Lucio Miele

Summary

Publications

  1. pmc Notch signaling in pediatric soft tissue sarcomas
    Rossella Rota
    Department of Oncohematology, Ospedale Pediatrico Bambino Gesu, IRCCS, Piazza Sant Onofrio 4, Roma, 00165, Italy
    BMC Med 10:141. 2012
  2. pmc Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy
    Jian Wei Gu
    University of Mississippi Cancer Institute, Jackson, MS, USA
    Vasc Cell 4:7. 2012
  3. pmc MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality
    Rossella Rota
    Department of Oncohematology, Ospedale Pediatrico Bambino Gesu, IRCCS, Roma, Italy
    Mol Cancer 10:120. 2011
  4. pmc Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications
    Roberta Ciarapica
    Department of Oncohematology, IRCCS, Ospedale Pediatrico Bambino Gesu, Roma, Italy
    BMC Med 9:63. 2011
  5. pmc Increased plasma levels of soluble vascular endothelial growth factor receptor 1 (sFlt-1) in women by moderate exercise and increased plasma levels of vascular endothelial growth factor in overweight/obese women
    Kristina L Makey
    Cancer Institute, and Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Eur J Cancer Prev 22:83-9. 2013
  6. pmc EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression
    Jian Wei Gu
    Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Vasc Cell 5:9. 2013
  7. ncbi request reprint Notch-associated microRNAs in cancer
    Yin Yuan Mo
    Cancer Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Curr Drug Targets 14:1157-66. 2013
  8. doi request reprint Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells
    Ingrid Espinoza
    Cancer Institute, University of Mississippi Medical Center, Jackson, MS, United States Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, United States
    Cancer Lett 341:41-5. 2013
  9. pmc Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast Cancer
    Chindo Hicks
    Cancer Institute, University of Mississippi Medical Center, Jackson, MS Department of Medicine, University of Mississippi Medical Center, Jackson, MS
    Cancer Inform 12:125-42. 2013
  10. pmc Targeting Notch to target cancer stem cells
    Antonio Pannuti
    University of Mississippi Cancer Institute, Jackson, MS 39216, USA
    Clin Cancer Res 16:3141-52. 2010

Collaborators

  • Jian Wei Gu
  • Todd Golde
  • Hua Tang
  • Kimberly Foreman
  • Xinchun Zhou
  • Yin Yuan Mo
  • Andrew D Smith
  • Chindo Hicks
  • Rossella Rota
  • Antonio Pannuti
  • Ingrid Espinoza
  • Roberta Ciarapica
  • Franco Locatelli
  • He Zhu
  • Kristina L Makey
  • Kandis Backus
  • Jesus Monico
  • Diana Bell
  • Antonio Giordano
  • Alexandra Brown
  • Ranjit Kumar
  • James Robinson
  • Dwight E Waddell
  • Mark Weber
  • Jack Lewin
  • Edmund Chinchar
  • Min Huang
  • Zhi He
  • Tejaswi Koganti
  • Mark Loftin
  • Samantha Redfield
  • Alexandra S Brown
  • Sharla G Patterson
  • Rozana Asfour
  • Paola Rizzo
  • Clodia Osipo
  • Barbara Osborne

