Paulette Mhawech-Fauceglia

Summary

Publications

  1. ncbi request reprint Challenges in array comparative genomic hybridization for the analysis of cancer samples
    Norma J Nowak
    New York State Center of Excellence in Bioinformatics and Life Sciences and Department of Biochemistry, University at Buffalo, Buffalo, New York 14203, USA
    Genet Med 9:585-95. 2007
  2. ncbi request reprint Prognostic significance of neuron-associated protein expression in non-muscle-invasive urothelial bladder cancer
    P Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
    J Clin Pathol 62:710-4. 2009
  3. pmc MET/HGF Signaling Pathway in Ovarian Carcinoma: Clinical Implications and Future Direction
    Paulette Mhawech-Fauceglia
    Department of Pathology, University of Southern California, Room 7A116, 1200 N State Street, Los Angeles, CA 90033 5000, USA
    Patholog Res Int 2012:960327. 2012
  4. doi request reprint ER+ /PR+ /TFF3+ /IMP3- immunoprofile distinguishes endometrioid from serous and clear cell carcinomas of the endometrium: a study of 401 cases
    Paulette Mhawech-Fauceglia
    Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA
    Histopathology 62:976-85. 2013
  5. ncbi request reprint Synuclein-γ (SNCG) protein expression is associated with poor outcome in endometrial adenocarcinoma
    Paulette Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Gynecol Oncol 124:148-52. 2012
  6. pmc Claudin7 and moesin in endometrial Adenocarcinoma; a retrospective study of 265 patients
    Paulette Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    BMC Res Notes 5:65. 2012
  7. ncbi request reprint Synovial sarcoma of the larynx in a 79-year-old woman, confirmed by karyotyping and fluorescence in situ hybridization analysis
    Paulette Mhawech-Fauceglia
    Department of Surgical Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Ann Diagn Pathol 11:223-7. 2007
  8. ncbi request reprint FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer
    P Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
    Eur J Surg Oncol 32:231-7. 2006
  9. pmc Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysis
    Paulette Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Clin Pathol 60:709-14. 2007
  10. pmc Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibody
    Paulette Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Clin Pathol 60:694-700. 2007

Detail Information

Publications85

  1. ncbi request reprint Challenges in array comparative genomic hybridization for the analysis of cancer samples
    Norma J Nowak
    New York State Center of Excellence in Bioinformatics and Life Sciences and Department of Biochemistry, University at Buffalo, Buffalo, New York 14203, USA
    Genet Med 9:585-95. 2007
    ....
  2. ncbi request reprint Prognostic significance of neuron-associated protein expression in non-muscle-invasive urothelial bladder cancer
    P Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
    J Clin Pathol 62:710-4. 2009
    ..Numerous novel genes have been identified in urothelial bladder cancer (UBC); genes including ninjurin, synuclein and neuropilin seem to be associated with invasive tumours and aggressive behaviour...
  3. pmc MET/HGF Signaling Pathway in Ovarian Carcinoma: Clinical Implications and Future Direction
    Paulette Mhawech-Fauceglia
    Department of Pathology, University of Southern California, Room 7A116, 1200 N State Street, Los Angeles, CA 90033 5000, USA
    Patholog Res Int 2012:960327. 2012
    ..In this paper, we will discuss the HGF/MET pathway in ovarian cancer, its clinical significance, and its potential use as a target therapy in the future...
  4. doi request reprint ER+ /PR+ /TFF3+ /IMP3- immunoprofile distinguishes endometrioid from serous and clear cell carcinomas of the endometrium: a study of 401 cases
    Paulette Mhawech-Fauceglia
    Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA
    Histopathology 62:976-85. 2013
    ..Differentiating endometrioid adenocarcinoma (EAC) from uterine serous carcinoma (USC) and clear cell carcinoma (CCC) of the endometrium can be challenging. We undertook an immunohistochemical study to address this issue...
