Jose Javier Miguel-Hidalgo

Summary

Publications

  1. ncbi request reprint Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216 4505, USA Electronic address
    J Psychiatr Res 55:101-9. 2014
  2. doi request reprint Apoptosis-related proteins and proliferation markers in the orbitofrontal cortex in major depressive disorder
    Jose J Miguel-Hidalgo
    Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA Electronic address
    J Affect Disord 158:62-70. 2014
  3. pmc Morphometric analysis of vascular pathology in the orbitofrontal cortex of older subjects with major depression
    Jose Javier Miguel-Hidalgo
    Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
    Int J Geriatr Psychiatry 28:959-70. 2013
  4. doi request reprint Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1-40
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State Street, Box 127, Jackson, MS 39216, USA
    Eur J Pharmacol 692:38-45. 2012
  5. pmc Glial and glutamatergic markers in depression, alcoholism, and their comorbidity
    Jose Javier Miguel-Hidalgo
    Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Affect Disord 127:230-40. 2010
  6. pmc Vascular and extravascular immunoreactivity for intercellular adhesion molecule 1 in the orbitofrontal cortex of subjects with major depression: age-dependent changes
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Affect Disord 132:422-31. 2011
  7. pmc Glia pathology in the prefrontal cortex in alcohol dependence with and without depressive symptoms
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Biol Psychiatry 52:1121-33. 2002
  8. pmc Unchanged packing density but altered size of neurofilament immunoreactive neurons in the prefrontal cortex in schizophrenia and major depression
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry, University of Mississippi Medical Center, 2500 North State Street, P O Box 127, Jackson, MS 39216, USA
    Schizophr Res 76:159-71. 2005
  9. pmc Distribution of ICAM-1 immunoreactivity during aging in the human orbitofrontal cortex
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Brain Behav Immun 21:100-11. 2007
  10. pmc Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients
    Grazyna Rajkowska
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Biol Psychiatry 58:297-306. 2005

