José Pedraza-Chaverri

Summary

Country: Mexico

Publications

  1. ncbi Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis
    J Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, DF
    Life Sci 62:PL 71-7. 1998
  2. ncbi Time course study of oxidative and nitrosative stress and antioxidant enzymes in K2Cr2O7-induced nephrotoxicity
    José Pedraza-Chaverri
    Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Facultad de Quimica, Ciudad Universitaria, 04510, Mexico, D F, Mexico
    BMC Nephrol 6:4. 2005
  3. ncbi Effect of heating on peroxynitrite scavenging capacity of garlic
    José Pedraza-Chaverri
    Departamento de Biologia, Facultad de Quimica, Edificio F, Segundo Piso, Ciudad Universitaria, Universidad Nacional Autonoma de Mexico UNAM, 04510 Mexico DF, Mexico
    Food Chem Toxicol 45:622-7. 2007
  4. ncbi S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo
    José Pedraza-Chaverri
    Departamento de Biologia, Universidad Nacional Autonoma de Mexico UNAM, Ciudad Universitaria, 04510, Mexico, d, F, Mexico
    BMC Clin Pharmacol 4:5. 2004
  5. ncbi Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats
    José Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico
    Mol Cell Biochem 254:125-30. 2003
  6. ncbi Hypochlorous acid scavenging capacity of garlic
    José Pedraza-Chaverri
    Departamento de Biologia, Facultad de Quimica, Edificio F, Lab 209, Universidad Nacional Autonoma de Mexico UNAM, 04510 Mexico City, Mexico
    Phytother Res 21:884-8. 2007
  7. ncbi Protective effects of garlic powder against potassium dichromate-induced oxidative stress and nephrotoxicity
    José Pedraza-Chaverri
    Facultad de Quimica, Departamento de Biologia, Edificio F, Segundo Piso, Laboratorio 209, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 D F, Mexico
    Food Chem Toxicol 46:619-27. 2008
  8. ncbi Medicinal properties of mangosteen (Garcinia mangostana)
    José Pedraza-Chaverri
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico
    Food Chem Toxicol 46:3227-39. 2008
  9. ncbi Diallyl disulfide ameliorates gentamicin-induced oxidative stress and nephropathy in rats
    José Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, Universidad Nacional Autonoma de Mexico UNAM, 04510, Mexico, D F, Mexico
    Eur J Pharmacol 473:71-8. 2003
  10. ncbi Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes
    J Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico UNAM, 04510, Distrito Federal, Mexico
    Free Radic Biol Med 29:602-11. 2000

Collaborators

Detail Information

Publications71

  1. ncbi Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis
    J Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, DF
    Life Sci 62:PL 71-7. 1998
    ..It was concluded that garlic blocks the L-NAME-induced hypertension by antagonizing in vivo the inhibitory effect of L-NAME on NO production...
  2. ncbi Time course study of oxidative and nitrosative stress and antioxidant enzymes in K2Cr2O7-induced nephrotoxicity
    José Pedraza-Chaverri
    Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Facultad de Quimica, Ciudad Universitaria, 04510, Mexico, D F, Mexico
    BMC Nephrol 6:4. 2005
    ....
  3. ncbi Effect of heating on peroxynitrite scavenging capacity of garlic
    José Pedraza-Chaverri
    Departamento de Biologia, Facultad de Quimica, Edificio F, Segundo Piso, Ciudad Universitaria, Universidad Nacional Autonoma de Mexico UNAM, 04510 Mexico DF, Mexico
    Food Chem Toxicol 45:622-7. 2007
    ..1 and 4.5mug/mL. The heating before or after garlic cutting was unable to eliminate the capacity of the extracts to scavenge ONOO(-); this capacity was significantly decreased in PG and MG...
  4. ncbi S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo
    José Pedraza-Chaverri
    Departamento de Biologia, Universidad Nacional Autonoma de Mexico UNAM, Ciudad Universitaria, 04510, Mexico, d, F, Mexico
    BMC Clin Pharmacol 4:5. 2004
    ..In addition, the in vitro reactive oxygen species scavenging properties of S-allylmercaptocysteine were studied...
