Masato Mitsuhashi

Summary

Publications

  1. doi request reprint Ex vivo simulation of leukocyte function: stimulation of specific subset of leukocytes in whole blood followed by the measurement of function-associated mRNAs
    Masato Mitsuhashi
    Hitachi Chemical Research Center, Inc Irvine, CA, United States
    J Immunol Methods 363:95-100. 2010
  2. doi request reprint Ex vivo simulation of the action of antileukemia drugs by measuring apoptosis-related mRNA in blood
    Masato Mitsuhashi
    Hitachi Chemical Research Center, Inc, Irvine, CA, USA
    Clin Chem 54:673-81. 2008
  3. ncbi request reprint Quantification of mRNA in whole blood by assessing recovery of RNA and efficiency of cDNA synthesis
    Masato Mitsuhashi
    Hitachi Chemical Research Center, Inc, Irvine, CA, USA
    Clin Chem 52:634-42. 2006
  4. doi request reprint Ex vivo simulation of IgG Fc and T-cell receptor functions: an application to inflammatory bowel disease
    Masato Mitsuhashi
    Hitachi Chemical Research Center, Inc, Irvine, California, USA
    Inflamm Bowel Dis 14:1061-7. 2008
  5. pmc Ex vivo induction of mRNA in human whole blood as a new platform of drug and dietary supplement development
    Masato Mitsuhashi
    Hitachi Chemical Research Center Inc, Irvine, CA, USA
    Pharm Res 25:1116-24. 2008
  6. ncbi request reprint A dried tofu-supplemented diet affects mRNA expression of inflammatory cytokines in human blood
    Vivian Tovar
    Hitachi Chemical Research Center, Inc, Irvine, CA 92617, USA
    J Nutr Sci Vitaminol (Tokyo) 56:396-410. 2010
  7. pmc Ex vivo TCR-induced leukocyte gene expression of inflammatory mediators is increased in type 1 diabetic patients but not in overweight children
    Jaime S Rosa
    Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, CA 92612, USA
    Diabetes Metab Res Rev 26:33-9. 2010
  8. ncbi request reprint Hepatic tissue sterol regulatory element binding protein 2 and low-density lipoprotein receptor in nephrotic syndrome
    Choong H Kim
    Division of Nephrology and Hypertension, University of California, Irvine, Orange, CA 92868, USA
    Metabolism 56:1377-82. 2007
  9. doi request reprint Altered kinetics of interleukin-6 and other inflammatory mediators during exercise in children with type 1 diabetes
    Jaime S Rosa
    Department of Pediatrics, Institute for Clinical Translational Science, School of Medicine, University of California, Irvine, CA 92612, USA
    J Investig Med 56:701-13. 2008
  10. ncbi request reprint PCR primer design
    David L Hyndman
    Software Development, Automation Biology Drug Discovery Department, Ribapharm Inc, Costa Mesa, CA, USA
    Methods Mol Biol 226:81-8. 2003

Collaborators

  • Stephan Targan
  • Katsuya Endo
  • Stacy R Oliver
  • Nosratola D Vaziri
  • Jaime S Rosa
  • Vivian Tovar
  • Mieko Ogura
  • Pietro R Galassetti
  • Rebecca L Flores
  • Andria M Pontello
  • Choong H Kim
  • David L Hyndman
  • Hiroko Matsunaga
  • Setsuo Hasegawa
  • Kazunori Saito
  • Ai Kobayashi
  • Michiko Kainuma
  • Masafumi Yohda
  • Sayaka Kimura
  • Frank P Zaldivar
  • Hyun J Kim
  • Kouichi Kobayashi
  • Nanae Hangai
  • Jeff H Hoger
  • Yoshimasa Aso
  • Hideki Kambara
  • Kazunori Okano
  • Masafumi Kawamura

