Fernando Pena

Summary

Country: Mexico

Publications

  1. ncbi Differential contribution of pacemaker properties to the generation of respiratory rhythms during normoxia and hypoxia
    Fernando Pena
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    Neuron 43:105-17. 2004
  2. ncbi Substance P-mediated modulation of pacemaker properties in the mammalian respiratory network
    Fernando Pena
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 24:7549-56. 2004
  3. ncbi Stabilization of bursting in respiratory pacemaker neurons
    Andrew K Tryba
    The University of Chicago, Department of Organismal Biology and Anatomy, Chicago, Illinois 60637, USA
    J Neurosci 23:3538-46. 2003
  4. ncbi Endogenous activation of serotonin-2A receptors is required for respiratory rhythm generation in vitro
    Fernando Pena
    Committee on Computational Neurobiology, Committee on Neurobiology, and Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 22:11055-64. 2002
  5. ncbi Pacemaker neurons and neuronal networks: an integrative view
    Jan Marino Ramirez
    Department of Organismal Biology and Anatomy, Committees on Neurobiology, Computational Neuroscience and Molecular Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Curr Opin Neurobiol 14:665-74. 2004
  6. doi Neuronal network properties underlying the generation of gasping
    Fernando Pena
    Department of Pharmacobiology, CINVESTAV Instituto Politecnico Nacional, Mexico City, Mexico
    Clin Exp Pharmacol Physiol 36:1218-28. 2009
  7. doi Beta-amyloid protein (25-35) disrupts hippocampal network activity: role of Fyn-kinase
    Fernando Pena
    Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados Sede Sur, Mexico, D F, Mexico
    Hippocampus 20:78-96. 2010
  8. ncbi Non-selective cation channel blockers: potential use in nervous system basic research and therapeutics
    Fernando Pena
    Departamento de Farmacobiologia, CINVESTAV Sede Sur, Calz de los Tenorios 235, Col Granjas Coapa, 14330, Mexico, D F, Mexico
    Mini Rev Med Chem 8:812-9. 2008
  9. doi Gasping generation in developing Swiss-Webster mice in vitro and in vivo
    Fernando Pena
    Departamento de Farmacobiologia, CINVESTAV Sede Sur, Calz de los Tenorios 235, Col Granjas Coapa, 14330, Mexico, DF, Mexico
    Neurochem Res 33:1492-500. 2008
  10. ncbi Contribution of pacemaker neurons to respiratory rhythms generation in vitro
    Fernando Pena
    Departamento de Farmacobiologia, CINVESTAV, Sede Sur
    Adv Exp Med Biol 605:114-8. 2008