  5. ncbi Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats
    José Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico
    Mol Cell Biochem 254:125-30. 2003
    ..The mechanism by which DAS has a protective effect on GM-induced nephrotoxicity may be related, at least in part, to the decrease in oxidative stress in renal cortex...
  6. ncbi Hypochlorous acid scavenging capacity of garlic
    José Pedraza-Chaverri
    Departamento de Biologia, Facultad de Quimica, Edificio F, Lab 209, Universidad Nacional Autonoma de Mexico UNAM, 04510 Mexico City, Mexico
    Phytother Res 21:884-8. 2007
    ..500 +/- 0.049 mg/mL. In summary, raw garlic concentration-dependently scavenged HOCl; this ability was eliminated in extracts of microwave-treated garlic cloves but not in heated extracts of raw garlic or extracts of boiled garlic cloves...
  7. ncbi Protective effects of garlic powder against potassium dichromate-induced oxidative stress and nephrotoxicity
    José Pedraza-Chaverri
    Facultad de Quimica, Departamento de Biologia, Edificio F, Segundo Piso, Laboratorio 209, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 D F, Mexico
    Food Chem Toxicol 46:619-27. 2008
    ..It is concluded that the ability of garlic powder to ameliorate K(2)Cr(2)O(7)-induced renal injury is associated with its antioxidant properties. Our data support the use of garlic powder as a renoprotective agent...
  8. ncbi Medicinal properties of mangosteen (Garcinia mangostana)
    José Pedraza-Chaverri
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico
    Food Chem Toxicol 46:3227-39. 2008
    ..The aim of this review is to summarize findings of beneficial properties of GML's extracts and xanthones isolated from this plant so far...
  9. ncbi Diallyl disulfide ameliorates gentamicin-induced oxidative stress and nephropathy in rats
    José Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, Universidad Nacional Autonoma de Mexico UNAM, 04510, Mexico, D F, Mexico
    Eur J Pharmacol 473:71-8. 2003
    ....
  10. ncbi Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes
    J Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico UNAM, 04510, Distrito Federal, Mexico
    Free Radic Biol Med 29:602-11. 2000
    ..CAT mRNA levels decreased in the GM group. The protective effect of garlic is associated with the prevention of the decrease of Mn-SOD and GPx activities and with the rise of lipoperoxidation in renal cortex...
  11. ncbi Effect of the in vivo catalase inhibition on aminonucleoside nephrosis
    J Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico, D F
    Free Radic Biol Med 27:245-53. 1999
    ..These data indicate that the in vivo catalase inhibition magnifies PAN-nephrosis, suggesting that H2O2 is produced in vivo and involved in the renal damage in this experimental disease...
  12. ncbi Reactive oxygen species scavenging capacity of different cooked garlic preparations
    José Pedraza-Chaverri
    Facultad de Quimica, Edificio B, Segundo Piso, Laboratorio 209, Departamento de Biologia, Universidad Nacional Autonoma de Mexico UNAM, Ciudad Universitaria, 04510, Mexico, D F, Mexico
    Life Sci 78:761-70. 2006
    ..The heating before or after garlic cutting was unable to eliminate the capacity of the extracts to scavenge H(2)O(2), O(2)(*-), and OH(*)...
  13. ncbi Soy protein diet ameliorates renal nitrotyrosine formation and chronic nephropathy induced by puromycin aminonucleoside
    José Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, Universidad Nacional Autonoma de Mexico UNAM, 04510, D F, Mexico, Mexico
    Life Sci 74:987-99. 2004
    ..The protective effect of a 20% soy protein diet on renal damage in chronic nephropathy induced by PAN was associated with the amelioration in the renal nitrotyrosine formation but not with the modulation of antioxidant enzymes...
  14. ncbi Curcumin induces Nrf2 nuclear translocation and prevents glomerular hypertension, hyperfiltration, oxidant stress, and the decrease in antioxidant enzymes in 5/6 nephrectomized rats
    Edilia Tapia
    Renal Pathophysiology Laboratory, Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, 14080 Mexico City, DF, Mexico
    Oxid Med Cell Longev 2012:269039. 2012
    ....