  5. ncbi request reprint Synuclein-γ (SNCG) protein expression is associated with poor outcome in endometrial adenocarcinoma
    Paulette Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Gynecol Oncol 124:148-52. 2012
    ..In previous study, we found SNCG mRNA to be overexpressed in uterine serous carcinoma compared to uterine endometrioid adenocarcinoma. The aim of this study is to explore the prognostic value of SNCG in patients with endometrial cancer...
  6. pmc Claudin7 and moesin in endometrial Adenocarcinoma; a retrospective study of 265 patients
    Paulette Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    BMC Res Notes 5:65. 2012
    ..abstract:..
  7. ncbi request reprint Synovial sarcoma of the larynx in a 79-year-old woman, confirmed by karyotyping and fluorescence in situ hybridization analysis
    Paulette Mhawech-Fauceglia
    Department of Surgical Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Ann Diagn Pathol 11:223-7. 2007
    ..Synovial sarcoma is an uncommon tumor of the head and neck and is an exceedingly rare finding in the larynx. Generally, it afflicts younger patients and most often occurs in the hypopharynx...
  8. ncbi request reprint FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer
    P Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
    Eur J Surg Oncol 32:231-7. 2006
    ....
  9. pmc Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysis
    Paulette Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Clin Pathol 60:709-14. 2007
    ..Aims and methods: To determine Pax-5 expression in other tumour types, immunohistochemistry was performed on 3758 benign and malignant tumours using multiple tumour microarrays, as well as on whole sections...
  10. pmc Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibody
    Paulette Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Clin Pathol 60:694-700. 2007
    ..However, it is also expressed in subsets of lymphoblastic lymphoma, Merkel cell carcinoma (MCC) and desmoplastic small round cell tumour (DSRCT)...
  11. doi request reprint 14-3-3sigma expression and prognostic value in patients with epithelial ovarian carcinoma: a high throughput tissue microarray analysis
    P Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Eur J Surg Oncol 35:763-7. 2009
    ..In the present study, our aim is to determine the value of 14-3-3sigma in predicting disease outcome in series of patients with epithelial ovarian cancer...
  12. ncbi request reprint Expression and clinical significance of the transforming growth factor-β signalling pathway in endometrial cancer
    Paulette Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Histopathology 59:63-72. 2011
    ..To evaluate the components of the transforming growth factor (TGF)-β-Smad signalling pathway in human endometrial cancer (EC)...
  13. doi request reprint Array-comparative genomic hybridization analysis of primary endometrial and ovarian high-grade neuroendocrine carcinoma associated with adenocarcinoma: mystery resolved?
    Paulette Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Int J Gynecol Pathol 27:539-46. 2008
    ..Because of the limited cases analyzed, a larger study is still needed to confirm our observation...
  14. doi request reprint Intraobserver and interobserver variability in distinguishing between endocervical and endometrial adenocarcinoma on problematic cases of cervical curettings
    Paulette Mhawech-Fauceglia
    Departments of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Int J Gynecol Pathol 27:431-6. 2008
    ..Lastly, even though the combination of morphology, age, and IHC is far from perfect in predicting the correct origin of the tumor, it is still the best available method...
  15. ncbi request reprint Diagnostic utility of FLI-1 monoclonal antibody and dual-colour, break-apart probe fluorescence in situ (FISH) analysis in Ewing's sarcoma/primitive neuroectodermal tumour (EWS/PNET). A comparative study with CD99 and FLI-1 polyclonal antibodies
    P Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Histopathology 49:569-75. 2006
    ....
  16. ncbi request reprint Prostate-specific membrane antigen (PSMA) protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate adenocarcinoma: an immunohistochemical study using mutiple tumour tissue microarray technique
    P Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Histopathology 50:472-83. 2007
    ..To determine prostate-specific membrane antigen (PSMA) expression in normal tissues and in 3161 benign and malignant tumours and subsequently to define its sensitivity and specificity in prostatic adenocarcinoma (PaC)...
  17. pmc Value of ezrin, maspin and nm23-H1 protein expressions in predicting outcome of patients with head and neck squamous-cell carcinoma treated with radical radiotherapy
    Paulette Mhawech-Fauceglia
    Department of Pathology, Geneva University Hospital, Geneva, Switzerland
    J Clin Pathol 60:185-9. 2007
    ..Prognostic factors in predicting outcomes in patients with head and neck squamous-cell carcinoma (HNSCC) are limited to the clinical-pathological parameters, including lymph node metastasis, location, grade and stage of the disease...
