Lorenza Gonzalez-Mariscal

Summary

Country: Mexico

Publications

  1. pmc Transmigration of neural stem cells across the blood brain barrier induced by glioma cells
    Monica Díaz-Coránguez
    Department of Physiology, Biophysics and Neuroscience, CINVESTAV, Mexico City, Mexico
    PLoS ONE 8:e60655. 2013
  2. doi request reprint ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis
    Lorenza Gonzalez-Mariscal
    Center of Research and Advanced Studies, CINVESTAV, Department of Physiology, Biophysics and Neuroscience, Mexico DF, Mexico
    Ann N Y Acad Sci 1257:133-41. 2012
  3. doi request reprint Identification of claudins by western blot and immunofluorescence in different cell lines and tissues
    Lorenza Gonzalez-Mariscal
    Department of Physiology, Biophysics, and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico DF, Mexico
    Methods Mol Biol 762:213-31. 2011
  4. ncbi request reprint The tight junction protein ZO-2 has several functional nuclear export signals
    Lorenza Gonzalez-Mariscal
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Ave Instituto Politecnico Nacional 2508, Mexico, D F, 07360, Mexico
    Exp Cell Res 312:3323-35. 2006
  5. ncbi request reprint Role of tight junctions in cell proliferation and cancer
    Lorenza Gonzalez-Mariscal
    Center for Research and Advanced Studies CINVESTAV, Department of Physiology, Biophysics and Neuroscience, Ave Instituto Politecnico Nacional 2508, Mexico, DF 07360, Mexico
    Prog Histochem Cytochem 42:1-57. 2007
  6. doi request reprint ZO proteins and redox-dependent processes
    Lorenza Gonzalez-Mariscal
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico DF, Mexico
    Antioxid Redox Signal 15:1235-53. 2011
  7. ncbi request reprint Crosstalk of tight junction components with signaling pathways
    Lorenza Gonzalez-Mariscal
    Center for Research and Advanced Studies CINVESTAV, Department of Physiology, Biophysics and Neuroscience, Ave Instituto Politecnico Nacional 2508, Mexico D F 07360, Mexico
    Biochim Biophys Acta 1778:729-56. 2008
  8. ncbi request reprint Inventions designed to enhance drug delivery across epithelial and endothelial cells through the paracellular pathway
    Lorenza Gonzalez-Mariscal
    Center of Research and Advanced Studies, Department of Physiology, Biophysics and Neuroscience, Ave IPN 2508, Mexico D F, 07360, Mexico
    Recent Pat Drug Deliv Formul 2:145-76. 2008
  9. ncbi request reprint Virus interaction with the apical junctional complex
    Lorenza Gonzalez-Mariscal
    Center for Research and Advanced Studies CINVESTAV, Department of Physiology, Biophysics and Neuroscience, Mexico D F, Mexico
    Front Biosci (Landmark Ed) 14:731-68. 2009
  10. doi request reprint The tight junction protein ZO-2 blocks cell cycle progression and inhibits cyclin D1 expression
    Lorenza Gonzalez-Mariscal
    Department of Physiology, Center for Research and Advanced Studies CINVESTAV, Mexico City, Mexico
    Ann N Y Acad Sci 1165:121-5. 2009

Collaborators

  • Arturo Ponce
  • Bibiana Chavez-Munguia
  • Jose Segovia
  • Otmar Huber
  • Monica Lamas
  • Jose Diaz-Chavez
  • Juan E Ludert
  • Daniel Martinez-Fong
  • J L Reyes
  • Felix Recillas-Targa
  • Martha Robles Flores
  • Susana Lopez
  • P Muriel
  • Miriam Huerta
  • Lourdes Alarcón
  • Esther Lopez-Bayghen
  • Socorro Islas
  • Rocio Tapia
  • Henry Puerta-Guardo
  • Erika Garay
  • Jesús Hernández-Monge
  • Arturo Raya-Sandino
  • Miguel Quirós
  • Monica Díaz-Coránguez
  • Pablo Bautista-García
  • Abigail Betanzos
  • Susana Lechuga
  • Eusebio Juaristi
  • David Chamorro
  • Sandra Hernandez
  • Samuel Liévano
  • C Adriana Mendoza-Rodríguez
  • Porfirio Nava
  • Blanca Estela Jaramillo
  • Adolfo López-Ornelas
  • Rosa María del Angel
  • Dolores Martin
  • Fernando Medina
  • Jose Ayala-Davila
  • Paul F Lambert
  • Patricio Gariglio
  • Bibiana Chávez-Mungía
  • Bibiana Chávez
  • Noemí Meraz-Cruz
  • Marco Popoca-Cuaya
  • Elizabeth Soria-Castro
  • Thomas Giannakouros
  • Maria C Namorado
  • Victor H Rosales
  • Orlando Vargas-Sierra
  • Oscar Medina-Contreras
  • Vianney Ortiz-Navarrete
  • Genaro Patino-Lopez
  • Ricardo Valle-Rios
  • Giovana Granados
  • Elsy Canche-Pool
  • Jesús Solano
  • Antonia Avila-Flores
  • Martha Robles-Flores
  • Teresa Mejia-Castillo
  • Hector Gonzalez-Aguilar
  • Jörg Weiske
  • Yamir Bandala
  • Leticia Ramírez
  • Ernesto Soto-Reyes
  • Bibiana Chavez Munguia
  • Rodrigo Munoz
  • Marco Cerbón
  • Jacqueline Moreno
  • José Amerena
  • Carlos F Arias
  • Elisa Azuara
  • Lissette Ponce
  • Jesús Vega

