Caroline Mitchell

Summary

Publications

  1. ncbi request reprint Correlation between Plasma, Intracellular, and Cervical Tissue Levels of Raltegravir at Steady-State Dosing in Healthy Women
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA
    Antimicrob Agents Chemother 58:3360-5. 2014
  2. pmc Pelvic inflammatory disease: current concepts in pathogenesis, diagnosis and treatment
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA Electronic address
    Infect Dis Clin North Am 27:793-809. 2013
  3. pmc Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 62:143-8. 2013
  4. pmc Effect of sexual debut on vaginal microbiota in a cohort of young women
    Caroline M Mitchell
    Department of Obstetrics and Gynecology and Fred Hutchinson Cancer Research Institute, University of Washington, Seattle, Washington, USA
    Obstet Gynecol 120:1306-13. 2012
  5. pmc Effect of sexual activity on vaginal colonization with hydrogen peroxide-producing lactobacilli and Gardnerella vaginalis
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
    Sex Transm Dis 38:1137-44. 2011
  6. pmc Cervicovaginal shedding of HIV type 1 is related to genital tract inflammation independent of changes in vaginal microbiota
    Caroline Mitchell
    University of Washington, Seattle, 98104, USA
    AIDS Res Hum Retroviruses 27:35-9. 2011
  7. pmc Interaction between lactobacilli, bacterial vaginosis-associated bacteria, and HIV Type 1 RNA and DNA Genital shedding in U.S. and Kenyan women
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    AIDS Res Hum Retroviruses 29:13-9. 2013
  8. pmc Detection of hydrogen peroxide-producing Lactobacillus species in the vagina: a comparison of culture and quantitative PCR among HIV-1 seropositive women
    Jennifer E Balkus
    Department of Epidemiology, University of Washington, Box 359909, 325 9th Avenue, Seattle, WA 98104, USA
    BMC Infect Dis 12:188. 2012
  9. pmc Behavioral predictors of colonization with Lactobacillus crispatus or Lactobacillus jensenii after treatment for bacterial vaginosis: a cohort study
    Caroline Mitchell
    Harborview Women s Clinic, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98105, USA
    Infect Dis Obstet Gynecol 2012:706540. 2012
  10. pmc Estimating volume of cervicovaginal secretions in cervicovaginal lavage fluid collected for measurement of genital HIV-1 RNA levels in women
    Caroline Mitchell
    University of Washington, Department of Obstetrics and Gynecology, Harborview Medical Center, 325 9th Ave, Box 359865, Seattle, WA 98104, USA
    J Clin Microbiol 49:735-6. 2011