Research Grants

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216 4505, USA Electronic address
    J Psychiatr Res 55:101-9. 2014
    ....
  2. doi request reprint Apoptosis-related proteins and proliferation markers in the orbitofrontal cortex in major depressive disorder
    Jose J Miguel-Hidalgo
    Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA Electronic address
    J Affect Disord 158:62-70. 2014
    ..It is still unclear whether changes in other relevant markers of cell vulnerability to degeneration and markers of cell proliferation are associated with MDD...
  3. pmc Morphometric analysis of vascular pathology in the orbitofrontal cortex of older subjects with major depression
    Jose Javier Miguel-Hidalgo
    Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
    Int J Geriatr Psychiatry 28:959-70. 2013
    ..Such studies should examine morphological changes in medium and small sized vessels that supply the cortical gray and white matter...
  4. doi request reprint Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1-40
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State Street, Box 127, Jackson, MS 39216, USA
    Eur J Pharmacol 692:38-45. 2012
    ..These data suggest that, in rats, memantine can prevent amyloid-triggered expression of apoptosis-related markers and concomitant cognitive deficits...
  5. pmc Glial and glutamatergic markers in depression, alcoholism, and their comorbidity
    Jose Javier Miguel-Hidalgo
    Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Affect Disord 127:230-40. 2010
    ..Low density of astrocytes in the PFC of "uncomplicated' alcoholics and MDD subjects may parallel altered glutamate transporters and GS in the PFC...
  6. pmc Vascular and extravascular immunoreactivity for intercellular adhesion molecule 1 in the orbitofrontal cortex of subjects with major depression: age-dependent changes
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Affect Disord 132:422-31. 2011
    ....
  7. pmc Glia pathology in the prefrontal cortex in alcohol dependence with and without depressive symptoms
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Biol Psychiatry 52:1121-33. 2002
    ..In alcohol dependence, often comorbid with depression, it is unclear whether there are changes in the density and size of glial cells in the dlPFC...
  8. pmc Unchanged packing density but altered size of neurofilament immunoreactive neurons in the prefrontal cortex in schizophrenia and major depression
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry, University of Mississippi Medical Center, 2500 North State Street, P O Box 127, Jackson, MS 39216, USA
    Schizophr Res 76:159-71. 2005
    ..In addition, the enlarged somal size in schizophrenia as compared to controls suggests that NF200 neurons may contribute differentially to unique cognitive disturbances present in schizophrenia and not in MDD subjects...
  9. pmc Distribution of ICAM-1 immunoreactivity during aging in the human orbitofrontal cortex
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Brain Behav Immun 21:100-11. 2007
    ..This increase may contribute to an enhanced risk for brain inflammatory processes during aging, although a role of extravascular ICAM-1 as a barrier to further inflammation cannot be ruled out...
  10. pmc Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients
    Grazyna Rajkowska
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Biol Psychiatry 58:297-306. 2005
    ..Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that might be related to increased vascular hyperintensities has not been examined...
  11. pmc Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression
    Xiaohong Si
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
    Neuropsychopharmacology 29:2088-96. 2004
    ..These findings indicate that a decrease in levels of GFAP may contribute to the pathophysiology of MDD, particularly in subjects of relatively young age...
  12. ncbi request reprint Layer-specific reductions in GFAP-reactive astroglia in the dorsolateral prefrontal cortex in schizophrenia
    Grazyna Rajkowska
    Laboratory of Quantitative Neuroanatomy, Department of Psychiatry and Human Behavior, Box 127, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA
    Schizophr Res 57:127-38. 2002
    ..Astroglial pathology in dlPFC may reflect disturbances of the neuron-glia interactions in layer V and may be related to the dysfunctional prefronto-striatal circuits, dopaminergic alterations and cognitive pathology in SCHZ...
  13. pmc Withdrawal from free-choice ethanol consumption results in increased packing density of glutamine synthetase-immunoreactive astrocytes in the prelimbic cortex of alcohol-preferring rats
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, 39216, USA
    Alcohol Alcohol 41:379-85. 2006
    ....
  14. pmc Ethanol increases TIEG2-MAO B cell death cascade in the prefrontal cortex of ethanol-preferring rats
    Xiao Ming Ou
    Division of Neurobiology and Behavioral Research, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Neurotox Res 19:511-8. 2011
    ....
  15. pmc Lower packing density of glial fibrillary acidic protein-immunoreactive astrocytes in the prelimbic cortex of alcohol-naive and alcohol-drinking alcohol-preferring rats as compared with alcohol-nonpreferring and Wistar rats
    Jose Javier Miguel-Hidalgo
    Center for Psychiatric Neuroscience, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Alcohol Clin Exp Res 29:766-72. 2005
    ..It is still unknown whether attrition in the numbers of astrocytes is only a consequence of prolonged alcohol abuse or also predates the exposure to alcohol in subjects at risk for alcohol dependence...
  16. ncbi request reprint Morphological brain changes in depression: can antidepressants reverse them?
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    CNS Drugs 16:361-72. 2002
    ....
  17. pmc GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression
    Grazyna Rajkowska
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Neuropsychopharmacology 32:471-82. 2007
    ..These cellular changes are consistent with recent neuroimaging studies revealing a reduction in the cortical levels of GABA in depression...
  18. pmc Longitudinal brain corticotropin releasing factor and somatostatin in a transgenic mouse (TG2576) model of Alzheimer's disease
    Jennifer Horgan
    Department of Pharmacology and Toxicology, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
    J Alzheimers Dis 12:115-27. 2007
    ....
  19. ncbi request reprint The role of glial cells in drug abuse
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Curr Drug Abuse Rev 2:72-82. 2009
    ..The available knowledge on the involvement of glial cells in addictive behaviors suggests that regulation of glutamate transport and neurotrophins may constitute new avenues for the treatment of drug addiction...

Research Grants2

  1. ALTERATIONS OF CORTICAL SYNAPTIC MARKERS IN ALCOHOL DEPENDENCE
    JOSE MIGUEL HIDALGO; Fiscal Year: 2002
    ..Thus, this proposal aims to assess in animal models of alcohol-dependence the ability of therapeutic interventions in preserving normal synaptic function...