Javier Milara

Summary

Publications

  1. doi request reprint Bafetinib inhibits functional responses of human eosinophils in vitro
    Javier Milara
    Clinical research unit UIC, University General Hospital Consortium, Av Tres Cruces s n, Valencia E 46014, Spain
    Eur J Pharmacol 715:172-80. 2013
  2. doi request reprint Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke
    Javier Milara
    Clinical research unit UIC, University General Hospital Consortium, Valencia, Spain
    Thorax 68:410-20. 2013
  3. doi request reprint Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition
    Javier Milara
    Research Unit, University General Hospital Consortium, Valencia, Spain
    Eur Respir J 41:1264-74. 2013
  4. doi request reprint Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries
    J Milara
    Clinic Research Unit, University General Hospital Consortium, Valencia, Spain
    Eur Respir J 39:927-38. 2012
  5. doi request reprint Neutrophil activation in severe, early-onset COPD patients versus healthy non-smoker subjects in vitro: effects of antioxidant therapy
    Javier Milara
    Research Unit, University General Hospital Consortium, and Department of Medicine, Faculty of Medicine, University of Valencia, Valencia, Spain
    Respiration 83:147-58. 2012
  6. pmc Aclidinium inhibits human lung fibroblast to myofibroblast transition
    Javier Milara
    Unidad de Investigacion, Consorcio Hospital General, Universitario, Avenida Tres Vruces s n, Valencia E 46014, Spain
    Thorax 67:229-37. 2012
  7. doi request reprint Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition
    Javier Milara
    Research Foundation, University General Hospital Consortium, Valencia, Spain
    Thorax 67:147-56. 2012
  8. doi request reprint Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis
    Javier Milara
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
    Eur J Pharmacol 609:132-9. 2009
  9. doi request reprint Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages
    J Milara
    Research Unit, University General Hospital Consortium, Valencia, Spain
    Clin Exp Allergy 41:535-46. 2011
  10. pmc Cigarette smoke exposure up-regulates endothelin receptor B in human pulmonary artery endothelial cells: molecular and functional consequences
    J Milara
    Research Unit, University General Hospital Consortium, Valencia, Spain
    Br J Pharmacol 161:1599-615. 2010

