Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteriesJ Milara
Clinic Research Unit, University General Hospital Consortium, Valencia, Spain
Eur Respir J 39:927-38. 2012
..These data may be of potential value to explain therapeutic effects of bosentan in some forms of disproportionate pulmonary hypertension in COPD patients...
- Neutrophil activation in severe, early-onset COPD patients versus healthy non-smoker subjects in vitro: effects of antioxidant therapy
Javier Milara
Research Unit, University General Hospital Consortium, and Department of Medicine, Faculty of Medicine, University of Valencia, Valencia, Spain
Respiration 83:147-58. 2012
..Severe, early-onset COPD is characterized by a rapid decline in the lung function at an early age; however, nothing is known about neutrophil activation in COPD patients...
Aclidinium inhibits human lung fibroblast to myofibroblast transitionJavier Milara
Unidad de Investigacion, Consorcio Hospital General, Universitario, Avenida Tres Vruces s n, Valencia E 46014, Spain
Thorax 67:229-37. 2012
..This study examines the role of aclidinium, a new long-acting muscarinic antagonist, on human fibroblast to myofibroblast transition...
- Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages
J Milara
Research Unit, University General Hospital Consortium, Valencia, Spain
Clin Exp Allergy 41:535-46. 2011
..Oxidative stress is present in airway diseases such as severe asthma or Chronic Obstructive Pulmonary Disease and contributes to the low response to glucocorticoids through the down-regulation of histone deacetylase (HDAC) activity...
- Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition
Javier Milara
Research Foundation, University General Hospital Consortium, Valencia, Spain
Thorax 67:147-56. 2012
..Sphingosine-1-phosphate (S1P) and sphingosine kinase 1 (SPHK1) have been implicated in lung myofibroblast transition, but their role in EMT and their expression in patients with IPF is unknown...
- Role of adenylate kinase type 7 expression on cilia motility: possible link in primary ciliary dyskinesia
Javier Milara
Research Unit, University General Hospital Consortium, Avenida Tres Cruces s n, Valencia, Spain
Am J Rhinol Allergy 24:181-5. 2010
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- Cigarette smoke exposure up-regulates endothelin receptor B in human pulmonary artery endothelial cells: molecular and functional consequences
J Milara
Research Unit, University General Hospital Consortium, Valencia, Spain
Br J Pharmacol 161:1599-615. 2010
..We studied the effect of cigarette smoke extract (CSE) on endothelin receptor B (ET(B) ) expression in human pulmonary artery endothelial cells (HPAECs) and its role in endothelial dysfunction...
- Extracellular calcium-sensing receptor mediates human bronchial epithelial wound repair
Javier Milara
University General Hospital Consortium, Valencia, Spain
Biochem Pharmacol 80:236-46. 2010
..Our data, for the first time, shows that CaSR plays an important role in airway epithelial repair, which may help to develop novel regenerative therapeutics allowing the rapid repair of lung damaged epithelium...
- Cigarette smoke-induced pulmonary endothelial dysfunction is partially suppressed by sildenafil
Javier Milara
Research Unit, University General Hospital Consortium, Valencia, Spain
Eur J Pharm Sci 39:363-72. 2010
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- Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis
Javier Milara
Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
Eur J Pharmacol 609:132-9. 2009
..This study demonstrates for the first time that S1P participates in the alveolar epithelial interactions in vitro...
- Nickel induces intracellular calcium mobilization and pathophysiological responses in human cultured airway epithelial cells
Julio Cortijo
Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain
Chem Biol Interact 183:25-33. 2010
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- Direct effect of cigarette smoke on human pulmonary artery tension
Jose Luis Ortiz
Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
Pulm Pharmacol Ther 23:222-8. 2010
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- Cilia motility and structure in primary and secondary ciliary dyskinesia
Miguel Armengot
Rhinology Unit, General and University Hospital, Medical School, Valencia University, Valencia, Spain
Am J Rhinol Allergy 24:175-80. 2010
..The aim of this work was to correlate nasal ciliary activity with clinical and structural abnormalities in PCD. A secondary aim was to evaluate the usefulness of high-resolution digital high-speed video (DHSV) in the diagnosis of PCD...
- Nasal ciliary beat frequency and beat pattern in retinal ciliopathies
Miguel Armengot
Rhinology Unit, General and University Hospital, Medical School, Valencia University, Valencia, Spain
Invest Ophthalmol Vis Sci 53:2076-9. 2012
..The purpose of this study was to evaluate the nasal ciliary beat frequency and beat pattern in patients with retinitis pigmentosa (RP) and Usher syndrome type II and compare it with that of healthy control subjects...
- Hawthorn extract inhibits human isolated neutrophil functions
Ernesto Dalli
Service of Cardiology, Associated University Hospital Arnau de Vilanova, Valencia, Spain
Pharmacol Res 57:445-50. 2008
..In conclusion, C. laevigata extract inhibited various functional outputs of activated human neutrophils which may be relevant to the pathophysiology of cardiac failure...
Tobacco, inflammation, and respiratory tract cancerJavier Milara
Clinical research unit UIC, University General Hospital Consortium, Valencia, Spain
Curr Pharm Des 18:3901-38. 2012
..In this review we focused in current knowledge on the mechanisms implicated in cigarette smoke-induced lung chronic inflammatory processes leading to lung carcinogenesis, as well as in current therapies based on novel molecular advances...
- Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke
Javier Milara
Clinical research unit UIC, University General Hospital Consortium, Valencia, Spain
Thorax 68:410-20. 2013
..This study examines the EMT process in human bronchial epithelial cells (HBECs) from non-smokers, smokers and patients with COPD as well as the in vitro effect of cigarette smoke extract (CSE) on EMT...
- Study of USH1 splicing variants through minigenes and transcript analysis from nasal epithelial cells
María José Aparisi
Research Group on Sensorineural Diseases, Instituto de Investigación Sanitaria La Fe, Valencia, Spain
PLoS ONE 8:e57506. 2013
..In addition, we could observe that the nasal ciliated epithelium of USH1 patients shows a lower ciliary beat frequency than control subjects...
- Relaxation by beta 3-adrenoceptor agonists of the isolated human internal anal sphincter
Cristina Ballester
Department of Surgery, University of Valencia, Valencia, Spain
Life Sci 86:358-64. 2010
..In this study, responses of beta(3)-adrenoceptor agonists were examined on human isolated internal anal sphincter (IAS) in order to explore their relaxant effects on hypertonicity of IAS...