  15. ncbi Tert-Butylhydroquinone pretreatment protects kidney from ischemia-reperfusion injury
    Carlos E Guerrero-Beltrán
    Department of Biology, Faculty of Chemistry, National and Autonomous University of Mexico Mexico City, Mexico
    J Nephrol 25:84-9. 2012
    ..tert-Butylhydroquinone (tBHQ) is a well-known antioxidant. In this study, we evaluated whether tBHQ pretreatment prevented renal damage induced by ischemia and reperfusion (I/R)...
  16. ncbi Selective iNOS inhibition reduces renal damage induced by cisplatin
    Yolanda I Chirino
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Mexico
    Toxicol Lett 176:48-57. 2008
    ....
  17. ncbi Deferoxamine pretreatment prevents Cr(VI)-induced nephrotoxicity and oxidant stress: role of Cr(VI) chelation
    Eduardo Molina-Jijón
    Faculty of Chemistry, Department of Biology, National Autonomous University of Mexico UNAM, University City, 04510, D F, Mexico
    Toxicology 291:93-101. 2012
    ..However, it cannot be excluded that the ability of DFO to chelate iron may also be involved in the protection observed in our study...
  18. ncbi Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs
    Esaú Floriano-Sánchez
    Escuela Superior de Medicina del Instituto Politecnico Nacional, Plan de San Luis y Salvador Díaz Mirón S N, Col Casco de Santo Tomas, Mexico, Mexico
    Free Radic Res 40:523-33. 2006
    ..It is concluded that NDGA is a potent in vitro scavenger of ONOO(-), (1)O(2), OH(v), and HOCl and is able to prevent lung tyrosine nitration in vivo...
  19. ncbi Antioxidant strategy to rescue synaptosomes from oxidative damage and energy failure in neurotoxic models in rats: protective role of S-allylcysteine
    Diana Elinos-Calderón
    Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Insurgentes Sur 3877, CP 14269, Mexico, D F, Mexico
    J Neural Transm 117:35-44. 2010
    ....
  20. ncbi Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: quinone oxidoreductase 1 and γ glutamyl cysteine ligase: studies in mitochondria isolated from rat kidney and in LLC-PK1 cells
    Carlos Enrique Guerrero-Beltrán
    Departamento de Biologia, Facultad de Quimica, Edificio F, Lab 209, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, D F, Mexico
    Toxicol Lett 199:80-92. 2010
    ..It is concluded that the protection exerted by SFN on mitochondrial alterations and NQO1 and γGCL enzymes may be involved in the renoprotection of SFN against CIS...
  21. ncbi Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage
    Perla D Maldonado
    Department of Biology, Universidad Nocional Autonoma de Mexico, Mexico D.F, Mexico
    Free Radic Biol Med 35:317-24. 2003
    ..In conclusion, SAC ameliorates the GM-induced ARF by a mechanism related, at least in part, to its ability to decrease oxidative stress and to preserve antioxidant enzymes activity in renal cortex...
  22. ncbi Preventive effect of tert-butylhydroquinone on cisplatin-induced nephrotoxicity in rats
    Jazmin M Pérez-Rojas
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Food Chem Toxicol 49:2631-7. 2011
    ..In conclusion, the present study indicates that the antioxidant activity of tBHQ is associated with its nephroprotective effect against CDDP-induced acute kidney injury in rats...
  23. ncbi Hypothyroidism attenuates protein tyrosine nitration, oxidative stress and renal damage induced by ischemia and reperfusion: effect unrelated to antioxidant enzymes activities
    Verónica M Tenorio-Velázquez
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510, Mexico, D F, Mexico
    BMC Nephrol 6:12. 2005
    ..In addition the activity of the antioxidant enzymes catalase, glutathione peroxidase, and superoxide dismutase was studied. Control and thyroidectomized (HTX) rats were studied 24 h of reperfusion after 60 min ischemia...
