Nibha Mishra

Summary

Publications

  1. doi request reprint Attenuating Aβ1-42-induced toxicity by a novel acetylcholinesterase inhibitor
    N Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, 835215 Ranchi, India Electronic address
    Neuroscience 250:309-19. 2013
  2. doi request reprint Additional acetyl cholinesterase inhibitory property of diaryl pyrazoline derivatives
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India
    Bioorg Med Chem Lett 23:702-5. 2013
  3. doi request reprint Modulations of brain amines and dopaminergic behavior by a novel, reversible and selective MAO-B inhibitor
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India
    Brain Res 1470:45-51. 2012
  4. doi request reprint Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra 835215, Ranchi, India
    J Ethnopharmacol 128:533-6. 2010
  5. doi request reprint Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835 215, India
    Bioorg Med Chem Lett 21:1969-73. 2011
  6. doi request reprint Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies
    Muthukumar Karuppasamy
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India
    Bioorg Med Chem 18:1875-81. 2010
  7. pmc Exploring different virtual screening strategies for acetylcholinesterase inhibitors
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India
    Biomed Res Int 2013:236850. 2013
  8. doi request reprint Development of CoMFA and CoMSIA models of cytotoxicity data of anti-HIV-1-phenylamino-1H-imidazole derivatives
    Arijit Basu
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra 835 215, Ranchi, India
    Eur J Med Chem 44:2400-7. 2009
  9. doi request reprint Synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones
    Kesavan Krishnan
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835 215, India
    Bioorg Med Chem Lett 18:6248-50. 2008
  10. doi request reprint Structure based virtual screening of GSK-3beta: importance of protein flexibility and induced fit
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835 215, India
    Bioorg Med Chem Lett 19:5582-5. 2009

Collaborators

Detail Information

Publications11

  1. doi request reprint Attenuating Aβ1-42-induced toxicity by a novel acetylcholinesterase inhibitor
    N Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, 835215 Ranchi, India Electronic address
    Neuroscience 250:309-19. 2013
    ..Therefore, NP-9 could be a promising lead molecule for AD, with effects against MAO-B, AChE, Aβ aggregation, and Aβ1-42 induced toxicity...
  2. doi request reprint Additional acetyl cholinesterase inhibitory property of diaryl pyrazoline derivatives
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India
    Bioorg Med Chem Lett 23:702-5. 2013
    ..Most of the compounds were found active at nano molar range, and are consistent with the docking results. The identified dual acting lead molecules may provide the basis for further exploring these chemical moieties...
  3. doi request reprint Modulations of brain amines and dopaminergic behavior by a novel, reversible and selective MAO-B inhibitor
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India
    Brain Res 1470:45-51. 2012
    ..The study provides a preclinical basis to NP-9 for MAO-B inhibition...
  4. doi request reprint Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra 835215, Ranchi, India
    J Ethnopharmacol 128:533-6. 2010
    ..To systematically investigate the anticonvulsant activity of methanol extract of Benkara malabarica roots and to provide a biochemical basis elucidating its mode of action...
  5. doi request reprint Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835 215, India
    Bioorg Med Chem Lett 21:1969-73. 2011
    ..All the compounds were found selective, reversible and active in nM range (100 times more potent than selegeline) towards MAO-B. Outstanding co-relation between predicted and experimental K(i) values were observed...
  6. doi request reprint Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies
    Muthukumar Karuppasamy
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India
    Bioorg Med Chem 18:1875-81. 2010
    ..Interestingly, the theoretical (K(i)) values obtained by molecular docking studies were in congruence with their experimental (K(i)) values...
  7. pmc Exploring different virtual screening strategies for acetylcholinesterase inhibitors
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India
    Biomed Res Int 2013:236850. 2013
    ..The shape- and electrostatic-based similarity search protocol emerged as a plausible solution for virtual screening of AChE inhibitors. ..
  8. doi request reprint Development of CoMFA and CoMSIA models of cytotoxicity data of anti-HIV-1-phenylamino-1H-imidazole derivatives
    Arijit Basu
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra 835 215, Ranchi, India
    Eur J Med Chem 44:2400-7. 2009
    ..The best CoMSIA model was obtained by using the SHE fields and employing 25% molecules in the test set (r(pred)(2) of 0.789 and r(m)(2) of 0.410)...
  9. doi request reprint Synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones
    Kesavan Krishnan
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835 215, India
    Bioorg Med Chem Lett 18:6248-50. 2008
    ..Guided by the activity of compounds 9 and 10, 11 new thiosemicarbazones (17-27) derived from p-hydroxy benzaldehyde were prepared and screened for their RR inhibitory activity. All the 11 compounds were more potent than HU...
  10. doi request reprint Structure based virtual screening of GSK-3beta: importance of protein flexibility and induced fit
    Nibha Mishra
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835 215, India
    Bioorg Med Chem Lett 19:5582-5. 2009
    ..This protocol provides an enrichment of 70% in top 1% of the dataset with a rank correlation of >0.9 and found better in comparison to earlier reported protocols...