Challenges in array comparative genomic hybridization for the analysis of cancer samplesNorma J Nowak
New York State Center of Excellence in Bioinformatics and Life Sciences and Department of Biochemistry, University at Buffalo, Buffalo, New York 14203, USA
Genet Med 9:585-95. 2007
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Prognostic significance of neuron-associated protein expression in non-muscle-invasive urothelial bladder cancerP Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
J Clin Pathol 62:710-4. 2009
..Numerous novel genes have been identified in urothelial bladder cancer (UBC); genes including ninjurin, synuclein and neuropilin seem to be associated with invasive tumours and aggressive behaviour...
Claudin7 and moesin in endometrial Adenocarcinoma; a retrospective study of 265 patientsPaulette Mhawech-Fauceglia
Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
BMC Res Notes 5:65. 2012
..abstract:..
Prostate-specific membrane antigen expression is a potential prognostic marker in endometrial adenocarcinomaPaulette Mhawech-Fauceglia
Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 17:571-7. 2008
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Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysisPaulette Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
J Clin Pathol 60:709-14. 2007
..Aims and methods: To determine Pax-5 expression in other tumour types, immunohistochemistry was performed on 3758 benign and malignant tumours using multiple tumour microarrays, as well as on whole sections...
Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibodyPaulette Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
J Clin Pathol 60:694-700. 2007
..However, it is also expressed in subsets of lymphoblastic lymphoma, Merkel cell carcinoma (MCC) and desmoplastic small round cell tumour (DSRCT)...
Microarray analysis reveals distinct gene expression profiles among different tumor histology, stage and disease outcomes in endometrial adenocarcinomaPaulette Mhawech-Fauceglia
Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
PLoS ONE 5:e15415. 2010
..early stage endometrioid adenocarcinoma (EAC) and uterine serous carcinoma (USC), as well as between disease outcomes in each of the two histological subtypes...
Prognostic factors in stages II/III/IV and stages III/IV endometrioid and serous adenocarcinoma of the endometriumP Mhawech-Fauceglia
Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
Eur J Surg Oncol 36:1195-201. 2010
..To explore and to compare the outcome of patients diagnosed with stage II/III/IV and stage III/IV endometrioid adenocarcinoma (EAC) with their serous carcinoma (USC) counterparts...
Submission of the entire lymph node dissection for histologic examination in gynecologic-oncologic specimens. Clinical and pathologic relevancePaulette Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
Gynecol Oncol 115:354-6. 2009
..We also evaluated the time required and cost-effectiveness for the laboratory...
Diagnostic utility of FLI-1 monoclonal antibody and dual-colour, break-apart probe fluorescence in situ (FISH) analysis in Ewing's sarcoma/primitive neuroectodermal tumour (EWS/PNET). A comparative study with CD99 and FLI-1 polyclonal antibodiesP Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Histopathology 49:569-75. 2006
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14-3-3sigma expression and prognostic value in patients with epithelial ovarian carcinoma: a high throughput tissue microarray analysisP Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Eur J Surg Oncol 35:763-7. 2009
..In the present study, our aim is to determine the value of 14-3-3sigma in predicting disease outcome in series of patients with epithelial ovarian cancer...
Array-comparative genomic hybridization analysis of primary endometrial and ovarian high-grade neuroendocrine carcinoma associated with adenocarcinoma: mystery resolved?Paulette Mhawech-Fauceglia
Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Int J Gynecol Pathol 27:539-46. 2008
..Because of the limited cases analyzed, a larger study is still needed to confirm our observation...
Prostate-specific membrane antigen (PSMA) protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate adenocarcinoma: an immunohistochemical study using mutiple tumour tissue microarray techniqueP Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Histopathology 50:472-83. 2007
..To determine prostate-specific membrane antigen (PSMA) expression in normal tissues and in 3161 benign and malignant tumours and subsequently to define its sensitivity and specificity in prostatic adenocarcinoma (PaC)...
