Patricia Méndez-Samperio

Summary

Country: Mexico

Publications

  1. ncbi Protein tyrosine kinase regulates FAS-mediated apoptosis in human BCG-infected monocytes
    P Mendez-Samperio
    Departamento de Immunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico, D F 11340 México
    J Interferon Cytokine Res 21:209-17. 2001
  2. pmc Mycobacterium bovis bacillus Calmette-Guerin induces CCL5 secretion via the Toll-like receptor 2-NF-kappaB and -Jun N-terminal kinase signaling pathways
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico, D F 11340, Mexico
    Clin Vaccine Immunol 15:277-83. 2008
  3. ncbi Mycobacterium bovis BCG Toll-like receptors 2 and 4 cooperation increases the innate epithelial immune response
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, IPN, Mexico, D F, Mexico
    Arch Med Res 39:33-9. 2008
  4. doi Sphingosine kinase, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 are required for CCL5 production in Mycobacterium bovis Bacillus Calmette-Guérin (BCG)-infected epithelial cells
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Prol Carpio y Plan de Ayala, Mexico, D F 11340, Mexico
    Cell Immunol 249:94-100. 2007
  5. doi Mycobacterium bovis Bacillus Calmette-Guérin (BCG) stimulates IL-10 production via the PI3K/Akt and p38 MAPK pathways in human lung epithelial cells
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico DF 11340, Mexico
    Cell Immunol 251:37-42. 2008
  6. pmc Expression and secretion of cathelicidin LL-37 in human epithelial cells after infection by Mycobacterium bovis Bacillus Calmette-Guérin
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Prol Carpio y Plan de Ayala México City, D F 11340, Mexico
    Clin Vaccine Immunol 15:1450-5. 2008
  7. doi Role of antimicrobial peptides in host defense against mycobacterial infections
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Mexico, D F 11340, Mexico
    Peptides 29:1836-41. 2008
  8. doi Regulation of human beta-defensin-2 by Mycobacterium bovis bacillus Calmette-Guérin (BCG): involvement of PKC, JNK, and PI3K in human lung epithelial cell line (A549)
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, D F 11340 México, Mexico
    Peptides 29:1657-63. 2008
  9. doi Expression and regulation of chemokines in mycobacterial infection
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Prol Carpio y Plan de Ayala, México D F 11340, Mexico
    J Infect 57:374-84. 2008
  10. doi Mycobacterium bovis Bacillus Calmette-Guérin (BCG)-induced activation of PI3K/Akt and NF-kB signaling pathways regulates expression of CXCL10 in epithelial cells
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN Prol Carpio y Plan de Ayala, Mexico, D F, Mexico
    Cell Immunol 256:12-8. 2009

Collaborators

  • Elena Miranda
  • Patricia Méndez Samperio
  • Marisol Hernández-Garay
  • Artemisa Trejo