Detail Information

Publications12

  1. doi request reprint Ex vivo simulation of leukocyte function: stimulation of specific subset of leukocytes in whole blood followed by the measurement of function-associated mRNAs
    Masato Mitsuhashi
    Hitachi Chemical Research Center, Inc Irvine, CA, United States
    J Immunol Methods 363:95-100. 2010
    ..The method introduced in this study will be a new paradigm for clinical cellular immunology...
  2. doi request reprint Ex vivo simulation of the action of antileukemia drugs by measuring apoptosis-related mRNA in blood
    Masato Mitsuhashi
    Hitachi Chemical Research Center, Inc, Irvine, CA, USA
    Clin Chem 54:673-81. 2008
    ....
  3. ncbi request reprint Quantification of mRNA in whole blood by assessing recovery of RNA and efficiency of cDNA synthesis
    Masato Mitsuhashi
    Hitachi Chemical Research Center, Inc, Irvine, CA, USA
    Clin Chem 52:634-42. 2006
    ..Current gene expression analysis relies on the assumption that the isolated RNA represents all species of mRNA in proportions equal to those in the original materials. No system is available for absolute quantification of mRNA...
  4. doi request reprint Ex vivo simulation of IgG Fc and T-cell receptor functions: an application to inflammatory bowel disease
    Masato Mitsuhashi
    Hitachi Chemical Research Center, Inc, Irvine, California, USA
    Inflamm Bowel Dis 14:1061-7. 2008
    ..Human leukocyte IgG Fc receptors (FcgammaR) and T-cell receptors (TCR) are primary molecules involved in inflammatory and immune pathways...
  5. pmc Ex vivo induction of mRNA in human whole blood as a new platform of drug and dietary supplement development
    Masato Mitsuhashi
    Hitachi Chemical Research Center Inc, Irvine, CA, USA
    Pharm Res 25:1116-24. 2008
    ..This model system was applied to study various fields of drug development...
  6. ncbi request reprint A dried tofu-supplemented diet affects mRNA expression of inflammatory cytokines in human blood
    Vivian Tovar
    Hitachi Chemical Research Center, Inc, Irvine, CA 92617, USA
    J Nutr Sci Vitaminol (Tokyo) 56:396-410. 2010
    ..The results also indicated that Koya tofu had a power to alter mRNA expression in leukocytes, and TNFSF15, IL6, and IL10 would be biomarkers for soy...
  7. pmc Ex vivo TCR-induced leukocyte gene expression of inflammatory mediators is increased in type 1 diabetic patients but not in overweight children
    Jaime S Rosa
    Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, CA 92612, USA
    Diabetes Metab Res Rev 26:33-9. 2010
    ..4 +/- 0.5 year, 4F/5 M), 23 overweight (OW, 12.3 +/- 0.5 year, 10F/13M, BMI% 97.1 +/- 0.5 and > 90.0), and 21 healthy (CL, 13.8 +/- 0.7 year, 9F/12 M, BMI% 59.6 +/- 4.6 and < 85.0) children...
  8. ncbi request reprint Hepatic tissue sterol regulatory element binding protein 2 and low-density lipoprotein receptor in nephrotic syndrome
    Choong H Kim
    Division of Nephrology and Hypertension, University of California, Irvine, Orange, CA 92868, USA
    Metabolism 56:1377-82. 2007
    ..This is because SREBP-2 expression and activity are, in part, regulated by intracellular as opposed to plasma cholesterol...
  9. doi request reprint Altered kinetics of interleukin-6 and other inflammatory mediators during exercise in children with type 1 diabetes
    Jaime S Rosa
    Department of Pediatrics, Institute for Clinical Translational Science, School of Medicine, University of California, Irvine, CA 92612, USA
    J Investig Med 56:701-13. 2008
    ..Relatively little is known, however, on most molecular aspects of immunomodulatory adaptation to exercise in diabetic children...
  10. ncbi request reprint PCR primer design
    David L Hyndman
    Software Development, Automation Biology Drug Discovery Department, Ribapharm Inc, Costa Mesa, CA, USA
    Methods Mol Biol 226:81-8. 2003
  11. ncbi request reprint Ex vivo simulation of drug action: quantification of drug-induced mRNA as a bridge between preclinical and clinical trials
    Masato Mitsuhashi
    Clin Chem 53:148-9. 2007
  12. ncbi request reprint Application of differential display to identify genes for lung cancer detection in peripheral blood
    Hiroko Matsunaga
    Hitachi Ltd, Central Research Laboratory, Tokyo, Japan
    Int J Cancer 100:592-9. 2002
    ..These new molecular markers may aid early detection, staging and follow-up of lung cancer patients by RNA isolated from blood...