Moises Selman

Summary

Country: Mexico

Publications

  1. ncbi Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy
    M Selman
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, CP 14080, Mexico DF, Mexico
    Ann Intern Med 134:136-51. 2001
  2. pmc Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias and Facultad de Ciencias, UNAM, Mexico DF, Mexico
    Respir Res 3:3. 2002
  3. doi MICA polymorphisms and decreased expression of the MICA receptor NKG2D contribute to idiopathic pulmonary fibrosis susceptibility
    Arnoldo Aquino-Galvez
    Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Mexico DF, Mexico
    Hum Genet 125:639-48. 2009
  4. doi Absence of Thy-1 results in TGF-β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts
    Gustavo Ramirez
    Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Lab Invest 91:1206-18. 2011
  5. doi Inflammatory response and dynamics of lung T cell subsets in Th1, Th2 biased and Th2 deficient mice during the development of hypersensitivity pneumonitis
    Luis Jimenez-Alvarez
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico DF, Mexico
    Exp Mol Pathol 88:407-15. 2010
  6. ncbi PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis
    Angel Camarena
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan 4502, Seccion XVI, CP 14080, Mexico City, DF, Mexico
    Respir Med 104:889-94. 2010
  7. doi MMP-1 polymorphisms and the risk of idiopathic pulmonary fibrosis
    Marco Checa
    Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Apartado Postal 21 630, Coyoacan, Mexico DF, CP 04000, Mexico
    Hum Genet 124:465-72. 2008
  8. ncbi Cigarette smoke exposure potentiates bleomycin-induced lung fibrosis in guinea pigs
    José Cisneros-Lira
    Facultad de Ciencias, UNAM, Apartado Postal 21 630, Coyoacán México DF, 04000, Mexico
    Am J Physiol Lung Cell Mol Physiol 285:L949-56. 2003
  9. pmc Accelerated variant of idiopathic pulmonary fibrosis: clinical behavior and gene expression pattern
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    PLoS ONE 2:e482. 2007
  10. ncbi FGF-1 reverts epithelial-mesenchymal transition induced by TGF-{beta}1 through MAPK/ERK kinase pathway
    Carlos Ramos
    Instituto Nacional de Enfermedades Respiratorias, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Am J Physiol Lung Cell Mol Physiol 299:L222-31. 2010

Collaborators

Detail Information

Publications49

  1. ncbi Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy
    M Selman
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, CP 14080, Mexico DF, Mexico
    Ann Intern Med 134:136-51. 2001
    ..Progress in understanding the fibrogenic mechanisms in the lung is likely to yield more effective therapies...
  2. pmc Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias and Facultad de Ciencias, UNAM, Mexico DF, Mexico
    Respir Res 3:3. 2002
    ..An evolving hypothesis proposes that IPF may result from epithelial micro-injuries and abnormal wound healing...
  3. doi MICA polymorphisms and decreased expression of the MICA receptor NKG2D contribute to idiopathic pulmonary fibrosis susceptibility
    Arnoldo Aquino-Galvez
    Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Mexico DF, Mexico
    Hum Genet 125:639-48. 2009
    ..These findings indicate that MICA polymorphisms and abnormal expression of the MICA receptor NKG2D might contribute to IPF susceptibility...
  4. doi Absence of Thy-1 results in TGF-β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts
    Gustavo Ramirez
    Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Lab Invest 91:1206-18. 2011
    ..These findings indicate that loss of Thy-1 in human lung fibroblasts induces a fibrogenic phenotype...
  5. doi Inflammatory response and dynamics of lung T cell subsets in Th1, Th2 biased and Th2 deficient mice during the development of hypersensitivity pneumonitis
    Luis Jimenez-Alvarez
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico DF, Mexico
    Exp Mol Pathol 88:407-15. 2010
    ..These results confirm a predominant role of the Th1 response in HP and suggest that the control of inflammation by Th2 biased mice may be related with the increase of NKT DN cells and regulatory NK and gammadelta T cells...