Detail Information

Publications28

  1. ncbi Protein tyrosine kinase regulates FAS-mediated apoptosis in human BCG-infected monocytes
    P Mendez-Samperio
    Departamento de Immunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico, D F 11340 México
    J Interferon Cytokine Res 21:209-17. 2001
    ..Collectively, these data demonstrate that Fas-induced apoptosis may represent an important mechanism for eliminating BCG-activated human monocytes and that this apoptosis is due, at least in part, to signaling via a PTK pathway...
  2. pmc Mycobacterium bovis bacillus Calmette-Guerin induces CCL5 secretion via the Toll-like receptor 2-NF-kappaB and -Jun N-terminal kinase signaling pathways
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico, D F 11340, Mexico
    Clin Vaccine Immunol 15:277-83. 2008
    ..bovis BCG activated IkappaB kinase alphabeta. These findings indicate that M. bovis BCG induces CCL5 production through mechanisms that include a TLR2-dependent component that requires JNK and NF-kappaB activities...
  3. ncbi Mycobacterium bovis BCG Toll-like receptors 2 and 4 cooperation increases the innate epithelial immune response
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, IPN, Mexico, D F, Mexico
    Arch Med Res 39:33-9. 2008
    ....
  4. doi Sphingosine kinase, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 are required for CCL5 production in Mycobacterium bovis Bacillus Calmette-Guérin (BCG)-infected epithelial cells
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Prol Carpio y Plan de Ayala, Mexico, D F 11340, Mexico
    Cell Immunol 249:94-100. 2007
    ..bovis BCG-induced CCL5 secretion is dependent on the SPK/PI3K/Akt/NF-kappaB and p300 signaling pathway. The regulatory pathways of M. bovis BCG-induced CCL5 production can potentially be exploited therapeutically...
  5. doi Mycobacterium bovis Bacillus Calmette-Guérin (BCG) stimulates IL-10 production via the PI3K/Akt and p38 MAPK pathways in human lung epithelial cells
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico DF 11340, Mexico
    Cell Immunol 251:37-42. 2008
    ..bovis BCG-induced phosphorylation of p38 MAPK. Collectively, these data suggest that the PI3K/Akt and p38 MAPK signaling pathways play an important role in the regulation of M. bovis BCG-induced IL-10 secretion in A549 cells...
  6. pmc Expression and secretion of cathelicidin LL-37 in human epithelial cells after infection by Mycobacterium bovis Bacillus Calmette-Guérin
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Prol Carpio y Plan de Ayala México City, D F 11340, Mexico
    Clin Vaccine Immunol 15:1450-5. 2008
    ..Thus, these results indicate that the MEK1/2 and p38 MAPK signaling pathways play a critical role in the regulation of inducible LL-37 gene expression in A549 cells infected with M. bovis BCG...
  7. doi Role of antimicrobial peptides in host defense against mycobacterial infections
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Mexico, D F 11340, Mexico
    Peptides 29:1836-41. 2008
    ..A concerted effort should now focus on the clinical application of antimicrobial peptides for their practical use...
  8. doi Regulation of human beta-defensin-2 by Mycobacterium bovis bacillus Calmette-Guérin (BCG): involvement of PKC, JNK, and PI3K in human lung epithelial cell line (A549)
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, D F 11340 México, Mexico
    Peptides 29:1657-63. 2008
    ..These studies are the first to show that M. bovis BCG-induced HBD-2 mRNA expression in A549 cells is regulated at least in part through activation of signaling proteins of PKC, JNK and PI3K...
  9. doi Expression and regulation of chemokines in mycobacterial infection
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Prol Carpio y Plan de Ayala, México D F 11340, Mexico
    J Infect 57:374-84. 2008
    ....
  10. doi Mycobacterium bovis Bacillus Calmette-Guérin (BCG)-induced activation of PI3K/Akt and NF-kB signaling pathways regulates expression of CXCL10 in epithelial cells
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN Prol Carpio y Plan de Ayala, Mexico, D F, Mexico
    Cell Immunol 256:12-8. 2009
    ..bovis BCG-induced activation of NF-kB. The functional association between PI3K/Akt and NF-kB demonstrates another mechanism in the regulation of M. bovis BCG-induced CXCL10 in A549 cells...
  11. doi Role of reactive oxygen species (ROS) in Mycobacterium bovis bacillus Calmette Guérin-mediated up-regulation of the human cathelicidin LL-37 in A549 cells
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Prol Carpio y Plan de Ayala, Mexico, D F 11340, Mexico
    Microb Pathog 47:252-7. 2009
    ..In conclusion, these findings demonstrate a novel regulatory mechanism for the expression of cathelicidin LL-37 in human epithelial cells stimulated with M. bovis BCG...
  12. doi Role of interleukin-12 family cytokines in the cellular response to mycobacterial disease
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Prol Carpio y Plan de Ayala, Mexico, DF 11340 Mexico
    Int J Infect Dis 14:e366-71. 2010
    ..This examination will help to improve our understanding of the immune response to mycobacterial infection and also improve vaccine design and immunotherapeutic intervention against tuberculosis...
  13. doi The human cathelicidin hCAP18/LL-37: a multifunctional peptide involved in mycobacterial infections
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Prol Carpio y Plan de Ayala, 11340 Mexico, D F, Mexico
    Peptides 31:1791-8. 2010
    ....
  14. ncbi Mycobacterium bovis bacillus Calmette-Guérin (BCG)-induced CXCL8 production is mediated through PKCalpha-dependent activation of the IKKalphabeta signaling pathway in epithelial cells
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico, D F 11340, Mexico
    Cell Immunol 245:111-8. 2007
    ..Altogether, these results represent the first evidence to date suggesting that M. bovis BCG activates the PI-PLC/PKCalpha/c-Src/IKKalphabeta signaling pathway to induce CXCL8 release in human epithelial cells...
