Induction of lepromin reactivity in cured lepromatous leprosy patients: impaired chemokine response dissociates protective immunity from delayed type hypersensitivityDipendra K Mitra
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Microbes Infect 11:1122-30. 2009
..Our data provide insights into the intricate relationship between DTH and immunity and highlight the persistent presence of effector immune mechanisms involving these two pathways in apparently unresponsive lepromatous leprosy patients...
Structural studies on molecular interactions between camel peptidoglycan recognition protein, CPGRP-S, and peptidoglycan moieties N-acetylglucosamine and N-acetylmuramic acidPradeep Sharma
Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India
J Biol Chem 287:22153-64. 2012
..This showed that CPGRP-S inhibited PGN-induced production of proinflammatory cytokines and down-regulated macrophage-mediated inflammation, indicating its potential applications as an antibacterial agent...
- Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site
Pradeep Sharma
Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India
Arch Biochem Biophys 529:1-10. 2013
..The concentrations of cytokines increased considerably with increasing concentrations of mycolic acid. However, their levels decreased substantially on adding CPGRP-S...
- Impaired expression of CD26 compromises T-cell recruitment in human visceral leishmaniasis
Ambak K Rai
Department of Transplant Immunology and Immunogenetics, AIIMS, New Delhi, India
Eur J Immunol 42:2782-91. 2012
..Our results indicate that, in VL patients, impaired expression and secretion of CD26 compromises chemokine activation and thus T-cell recruitment, eventually resulting in a deficient state of local immunity at pathologic sites...
- FoxP3+ regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis
Prabhat K Sharma
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Am J Respir Crit Care Med 179:1061-70. 2009
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- Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis
Ambak K Rai
Cellular Immunology Division, Department of TII, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
PLoS ONE 7:e31551. 2012
..Our results suggest that IL-10 plays an important role in suppression of host immunity in human VL and possibly determines the efficacy of chemotherapy...
- Association of Intracellular T(H)1-T(H)2 Balance in CD4+ T-cells and MIP-1α in CD8+ T-cells with Disease Severity in Adults with Dengue
Tamilarasu Kadhiravan
Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
Immune Netw 10:164-72. 2010
..We tested the hypothesis that dengue haemorrhagic fever (DHF) is associated with a T(H)1-skewed immune response as opposed to dengue fever (DF)...
- Clinical significance of sperm DNA damage threshold value in the assessment of male infertility
Sundararajan Venkatesh
Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
Reprod Sci 18:1005-13. 2011
..Thus, DFI is a good prognostic marker as cases with higher sperm DFI may have poor success rate even after assisted conception and may experience recurrent pregnancy loss (RPL) and should be counseled accordingly...
- Structural basis of recognition of pathogen-associated molecular patterns and inhibition of proinflammatory cytokines by camel peptidoglycan recognition protein
Pradeep Sharma
Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India
J Biol Chem 286:16208-17. 2011
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Polarized helper T cells in tubercular pleural effusion: phenotypic identity and selective recruitmentDipendra K Mitra
Departments of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Eur J Immunol 35:2367-75. 2005
..Findings of the present study provide mechanistic insights into the critical events of T cell trafficking in tuberculosis and may help designing better therapeutic modalities...