Detail Information

Publications19

  1. pmc Notch signaling in pediatric soft tissue sarcomas
    Rossella Rota
    Department of Oncohematology, Ospedale Pediatrico Bambino Gesu, IRCCS, Piazza Sant Onofrio 4, Roma, 00165, Italy
    BMC Med 10:141. 2012
    ..The potential challenges and opportunities of targeting Notch signaling in the treatment of pediatric soft tissue sarcomas are also discussed...
  2. pmc Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy
    Jian Wei Gu
    University of Mississippi Cancer Institute, Jackson, MS, USA
    Vasc Cell 4:7. 2012
    ..Understanding how Notch interacts with other factors that control endothelial cell functions and angiogenesis in cancers could pave the way to innovative therapeutic strategies that simultaneously target angiogenesis and CSC...
  3. pmc MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality
    Rossella Rota
    Department of Oncohematology, Ospedale Pediatrico Bambino Gesu, IRCCS, Roma, Italy
    Mol Cancer 10:120. 2011
    ..Additionally, we examine the potential of microRNAs as prognostic and diagnostic markers in this soft-tissue sarcoma, and discuss possible therapeutic applications and challenges of a "microRNA therapy"...
  4. pmc Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications
    Roberta Ciarapica
    Department of Oncohematology, IRCCS, Ospedale Pediatrico Bambino Gesu, Roma, Italy
    BMC Med 9:63. 2011
    ..Finally, the therapeutic potential of epigenetic therapies modulating EZH2-mediated gene repression is considered...
  5. pmc Increased plasma levels of soluble vascular endothelial growth factor receptor 1 (sFlt-1) in women by moderate exercise and increased plasma levels of vascular endothelial growth factor in overweight/obese women
    Kristina L Makey
    Cancer Institute, and Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Eur J Cancer Prev 22:83-9. 2013
    ....
  6. pmc EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression
    Jian Wei Gu
    Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Vasc Cell 5:9. 2013
    ....
  7. ncbi request reprint Notch-associated microRNAs in cancer
    Yin Yuan Mo
    Cancer Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Curr Drug Targets 14:1157-66. 2013
    ..We also highlight the therapeutic potential of targeting Notch signaling and related microRNAs. ..
  8. doi request reprint Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells
    Ingrid Espinoza
    Cancer Institute, University of Mississippi Medical Center, Jackson, MS, United States Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, United States
    Cancer Lett 341:41-5. 2013
    ..We describe how accumulated evidence suggests that Notch inhibition is an attractive strategy for the treatment of several cancers, at least in part because of its potential to reverse or prevent EMT. ..
  9. pmc Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast Cancer
    Chindo Hicks
    Cancer Institute, University of Mississippi Medical Center, Jackson, MS Department of Medicine, University of Mississippi Medical Center, Jackson, MS
    Cancer Inform 12:125-42. 2013
    ....
  10. pmc Targeting Notch to target cancer stem cells
    Antonio Pannuti
    University of Mississippi Cancer Institute, Jackson, MS 39216, USA
    Clin Cancer Res 16:3141-52. 2010
    ..This article summarizes the most recent developments in the field of Notch-targeted cancer therapeutics, with emphasis on CSC...
  11. pmc Notch inhibitors for cancer treatment
    Ingrid Espinoza
    University of Mississippi, Cancer Institute, Jackson, MS, United States
    Pharmacol Ther 139:95-110. 2013
    ..In this review, we describe the basics of Notch signaling and the role of Notch in normal and cancer stem cells as a logic way to develop different Notch inhibitors and their current stage of progress for cancer patient's treatment. ..
  12. pmc An Integrative Genomics Approach for Associating GWAS Information with Triple-Negative Breast Cancer
    Chindo Hicks
    Cancer Institute, University of Mississippi Medical Center, Jackson, MS Department of Medicine, University of Mississippi Medical Center, Jackson, MS
    Cancer Inform 12:1-20. 2013
    ..The results provide convincing evidence that integrating GWAS information with gene expression data provides a unified and powerful approach for biomarker discovery in TNBC...
  13. pmc An integrative genomics approach to biomarker discovery in breast cancer
    Chindo Hicks
    Cancer Institute, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS, USA
    Cancer Inform 10:185-204. 2011
    ..Integrative analysis combining GWAS information with gene expression data provides functional bridges between GWAS findings and biological pathways involved in breast cancer...
  14. ncbi request reprint Elevated expression of notch1 is associated with metastasis of human malignancies
    He Zhu
    1University of Mississippi Medical Center, Jackson, MS, USA
    Int J Surg Pathol 21:449-54. 2013
    ....
  15. ncbi request reprint A magnifying glass on glioblastoma stem cell signaling pathways
    Diana Bell
    Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA
    Cancer Biol Ther 11:765-8. 2011
  16. pmc Postmenopausal obesity promotes tumor angiogenesis and breast cancer progression in mice
    Jian Wei Gu
    Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA
    Cancer Biol Ther 11:910-7. 2011
    ....
  17. pmc Associating GWAS Information with the Notch Signaling Pathway Using Transcription Profiling
    Chindo Hicks
    Cancer Institute, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Cancer Inform 10:93-108. 2011
    ..Additionally, we identified other SNP-associated biological pathways relevant to breast cancer, including the P53, apoptosis and MAP kinase pathways...