Synovial sarcoma of the larynx in a 79-year-old woman, confirmed by karyotyping and fluorescence in situ hybridization analysisPaulette Mhawech-Fauceglia
Department of Surgical Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Ann Diagn Pathol 11:223-7. 2007
..Synovial sarcoma is an uncommon tumor of the head and neck and is an exceedingly rare finding in the larynx. Generally, it afflicts younger patients and most often occurs in the hypopharynx...
Predicting outcome in minimally invasive (T1a and T1b) urothelial bladder carcinoma using a panel of biomarkers: a high throughput tissue microarray analysisPaulette Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, NY, USA
BJU Int 100:1182-7. 2007
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Intraobserver and interobserver variability in distinguishing between endocervical and endometrial adenocarcinoma on problematic cases of cervical curettingsPaulette Mhawech-Fauceglia
Departments of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Int J Gynecol Pathol 27:431-6. 2008
..Lastly, even though the combination of morphology, age, and IHC is far from perfect in predicting the correct origin of the tumor, it is still the best available method...
Gene expression profiles in stage I uterine serous carcinoma in comparison to grade 3 and grade 1 stage I endometrioid adenocarcinomaPaulette Mhawech-Fauceglia
Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
PLoS ONE 6:e18066. 2011
..This study applied the whole genome expression profiling to explore the expression difference of stage I USC (n?=?11) relative to stage I EAC-G3 (n?=?11) and stage I EAC-G1 (n?=?11), respectively...
Value of ezrin, maspin and nm23-H1 protein expressions in predicting outcome of patients with head and neck squamous-cell carcinoma treated with radical radiotherapyPaulette Mhawech-Fauceglia
Department of Pathology, Geneva University Hospital, Geneva, Switzerland
J Clin Pathol 60:185-9. 2007
..Prognostic factors in predicting outcomes in patients with head and neck squamous-cell carcinoma (HNSCC) are limited to the clinical-pathological parameters, including lymph node metastasis, location, grade and stage of the disease...
EB-D fibronectin expression in squamous cell carcinoma of the head and neckPaulette Mhawech
Department of Pathology, Geneva University Hospital, CMU Michel Servet 1, Geneva 1211, Switzerland
Oral Oncol 41:82-8. 2005
..Patients having tumors expressing the ED-B FN had a trend to a significant lower overall survival in the multivariate analysis (p=0.06). Our study showed that ED-B FN expression might have a prognostic value in patients with HNSCC...
Immunohistochemical expression of 14-3-3 sigma protein in human urological and gynecological tumors using a multi-tumor microarray analysisPaulette Mhawech
Department of Pathology, Geneva University Hospital, CMU, Michel Servet 1, 1211 Geneva 4, Switzerland
Pathol Int 55:77-82. 2005
..Finally, as with all immunohistochemical markers, we can optimize the utility of this protein to distinguish tumor mimics by including it in an appropriate immunohistochemical panel...
14-3-3 proteins--an updatePaulette Mhawech
Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cell Res 15:228-36. 2005
..Gene silencing of 14-3-3sigma by CpG methylation has been found in many human cancer types. This suggests that therapy-targeting 14-3-3sigma may be beneficial for future cancer treatment...
FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancerP Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
Eur J Surg Oncol 32:231-7. 2006
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Genetic alterations in urothelial bladder carcinoma: an updated reviewPaulette Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer 106:1205-16. 2006
..Finally, murine leukemia viral oncogene homologue 1 (RAF1) and CD9 are involved in the progression from papillary pT1 tumors to pT2 tumors...
Raf1, Aurora-A/STK15 and E-cadherin biomarkers expression in patients with pTa/pT1 urothelial bladder carcinoma; a retrospective TMA study of 246 patients with long-term follow-upP Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
Eur J Surg Oncol 32:439-44. 2006
..The study was designed to evaluate Raf1, Aurora-A/STK15 and E-cadherin (E-CD) protein expression and their prognostic value in patients with pTa/pT1 tumours...