  18. pmc Gene expression profiles in stage I uterine serous carcinoma in comparison to grade 3 and grade 1 stage I endometrioid adenocarcinoma
    Paulette Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 6:e18066. 2011
    ..This study applied the whole genome expression profiling to explore the expression difference of stage I USC (n = 11) relative to stage I EAC-G3 (n = 11) and stage I EAC-G1 (n = 11), respectively...
  19. doi request reprint Prognostic factors in stages II/III/IV and stages III/IV endometrioid and serous adenocarcinoma of the endometrium
    P Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Eur J Surg Oncol 36:1195-201. 2010
    ..To explore and to compare the outcome of patients diagnosed with stage II/III/IV and stage III/IV endometrioid adenocarcinoma (EAC) with their serous carcinoma (USC) counterparts...
  20. doi request reprint Submission of the entire lymph node dissection for histologic examination in gynecologic-oncologic specimens. Clinical and pathologic relevance
    Paulette Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
    Gynecol Oncol 115:354-6. 2009
    ..We also evaluated the time required and cost-effectiveness for the laboratory...
  21. pmc Microarray analysis reveals distinct gene expression profiles among different tumor histology, stage and disease outcomes in endometrial adenocarcinoma
    Paulette Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 5:e15415. 2010
    ..early stage endometrioid adenocarcinoma (EAC) and uterine serous carcinoma (USC), as well as between disease outcomes in each of the two histological subtypes...
  22. ncbi request reprint Downregulation of 14-3-3sigma in ovary, prostate and endometrial carcinomas is associated with CpG island methylation
    Paulette Mhawech
    Department of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland
    Mod Pathol 18:340-8. 2005
    ..Loss of 14-3-3sigma expression due to promoter hypermethylation may represent the most frequent molecular aberration in ovarian, endometrial and prostate adenocarcinomas...
  23. ncbi request reprint EB-D fibronectin expression in squamous cell carcinoma of the head and neck
    Paulette Mhawech
    Department of Pathology, Geneva University Hospital, CMU Michel Servet 1, Geneva 1211, Switzerland
    Oral Oncol 41:82-8. 2005
    ..Patients having tumors expressing the ED-B FN had a trend to a significant lower overall survival in the multivariate analysis (p=0.06). Our study showed that ED-B FN expression might have a prognostic value in patients with HNSCC...
  24. ncbi request reprint Predicting outcome in minimally invasive (T1a and T1b) urothelial bladder carcinoma using a panel of biomarkers: a high throughput tissue microarray analysis
    Paulette Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, NY, USA
    BJU Int 100:1182-7. 2007
    ....
  25. ncbi request reprint Immunohistochemical expression of 14-3-3 sigma protein in human urological and gynecological tumors using a multi-tumor microarray analysis
    Paulette Mhawech
    Department of Pathology, Geneva University Hospital, CMU, Michel Servet 1, 1211 Geneva 4, Switzerland
    Pathol Int 55:77-82. 2005
    ..Finally, as with all immunohistochemical markers, we can optimize the utility of this protein to distinguish tumor mimics by including it in an appropriate immunohistochemical panel...
  26. ncbi request reprint 14-3-3 proteins--an update
    Paulette Mhawech
    Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cell Res 15:228-36. 2005
    ..Gene silencing of 14-3-3sigma by CpG methylation has been found in many human cancer types. This suggests that therapy-targeting 14-3-3sigma may be beneficial for future cancer treatment...
  27. ncbi request reprint Genetic alterations in urothelial bladder carcinoma: an updated review
    Paulette Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer 106:1205-16. 2006
    ..Finally, murine leukemia viral oncogene homologue 1 (RAF1) and CD9 are involved in the progression from papillary pT1 tumors to pT2 tumors...
