate cancer model
    Kazuki Yamanaka
    Prostate Centre, Vancouver General Hospital, British Columbia, Canada
    Mol Cancer Ther 4:187-95. 2005
    ....
  85. ncbi request reprint Significance of Aurora-A expression in renal cell carcinoma
    Toshifumi Kurahashi
    Department of Urology, Kobe University School of Medicine, Kobe, Japan
    Urol Oncol 25:128-33. 2007
    ..In conclusion, despite the detection in the majority of RCC tissues, Aurora-A expression failed to show the significant association with major pathologic factors and prognosis in patients with RCC...
  86. ncbi request reprint Predictors of prostate cancer on repeat transrectal ultrasound-guided systematic prostate biopsy
    Soo Jeon Park
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    Int J Urol 10:68-71. 2003
    ..We analyzed the outcome of repeated transrectal ultrasound (TRUS)-guided systematic prostate biopsy in Japanese men whose clinical findings were suspected of prostate cancer after previous negative biopsies...
  87. ncbi request reprint Improved sensitivity for detecting micrometastases in pelvic lymph nodes by real-time reverse transcriptase polymerase chain reaction (RT-PCR) compared with conventional RT-PCR in patients with clinically localized prostate cancer undergoing radical prost
    Tomoaki Terakawa
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    BJU Int 103:1074-8. 2009
    ....
  88. ncbi request reprint Introduction of midkine gene into human bladder cancer cells enhances their malignant phenotype but increases their sensitivity to antiangiogenic therapy
    Mototsugu Muramaki
    Division of Urology, Department of Organ Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Clin Cancer Res 9:5152-60. 2003
    ....
  89. ncbi request reprint Enhanced radiation sensitivity in prostate cancer by inhibition of the cell survival protein clusterin
    Tobias Zellweger
    The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia V6H 3Z6, Canada
    Clin Cancer Res 8:3276-84. 2002
    ..Experimental Design: Radiation sensitivities were compared in parental and clusterin-overexpressing LNCaP cells and in PC-3 cells and tumors treated with antisense or mismatch clusterin oligonucleotides...
  90. ncbi request reprint Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and gemcitabine in a human bladder cancer KoTCC-1 model
    Mototsugu Muramaki
    Division of Urology, Department of Organ Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Urol 172:1485-9. 2004
    ..We evaluated the effectiveness of combined treatment with TNP-470 and gemcitabine in vitro and in vivo using highly metastatic human bladder cancer KoTCC-1 cells...
  91. ncbi request reprint Clinical outcome of conservative therapy for stage T1, grade 3 transitional cell carcinoma of the bladder
    Isao Hara
    Department of Urology, Kobe University School of Medicine, Kobe, Japan
    Int J Urol 10:19-24. 2003
    ....
  92. ncbi request reprint Persistent expression of Aurora-A after neoadjuvant hormonal therapy as a predictor of a poor clinical outcome in patients undergoing radical prostatectomy for prostate cancer
    Junya Furukawa
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    BJU Int 100:310-4. 2007
    ....
  93. ncbi request reprint Introducing the clusterin gene into human renal cell carcinoma cells enhances their metastatic potential
    Hideaki Miyake
    Department of Urology, Kobe University School of Medicine, Kobe, Japan
    J Urol 167:2203-8. 2002
    ....
  94. ncbi request reprint Oncological outcome of laparoscopic prostatectomy
    Isao Hara
    Division of Urology, Kobe University School of Medicine, Kobe, Japan
    Int J Urol 14:515-20. 2007
    ..Oncological outcomes including surgical margin status and biological progression-free survival (bPFS) were analyzed in patients who underwent laparoscopic prostatectomy (LRP) only...
  95. ncbi request reprint Limited usefulness of the free-to-total prostate-specific antigen ratio for the diagnosis and staging of prostate cancer in Japanese men
    Iori Sakai
    Department of Urology, Hyogo Medical Center for Adults, 13 70 Kitaohji cho, Akashi 673 8558, Japan
    Int J Clin Oncol 9:64-7. 2004
    ....
  96. ncbi request reprint Castration-induced increases in insulin-like growth factor-binding protein 2 promotes proliferation of androgen-independent human prostate LNCaP tumors
    Satoshi Kiyama
    The Prostate Centre, Vancouver General Hospital, and Division of Urology, University of British Columbia, Canada
    Cancer Res 63:3575-84. 2003
    ..Inhibiting IGFBP-2 expression using ASO technology may offer a treatment strategy to delay AI progression...
  97. ncbi request reprint Targeting anti-apoptotic genes upregulated by androgen withdrawal using antisense oligonucleotides to enhance androgen- and chemo-sensitivity in prostate cancer
    Martin E Gleave
    The Prostate Centre, Vancouver General Hospital, British Columbia, Canada
    Invest New Drugs 20:145-58. 2002
    ....
  98. doi request reprint Risk factors for intravesical recurrence after surgical management of transitional cell carcinoma of the upper urinary tract
    Tomoaki Terakawa
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    Urology 71:123-7. 2008
    ..To identify risk factors for developing subsequent bladder cancer in patients undergoing surgical management of transitional cell carcinoma (TCC) of the upper urinary tract...
  99. ncbi request reprint Prognostic analysis of Japanese men with metastatic germ cell tumors showing favorable response to bleomycin, etoposide and cisplatin as first-line chemotherapy
    Masafumi Kumano
    Division of Urology, Kobe University Graduate School of Medicine
    Hinyokika Kiyo 53:851-6. 2007
    ..These findings suggested that patients with metastatic GCTs, regardless of histological subtype (i.e., seminoma or nonseminoma), who showed favorable response to first-line BEP chemotherapy, could achieve an excellent prognostic outcome...
  100. ncbi request reprint [Molecular targeted therapy for renal cell carcinoma and other urological cancers]
    Hideaki Miyake
    Division of Urology, Kobe University Graduate School of Medicine
    Nihon Rinsho 68:1871-5. 2010
    ..Finally, the prospects for the use of molecular targeted agents against urological cancers other than RCC are mentioned...