Detail Information

Publications16

  1. ncbi request reprint Correlation between Plasma, Intracellular, and Cervical Tissue Levels of Raltegravir at Steady-State Dosing in Healthy Women
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA
    Antimicrob Agents Chemother 58:3360-5. 2014
    ....
  2. pmc Pelvic inflammatory disease: current concepts in pathogenesis, diagnosis and treatment
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA Electronic address
    Infect Dis Clin North Am 27:793-809. 2013
    ..Antibiotic therapy should be started early, and given for an adequate period of time to reduce the risk of complications. Coverage for anaerobic organisms should be considered in most cases...
  3. pmc Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 62:143-8. 2013
    ..01). HIV-1 DNA shedding was associated with increased concentrations of IL-1β and IL-6 and lower secretory leukocyte protease inhibitor among US women but not Kenyan women...
  4. pmc Effect of sexual debut on vaginal microbiota in a cohort of young women
    Caroline M Mitchell
    Department of Obstetrics and Gynecology and Fred Hutchinson Cancer Research Institute, University of Washington, Seattle, Washington, USA
    Obstet Gynecol 120:1306-13. 2012
    ..Bacterial vaginosis is uncommon in women who are virgins. We estimated effects of sexual debut on vaginal bacterial colonization...
  5. pmc Effect of sexual activity on vaginal colonization with hydrogen peroxide-producing lactobacilli and Gardnerella vaginalis
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
    Sex Transm Dis 38:1137-44. 2011
    ..Bacterial vaginosis is associated with sexual activity, but mechanisms for this association are unclear...
  6. pmc Cervicovaginal shedding of HIV type 1 is related to genital tract inflammation independent of changes in vaginal microbiota
    Caroline Mitchell
    University of Washington, Seattle, 98104, USA
    AIDS Res Hum Retroviruses 27:35-9. 2011
    ..This association suggests that there may be additional, noninfectious causes of inflammation that increase cervicovaginal HIV-1 shedding...
  7. pmc Interaction between lactobacilli, bacterial vaginosis-associated bacteria, and HIV Type 1 RNA and DNA Genital shedding in U.S. and Kenyan women
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    AIDS Res Hum Retroviruses 29:13-9. 2013
    ..6; 0.40, 0.91). Vaginal Lactobacillus species were associated with lower risk of genital HIV-1 shedding, while the presence of certain BV-associated species may increase that risk...
  8. pmc Detection of hydrogen peroxide-producing Lactobacillus species in the vagina: a comparison of culture and quantitative PCR among HIV-1 seropositive women
    Jennifer E Balkus
    Department of Epidemiology, University of Washington, Box 359909, 325 9th Avenue, Seattle, WA 98104, USA
    BMC Infect Dis 12:188. 2012
    ..We assessed the concordance of H(2)O(2)-producing Lactobacillus detected by culture with quantitative PCR (qPCR) detection of Lactobacillus species commonly assumed to be H(2)O(2)-producers...
  9. pmc Behavioral predictors of colonization with Lactobacillus crispatus or Lactobacillus jensenii after treatment for bacterial vaginosis: a cohort study
    Caroline Mitchell
    Harborview Women s Clinic, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98105, USA
    Infect Dis Obstet Gynecol 2012:706540. 2012
    ..Evaluate predictors of vaginal colonization with lactobacilli after treatment for bacterial vaginosis (BV)...
  10. pmc Estimating volume of cervicovaginal secretions in cervicovaginal lavage fluid collected for measurement of genital HIV-1 RNA levels in women
    Caroline Mitchell
    University of Washington, Department of Obstetrics and Gynecology, Harborview Medical Center, 325 9th Ave, Box 359865, Seattle, WA 98104, USA
    J Clin Microbiol 49:735-6. 2011
    ..Thirty-eight women provided 275 cervicovaginal specimens. The estimated median volume of cervicovaginal fluid was 0.51 ml (interquartile range, 0.33, 0.69)...
  11. pmc Detection of fastidious vaginal bacteria in women with HIV infection and bacterial vaginosis
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, P O Box 356460, Seattle, WA 98195, USA
    Infect Dis Obstet Gynecol 2009:236919. 2009
    ..Fastidious bacteria have been associated with bacterial vaginosis (BV) using PCR methods. We assessed the prevalence of these bacteria in HIV-1 infected women and their relationship with vaginal pH and shedding of HIV-1 RNA...
  12. pmc Associations between vaginal bacteria and levels of vaginal defensins in pregnant women
    Caroline Mitchell
    Department of Obstetrics and Gynecology, Harborview Women s Clinic, University of Washington School of Medicine, Seattle, WA, USA
    Am J Obstet Gynecol 208:132.e1-7. 2013
    ..We evaluated vaginal defensin concentrations and levels of bacterial vaginosis-associated bacterial species in pregnant women...
  13. pmc Effects of pregnancy and bacterial vaginosis on proinflammatory cytokine and secretory leukocyte protease inhibitor concentrations in vaginal secretions
    Jennifer Balkus
    Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA
    J Pregnancy 2010:385981. 2010
    ..Pregnancy and BV were both independently associated with increased vaginal concentrations of IL-1β and IL-8; pregnant women had increased concentrations of SLPI, while women with BV had decreased SLPI concentrations...
  14. pmc Cross-contamination during processing of dried blood spots used for rapid diagnosis of HIV-1 infection of infants is rare and avoidable
    Caroline Mitchell
    University of Washington, Department of Obstetrics and Gynecology, 1959 NE Pacific St, Seattle, WA 98195, United States
    J Virol Methods 163:489-91. 2010
    ..This study outlines procedures that minimize false-positive results for nested PCR of HIV-1 DNA from DBS...
  15. pmc Changes in the vaginal microenvironment with metronidazole treatment for bacterial vaginosis in early pregnancy
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
    J Womens Health (Larchmt) 18:1817-24. 2009
    ..We examined whether oral or vaginal metronidazole treatment for BV in early pregnancy was more effective in restoring the normal vaginal environment...
  16. ncbi request reprint Bacterial vaginosis and the cervicovaginal immune response
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    Am J Reprod Immunol 71:555-63. 2014
    ..We focus on inflammatory markers that are proposed to increase the risk of HIV-1 acquisition. ..