  28. ncbi request reprint Raf1, Aurora-A/STK15 and E-cadherin biomarkers expression in patients with pTa/pT1 urothelial bladder carcinoma; a retrospective TMA study of 246 patients with long-term follow-up
    P Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
    Eur J Surg Oncol 32:439-44. 2006
    ..The study was designed to evaluate Raf1, Aurora-A/STK15 and E-cadherin (E-CD) protein expression and their prognostic value in patients with pTa/pT1 tumours...
  29. doi request reprint Prostate-specific membrane antigen expression is a potential prognostic marker in endometrial adenocarcinoma
    Paulette Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 17:571-7. 2008
    ....
  30. doi request reprint Association of TSC1/hamartin, 14-3-3sigma, and p27 expression with tumor outcomes in patients with pTa/pT1 urothelial bladder carcinoma
    Paulette Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Am J Clin Pathol 129:918-23. 2008
    ..In a subset of pTa/pT1 tumors, hamartin has a role in bladder carcinogenesis by positively regulating 14-3-3sigma and p27...
  31. doi request reprint Trefoil factor family 3 (TFF3) expression and its interaction with estrogen receptor (ER) in endometrial adenocarcinoma
    Paulette Mhawech-Fauceglia
    Department of Pathology at University of Southern California, Los Angeles, CA, USA
    Gynecol Oncol 130:174-80. 2013
    ..The aims of this study are to determine the expression and the prognostic value of TFF3 in a large series of human endometrial cancer and its relation with ER...
  32. ncbi request reprint Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors
    Kerry J Rodabaugh
    Department of Gynecologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York, USA
    Int J Gynecol Pathol 26:10-5. 2007
    ..Furthermore, these results suggest that PDEF is a potential marker and target in ovarian cancer...
  33. doi request reprint Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer
    Yao Tseng Chen
    Departments of Pathology and Surgery, Weill Cornell Medical College, New York, NY 10065, USA
    Int J Cancer 124:2893-8. 2009
    ..In summary, the expression frequency and characteristics of CT45 expression are similar to other CT cancer vaccine targets currently in clinical trials, e.g., NY-ESO-1 and MAGE-A, suggesting CT45 as a potentially useful cancer target...
  34. doi request reprint IMP3 distinguishes uterine serous carcinoma from endometrial endometrioid adenocarcinoma
    Paulette Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Am J Clin Pathol 133:899-908. 2010
    ..IMP3 immunoexpression and the IMP3+/PTEN+ pattern are the best independent and combination markers, respectively, to predict USCs. We strongly recommend using them in difficult and challenging cases...
  35. ncbi request reprint Treatment of early-stage uterine papillary serous carcinoma at Roswell Park Cancer Institute, 1992-2006
    Nana E Tchabo
    Division of Gynecologic Oncology, Department of Surgery, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Gynecol Oncol 115:249-56. 2009
    ..Optimal management of early-stage uterine papillary serous carcinoma (UPSC) remains controversial. We reviewed our outcomes in this patient population...
  36. pmc Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
    Junko Matsuzaki
    Departments of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 107:7875-80. 2010
    ....
  37. doi request reprint Array-based comparative genomic hybridization (aCGH) analysis is a useful tool for distinguishing primary pulmonary from metastatic neuroendocrine carcinoma to the lung
    Paulette Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Appl Immunohistochem Mol Morphol 16:291-5. 2008
    ..In conclusion, aCGH is a powerful tool that is capable of revealing tumor gene fingerprinting and it can be used in routine surgical pathology especially in those cases where the other conventional techniques are not helpful...
  38. ncbi request reprint Expression of cell cycle proteins in T1a and T1b urothelial bladder carcinoma and their value in predicting tumor progression
    Paulette Mhawech
    Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland
    Cancer 100:2367-75. 2004
    ....
  39. pmc Elevated expression of the serine-arginine protein kinase 1 gene in ovarian cancer and its role in Cisplatin cytotoxicity in vitro
    Kunle Odunsi
    Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA
    PLoS ONE 7:e51030. 2012
    ..Together, these results suggest that elevated SRPK1 expression may play a role in ovarian tumorigenesis and SRPK1 may be a potential target for ovarian cancer therapy...