Detail Information

Publications34

  1. pmc Transmigration of neural stem cells across the blood brain barrier induced by glioma cells
    Monica Díaz-Coránguez
    Department of Physiology, Biophysics and Neuroscience, CINVESTAV, Mexico City, Mexico
    PLoS ONE 8:e60655. 2013
    ..In nude mice we found that ReNcells CX injected into systemic circulation passed the BBB and reached intracranial gliomas, which overexpressed HGF, VEGF and zonulin/prehaptoglobin 2...
  2. doi request reprint ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis
    Lorenza Gonzalez-Mariscal
    Center of Research and Advanced Studies, CINVESTAV, Department of Physiology, Biophysics and Neuroscience, Mexico DF, Mexico
    Ann N Y Acad Sci 1257:133-41. 2012
    ..ZO-2 inhibits the Wnt signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer...
  3. doi request reprint Identification of claudins by western blot and immunofluorescence in different cell lines and tissues
    Lorenza Gonzalez-Mariscal
    Department of Physiology, Biophysics, and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico DF, Mexico
    Methods Mol Biol 762:213-31. 2011
    ..In this chapter, we describe in detail protocols used for western blot and immunofluorescence detection of claudins in epithelial cell lines and in various tissue samples...
  4. ncbi request reprint The tight junction protein ZO-2 has several functional nuclear export signals
    Lorenza Gonzalez-Mariscal
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Ave Instituto Politecnico Nacional 2508, Mexico, D F, 07360, Mexico
    Exp Cell Res 312:3323-35. 2006
    ..Moreover, the transfection of MDCK cells with full-length ZO-2 revealed that the mutation of any of the NES present in the molecule was sufficient to induce nuclear accumulation of the protein...
  5. ncbi request reprint Role of tight junctions in cell proliferation and cancer
    Lorenza Gonzalez-Mariscal
    Center for Research and Advanced Studies CINVESTAV, Department of Physiology, Biophysics and Neuroscience, Ave Instituto Politecnico Nacional 2508, Mexico, DF 07360, Mexico
    Prog Histochem Cytochem 42:1-57. 2007
    ..Instead the implication of tight junctions (TJs) in this process is starting to be unraveled. The aim of this article is to review the role of TJ proteins in cell proliferation and cancer...
  6. doi request reprint ZO proteins and redox-dependent processes
    Lorenza Gonzalez-Mariscal
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico DF, Mexico
    Antioxid Redox Signal 15:1235-53. 2011
    ..ZO proteins are also present at the nucleus of proliferating cells...
  7. ncbi request reprint Crosstalk of tight junction components with signaling pathways
    Lorenza Gonzalez-Mariscal
    Center for Research and Advanced Studies CINVESTAV, Department of Physiology, Biophysics and Neuroscience, Ave Instituto Politecnico Nacional 2508, Mexico D F 07360, Mexico
    Biochim Biophys Acta 1778:729-56. 2008
    ..We also report how the phosphorylation of the main TJ components, claudins, occludin and ZO proteins, impacts epithelial and endothelial cell function...
  8. ncbi request reprint Inventions designed to enhance drug delivery across epithelial and endothelial cells through the paracellular pathway
    Lorenza Gonzalez-Mariscal
    Center of Research and Advanced Studies, Department of Physiology, Biophysics and Neuroscience, Ave IPN 2508, Mexico D F, 07360, Mexico
    Recent Pat Drug Deliv Formul 2:145-76. 2008
    ....
  9. ncbi request reprint Virus interaction with the apical junctional complex
    Lorenza Gonzalez-Mariscal
    Center for Research and Advanced Studies CINVESTAV, Department of Physiology, Biophysics and Neuroscience, Mexico D F, Mexico
    Front Biosci (Landmark Ed) 14:731-68. 2009
    ..Therefore targeting proteins of the AJC constitutes a strategy that might allow viruses to bypass the physical barrier that blocks their access to receptors expressed on the basolateral surface of epithelial cells...
  10. doi request reprint The tight junction protein ZO-2 blocks cell cycle progression and inhibits cyclin D1 expression
    Lorenza Gonzalez-Mariscal
    Department of Physiology, Center for Research and Advanced Studies CINVESTAV, Mexico City, Mexico
    Ann N Y Acad Sci 1165:121-5. 2009
    ..We have further found that ZO-2 transfection into epithelial MDCK cells triggers a diminished expression of CD1 protein and decreases the rate of cell proliferation in a wound-healing assay...
  11. ncbi request reprint Tight junction proteins ZO-1, ZO-2, and occludin along isolated renal tubules
    L Gonzalez-Mariscal
    Department of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies CINVESTAV, Mexico City, Mexico
    Kidney Int 57:2386-402. 2000
    ..The differential expression of three tight junction proteins, ZO-1, ZO-2, and occludin, along isolated rabbit renal tubules is examined in this article...
  12. ncbi request reprint Critical role of tight junctions in drug delivery across epithelial and endothelial cell layers
    L Gonzalez-Mariscal