  6. ncbi PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis
    Angel Camarena
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan 4502, Seccion XVI, CP 14080, Mexico City, DF, Mexico
    Respir Med 104:889-94. 2010
    ..However, PSMB9-RH/PSMB8 KQ haplotype was significantly increased in HP patients (OR = 6.77, CI = 1.34-65.31, p < 0.02). These findings suggest that PSMB8 KQ genotype could increase the risk to develop hypersensitivity pneumonitis...
  7. doi MMP-1 polymorphisms and the risk of idiopathic pulmonary fibrosis
    Marco Checa
    Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Apartado Postal 21 630, Coyoacan, Mexico DF, CP 04000, Mexico
    Hum Genet 124:465-72. 2008
    ..3; CI 1.15-4.97). These findings indicate that polymorphisms of the MMP-1 promoter may confer increased risk for IPF and reveal a putative gene-environment interaction between the -755 MMP-1 polymorphism and smoking in this disease...
  8. ncbi Cigarette smoke exposure potentiates bleomycin-induced lung fibrosis in guinea pigs
    José Cisneros-Lira
    Facultad de Ciencias, UNAM, Apartado Postal 21 630, Coyoacán México DF, 04000, Mexico
    Am J Physiol Lung Cell Mol Physiol 285:L949-56. 2003
    ....
  9. pmc Accelerated variant of idiopathic pulmonary fibrosis: clinical behavior and gene expression pattern
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    PLoS ONE 2:e482. 2007
    ..However, a subset of patients has a short duration of symptoms with rapid progression to end-stage disease. In this study, we evaluated clinical and molecular features of "rapid" and "slow" progressors with IPF...
  10. ncbi FGF-1 reverts epithelial-mesenchymal transition induced by TGF-{beta}1 through MAPK/ERK kinase pathway
    Carlos Ramos
    Instituto Nacional de Enfermedades Respiratorias, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Am J Physiol Lung Cell Mol Physiol 299:L222-31. 2010
    ..These findings indicate that TGF-beta1-induced EMT is reversed by FGF-1 and suggest therapeutic approaches to target this process in IPF...
  11. doi Expression of matrix metalloproteases by fibrocytes: possible role in migration and homing
    Carolina García-de-Alba
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico DF, Mexico
    Am J Respir Crit Care Med 182:1144-52. 2010
    ..However, the mechanisms involved in their migration, subsequent homing, and local role remain unclear. Matrix metalloproteinases (MMPs) facilitate cell migration and have been implicated in the pathogenesis of pulmonary fibrosis...
  12. ncbi Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice
    Annie Pardo
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col Seccion XVI, Mexico DF, CP 14080, Mexico
    Am J Respir Crit Care Med 167:925-32. 2003
    ..These findings suggest that increased neutrophils and matrix metalloproteinase-9 during the early inflammatory response and adequate thiol reserves are key elements in the fibrotic response after bleomycin-induced pulmonary injury...
  13. ncbi Functional diversity of T-cell subpopulations in subacute and chronic hypersensitivity pneumonitis
    Lourdes Barrera
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, CP 14080, Mexico DF, Mexico
    Am J Respir Crit Care Med 177:44-55. 2008
    ..Hypersensitivity pneumonitis (HP) exhibits a diverse outcome. Patients with acute/subacute HP usually improve, whereas patients with chronic disease often progress to fibrosis. However, the mechanisms underlying this difference are unknown...
  14. ncbi Matrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in Guinea pigs
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan, Mexico
    Chest 123:1633-41. 2003
    ..To evaluate the effect of CP-471,474 (Pfizer Global Research and Development; Groton, CT), a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) in an experimental model of emphysema...
  15. ncbi Up-regulation of L-selectin and E-selectin in hypersensitivity pneumonitis
    Carmen Navarro
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Mexico DF, Mexico
    Chest 121:354-60. 2002
    ..Hypersensitivity pneumonitis (HP) is a lymphocytic alveolitis, and we hypothesized that the overexpression of selectins could play a role in this process...
  16. doi Transporter associated with antigen processing (TAP) 1 gene polymorphisms in patients with hypersensitivity pneumonitis
    Arnoldo Aquino-Galvez
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col Seccion XVI, 14080, Mexico City, Mexico
    Exp Mol Pathol 84:173-7. 2008
    ..002, OR=0.07, CI=0.0-0.57). These findings suggest that TAP1 gene polymorphisms are related to HP risk, and highlight the importance of the MHC in the development of this disease...