  40. ncbi request reprint Expression of poly (adenosine diphosphate-ribose) polymerase and p53 in epithelial ovarian cancer and their role in prognosis and disease outcome
    Heidi Godoy
    Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Int J Gynecol Pathol 30:139-44. 2011
    ..Additional studies are warranted to evaluate the role of PARP and PARP inhibitors in the setting of adjuvant chemotherapy...
  41. pmc Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients
    Kunle Odunsi
    Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 109:5797-802. 2012
    ....
  42. ncbi request reprint Developmentally restricted differentiation antigens are targets for immunotherapy in epithelial ovarian carcinoma
    Heidi Godoy
    Roswell Park Cancer Institute, Buffalo, New York
    Int J Gynecol Pathol 32:536-40. 2013
    ..The tissue-restricted expression of tastin and bystin and their abundant expression in EOCs and advanced-stage disease make these developmentally restricted antigens attractive targets for antigen-specific immunotherapy in EOCs. ..
  43. pmc Intraepithelial T cells and tumor-associated macrophages in ovarian cancer patients
    Paulette Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Immun 13:1. 2013
    ..Thus, therapeutic strategies to modulate tumor T(reg) infiltration could be beneficial for patients with familial ovarian cancer...
  44. ncbi request reprint Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer
    Feng Qian
    Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 69:5498-504. 2009
    ....
  45. ncbi request reprint Clinical and pathological predictive factors in women with adult-type granulosa cell tumor of the ovary
    Jeannine Villella
    Department of Gynecologic Oncology Surgery, Roswell Park Cancer Institute, Buffalo, New York 12463, USA
    Int J Gynecol Pathol 26:154-9. 2007
    ..Multi-institutional collaboration is imperative to create a comprehensive national database for investigation into ways that may better indicate prognosis in these patients...
  46. ncbi request reprint Characterization of a putative ovarian oncogene, elongation factor 1alpha, isolated by panning a synthetic phage display single-chain variable fragment library with cultured human ovarian cancer cells
    Sameer Sharma
    Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 13:5889-96. 2007
    ..In an effort to identify cell surface targets and single short-chain antibody (scFv) for ovarian cancer therapy, we used a phage display approach to isolate an antibody with high reactivity against ovarian cancer...
  47. pmc Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer
    Kunle Odunsi
    Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 104:12837-42. 2007
    ....
  48. pmc Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage
    Anna Woloszynska-Read
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, SUNY Buffalo, Buffalo, New York 14263, USA
    Clin Cancer Res 17:2170-80. 2011
    ..In addition, the potential mechanisms leading to DNA hypomethylation, and its clinicopathologic significance in EOC, have not been determined...
  49. ncbi request reprint Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer
    Kunle Odunsi
    Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, 14263 Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, 14263 Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY, 14263
    Cancer Immunol Res 2:37-49. 2014
    ..Based on these encouraging results, evaluation of similar combinatorial chemo-immunotherapy regimens in EOC and other tumor types is warranted. ..
  50. pmc Expression and serum immunoreactivity of developmentally restricted differentiation antigens in epithelial ovarian cancer
    Nana E Tchabo
    Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Immun 9:6. 2009
    ....
  51. doi request reprint A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro
    Janet Myungjin Lee
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Lab Invest 93:528-42. 2013
    ..These findings could also impact in vitro modeling approaches and drug development strategies for other solid tumor types...
  52. ncbi request reprint Pair Box 8 (PAX8) protein expression in high grade, late stage (stages III and IV) ovarian serous carcinoma
    Paulette Mhawech-Fauceglia
    Department of Pathology, University of Southern California, Los Angeles, CA 90033 5000, USA
    Gynecol Oncol 127:198-201. 2012
    ..The prognostic value of PAX8 in OSC is still widely unknown. The aim of this study was to evaluate PAX8 as a prognostic biomarker in patients with advanced stage OSC...
