Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1-40Jose Javier Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State Street, Box 127, Jackson, MS 39216, USA
Eur J Pharmacol 692:38-45. 2012
..These data suggest that, in rats, memantine can prevent amyloid-triggered expression of apoptosis-related markers and concomitant cognitive deficits...
Vascular and extravascular immunoreactivity for intercellular adhesion molecule 1 in the orbitofrontal cortex of subjects with major depression: age-dependent changesJose Javier Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
J Affect Disord 132:422-31. 2011
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- Glial and glutamatergic markers in depression, alcoholism, and their comorbidity
Jose Javier Miguel-Hidalgo
Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
J Affect Disord 127:230-40. 2010
..Low density of astrocytes in the PFC of "uncomplicated' alcoholics and MDD subjects may parallel altered glutamate transporters and GS in the PFC...
- Glia pathology in the prefrontal cortex in alcohol dependence with and without depressive symptoms
Jose Javier Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, USA
Biol Psychiatry 52:1121-33. 2002
..In alcohol dependence, often comorbid with depression, it is unclear whether there are changes in the density and size of glial cells in the dlPFC...
- Distribution of ICAM-1 immunoreactivity during aging in the human orbitofrontal cortex
Jose Javier Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
Brain Behav Immun 21:100-11. 2007
..This increase may contribute to an enhanced risk for brain inflammatory processes during aging, although a role of extravascular ICAM-1 as a barrier to further inflammation cannot be ruled out...
- Unchanged packing density but altered size of neurofilament immunoreactive neurons in the prefrontal cortex in schizophrenia and major depression
Jose Javier Miguel-Hidalgo
Department of Psychiatry, University of Mississippi Medical Center, 2500 North State Street, P O Box 127, Jackson, MS 39216, USA
Schizophr Res 76:159-71. 2005
..In addition, the enlarged somal size in schizophrenia as compared to controls suggests that NF200 neurons may contribute differentially to unique cognitive disturbances present in schizophrenia and not in MDD subjects...
- Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients
Grazyna Rajkowska
Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
Biol Psychiatry 58:297-306. 2005
..Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that might be related to increased vascular hyperintensities has not been examined...
Layer-specific reductions in GFAP-reactive astroglia in the dorsolateral prefrontal cortex in schizophreniaGrazyna Rajkowska
Laboratory of Quantitative Neuroanatomy, Department of Psychiatry and Human Behavior, Box 127, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA
Schizophr Res 57:127-38. 2002
..Astroglial pathology in dlPFC may reflect disturbances of the neuron-glia interactions in layer V and may be related to the dysfunctional prefronto-striatal circuits, dopaminergic alterations and cognitive pathology in SCHZ...
- Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression
Xiaohong Si
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
Neuropsychopharmacology 29:2088-96. 2004
..These findings indicate that a decrease in levels of GFAP may contribute to the pathophysiology of MDD, particularly in subjects of relatively young age...
- Withdrawal from free-choice ethanol consumption results in increased packing density of glutamine synthetase-immunoreactive astrocytes in the prelimbic cortex of alcohol-preferring rats
Jose Javier Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, 39216, USA
Alcohol Alcohol 41:379-85. 2006
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- Ethanol increases TIEG2-MAO B cell death cascade in the prefrontal cortex of ethanol-preferring rats
Xiao Ming Ou
Division of Neurobiology and Behavioral Research, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
Neurotox Res 19:511-8. 2011
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- Morphological brain changes in depression: can antidepressants reverse them?
Jose Javier Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
CNS Drugs 16:361-72. 2002
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- Lower packing density of glial fibrillary acidic protein-immunoreactive astrocytes in the prelimbic cortex of alcohol-naive and alcohol-drinking alcohol-preferring rats as compared with alcohol-nonpreferring and Wistar rats
Jose Javier Miguel-Hidalgo
Center for Psychiatric Neuroscience, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
Alcohol Clin Exp Res 29:766-72. 2005
..It is still unknown whether attrition in the numbers of astrocytes is only a consequence of prolonged alcohol abuse or also predates the exposure to alcohol in subjects at risk for alcohol dependence...
- GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression
Grazyna Rajkowska
Department of Psychiatry, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
Neuropsychopharmacology 32:471-82. 2007
..These cellular changes are consistent with recent neuroimaging studies revealing a reduction in the cortical levels of GABA in depression...
- The role of glial cells in drug abuse
Jose Javier Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
Curr Drug Abuse Rev 2:72-82. 2009
..The available knowledge on the involvement of glial cells in addictive behaviors suggests that regulation of glutamate transport and neurotrophins may constitute new avenues for the treatment of drug addiction...
- Longitudinal brain corticotropin releasing factor and somatostatin in a transgenic mouse (TG2576) model of Alzheimer's disease
Jennifer Horgan
Department of Pharmacology and Toxicology, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
J Alzheimers Dis 12:115-27. 2007
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