  24. ncbi S-allylcysteine ameliorates ischemia and reperfusion induced renal damage
    Sabina Segoviano-Murillo
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico UNAM, Ciudad Universitaria, 04510, Mexico DF, Mexico
    Phytother Res 22:836-40. 2008
    ..This protective effect was associated with a decrease in the immunostaining for 4-HNE. It is concluded that the antioxidant properties of SAC are involved in its protective effect on renal ischemia and reperfusion injury...
  25. ncbi Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats
    Leobardo Gaona-Gaona
    Departamento de Biologia, Facultad de Química UNAM, UNAM, Mexico, D F, Mexico
    Toxicology 286:20-7. 2011
    ..The hepatoprotective effect of SFN was associated to the preservation of mitochondrial function, antioxidant enzymes and prevention of liver and mitochondrial oxidant stress...
  26. ncbi Garlic powder ameliorates cisplatin-induced nephrotoxicity and oxidative stress
    Ana Carolina Razo-Rodríguez
    Department of Biology, School of Chemistry, National Autonomous University of Mexico, Mexico, DF, Mexico
    J Med Food 11:582-6. 2008
    ..It is concluded that the ability of garlic powder to ameliorate cisplatin-induced renal injury is associated with its antioxidant properties. Our data support the use of garlic powder as a renoprotective agent...
  27. ncbi Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats
    Perla D Maldonado
    Department of Biology, Faculty of Chemistry, , Ciudad Universitaria, 04510 D.F, , Mexico
    Life Sci 73:2543-56. 2003
    ..These data suggest that AGE may be a useful agent for the prevention of GM-nephrotoxicity...
  28. ncbi Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress
    Silvia Guzmán-Beltrán
    Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico UNAM, 04510 Mexico DF, Mexico
    Neurosci Lett 447:167-71. 2008
    ..Our study identifies NDGA as a new potential therapeutic tool to activate the Nrf2/HO-1 axis for protection against oxidative stress...
  29. ncbi Curcumin prevents Cr(VI)-induced renal oxidant damage by a mitochondrial pathway
    Eduardo Molina-Jijón
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, 04510 University City, DF, Mexico
    Free Radic Biol Med 51:1543-57. 2011
    ..These findings suggest that the preservation of mitochondrial function plays a key role in the protective effects of curcumin pretreatment against K(2)Cr(2)O(7)-induced renal oxidant damage...
  30. ncbi Protective effect of S-allylcysteine on 3-nitropropionic acid-induced lipid peroxidation and mitochondrial dysfunction in rat brain synaptosomes
    Verónica Pérez-De La Cruz
    Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez S S A, Mexico 14269, D F, Mexico
    Brain Res Bull 68:379-83. 2006
    ..These findings suggest that the protective actions that S-allylcysteine exert on the in vitro neurotoxicity induced by 3-nitropropionic acid are mediated by its antioxidant properties...
  31. ncbi Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats
    Yolanda I Chirino
    Departamento de Biologia, Facultad de Quimica, Edificio B, Segundo Piso, Lab 209, Ciudad Universitaria, UNAM, Mexico D F Mexico
    BMC Pharmacol 4:20. 2004
    ....
  32. ncbi Protective effects of apocynin against cisplatin-induced oxidative stress and nephrotoxicity
    Yolanda I Chirino
    Facultad de Quimica, Departamento de Biologia, Edificio F, Segundo Piso, Laboratorio 209, Universidad Nacional Autonoma de Mexico, 04510 Mexico D F, Mexico
    Toxicology 245:18-23. 2008
    ..Our data suggest that O(2)(-) derived from NADPH oxidase triggers some of the side effects due to cisplatin administration...
  33. ncbi Nordihydroguaiaretic acid attenuates potassium dichromate-induced oxidative stress and nephrotoxicity
    Paola Yam-Canul
    Facultad de Quimica, Departamento de Biologia, Edificio F, Segundo Piso, Laboratorio 209, Universidad Nacional Autonoma de Mexico UNAM, Ciudad Universitaria, Mexico, Mexico
    Food Chem Toxicol 46:1089-96. 2008
    ..These data strongly suggest that the antioxidant properties of NDGA are involved in its renoprotective effect in K(2)Cr(2)O(7)-treated rats...