Collaborators

Detail Information

Publications23

  1. doi request reprint Bafetinib inhibits functional responses of human eosinophils in vitro
    Javier Milara
    Clinical research unit UIC, University General Hospital Consortium, Av Tres Cruces s n, Valencia E 46014, Spain
    Eur J Pharmacol 715:172-80. 2013
    ..Therefore, future anti-allergic therapies based on bafetinib, could help to suppress excessive inflammatory response of eosinophils at inflammatory sites...
  2. doi request reprint Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke
    Javier Milara
    Clinical research unit UIC, University General Hospital Consortium, Valencia, Spain
    Thorax 68:410-20. 2013
    ..This study examines the EMT process in human bronchial epithelial cells (HBECs) from non-smokers, smokers and patients with COPD as well as the in vitro effect of cigarette smoke extract (CSE) on EMT...
  3. doi request reprint Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition
    Javier Milara
    Research Unit, University General Hospital Consortium, Valencia, Spain
    Eur Respir J 41:1264-74. 2013
    ..A non-neuronal cholinergic system is implicated in cigarette smoke-induced bronchial fibroblast-to-myofibroblast transition, which is inhibited by aclidinium bromide...
  4. doi request reprint Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries
    J Milara
    Clinic Research Unit, University General Hospital Consortium, Valencia, Spain
    Eur Respir J 39:927-38. 2012
    ..These data may be of potential value to explain therapeutic effects of bosentan in some forms of disproportionate pulmonary hypertension in COPD patients...
  5. doi request reprint Neutrophil activation in severe, early-onset COPD patients versus healthy non-smoker subjects in vitro: effects of antioxidant therapy
    Javier Milara
    Research Unit, University General Hospital Consortium, and Department of Medicine, Faculty of Medicine, University of Valencia, Valencia, Spain
    Respiration 83:147-58. 2012
    ..Severe, early-onset COPD is characterized by a rapid decline in the lung function at an early age; however, nothing is known about neutrophil activation in COPD patients...
  6. pmc Aclidinium inhibits human lung fibroblast to myofibroblast transition
    Javier Milara
    Unidad de Investigacion, Consorcio Hospital General, Universitario, Avenida Tres Vruces s n, Valencia E 46014, Spain
    Thorax 67:229-37. 2012
    ..This study examines the role of aclidinium, a new long-acting muscarinic antagonist, on human fibroblast to myofibroblast transition...
  7. doi request reprint Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition
    Javier Milara
    Research Foundation, University General Hospital Consortium, Valencia, Spain
    Thorax 67:147-56. 2012
    ..Sphingosine-1-phosphate (S1P) and sphingosine kinase 1 (SPHK1) have been implicated in lung myofibroblast transition, but their role in EMT and their expression in patients with IPF is unknown...
  8. doi request reprint Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis
    Javier Milara
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
    Eur J Pharmacol 609:132-9. 2009
    ..This study demonstrates for the first time that S1P participates in the alveolar epithelial interactions in vitro...
  9. doi request reprint Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages
    J Milara
    Research Unit, University General Hospital Consortium, Valencia, Spain
    Clin Exp Allergy 41:535-46. 2011
    ..Oxidative stress is present in airway diseases such as severe asthma or Chronic Obstructive Pulmonary Disease and contributes to the low response to glucocorticoids through the down-regulation of histone deacetylase (HDAC) activity...
  10. pmc Cigarette smoke exposure up-regulates endothelin receptor B in human pulmonary artery endothelial cells: molecular and functional consequences
    J Milara
    Research Unit, University General Hospital Consortium, Valencia, Spain
    Br J Pharmacol 161:1599-615. 2010
    ..We studied the effect of cigarette smoke extract (CSE) on endothelin receptor B (ET(B) ) expression in human pulmonary artery endothelial cells (HPAECs) and its role in endothelial dysfunction...
  11. doi request reprint Role of adenylate kinase type 7 expression on cilia motility: possible link in primary ciliary dyskinesia
    Javier Milara
    Research Unit, University General Hospital Consortium, Avenida Tres Cruces s n, Valencia, Spain
    Am J Rhinol Allergy 24:181-5. 2010
    ....
  12. doi request reprint Extracellular calcium-sensing receptor mediates human bronchial epithelial wound repair
    Javier Milara
    University General Hospital Consortium, Valencia, Spain
    Biochem Pharmacol 80:236-46. 2010
    ..Our data, for the first time, shows that CaSR plays an important role in airway epithelial repair, which may help to develop novel regenerative therapeutics allowing the rapid repair of lung damaged epithelium...
  13. doi request reprint Cigarette smoke-induced pulmonary endothelial dysfunction is partially suppressed by sildenafil
    Javier Milara
    Research Unit, University General Hospital Consortium, Valencia, Spain
    Eur J Pharm Sci 39:363-72. 2010
    ....
  14. doi request reprint Nickel induces intracellular calcium mobilization and pathophysiological responses in human cultured airway epithelial cells
    Julio Cortijo
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Chem Biol Interact 183:25-33. 2010
    ....
  15. doi request reprint Direct effect of cigarette smoke on human pulmonary artery tension
    Jose Luis Ortiz
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
    Pulm Pharmacol Ther 23:222-8. 2010
    ....
  16. doi request reprint Cilia motility and structure in primary and secondary ciliary dyskinesia
    Miguel Armengot
    Rhinology Unit, General and University Hospital, Medical School, Valencia University, Valencia, Spain
    Am J Rhinol Allergy 24:175-80. 2010
    ..The aim of this work was to correlate nasal ciliary activity with clinical and structural abnormalities in PCD. A secondary aim was to evaluate the usefulness of high-resolution digital high-speed video (DHSV) in the diagnosis of PCD...
  17. doi request reprint Nasal ciliary beat frequency and beat pattern in retinal ciliopathies
    Miguel Armengot
    Rhinology Unit, General and University Hospital, Medical School, Valencia University, Valencia, Spain
    Invest Ophthalmol Vis Sci 53:2076-9. 2012
    ..The purpose of this study was to evaluate the nasal ciliary beat frequency and beat pattern in patients with retinitis pigmentosa (RP) and Usher syndrome type II and compare it with that of healthy control subjects...
  18. ncbi request reprint Tobacco, inflammation, and respiratory tract cancer
    Javier Milara
    Clinical research unit UIC, University General Hospital Consortium, Valencia, Spain
    Curr Pharm Des 18:3901-38. 2012
    ..In this review we focused in current knowledge on the mechanisms implicated in cigarette smoke-induced lung chronic inflammatory processes leading to lung carcinogenesis, as well as in current therapies based on novel molecular advances...
  19. pmc Study of USH1 splicing variants through minigenes and transcript analysis from nasal epithelial cells
    María José Aparisi
    Research Group on Sensorineural Diseases, Instituto de Investigación Sanitaria La Fe, Valencia, Spain
    PLoS ONE 8:e57506. 2013
    ..In addition, we could observe that the nasal ciliated epithelium of USH1 patients shows a lower ciliary beat frequency than control subjects...
  20. doi request reprint Hawthorn extract inhibits human isolated neutrophil functions
    Ernesto Dalli
    Service of Cardiology, Associated University Hospital Arnau de Vilanova, Valencia, Spain
    Pharmacol Res 57:445-50. 2008
    ..In conclusion, C. laevigata extract inhibited various functional outputs of activated human neutrophils which may be relevant to the pathophysiology of cardiac failure...
  21. doi request reprint Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis
    Patricia Almudever
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Thorax 68:938-48. 2013
    ....
  22. doi request reprint Relaxation by beta 3-adrenoceptor agonists of the isolated human internal anal sphincter
    Cristina Ballester
    Department of Surgery, University of Valencia, Valencia, Spain
    Life Sci 86:358-64. 2010
    ..In this study, responses of beta(3)-adrenoceptor agonists were examined on human isolated internal anal sphincter (IAS) in order to explore their relaxant effects on hypertonicity of IAS...
  23. doi request reprint Effects of long-term azithromycin therapy on airway oxidative stress markers in non-cystic fibrosis bronchiectasis
    Afredo De Diego
    Department of Pneumology, University Hospital La Fe, Valencia, Spain
    Respirology 18:1056-62. 2013
    ..To explore the effect of long-term therapy with azithromycin in regards to airway oxidative stress markers in exhaled breath condensate (EBC) of adult patients with stable non-cystic fibrosis (CF) bronchiectasis...