  17. pmc Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs?
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    PLoS Med 5:e62. 2008
  18. ncbi Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502 CP 14080, Mexico DF, Mexico
    Proc Am Thorac Soc 3:364-72. 2006
    ..In this article, some characteristics of the alveolar epithelium are briefly outlined, and the fibrogenic mechanisms specifically operated by active abnormal epithelial cells are examined...
  19. doi Morphologic diversity of chronic pigeon breeder's disease: clinical features and survival
    Miguel Gaxiola
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan 4502 CP 14080, Mexico DF, Mexico
    Respir Med 105:608-14. 2011
    ..07). These findings demonstrate that a variety of histopathologic and imaging patterns are seen in PBD, and the presence of a UIP-like pattern confers the worst prognosis...
  20. ncbi The epithelial/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan, Mexico
    Am J Respir Cell Mol Biol 29:S93-7. 2003
  21. doi Familial pulmonary fibrosis is the strongest risk factor for idiopathic pulmonary fibrosis
    Cecilia García-Sancho
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan 4502, 14080 Mexico DF, Mexico
    Respir Med 105:1902-7. 2011
    ..These findings indicate that family history of pulmonary fibrosis is a strong risk factor for IPF. Also, we confirmed that occupational exposures, gastroesophageal reflux and former smoking increase the risk for this disease...
  22. ncbi Acidic fibroblast growth factor decreases alpha-smooth muscle actin expression and induces apoptosis in human normal lung fibroblasts
    Carlos Ramos
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, CP 14080, Mexico DF, Mexico
    Am J Physiol Lung Cell Mol Physiol 291:L871-9. 2006
    ..FGF-1 alone exhibited similar but lower effects. These findings suggest that FGF-1 can have an antifibrogenic role, inducing apoptosis of fibroblasts and inhibiting myofibroblast differentiation...
  23. ncbi Local and circulating microchimerism is associated with hypersensitivity pneumonitis
    Martha L Bustos
    Instituto Nacional de Enfermedades Respiratorias, Mexico, DF, Mexico
    Am J Respir Crit Care Med 176:90-5. 2007
    ..Microchimerism has been implicated in the pathogenesis of autoimmune diseases, especially in those showing increased incidence after childbearing age...
  24. ncbi Major histocompatibility complex and alveolar epithelial apoptosis in idiopathic pulmonary fibrosis
    Ramcés Falfán-Valencia
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, CP 14080, Mexico DF, Mexico
    Hum Genet 118:235-44. 2005
    ..01). These findings suggest that some MHC polymorphisms confer susceptibility to IPF, which might be related with the induction of epithelial cell apoptosis, a critical process in the development of the disease...
  25. doi Gene expression profiles reveal molecular mechanisms involved in the progression and resolution of bleomycin-induced lung fibrosis
    Sandra Cabrera
    Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Am J Physiol Lung Cell Mol Physiol 304:L593-601. 2013
    ..Our findings corroborate the reversibility of bleomycin-induced lung fibrosis and reveal transcriptional signatures that characterize the progression and resolution...
  26. ncbi Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro and expressed in fibroblastic foci in vivo in idiopathic pulmonary fibrosis
    Jorge García-Alvarez
    Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Exp Lung Res 32:201-14. 2006
    ..Our findings suggest that TGF-beta1-induced TIMP3 may be an important mediator in lung fibrogenesis...
  27. doi Genetic susceptibility to multicase hypersensitivity pneumonitis is associated with the TNF-238 GG genotype of the promoter region and HLA-DRB1*04 bearing HLA haplotypes
    Ramcés Falfán-Valencia
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan 4502, Tlalpan, 14080 Mexico City, Mexico
    Respir Med 108:211-7. 2014
    ..01, OR = 6.93). These findings indicate that genes located within the MHC region confer susceptibility to familial HP in Mexicans. ..