  34. ncbi Copper blocks quinolinic acid neurotoxicity in rats: contribution of antioxidant systems
    Abel Santamaria
    Laboratorio de Aminoácidos Excitadores Departamento de Neuroquímica, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico, D F, Mexico
    Free Radic Biol Med 35:418-27. 2003
    ..5 and 10.0 mg/kg). These results show that at low doses, copper exerts a protective effect on in vivo QUIN neurotoxicity...
  35. ncbi Protective effect of α-mangostin on cardiac reperfusion damage by attenuation of oxidative stress
    Mabel Buelna-Chontal
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City, Mexico
    J Med Food 14:1370-4. 2011
    ..In summary, α-M induces a protective effect in postischemic heart associated to the prevention of oxidative stress secondary to reperfusion injury...
  36. ncbi Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions
    María L Haces
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico UNAM, Mexico D F, Mexico
    Exp Neurol 211:85-96. 2008
    ..Our data suggest that the antioxidant capacity contributes to protection of ketone bodies against oxidative damage in in vitro and in vivo models associated with free radical production and energy impairment...
  37. ncbi Curcumin protects from cardiac reperfusion damage by attenuation of oxidant stress and mitochondrial dysfunction
    Alfredo González-Salazar
    Departamento de Biologia, UNAM, Edificio F, Segundo Piso, Ciudad Universitaria, Mexico D F
    Cardiovasc Toxicol 11:357-64. 2011
    ..In conclusion, the protective effect of curcumin was associated with the attenuation of oxidant stress and mitochondrial dysfunction secondary to I/R injury...
  38. ncbi Heme oxygenase-1 induction prevents neuronal damage triggered during mitochondrial inhibition: role of CO and bilirubin
    Marisol Orozco-Ibarra
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico DF, Mexico
    Int J Biochem Cell Biol 41:1304-14. 2009
    ..The present results increase our knowledge about the role of HO-1 in neuropathological conditions...
  39. ncbi S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, SS, Mexico City, D F, Mexico
    J Nutr Biochem 22:937-44. 2011
    ..These findings suggest that in mice, SAC attenuates MPP(+)-induced neurotoxicity in the striatum and that an antioxidant effect against oxidative stress may be partly responsible for its observed neuroprotective effects...
  40. ncbi Sulforaphane protects against cisplatin-induced nephrotoxicity
    Carlos Enrique Guerrero-Beltrán
    Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Edificio F, Mexico City, Mexico
    Toxicol Lett 192:278-85. 2010
    ..The renoprotective effect of SFN on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and the preservation of antioxidant enzymes...
  41. ncbi PJ34, a poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity
    Paola Yam-Canul
    Department of Biology, School of Chemistry, National Autonomous University of Mexico, DF, Mexico
    Basic Clin Pharmacol Toxicol 102:483-8. 2008
    ..It is concluded that PARP-1 is activated and involved, at least in part, in K(2)Cr(2)O(7)-induced nephrotoxicity in rats...
  42. ncbi Time-related changes in constitutive and inducible nitric oxide synthases in the rat striatum in a model of Huntington's disease
    Penelope Aguilera
    Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico, DF 14269, Mexico
    Neurotoxicology 28:1200-7. 2007
    ..Our results support the participation of Ca(2+)-dependent NOS isoforms during the toxic events produced at early times after QUIN injection...
  43. ncbi Impaired testicular cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory (StAR) protein expression in rats with nephrotic syndrome
    Marta Menjivar
    Department of Biology, Faculty of Chemistry, Universidad Nacional Autonoma de Mexico, Mexico 04510, Mexico City, Mexico
    Mol Cell Endocrinol 209:1-7. 2003
    ..In conclusion, this study demonstrates that the expression of P450scc and StAR protein are highly impaired during nephrotic syndrome...