  53. pmc The role of hypoxic-inducible factor (HIF1α) and aldolaseC protein in endometrial carcinogenesis: a retrospective study of 279 patients
    Paulette Mhawech-Fauceglia
    Department of Pathology, University of Southern California, Los Angeles, California, USA
    BMJ Open 2:. 2012
    ....
  54. pmc Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancer
    Anna Woloszynska-Read
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Cancer Res 14:3283-90. 2008
    ..We tested the hypothesis that promoter and global genomic DNA methylation status correlates with intertumor and intratumor NY-ESO-1 expression status in EOC...
  55. ncbi request reprint Human achaete-scute homologue (hASH1) mRNA level as a diagnostic marker to distinguish esthesioneuroblastoma from poorly differentiated tumors arising in the sinonasal tract
    Paulette Mhawech
    Department of Clinical Pathology, Geneva University Hospital, Switzerland
    Am J Clin Pathol 122:100-5. 2004
    ..The hASH1 mRNA level might represent a useful tool for distinguishing esthesioneuroblastoma from poorly differentiated tumors of the sinonasal region...
  56. ncbi request reprint Ovarian primary primitive neurectodermal tumor coexisting with endometrioid adenocarcinoma: a case report
    Gabor Fischer
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Int J Gynecol Pathol 25:151-4. 2006
    ..She was treated with debulking surgery followed by chemotherapy. The patient was still asymptomatic at the 6-month follow-up...
  57. pmc Ovarian cancer spheroid cells with stem cell-like properties contribute to tumor generation, metastasis and chemotherapy resistance through hypoxia-resistant metabolism
    Jianqun Liao
    Departments of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, United States of America Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 9:e84941. 2014
    ..This study provides insight into the relationship between tumor dissemination and metabolic attributes of human cancer stem cells and has clinical implications for cancer therapy. ..
  58. pmc Histologic parameters predictive of disease outcome in women with advanced stage ovarian carcinoma treated with neoadjuvant chemotherapy
    Damanzoopinder Samrao
    Department of Pathology, University of Southern California, Los Angeles, CA
    Transl Oncol 5:469-74. 2012
    ..059 and P = 0.0234, respectively). We suggest that the assessment of fibrosis and necrosis should be implemented in pathologic evaluation and prospectively validated in future studies...
  59. ncbi request reprint Desmoplastic small round cell tumor (DSRCT) with ovarian involvement in 2 young women
    Xueping Fang
    Department of Pathology and Laboratory Medicine at Kaleida Health System, Buffalo General Hospital Radiation Medicine, Buffalo, NY, USA
    Appl Immunohistochem Mol Morphol 16:94-9. 2008
    ..To gain additional insight on DSRCT with ovarian involvement, the literature was reviewed and summarized...
  60. ncbi request reprint Motility-related protein 1 (MRP-1/CD9) expression in urothelial bladder carcinoma and its relation to tumor recurrence and progression
    Paulette Mhawech
    Department of Pathology, Geneva University Hospital, Geneva, Switzerland
    Cancer 98:1649-57. 2003
    ....
  61. ncbi request reprint MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-kappa B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells
    Liza Ho
    Department of Clinical Pathology, Geneva University Hospital, Centre Medical Universitaire, Geneva, Switzerland
    Blood 105:2891-9. 2005
    ..Our findings support a model in which NF-kappa B signaling, once activated in a CD40-dependent immune response, is maintained and enhanced through deregulation of MALT1 or formation of an API2-MALT1 fusion...
  62. doi request reprint Malignant mixed müllerian tumor of primary peritoneal origin
    Margaux Kanis
    School of Medicine, University at Buffalo, Buffalo, NY 14214, USA
    Ann Diagn Pathol 15:273-7. 2011
    ..The peritoneum and ovaries, with their common embryologic origin, likely account for the peritoneum's ability to undergo a similar malignant transformation, with the resultant genesis of an MMMT of peritoneal origin...
  63. doi request reprint Female adnexal tumor of probable Wolffian origin (FATWO) with recurrence 3 years postsurgery
    Susanna Syriac
    Department of Surgical Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Gynecol Pathol 30:231-5. 2011
    ..However, collective data are needed from multiple centers to determine its effectiveness in these patients...