Synuclein-? (SNCG) protein expression is associated with poor outcome in endometrial adenocarcinomaPaulette Mhawech-Fauceglia
Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
Gynecol Oncol 124:148-52. 2012
..In previous study, we found SNCG mRNA to be overexpressed in uterine serous carcinoma compared to uterine endometrioid adenocarcinoma. The aim of this study is to explore the prognostic value of SNCG in patients with endometrial cancer...
Expression and clinical significance of the transforming growth factor-? signalling pathway in endometrial cancerPaulette Mhawech-Fauceglia
Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
Histopathology 59:63-72. 2011
..To evaluate the components of the transforming growth factor (TGF)-?-Smad signalling pathway in human endometrial cancer (EC)...
Downregulation of 14-3-3sigma in ovary, prostate and endometrial carcinomas is associated with CpG island methylationPaulette Mhawech
Department of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland
Mod Pathol 18:340-8. 2005
..Loss of 14-3-3sigma expression due to promoter hypermethylation may represent the most frequent molecular aberration in ovarian, endometrial and prostate adenocarcinomas...
Expression of cell cycle proteins in T1a and T1b urothelial bladder carcinoma and their value in predicting tumor progressionPaulette Mhawech
Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland
Cancer 100:2367-75. 2004
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Human achaete-scute homologue (hASH1) mRNA level as a diagnostic marker to distinguish esthesioneuroblastoma from poorly differentiated tumors arising in the sinonasal tractPaulette Mhawech
Department of Clinical Pathology, Geneva University Hospital, Switzerland
Am J Clin Pathol 122:100-5. 2004
..The hASH1 mRNA level might represent a useful tool for distinguishing esthesioneuroblastoma from poorly differentiated tumors of the sinonasal region...
Ovarian primary primitive neurectodermal tumor coexisting with endometrioid adenocarcinoma: a case reportGabor Fischer
Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Int J Gynecol Pathol 25:151-4. 2006
..She was treated with debulking surgery followed by chemotherapy. The patient was still asymptomatic at the 6-month follow-up...
Association of TSC1/hamartin, 14-3-3sigma, and p27 expression with tumor outcomes in patients with pTa/pT1 urothelial bladder carcinomaPaulette Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Am J Clin Pathol 129:918-23. 2008
..In a subset of pTa/pT1 tumors, hamartin has a role in bladder carcinogenesis by positively regulating 14-3-3sigma and p27...
Motility-related protein 1 (MRP-1/CD9) expression in urothelial bladder carcinoma and its relation to tumor recurrence and progressionPaulette Mhawech
Department of Pathology, Geneva University Hospital, Geneva, Switzerland
Cancer 98:1649-57. 2003
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MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-kappa B-dependent proliferative advantage and resistance against FAS-induced cell death in B cellsLiza Ho
Department of Clinical Pathology, Geneva University Hospital, Centre Medical Universitaire, Geneva, Switzerland
Blood 105:2891-9. 2005
..Our findings support a model in which NF-kappa B signaling, once activated in a CD40-dependent immune response, is maintained and enhanced through deregulation of MALT1 or formation of an API2-MALT1 fusion...
Ovarian carcinomas in endometriosis: an immunohistochemical and comparative genomic hybridization studyPaulette Mhawech
Department of Pathology, Geneva University Hospital, Switzerland
Int J Gynecol Pathol 21:401-6. 2002
..However, our results are limited by the number of cases examined and a definite conclusion on the pathogenesis of this process should be followed by future studies with a larger number of cases...
Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancerYao Tseng Chen
Departments of Pathology and Surgery, Weill Cornell Medical College, New York, NY 10065, USA
Int J Cancer 124:2893-8. 2009
..In summary, the expression frequency and characteristics of CT45 expression are similar to other CT cancer vaccine targets currently in clinical trials, e.g., NY-ESO-1 and MAGE-A, suggesting CT45 as a potentially useful cancer target...