  44. ncbi Renoprotection by alpha-Mangostin is related to the attenuation in renal oxidative/nitrosative stress induced by cisplatin nephrotoxicity
    Jazmin M Pérez-Rojas
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Edificio F, Mexico City, Mexico
    Free Radic Res 43:1122-32. 2009
    ..In conclusion the renoprotective effect of alpha-M on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and inflammatory and fibrotic markers and preservation of catalase activity...
  45. ncbi The alpha-mangostin prevention on cisplatin-induced apoptotic death in LLC-PK1 cells is associated to an inhibition of ROS production and p53 induction
    Yesennia Sánchez-Pérez
    Subdireccion de Investigacion Basica, Instituto Nacional de Cancerologia, San Fernando No 22, Tlalpan, 14080 Mexico, DF, Mexico
    Chem Biol Interact 188:144-50. 2010
    ..In conclusion, the preventive effect of alpha-M on CDDP-induced apoptotic death is associated to the inhibition of p53 expression and ROS generation...
  46. ncbi The effect of nordihydroguaiaretic acid on iodoacetate-induced toxicity in cultured neurons
    Noemí Cárdenas-Rodríguez
    Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autónoma de México CP 04510, Mexico DF, Mexico
    J Biochem Mol Toxicol 23:137-42. 2009
    ..Furthermore, NDGA could prevent the inhibitory effect of IAA on aconitase activity, a marker of oxidative stress, suggesting that the protective effect of NDGA on IAA neurotoxicity was associated with the prevention of oxidative stress...
  47. ncbi [Role of peroxynitrite anion in different diseases]
    Yolanda I Chirino
    Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico
    Rev Invest Clin 58:350-8. 2006
    ..Finally, these metalloporphyrins may be of potential therapeutic value in diseases related to ONOO- production...
  48. ncbi ROS scavenging capacity and neuroprotective effect of alpha-mangostin against 3-nitropropionic acid in cerebellar granule neurons
    José Pedraza-Chaverri
    Departamento de Biologia, Facultad de Quimica, Laboratorio 209, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico, Mexico
    Exp Toxicol Pathol 61:491-501. 2009
    ..It is concluded that alpha-mangostin is able to scavenge directly several ROS and has a neuroprotective effect against 3-NP in primary cultures of CGNs, which is associated with its ability to ameliorate 3-NP-induced ROS production...
  49. ncbi Calcium-dependent production of reactive oxygen species is involved in neuronal damage induced during glycolysis inhibition in cultured hippocampal neurons
    Karla Hernández-Fonseca
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico UNAM, Mexico D F, Mexico
    J Neurosci Res 86:1768-80. 2008
    ....
  50. ncbi EGb761 protects against nigrostriatal dopaminergic neurotoxicity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice: role of oxidative stress
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, SS, Av Insurgentes Sur No 3877, Col La Fama C P 14269, Mexico, D F, Mexico
    Eur J Neurosci 28:41-50. 2008
    ....
  51. ncbi S-allylcysteine scavenges singlet oxygen and hypochlorous acid and protects LLC-PK(1) cells of potassium dichromate-induced toxicity
    Omar Noel Medina Campos
    Facultad de Quimica, Departamento de Biologia, Edificio F, Sequndo Piso, Laboratorio 209, Universidad Nacional Autonoma de Mexico UNAM, Ciudad Universitaria, 04510, D F, Mexico
    Food Chem Toxicol 45:2030-9. 2007
    ..It was showed for the first time that SAC is able to scavenge (1)O(2) and HOCl and to ameliorate the K(2)Cr(2)O(7)-induced toxicity...
  52. ncbi Protective effect of sulforaphane against oxidative stress: recent advances
    Carlos Enrique Guerrero-Beltrán
    Departamento de Biologia, Universidad Nacional Autonoma de Mexico, 04510 Mexico, DF, Mexico
    Exp Toxicol Pathol 64:503-8. 2012
    ..In conclusion, sulforaphane is a promising antioxidant agent that is effective to attenuate oxidative stress and tissue/cell damage in different in vivo and in vitro experimental paradigms...