Detail Information

Publications17

  1. ncbi Differential contribution of pacemaker properties to the generation of respiratory rhythms during normoxia and hypoxia
    Fernando Pena
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    Neuron 43:105-17. 2004
    ..We propose that respiratory rhythm generation in normoxia depends on a heterogeneous population of pacemaker neurons, while during hypoxia the respiratory rhythm is driven by only one type of pacemaker...
  2. ncbi Substance P-mediated modulation of pacemaker properties in the mammalian respiratory network
    Fernando Pena
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 24:7549-56. 2004
    ..This finding may have clinical implications for Rett syndrome in which SP levels along with other neuromodulators are decreased in the brainstem...
  3. ncbi Stabilization of bursting in respiratory pacemaker neurons
    Andrew K Tryba
    The University of Chicago, Department of Organismal Biology and Anatomy, Chicago, Illinois 60637, USA
    J Neurosci 23:3538-46. 2003
    ..001; n = 14). We conclude that respiratory pacemaker neurons possess membrane properties that stabilize their bursting against changes in [K+]o and imposed changes in V(m)...
  4. ncbi Endogenous activation of serotonin-2A receptors is required for respiratory rhythm generation in vitro
    Fernando Pena
    Committee on Computational Neurobiology, Committee on Neurobiology, and Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 22:11055-64. 2002
    ..We conclude that endogenously activated 5-HT(2A) receptors are required for maintaining fictive respiratory activity in the brainstem slice by modulating sodium conductances via a PKC pathway...
  5. ncbi Pacemaker neurons and neuronal networks: an integrative view
    Jan Marino Ramirez
    Department of Organismal Biology and Anatomy, Committees on Neurobiology, Computational Neuroscience and Molecular Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Curr Opin Neurobiol 14:665-74. 2004
    ....
  6. doi Neuronal network properties underlying the generation of gasping
    Fernando Pena
    Department of Pharmacobiology, CINVESTAV Instituto Politecnico Nacional, Mexico City, Mexico
    Clin Exp Pharmacol Physiol 36:1218-28. 2009
    ..Finally, I review changes in the hypoxic response during postnatal development and the contribution of several neuromodulators to such a response...
  7. doi Beta-amyloid protein (25-35) disrupts hippocampal network activity: role of Fyn-kinase
    Fernando Pena
    Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados Sede Sur, Mexico, D F, Mexico
    Hippocampus 20:78-96. 2010
    ..We propose that such alteration might be related to the cognitive impairment observed, at least, during the early phases of Alzheimer's disease...
  8. ncbi Non-selective cation channel blockers: potential use in nervous system basic research and therapeutics
    Fernando Pena
    Departamento de Farmacobiologia, CINVESTAV Sede Sur, Calz de los Tenorios 235, Col Granjas Coapa, 14330, Mexico, D F, Mexico
    Mini Rev Med Chem 8:812-9. 2008
    ..This review focuses on the pharmacological properties of such drugs and their potential use for the understanding of the nervous system as well as for the treatment of neurological diseases...
  9. doi Gasping generation in developing Swiss-Webster mice in vitro and in vivo
    Fernando Pena
    Departamento de Farmacobiologia, CINVESTAV Sede Sur, Calz de los Tenorios 235, Col Granjas Coapa, 14330, Mexico, DF, Mexico
    Neurochem Res 33:1492-500. 2008
    ..We conclude that the inability of mice to gasp during late postnatal development might be determined by a progressive uncoupling between the respiratory rhythm generator and its motor outputs in hypoxia...
  10. ncbi Contribution of pacemaker neurons to respiratory rhythms generation in vitro
    Fernando Pena
    Departamento de Farmacobiologia, CINVESTAV, Sede Sur
    Adv Exp Med Biol 605:114-8. 2008
    ..Thus, at least two types of pacemaker bursting mechanisms are present in the PBC and underlie fictive eupnea, whereas only one burst mechanism seems to be critical for gasping generation in vitro...
  11. ncbi Effects of riluzole and flufenamic acid on eupnea and gasping of neonatal mice in vivo
    Fernando Pena
    Departamento de Farmacobiologia, CINVESTAV Sede Sur, Calz de los Tenorios 235, Col Granjas Coapa, 14330 Mexico, D F, Mexico
    Neurosci Lett 415:288-93. 2007
    ....
  12. ncbi Breathing generation and potential pharmacotherapeutic approaches to central respiratory disorders
    Fernando Pena
    Departamento de Farmacobiologia, CINVESTAV Sede Sur, Mexico, D F Mexico
    Curr Med Chem 13:2681-93. 2006
    ..Possible effects of these drugs on the central respiratory network are discussed and putative therapeutic targets for the development of future pharmacological therapies suggested...
  13. ncbi Epileptiform activity induced by pharmacologic reduction of M-current in the developing hippocampus in vitro
    Fernando Pena
    Departamento de Farmacobiologia, Cinvestav Coapa, Mexico City, Mexico
    Epilepsia 47:47-54. 2006
    ..In an attempt to develop an in vitro model of this disease, we tested whether blocking M-current with linopirdine induces epileptiform activity in brain slices from animals of different ages...
  14. ncbi Hypoxia-induced changes in neuronal network properties
    Fernando Pena
    Departamento de Farmacobiologia, Cinvestav Coapa, Mexico
    Mol Neurobiol 32:251-83. 2005
    ....
  15. doi PACAP modulates the respiratory rhythm generated in the brainstem slice preparation
    Fernando Pena
    Departamento de Farmacobiologia, CINVESTAV IPN, Mexico, DF, Mexico
    Adv Exp Med Biol 669:119-22. 2010
    ..In conclusion, PACAP is a neuromodulator of the PreBötC suggesting that alterations in such neuromodulation might be involved in the sudden infant death-like phenotype...
  16. ncbi Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice
    Jean Charles Viemari
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 25:11521-30. 2005
    ..We hypothesize that breathing disturbances in Mecp2-/y mice, and probably Rett patients, originate in part from a deficiency in noradrenergic and serotonergic modulation of the medullary respiratory network...
  17. ncbi Synchrony levels during evoked seizure-like bursts in mouse neocortical slices
    Wim van Drongelen
    Department of Pediatrics, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurophysiol 90:1571-80. 2003
    ..We conclude that the increased population activity during the SLA is attributed to recruitment of neurons rather than to increased synchrony of each of the individual elements...