Research Topics
| Xochitl Perez-MartinezSummaryCountry: Mexico Publications
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Publications
Protein synthesis and assembly in mitochondrial disordersXochitl Perez-Martinez
Departamento de Bioquimica, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico
Curr Top Med Chem 8:1335-50. 2008..In the present review we will discuss the most recent advances in the understanding of the mechanisms and factors that govern mammalian mitochondrial translation/protein insertion, as well as known pathologies associated with them...
The carboxyl-terminal end of Cox1 is required for feedback assembly regulation of Cox1 synthesis in Saccharomyces cerevisiae mitochondriaMiguel Shingú-Vázquez
Departamento de Genetica Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico DF 04510, Mexico
J Biol Chem 285:34382-9. 2010..Our data suggest a novel activity of Pet54 required for normal synthesis of Cox1 that is independent of the Cox1 C-terminal end...
Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces cerevisiae mitochondriaXochitl Perez-Martinez
Departamento de Bioquimica, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico D F 04510, Mexico
Mol Biol Cell 20:4371-80. 2009..Regulation of COX1 mRNA translation by Mss51 seems to be an example of a homeostatic mechanism in which a positive effector of gene expression interacts with the product it regulates in a posttranslational assembly process...
Structure of nuclear-localized cox3 genes in Chlamydomonas reinhardtii and in its colorless close relative Polytomella spXochitl Perez-Martinez
Departamento de Genetica Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 243, 04510, D F, Mexico
Curr Genet 40:399-404. 2002..reinhardtii after the cox3 gene was transferred to the nucleus. The data also support the evolutionary hypothesis of a recent acquisition of introns in C. reinhardtii...
The cytosol-synthesized subunit II (Cox2) precursor with the point mutation W56R is correctly processed in yeast mitochondria to rescue cytochrome oxidaseValentín Cruz-Torres
Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico D F, Mexico
Biochim Biophys Acta 1817:2128-39. 2012..Still, the allotopically-expressed Cox2(W56R) restores CcO activity and allows mitochondrial Cox1 synthesis to advance at WT levels...
Genetic correction of mitochondrial diseases: using the natural migration of mitochondrial genes to the nucleus in chlorophyte algae as a model systemDiego González-Halphen
Departamento de Genetica Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, 04510 Mexico D F, Mexico
Ann N Y Acad Sci 1019:232-9. 2004..Information derived from these studies should be applicable toward the development of genetic therapies for human diseases resulting from mutations in mtDNA-encoded polypeptides...
The pentatricopeptide repeats present in Pet309 are necessary for translation but not for stability of the mitochondrial COX1 mRNA in yeastFaviola Tavares-Carreón
Departamento de Bioquimica, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Circuito exterior s n, Ciudad Universitaria, Apartado Postal 70 243, Mexico City 04510, Mexico
J Biol Chem 283:1472-9. 2008..Our results show that the RNA metabolism function of Pet309 is found in at least two separate domains of the protein...
In Saccharomyces cerevisiae, the phosphate carrier is a component of the mitochondrial unselective channelManuel Gutiérrez-Aguilar
Depto de Bioquimica, Instituto de Fisiologia Celular, UNAM, Mexico City, Mexico
Arch Biochem Biophys 494:184-91. 2010..1 kDa PEG evidenced a higher sensitivity in mitochondria from the mutant strain. The above data suggest that the phosphate carrier is the phosphate sensor in YMUC and contributes to the structure of this channel...