  64. ncbi request reprint OY-TES-1 expression and serum immunoreactivity in epithelial ovarian cancer
    Jonathan Tammela
    Department of Gynecologic Oncology, Roswell Park Cancer Institute Buffalo, NY 14263, USA
    Int J Oncol 29:903-10. 2006
    ..These findings make OY-TES-1 an attractive target for antigen-specific immunotherapy in EOC...
  65. ncbi request reprint Ovarian carcinomas in endometriosis: an immunohistochemical and comparative genomic hybridization study
    Paulette Mhawech
    Department of Pathology, Geneva University Hospital, Switzerland
    Int J Gynecol Pathol 21:401-6. 2002
    ..However, our results are limited by the number of cases examined and a definite conclusion on the pathogenesis of this process should be followed by future studies with a larger number of cases...
  66. doi request reprint The use of bevacizumab in refractory ovarian granulosa-cell carcinoma with symptomatic relief of ascites: a case report
    Joshua P Kesterson
    Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Gynecol Oncol 111:527-9. 2008
    ..The potential role of bevacizumab in the treatment of ovarian granulosa-cell tumors has not been evaluated...
  67. ncbi request reprint Ewing sarcoma/primitive neuroectodermal tumor of the kidney: a case report. Diagnosed by immunohistochemistry and molecular analysis
    Rakhee Saxena
    Department of Surgical Pathology and Laboratory Medicine, Buffalo General Hospital, Buffalo, NY 14263, USA
    Ann Diagn Pathol 10:363-6. 2006
    ..It has a rapid clinical progression with early metastasis and death. Few cases with documented t(11;22) have been reported in the literature...
  68. pmc AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers
    Michael J Gray
    Women s Cancer Program, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Int J Cancer 133:21-30. 2013
    ..Targeted therapies that reduce GRP78 expression or activity in cancers may serve to increase the effectiveness of current therapies for EC patients...
  69. ncbi request reprint Clinically aggressive primary solid pseudopapillary tumor of the ovary in a 45-year-old woman
    Susanna Syriac
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Ann Diagn Pathol 16:498-503. 2012
    ..Despite chemotherapy, the patient's condition had worsened, and she died of her disease 8 months after the initial diagnosis. We discuss the differential diagnosis of this tumor and the hypothesis of its origin...
  70. ncbi request reprint Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Agric Food Chem 54:9370-6. 2006
    ..In conclusion, broccoli sprout ITC extract is a potent inducer of GST and NQO1 in the bladder and is a promising agent for prevention of bladder cancer...
  71. doi request reprint Ovarian yolk sac tumor associated with major fibrosarcoma component in a 13-year-old girl
    Liaqat Ali
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Gynecol Pathol 29:252-5. 2010
    ..Owing to the rarity of this entity, the prognosis of this patient is widely unknown and it is yet still to be seen...
  72. doi request reprint Primary vaginal adenocarcinoma arising in vaginal adenosis after CO2 laser vaporization and 5-fluorouracil therapy
    Tamera A Paczos
    Department of Pathology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, USA
    Int J Gynecol Pathol 29:193-6. 2010
    ..Herein, we highlight these important findings and shed some light on the pathogenesis of vaginal adenosis and the subsequent development of vaginal adenocarcinoma...
  73. ncbi request reprint Potential predictive patterns of minimal residual disease detected by immunohistochemistry on bone marrow biopsy specimens during a long-term follow-up in patients treated with cladribine for hairy cell leukemia
    Paulette Mhawech-Fauceglia
    Department of Pathology, Geneva University Hospital, Geneva, Switzerland
    Arch Pathol Lab Med 130:374-7. 2006
    ..Minimal residual disease (MRD) in patients treated for hairy cell (HC) leukemia as assessed by immunohistochemistry has not been included routinely in evaluation of treatment results...
  74. doi request reprint Sam-pointed domain containing Ets transcription factor in luminal breast cancer pathogenesis
    Ashwani K Sood
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 18:1899-903. 2009
    ..Based on these results, we hypothesize that SPDEF has a function in the specification of the progenitor cells of the luminal epithelial lineage that become targets of oncogenesis in luminal breast cancer...