  28. ncbi Immunopathology, diagnosis, and management of hypersensitivity pneumonitis
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico DF, Mexico
    Semin Respir Crit Care Med 33:543-54. 2012
    ..In this review we summarize the current evidence regarding the diagnostic criteria and therapeutic strategies as well as the immunopathological mechanisms putatively implicated in the development of the disease...
  29. doi Role of Sonic Hedgehog in idiopathic pulmonary fibrosis
    Alfredo Lozano Bolaños
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico
    Am J Physiol Lung Cell Mol Physiol 303:L978-90. 2012
    ..These findings indicate that the SHH pathway is activated in IPF lungs and that SHH may contribute to IPF pathogenesis by increasing the proliferation, migration, extracellular matrix production, and survival of fibroblasts...
  30. doi Hypermethylation-mediated silencing of p14(ARF) in fibroblasts from idiopathic pulmonary fibrosis
    Jose Cisneros
    Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Mexico
    Am J Physiol Lung Cell Mol Physiol 303:L295-303. 2012
    ..05). These findings demonstrate that many IPF fibroblasts have reduced expression of the proapoptotic p14(ARF) attributable to promoter hypermethylation and indicate that epigenetic mechanisms may underlie their resistance to apoptosis...
  31. doi Idiopathic pulmonary fibrosis and emphysema: decreased survival associated with severe pulmonary arterial hypertension
    Mayra Mejia
    Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    Chest 136:10-5. 2009
    ..In this article we compare clinical features, smoking history, pulmonary function, estimated systolic pulmonary artery pressure (eSPAP), and mortality in IPF with emphysema vs IPF without emphysematous changes...
  32. doi Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans
    Guoying Yu
    Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Am J Respir Crit Care Med 186:752-62. 2012
    ..Based on the temporal heterogeneity of IPF, we hypothesized that hyperplastic alveolar epithelial cells regulate the fibrotic response...
  33. ncbi Idiopathic pulmonary fibrosis: misunderstandings between epithelial cells and fibroblasts?
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, CP 14080, Mexico DF, Mexico
    Sarcoidosis Vasc Diffuse Lung Dis 21:165-72. 2004
    ..This aberrant repair process annihilates the lung architecture leading to the honeycomb remodeling...
  34. doi Hypersensitivity pneumonitis: insights in diagnosis and pathobiology
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, CP 14080 México DF, Mexico
    Am J Respir Crit Care Med 186:314-24. 2012
    ..Corticosteroids are generally used, although their long-term efficacy has not been proved in prospective clinical trials. Lung transplantation should be recommended in cases of progressive end-stage illness...
  35. doi Inflammatory profiles in severe pneumonia associated with the pandemic influenza A/H1N1 virus isolated in Mexico City
    Joaquin Zuniga
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico DF, Mexico
    Autoimmunity 44:562-70. 2011
    ..These findings suggest that it is possible to identify biomarkers of severe pneumonia and also suggest the therapeutic use of immunomodulatory drugs in patients with severe pneumonia associated with A/H1N1 infection...
  36. doi Hypersensitivity pneumonitis caused by fungi
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan 4502, CP 14080, Mexico DF, Mexico
    Proc Am Thorac Soc 7:229-36. 2010
    ....
  37. doi Risk factors for idiopathic pulmonary fibrosis in a Mexican population. A case-control study
    Ma Cecilia García-Sancho Figueroa
    Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico DF, Mexico
    Respir Med 104:305-9. 2010
    ..Our results provide additional evidence of a putative relationship between DM2 and idiopathic pulmonary fibrosis. Experimental research is necessary for thorough assessment of the pathogenic mechanisms involved in this association...
  38. ncbi Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Mexico DF, Mexico
    Drugs 64:405-30. 2004
    ..Stem cell progenitors of the alveolar epithelial cells and genetic and epigenetic therapies are attractive future approaches for this and other fibrotic lung disorders...
  39. doi Aging and interstitial lung diseases: unraveling an old forgotten player in the pathogenesis of lung fibrosis
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan, Mexico DF, Mexico
    Semin Respir Crit Care Med 31:607-17. 2010
    ..Here, we review the emerging concepts highlighting the putative aging-associated abnormalities involved in some human ILDs...