Treatment of early-stage uterine papillary serous carcinoma at Roswell Park Cancer Institute, 1992-2006Nana E Tchabo
Division of Gynecologic Oncology, Department of Surgery, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Gynecol Oncol 115:249-56. 2009
..Optimal management of early-stage uterine papillary serous carcinoma (UPSC) remains controversial. We reviewed our outcomes in this patient population...
Pathologic quiz case. Uterine polypoid mass in a postmenopausal patient following tamoxifen treatment for breast cancerPaulette Mhawech
Department of Pathology, Geneva University Hospital, Switzerland
Arch Pathol Lab Med 126:1125-6. 2002
IMP3 distinguishes uterine serous carcinoma from endometrial endometrioid adenocarcinomaPaulette Mhawech-Fauceglia
Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Am J Clin Pathol 133:899-908. 2010
..IMP3 immunoexpression and the IMP3+/PTEN+ pattern are the best independent and combination markers, respectively, to predict USCs. We strongly recommend using them in difficult and challenging cases...
Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumorsKerry J Rodabaugh
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York, USA
Int J Gynecol Pathol 26:10-5. 2007
..Furthermore, these results suggest that PDEF is a potential marker and target in ovarian cancer...
Role of the tumour necrosis family ligand APRIL in solid tumour development: Retrospective studies in bladder, ovarian and head and neck carcinomasP Mhawech-Fauceglia
Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
Eur J Cancer 44:2097-100. 2008
..This indicates that APRIL is not potent enough to promote the development of solid tumour cells under the pressure of chemotherapy...
Ewing sarcoma/primitive neuroectodermal tumor of the kidney: a case report. Diagnosed by immunohistochemistry and molecular analysisRakhee Saxena
Department of Surgical Pathology and Laboratory Medicine, Buffalo General Hospital, Buffalo, NY 14263, USA
Ann Diagn Pathol 10:363-6. 2006
..Cytogenetic analysis is an important supportive tool to immunohistochemistry in making the final diagnosis...
The recurrence of cervical intraepithelial neoplasia in HIV-positive women: a review of the literaturePierre Marie Tebeu
Department of Obstetrics and Gynaecology, Geneva University Hospitals, Geneva, Switzerland
Int J STD AIDS 17:507-11. 2006
..Despite the fact that the evidence is limited because of the few number of eligible studies, this issue should be considered in the management of HIV-positive patient with CIN...
Expression and serum immunoreactivity of developmentally restricted differentiation antigens in epithelial ovarian cancerNana E Tchabo
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Cancer Immun 9:6. 2009
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Sam-pointed domain containing Ets transcription factor in luminal breast cancer pathogenesisAshwani K Sood
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 18:1899-903. 2009
..Based on these results, we hypothesize that SPDEF has a function in the specification of the progenitor cells of the luminal epithelial lineage that become targets of oncogenesis in luminal breast cancer...
Uterine carcinosarcoma associated with hereditary nonpolyposis colorectal cancerStacey A South
Division of Gynecologic Oncology, Department of Surgical Oncology, Clinical Genetics Service, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Obstet Gynecol 110:543-5. 2007
..Numerous neoplasms are known to be associated with this condition. Sarcomas have also been reported within families with HNPCC. The challenge is determining if these cancers are sporadic or hereditary...
Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancerKunle Odunsi
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Proc Natl Acad Sci U S A 104:12837-42. 2007
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Potential predictive patterns of minimal residual disease detected by immunohistochemistry on bone marrow biopsy specimens during a long-term follow-up in patients treated with cladribine for hairy cell leukemiaPaulette Mhawech-Fauceglia
Department of Pathology, Geneva University Hospital, Geneva, Switzerland
Arch Pathol Lab Med 130:374-7. 2006
..Minimal residual disease (MRD) in patients treated for hairy cell (HC) leukemia as assessed by immunohistochemistry has not been included routinely in evaluation of treatment results...