  53. ncbi HO-1 induction attenuates renal damage and oxidative stress induced by K2Cr2O7
    Diana Barrera
    Department of Biology, School of Chemistry, , Ciudad Universitaria, 04510 Mexico City, Mexico
    Free Radic Biol Med 34:1390-8. 2003
    ..Our data suggest that HO-1 overexpression induced by SnCl(2) is responsible for the attenuation of renal damage and oxidative stress induced by K(2)Cr(2)O(7)...
  54. ncbi Evaluation of oxidative stress in D-serine induced nephrotoxicity
    Marisol Orozco Ibarra
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico UNAM, Ciudad Universitaria, 04510, DF, Mexico
    Toxicology 229:123-35. 2007
    ..Our data taken as a whole suggest that oxidative stress is not involved in the early phase of the nephrotoxicity induced by d-serine...
  55. ncbi Antihyperglycemic effect of constituents from Hintonia standleyana in streptozotocin-induced diabetic rats
    José A Guerrero-Analco
    Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico DF, Mexico
    Planta Med 71:1099-105. 2005
    ..05). These results showed that the antihyperglycemic active principles of H. standleyana are both 4-phenylcoumarins and cucurbitacin glycosides...
  56. ncbi Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity
    Yolanda I Chirino
    Subdireccion de Investigacion Basica, Instituto Nacional de Cancerologia, Tlalpan, DF, Mexico
    Exp Toxicol Pathol 61:223-42. 2009
    ....
  57. ncbi Increased cyclosporine bioavailability induced by experimental nephrotic syndrome in rats
    Mara Medeiros
    Departamento de Nefrologia, Hospital Infantil de Mexico Federico Gomez, Dr Marquez 162, Col Doctores, Mexico, DF 06720, Mexico
    Can J Physiol Pharmacol 85:502-6. 2007
    ....
  58. ncbi Protective effect of SnCl2 on K2Cr2O7-induced nephrotoxicity in rats: the indispensability of HO-1 preinduction and lack of association with some antioxidant enzymes
    Diana Barrera
    , , , Edificio B, Segundo Piso, Lab 209, Ciudad Universitaria, , DF,
    Life Sci 73:3027-41. 2003
    ....
  59. ncbi 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors
    Julio C Tobón-Velasco
    Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía S S A, Mexico City, Mexico
    Toxicology 304:109-19. 2013
    ..In turn, these cellular events inhibit the activation of cytoprotective mechanisms, thereby leading to a condition of general damage...
  60. ncbi Neuroprotective effect of α-mangostin and curcumin against iodoacetate-induced cell death
    Laura María Reyes-Fermín
    Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico, DF, Mexico
    Nutr Neurosci 15:34-41. 2012
    ..Furthermore, it has been shown that the induction of heme oxygenase-1 (HO-1) protects against IAA-induced neuronal death...
  61. ncbi S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades
    Julio César Tobón-Velasco
    Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía S S A, Mexico City, Mexico
    Free Radic Biol Med 53:1024-40. 2012
    ....
  62. ncbi Steroidogenic impairment due to reduced ovarian transcription of cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory protein (StAR) during experimental nephrotic syndrome
    Miguel Peña-Rico
    Department of Biology, Faculty of Chemistry, Universidad Nacional Autonoma de Mexico, CP 04510, Mexico City, Mexico
    Life Sci 79:702-8. 2006
    ..This study demonstrates that the mechanism by which ovarian steroid biosynthesis is altered during acute nephrosis involves damage at the P450scc and StAR mRNA synthesis and processing...
  63. ncbi Malondialdehyde and superoxide dismutase correlate with FEV(1) in patients with COPD associated with wood smoke exposure and tobacco smoking
    Martha Montaño
    Departamento de Investigación en Fibrosis Pulmonar, Instituto Nacional de, Enfermedades Respiratorias Ismael Cosío Villegas, D F, Mexico
    Inhal Toxicol 22:868-74. 2010
    ..001). These results indicate a role for oxidative stress in COPD associated with wood smoke similar to that observed with tobacco smoking in subjects who ceased at least 10 years previous to this study...