  15. ncbi Mycobacterium bovis-mediated induction of human beta-defensin-2 in epithelial cells is controlled by intracellular calcium and p38MAPK
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, México D F 11340, Mexico
    J Infect 54:469-74. 2007
    ..Together, these data suggest that M. bovis BCG induces HBD-2 mRNA expression in A549 lung epithelial cells at least in part mediated through intracellular calcium flux as well as activation of signaling protein of p38MAPK, but not ERK...
  16. ncbi Signals involved in mycobacteria-induced CXCL-8 production by human monocytes
    P Mendez-Samperio
    Departamento de Immunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico, D F 11340 México
    J Interferon Cytokine Res 22:189-97. 2002
    ..bovis. These results show intracellular signaling pathways and a transcription factor involved in the M. bovis-mediated upregulation of CXCL-8 biosynthesis and release by human monocytes...
  17. pmc Regulation of interleukin-8 by interleukin-10 and transforming growth factor beta in human monocytes infected with mycobacterium bovis
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico, D F 11340 México
    Clin Diagn Lab Immunol 9:802-7. 2002
    ..bovis BCG. These data will aid in our understanding of the mechanisms involved in regulating the protective immune response to stimulation with M. bovis BCG...
  18. pmc NF-kappaB is involved in regulation of CD40 ligand expression on Mycobacterium bovis bacillus Calmette-Guérin-activated human T cells
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, México D F 11340, Mexico
    Clin Diagn Lab Immunol 10:376-82. 2003
    ..These data strongly suggest that CD40L expression by BCG-activated CD4(+) T cells is regulated via the PKC pathway and by NF-kappaB DNA binding activity...
  19. ncbi Infection of human monocytes with Mycobacterium bovis BCG induces production of CC-chemokines
    P Mendez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico, Mexico
    J Infect 47:139-47. 2003
    ..This study investigated whether infection of human monocytes with Mycobacterium bovis bacillus Calmette-Guérin (BCG) elicits secretion of RANTES, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta...
  20. ncbi Differential induction of TNF-alpha and NOS2 by mitogen-activated protein kinase signaling pathways during Mycobacterium bovis infection
    P Mendez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico DF, Mexico
    J Infect 48:66-73. 2004
    ..These results suggest that ERK1/2 and p38 kinases differentially regulate the M. bovis BCG-mediated induction of TNF-alpha and NOS2 in human monocytes...
  21. pmc Secretion of interleukin-8 by human-derived cell lines infected with Mycobacterium bovis
    Patricia Méndez-Samperio
    Departmento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Mexico, D F, Mexico
    Mediators Inflamm 13:45-9. 2004
    ..bovis BCG...
  22. pmc Role of type I interferon in the bacillus Calmette-Guérin-induced expression of CXCL10 from human monocytes
    Patricia Méndez Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico, D F 11340 México
    Mediators Inflamm 13:343-8. 2004
    ..In this study, our experiments were designed to determine the role of interferon (IFN)-alphabeta in the production of CXCL10 by human monocytes infected with Mycobacterium bovis bacillus Calmette-Guerin (BCG)...
  23. ncbi Activation of ERK1/2 and TNF-alpha production are mediated by calcium/calmodulin, and PKA signaling pathways during Mycobacterium bovis infection
    P Mendez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, 11340 Mexico, DF, Mexico
    J Infect 52:147-53. 2006
    ..bovis-infected human monocytes. These results indicate that the Ca2+/calmodulin, and PKA pathways play important regulatory roles in monocyte signaling upon M. bovis infection...
  24. ncbi Mycobacterium bovis Bacillus Calmette-Guérin (BCG) stimulates human beta-defensin-2 gene transcription in human epithelial cells
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN Carpio y Plan de Ayala, Mexico, D F 11340, Mexico
    Cell Immunol 239:61-6. 2006
    ..Studies of hbetaD-2 mRNA regulation in epithelial cells infected with M. bovis BCG provide insight into how its expression may be enhanced to control Mycobacterium tuberculosis infection...
  25. doi Reactive oxygen species-activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium bovis bacillus Calmette Guérin (BCG)-induced CCL2 secretion in human monocytic cell line THP-1
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, IPN, Mexico, D F, Mexico
    Arch Med Res 41:579-85. 2010
    ....
  26. pmc Expression and secretion of CXCL-8 and CXCL-10 from mycobacterium bovis BCG-infected human epithelial cells: role of IL-4
    Patricia Méndez-Samperio
    Departamento de Immunologia, Escuela Nacional de Ciencias biologias, IPN, Carpio y Plan de Ayala, Mexico, DF 11340, Mexico
    Mediators Inflamm 2006:67451. 2006
    ..bovis BCG-infected human epithelial cells can have an active role in a local inflammatory immune response via the secretion of CXC chemokines which can be selectively regulated by Th2-derived cytokines...
  27. ncbi Mycobacterium bovis BCG induces CXC chemokine ligand 8 secretion via the MEK-dependent signal pathway in human epithelial cells
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala, Mexico, D F 11340, Mexico
    Cell Immunol 234:9-15. 2005
    ..bovis BCG occurs at the transcription level. Collectively, the findings reported in the present study suggest that MEK signaling is essential for the induction of CXCL8 in epithelial cells in response to M. bovis BCG...
  28. ncbi Transforming growth factor-beta decreases survival of Mycobacterium bovis-activated T cells
    Marisol Hernández-Garay
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, ENCB, Instituto Politecnico Nacional, IPN, Mexico City, Mexico
    Arch Med Res 34:20-5. 2003
    ..In this study, our experiments were designed to determine effects of transforming growth factor (TGF)-beta on M. bovis-induced T-cell activation and survival...