Characterization of a putative ovarian oncogene, elongation factor 1alpha, isolated by panning a synthetic phage display single-chain variable fragment library with cultured human ovarian cancer cellsSameer Sharma
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Clin Cancer Res 13:5889-96. 2007
..In an effort to identify cell surface targets and single short-chain antibody (scFv) for ovarian cancer therapy, we used a phage display approach to isolate an antibody with high reactivity against ovarian cancer...
Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sproutsYuesheng Zhang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
J Agric Food Chem 54:9370-6. 2006
..In conclusion, broccoli sprout ITC extract is a potent inducer of GST and NQO1 in the bladder and is a promising agent for prevention of bladder cancer...
Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancerFeng Qian
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer Res 69:5498-504. 2009
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Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancerAnna Woloszynska-Read
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Clin Cancer Res 14:3283-90. 2008
..We tested the hypothesis that promoter and global genomic DNA methylation status correlates with intertumor and intratumor NY-ESO-1 expression status in EOC...
Primary vaginal adenocarcinoma arising in vaginal adenosis after CO2 laser vaporization and 5-fluorouracil therapyTamera A Paczos
Department of Pathology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, USA
Int J Gynecol Pathol 29:193-6. 2010
..Herein, we highlight these important findings and shed some light on the pathogenesis of vaginal adenosis and the subsequent development of vaginal adenocarcinoma...
Clinical and pathological predictive factors in women with adult-type granulosa cell tumor of the ovaryJeannine Villella
Department of Gynecologic Oncology Surgery, Roswell Park Cancer Institute, Buffalo, New York 12463, USA
Int J Gynecol Pathol 26:154-9. 2007
..Multi-institutional collaboration is imperative to create a comprehensive national database for investigation into ways that may better indicate prognosis in these patients...
5,6-Dihydrocyclopenta[c][1,2]-dithiole-3(4H)-thione is a promising cancer chemopreventive agent in the urinary bladderJoseph D Paonessa
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Chem Biol Interact 180:119-26. 2009
..In conclusion, CPDT potently and preferentially induces Phase 2 enzymes in the bladder epithelium and Nrf2 is its key mediator...
Primary squamous cell carcinoma of the endometrium: a case reportN E Tchabo
Division of Gynecologic Oncology, Department of Surgery, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Eur J Gynaecol Oncol 29:527-30. 2008
..Primary squamous cell carcinoma of the endometrium (PSCCE) is an extremely rare entity...
The source of APRIL up-regulation in human solid tumor lesionsP Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA
J Leukoc Biol 80:697-704. 2006
..Taken together, our analysis indicates a potential role for HSPG/APRIL interactions in the development of solid tumors...
Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressivenessJuerg Schwaller
Department of Research, University Hospital, Basel, Switzerland
Blood 109:331-8. 2007
..Hence, APRIL produced by inflammatory cells infiltrating lymphoma lesions may increase tumor aggressiveness and affect disease outcome...
OY-TES-1 expression and serum immunoreactivity in epithelial ovarian cancerJonathan Tammela
Department of Gynecologic Oncology, Roswell Park Cancer Institute Buffalo, NY 14263, USA
Int J Oncol 29:903-10. 2006
..These findings make OY-TES-1 an attractive target for antigen-specific immunotherapy in EOC...
No association of NAD(P)H quinone oxidoreductase 1 expression with p53 expression or tumour outcome in patients with superficial and minimally invasive urothelial bladder cancersPaulette Mhawech-Fauceglia
BJU Int 102:639. 2008
Desmoplastic small round cell tumor (DSRCT) with ovarian involvement in 2 young womenXueping Fang
Department of Pathology and Laboratory Medicine at Kaleida Health System, Buffalo General Hospital Radiation Medicine, Buffalo, NY, USA
Appl Immunohistochem Mol Morphol 16:94-9. 2008
..To gain additional insight on DSRCT with ovarian involvement, the literature was reviewed and summarized...