Toshiyuki Miura

Summary

Publications

  1. pmc HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers
    Toshiyuki Miura
    Ragon Institute formerly Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 83:3407-12. 2009
  2. pmc HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition
    Toshiyuki Miura
    Ragon Institute, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:2743-55. 2009
  3. pmc Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 82:8422-30. 2008
  4. pmc HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:140-9. 2009
  5. pmc Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes
    Huabiao Chen
    Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Virol 83:3138-49. 2009
  6. doi request reprint Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy
    Florencia Pereyra
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    J Infect Dis 197:563-71. 2008
  7. pmc Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters
    Florencia Pereyra
    The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, 149 13th St, Charlestown, MA 02129, USA
    J Infect Dis 200:984-90. 2009
  8. pmc A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, and Harvard University Center for AIDS Research, Boston, MA 02129, USA
    J Exp Med 204:2813-24. 2007
  9. pmc Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A
    Mark A Brockman
    Partners AIDS Research Center, Massachusetts General Hospital East, CNY 6625, Charlestown, MA 02129, USA
    J Virol 81:12608-18. 2007
  10. pmc Coordinate linkage of HIV evolution reveals regions of immunological vulnerability
    Vincent Dahirel
    Ragon Institute of Massachusetts General Hospital, and Harvard University, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 108:11530-5. 2011

Collaborators

Detail Information

Publications13

  1. pmc HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers
    Toshiyuki Miura
    Ragon Institute formerly Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 83:3407-12. 2009
    ..These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HIV-1 infection...
  2. pmc HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition
    Toshiyuki Miura
    Ragon Institute, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:2743-55. 2009
    ..These data suggest a dual mechanism for durable control of HIV replication, consisting of viral fitness loss resulting from CTL escape mutations together with strong CD8 T-cell immune responses to the arising variant epitopes...
  3. pmc Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 82:8422-30. 2008
    ..These results indicate that the spontaneous control of HIV replication is not attributable to shared viral genetic defects or shared viral polymorphisms...
  4. pmc HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:140-9. 2009
    ....
  5. pmc Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes
    Huabiao Chen
    Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Virol 83:3138-49. 2009
    ....
  6. doi request reprint Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy
    Florencia Pereyra
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    J Infect Dis 197:563-71. 2008
    ..The mechanisms behind this outcome remain largely unknown, and a better understanding of them will likely influence future vaccine strategies...
  7. pmc Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters
    Florencia Pereyra
    The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, 149 13th St, Charlestown, MA 02129, USA
    J Infect Dis 200:984-90. 2009
    ..Here, we quantify plasma HIV-1 RNA in elite controllers and correlate this with specific immunologic parameters...
  8. pmc A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, and Harvard University Center for AIDS Research, Boston, MA 02129, USA
    J Exp Med 204:2813-24. 2007
    ....
  9. pmc Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A
    Mark A Brockman
    Partners AIDS Research Center, Massachusetts General Hospital East, CNY 6625, Charlestown, MA 02129, USA
    J Virol 81:12608-18. 2007
    ....
  10. pmc Coordinate linkage of HIV evolution reveals regions of immunological vulnerability
    Vincent Dahirel
    Ragon Institute of Massachusetts General Hospital, and Harvard University, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 108:11530-5. 2011
    ..Targeting such regions with higher order evolutionary constraints provides a novel approach to immunogen design for a vaccine against HIV and other rapidly mutating viruses...
  11. ncbi request reprint Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction
    Daniel E Kaufmann
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 8:1246-54. 2007
    ..These data, indicating a reversible immunoregulatory pathway selectively associated with CD4(+) T cell dysfunction, provide a potential target for immunotherapy in HIV-infected patients...
  12. ncbi request reprint Increased sequence diversity coverage improves detection of HIV-specific T cell responses
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Immunol 179:6638-50. 2007
    ..Toggled peptides therefore afford a cost-effective and significantly more complete view of the host immune response to HIV and are directly applicable to other variable pathogens...
  13. pmc Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes
    Xu G Yu
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Room 5212, Charlestown, MA 02129, USA
    J Virol 81:1619-31. 2007
    ..These data show the influence of HLA allele subtypes on TCR selection and indicate that extensive TCR diversity is not a prerequisite to prevention of allowable viral mutations...