  40. ncbi MMP-1: the elder of the family
    Annie Pardo
    Facultad de Ciencias, Universidad Nacional Autónoma de México and Instituto Nacional de Enfermedades Respiratorias, Apartado Postal 21 630, Coyoacan, Mexico, DF, CP 04000, Mexico
    Int J Biochem Cell Biol 37:283-8. 2005
    ..Likewise, it seems to be implicated in a variety of human diseases including cancer, rheumatoid arthritis, pulmonary emphysema and fibrotic disorders, suggesting that its inhibition or stimulation may open therapeutic avenues...
  41. doi Emerging drugs for idiopathic pulmonary fibrosis
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, CP 14080, Mexico DF, Mexico
    Expert Opin Emerg Drugs 16:341-62. 2011
    ..Actually, regardless of extensive research, no current therapy has been shown to either reverse or stop the progression of this disease...
  42. ncbi Matrix metalloproteases in aberrant fibrotic tissue remodeling
    Annie Pardo
    Universidad Nacional Autonoma de Mexico, Facultad de Ciencias, Ciudad Universitaria, CP 04510, Mexico DF, Mexico
    Proc Am Thorac Soc 3:383-8. 2006
    ..Consequently, MMPs may play a central role in several interrelated processes observed in fibrosis such as ECM remodeling, basement-membrane breakdown, epithelial-cell apoptosis, cell migration, and angiogenesis...
  43. ncbi Detection of human papillomavirus and relevant tumor suppressors and oncoproteins in laryngeal tumors
    María E Manjarrez
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan, Mexico
    Clin Cancer Res 12:6946-51. 2006
    ..In this study, we evaluated the levels of two suppressor proteins (pRb and p53) and two oncogenic proteins (c-Myc and Bcl-2), as well as the apoptotic levels and the presence of human papillomavirus (HPV) in both tumor types...
  44. ncbi Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Mexico DF, Mexico
    Hum Genet 113:542-50. 2003
    ..These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis...
  45. ncbi Unbalanced collagenases/TIMP-1 expression and epithelial apoptosis in experimental lung fibrosis
    Victor Ruiz
    Instituto Nacional de Enfermedades Respiratorias, Mexico City, DF, CP 14080, Mexico
    Am J Physiol Lung Cell Mol Physiol 285:L1026-36. 2003
    ..Resistant animals behave as controls. These findings suggest that an imbalance between collagenases and TIMPs, excessive gelatinolytic activity, and epithelial apoptosis participate in the fibrotic response in this experimental model...
  46. ncbi Hypersensitivity pneumonitis: a multifaceted deceiving disorder
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, CP 14080, Mexico DF, Mexico
    Clin Chest Med 25:531-47, vi. 2004
    ..New anti-inflammatory, immunoregulatory, and antifibrotic drugs are urgently needed for this and other interstitial lung diseases...
  47. ncbi Preoperative risk factors associated with mortality in lung biopsy patients with interstitial lung disease
    G Carrillo
    Instituto Nacional de Enfermedades Respiratorias, Mexico DF
    J Invest Surg 18:39-45. 2005
    ..005). These data suggest that PaCO2/PaO2 ratio appears to be a predictor of mortality in this subset of patients. Its prospective use has reduced early mortality after surgery less than 1% in the last decade...
  48. ncbi Lack of local neurogenic involvement in the hyperreactivity induced by epithelium removal in guinea pig trachea
    L M Montano
    Depto de Fisiología y Farmacología, Facultad de Medicina Veterinaria y Zootecnia, UNAM, Mexico, DF
    Res Exp Med (Berl) 190:43-8. 1990
    ..Tetrodotoxin, tetracaine or hexamethonium did not modify the enhanced sensitivity of denuded tracheas to histamine, suggesting that, at least under these experimental conditions, local axon or ganglionic reflexes are not involved...
  49. ncbi Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression
    C Ramos
    Instituto Nacional de Enfermedades Respiratorias, Mexico DF, Mexico
    Am J Respir Cell Mol Biol 24:591-8. 2001
    ..These results suggest that fibroblasts from IPF exhibit a profibrotic secretory phenotype, with lower growth rate and increased spontaneous apoptosis...