  75. ncbi request reprint Uterine carcinosarcoma associated with hereditary nonpolyposis colorectal cancer
    Stacey A South
    Division of Gynecologic Oncology, Department of Surgical Oncology, Clinical Genetics Service, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Obstet Gynecol 110:543-5. 2007
    ..Numerous neoplasms are known to be associated with this condition. Sarcomas have also been reported within families with HNPCC. The challenge is determining if these cancers are sporadic or hereditary...
  76. ncbi request reprint Pathologic quiz case. Uterine polypoid mass in a postmenopausal patient following tamoxifen treatment for breast cancer
    Paulette Mhawech
    Department of Pathology, Geneva University Hospital, Switzerland
    Arch Pathol Lab Med 126:1125-6. 2002
  77. doi request reprint Role of the tumour necrosis family ligand APRIL in solid tumour development: Retrospective studies in bladder, ovarian and head and neck carcinomas
    P Mhawech-Fauceglia
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Eur J Cancer 44:2097-100. 2008
    ..This indicates that APRIL is not potent enough to promote the development of solid tumour cells under the pressure of chemotherapy...
  78. doi request reprint Epithelioid sarcoma of the vulva in a 17-year-old pregnant woman
    Har Rai
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 12463, USA
    Appl Immunohistochem Mol Morphol 17:270-3. 2009
    ....
  79. pmc 5,6-Dihydrocyclopenta[c][1,2]-dithiole-3(4H)-thione is a promising cancer chemopreventive agent in the urinary bladder
    Joseph D Paonessa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Chem Biol Interact 180:119-26. 2009
    ..In conclusion, CPDT potently and preferentially induces Phase 2 enzymes in the bladder epithelium and Nrf2 is its key mediator...
  80. doi request reprint Pathogenesis of mediastinal paravertebral müllerian cysts of Hattori: developmental endosalpingiosis-müllerianosis
    Ronald E Batt
    Department of Gynecology Obstetrics, University at Buffalo, State University of New York, Buffalo, NY 14222, USA
    Int J Gynecol Pathol 29:546-51. 2010
    ..We explain the pathogenesis and thoracic location of posterior mediastinal endosalpingiotic cysts by Ludwig's theory of pathogenesis for the Mayer-Rokitansky-Küster-Hauser syndrome...
  81. ncbi request reprint The recurrence of cervical intraepithelial neoplasia in HIV-positive women: a review of the literature
    Pierre Marie Tebeu
    Department of Obstetrics and Gynaecology, Geneva University Hospitals, Geneva, Switzerland
    Int J STD AIDS 17:507-11. 2006
    ..Despite the fact that the evidence is limited because of the few number of eligible studies, this issue should be considered in the management of HIV-positive patient with CIN...
  82. ncbi request reprint The source of APRIL up-regulation in human solid tumor lesions
    P Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA
    J Leukoc Biol 80:697-704. 2006
    ..Taken together, our analysis indicates a potential role for HSPG/APRIL interactions in the development of solid tumors...
  83. ncbi request reprint Primary squamous cell carcinoma of the endometrium: a case report
    N E Tchabo
    Division of Gynecologic Oncology, Department of Surgery, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Eur J Gynaecol Oncol 29:527-30. 2008
    ..Primary squamous cell carcinoma of the endometrium (PSCCE) is an extremely rare entity...
  84. ncbi request reprint Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness
    Juerg Schwaller
    Department of Research, University Hospital, Basel, Switzerland
    Blood 109:331-8. 2007
    ..Hence, APRIL produced by inflammatory cells infiltrating lymphoma lesions may increase tumor aggressiveness and affect disease outcome...
  85. doi request reprint No association of NAD(P)H quinone oxidoreductase 1 expression with p53 expression or tumour outcome in patients with superficial and minimally invasive urothelial bladder cancers
    Paulette Mhawech-Fauceglia
    BJU Int 102:639. 2008