Challenges to pediatric HIV care and treatment in South AfricaTammy Meyers
Harriet Shezi Children s Clinic, Chris Hani Baragwanath Hospital, Johannesburg, South Africa
J Infect Dis 196:S474-81. 2007
..This article delineates the challenges to pediatric HIV care in South Africa and provides some practical recommendations to improve it...
Changes in pediatric HIV-related hospital admissions and mortality in Soweto, South Africa, 1996-2011: light at the end of the tunnel?Tammy Meyers
Department of Paediatrics, Harriet Shezi Clinic, Chris Hani Baragwanath Hospital, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
J Acquir Immune Defic Syndr 60:503-10. 2012
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- Antiretroviral therapy responses among children attending a large public clinic in Soweto, South Africa
Tammy M Meyers
Department of Paediatrics, Harriet Shezi Children s Clinic, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Pediatr Infect Dis J 30:974-9. 2011
..The aim of this study was to determine treatment responses of children in a routine setting where first-line therapy with lopinavir/ritonavir is routinely included for young children...
- Reuse of nevirapine in exposed HIV-infected children after protease inhibitor-based viral suppression: a randomized controlled trial
Ashraf Coovadia
Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa
JAMA 304:1082-90. 2010
..However, there are limitations of continuing PI-based therapy indefinitely and reuse of nevirapine has many advantages...
- HIV-1 drug resistance at antiretroviral treatment initiation in children previously exposed to single-dose nevirapine
Gillian M Hunt
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
AIDS 25:1461-9. 2011
..To describe the prevalence of HIV-1 drug resistance mutations at the time of treatment initiation in a large cohort of HIV-infected children previously exposed to single-dose nevirapine (sdNVP) for prevention of transmission...
- Lipid profiles in young HIV-infected children initiating and changing antiretroviral therapy
Renate Strehlau
Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa
J Acquir Immune Defic Syndr 60:369-76. 2012
..Here we examined lipid profile changes in a cohort of young children before and after suppression on an initial ritonavir-boosted lopinavir (LPV/r)-based regimen and after switch to a nevirapine (NVP)-based regimen...
- Persistent minority K103N mutations among women exposed to single-dose nevirapine and virologic response to nonnucleoside reverse-transcriptase inhibitor-based therapy
Ashraf Coovadia
Empilweni Clinic, Coronation Women and Children Hospital, Johannesburg, South Africa
Clin Infect Dis 48:462-72. 2009
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- 4E10-resistant variants in a human immunodeficiency virus type 1 subtype C-infected individual with an anti-membrane-proximal external region-neutralizing antibody response
Elin S Gray
National Institute for Communicable Diseases, Johannesburg, Private Bag X4, Sandringham 2131, Johannesburg, South Africa
J Virol 82:2367-75. 2008
..Collectively, these genetic changes in the face of a neutralizing antibody response to the MPER strongly suggested immune escape from antibody responses targeting this region...
Surgeons are failing to recognize children with HIV infectionDouglas M Bowley
Division of Paediatric Surgery, University of the Witwatersrand, Johannesburg 2000, South Africa
J Pediatr Surg 42:431-4. 2007
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- Insensitivity of paediatric HIV-1 subtype C viruses to broadly neutralising monoclonal antibodies raised against subtype B
Elin Solomonovna Gray
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
PLoS Med 3:e255. 2006
..It is therefore recommended that 2G12 and 2F5 MAbs not be used for passive immunization experiments in southern Africa and other regions where HIV-1 subtype C viruses predominate...
- Effect of baseline immune suppression on growth recovery in HIV positive South African children receiving antiretroviral treatment
Lydia Feinstein
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Acquir Immune Defic Syndr 61:235-42. 2012
..Growth failure is common among children infected with HIV. The degree of growth recovery and its determinants in children initiating combination antiretroviral therapy (cART) are not well understood...
- Neurodevelopmental delay among HIV-infected preschool children receiving antiretroviral therapy and healthy preschool children in Soweto, South Africa
Sarah Lowick
WITS Reproductive Health and HIV Institute, Faculty of Health Sciences, University of Witwatersrand, Johannesburg
Psychol Health Med 17:599-610. 2012
..Early initiation of ART in HIV-infected infants may improve cognitive functioning among this group; however, intervention strategies which optimize early cognitive development for all children in the area need to be urgently considered...
- Genotypic and phenotypic characterization of viral isolates from HIV-1 subtype C-infected children with slow and rapid disease progression
Isaac Choge
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
AIDS Res Hum Retroviruses 22:458-65. 2006
..Similar to adults, CXCR4 usage was uncommon among HIV-1 subtype C isolates from pediatric infections...
- Polymorphisms in Nef associated with different clinical outcomes in HIV type 1 subtype C-infected children
Polly R Walker
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
AIDS Res Hum Retroviruses 23:204-15. 2007
..These data broadly reflect previous studies on subtype B, corroborate the decreased cytopathicity of SP viruses, but also highlight potential subtype differences that require further investigation...
- Barriers to disclosure to children with HIV
Fiona G Kouyoumdjian
Dalhousie University Medical School, Halifax, Nova Scotia, Canada
J Trop Pediatr 51:285-7. 2005
..Health care and social service providers could facilitate disclosure of illness to children with HIV...