  64. ncbi Nordihydroguaiaretic acid attenuates the oxidative stress-induced decrease of CD33 expression in human monocytes
    Silvia Guzmán-Beltrán
    Departamento de Microbiología en Investigación, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Calzada de Tlalpan 4502, Seccion XVI, 14080 Mexico, DF, Mexico
    Oxid Med Cell Longev 2013:375893. 2013
    ..These results suggest that NDGA has a protective effect on CD33 expression, which is associated with its antioxidant activity in human MNs...
  65. ncbi Acetonic and Methanolic Extracts of Heterotheca inuloides, and Quercetin, Decrease CCl(4)-Oxidative Stress in Several Rat Tissues
    Elvia Coballase-Urrutia
    Laboratorio de Neuroquimica, Instituto Nacional de Pediatria, Insurgentes Sur 3700 C, 04530 Mexico, DF, Mexico
    Evid Based Complement Alternat Med 2013:659165. 2013
    ..The present results strongly suggest that the chemopreventive effect of the extracts used and quercetin, against CCl(4) toxicity, is associated with their antioxidant properties and corroborated previous results obtained in liver tissue...
  66. ncbi Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy
    Carlos Enrique Guerrero-Beltrán
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
    J Nutr Biochem 23:494-500. 2012
    ..SFN is able to prevent the CIS-induced renal injury by modulating these pathways, providing a novel approach for preventing this devastating complication of chemotherapy...
  67. ncbi Antidiabetic properties of selected Mexican copalchis of the Rubiaceae family
    José Guerrero Analco
    Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico DF, 04510, Mexico
    Phytochemistry 68:2087-95. 2007
    ..latiflora regulated hepatic glycogen and plasma insulin levels (p<0.05). These data suggest that its antihyperglycemic effect is due in part to stimulation of insulin secretion and regulation of hepatic glycogen metabolism...
  68. ncbi Comparison of antioxidant activity of hydroethanolic fresh and aged garlic extracts and their effects on cerebral ischemia
    Maria Isabel Cervantes
    Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Insurgentes Sur 3877, Col La Fama, Mexico, D F C P 14269, Mexico Unidad de Investigación Médica en Farmacología, Hospital de Especialidades 2 Piso CORCE, Centro Medico Nacional Siglo XXI, Av Cuauhtemoc 330, Col Doctores, Mexico, D F C P 06720, Mexico Electronic address
    Food Chem 140:343-52. 2013
    ..These results indicate that antioxidants present in garlic extracts may regulate ROS concentrations during ischemia, favour pro-survival pathways, and attenuate mitochondrial dysfunction...
  69. ncbi Phenylpropanoid glycoside analogues: enzymatic synthesis, antioxidant activity and theoretical study of their free radical scavenger mechanism
    Agustín López-Munguía
    Departamento Ingeniería Celular y Biocatálisis, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    PLoS ONE 6:e20115. 2011
    ..The enzymatic process reported in this study is an efficient and versatile route to obtain PPGs from different phenylpropanoid acids, sugars and phenolic alcohols...
  70. ncbi Neuroprotective role of heme-oxygenase 1 against iodoacetate-induced toxicity in rat cerebellar granule neurons: Role of bilirubin
    Susana González-Reyes
    Departamento de Biologia, Universidad Nacional Autonoma de Mexico, DF, Mexico
    Free Radic Res 43:214-23. 2009
    ..The protective effect elicited by CoPP was reproduced by bilirubin addition, suggesting that this molecule may be involved in the protective effect of HO-1 induction in this experimental model...
  71. ncbi Poly(ADP-ribose) polymerase-1 is involved in the neuronal death induced by quinolinic acid in rats
    Perla Deyanira Maldonado
    Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico, D F 14269, Mexico
    Neurosci Lett 425:28-33. 2007
    ..The protective effect of PJ-34 suggests that PARP-1 activation is playing an active role in the neuronal death induced by quinolinic acid...