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Ave Politécnico Nacional 2508, Mexico D F, 07360, Mexico
    J Membr Biol 207:55-68. 2005
    ....
  13. ncbi request reprint Tight junctions, from tight intercellular seals to sophisticated protein complexes involved in drug delivery, pathogens interaction and cell proliferation
    Lorenza Gonzalez-Mariscal
    Center for Research and Advanced Studies CINVESTAV, Department of Physiology, Biophysics and Neuroscience, Mexico D F, 07000, Mexico
    Adv Drug Deliv Rev 57:811-4. 2005
    ..This new knowledge has in turn given rise to novel strategies for enhancing the paracellular flux of poorly absorbed therapeutics...
  14. ncbi request reprint MAGUK proteins: structure and role in the tight junction
    L Gonzalez-Mariscal
    Department of Physiology, Biophysics and Neurosciences, Center of Research and Advanced Studies CINVESTAV, Ap Postal 14 740, Mexico DF, 07000, Mexico
    Semin Cell Dev Biol 11:315-24. 2000
    ..ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression...
  15. ncbi request reprint Tight junction proteins
    L Gonzalez-Mariscal
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Ave Politécnico Nacional 2508, Mexico DF, 07000, Mexico
    Prog Biophys Mol Biol 81:1-44. 2003
    ....
  16. pmc Phosphorylation of zona occludens-2 by protein kinase C epsilon regulates its nuclear exportation
    David Chamorro
    Departments of Physiology, Biophysics, and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico, D F, 07360, Mexico
    Mol Biol Cell 20:4120-9. 2009
    ..These results constitute novel information for understanding the mechanisms that regulate the intracellular fate of ZO-2...
  17. ncbi request reprint The tight junction protein ZO-2 associates with Jun, Fos and C/EBP transcription factors in epithelial cells
    Abigail Betanzos
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico DF, 07000, Mexico
    Exp Cell Res 292:51-66. 2004
    ....
  18. doi request reprint Identification of ZASP, a novel protein associated to Zona occludens-2
    Susana Lechuga
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico, DF 07360, Mexico
    Exp Cell Res 316:3124-39. 2010
    ..ZASP over-expression blocks the inhibitory activity of ZO-2 on cyclin D1 gene transcription and protein expression. The identification of ZASP helps to unfold the complex nuclear molecular arrays that form on ZO-2 scaffolds...
  19. pmc Zona occludens-2 inhibits cyclin D1 expression and cell proliferation and exhibits changes in localization along the cell cycle
    Rocio Tapia
    Department of Physiology, Biophysics, and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico, D F, 07360, Mexico
    Mol Biol Cell 20:1102-17. 2009
    ..These results thus explain why in confluent quiescent epithelia ZO-2 is absent from the nucleus and localizes at the cellular borders, whereas in sparse proliferating cultures ZO-2 is conspicuously present at the nucleus...
  20. pmc The intracellular fate of zonula occludens 2 is regulated by the phosphorylation of SR repeats and the phosphorylation/O-GlcNAcylation of S257
    Miguel Quirós
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico City 07000, México Department of Chemistry, Aristotele University of Thessaloniki, Thessaloniki 54621, Greece
    Mol Biol Cell 24:2528-43. 2013
    ..These results reveal novel posttranslational modifications of ZO-2 that regulate the intracellular fate of this protein. ..
  21. ncbi request reprint Characterization of the tight junction protein ZO-2 localized at the nucleus of epithelial cells
    Blanca Estela Jaramillo
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico D F, 07000, Mexico
    Exp Cell Res 297:247-58. 2004
    ..ZO-2 displays two putative NES. However, only the second one appears to be functional, as when conjugated to ovalbumin (OV), it is able to translocate this protein from the nucleus to the cytoplasm in a leptomycin B-sensitive way...
  22. ncbi request reprint The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells
    Porfirio Nava
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico DF 07000, Mexico
    J Cell Sci 117:5509-19. 2004
    ..VP8 given orally to diabetic rats allows the enteral administration of insulin, thus indicating that it can be employed to modulate epithelial permeability...
  23. ncbi request reprint Nuclear localization of the tight junction protein ZO-2 in epithelial cells
    Socorro Islas
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, D F, 07000, Mexico
    Exp Cell Res 274:138-48. 2002
    ..ZO-2 that shuttles from the cell periphery into the nucleus is not newly synthesized but originates from a preexistent pool. The movement of this protein is mediated by the actin cytoskeleton...
  24. ncbi request reprint ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architecture
    Sandra Hernandez
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico City, Mexico
    Exp Cell Res 313:1533-47. 2007
    ....
  25. ncbi request reprint The renal segmental distribution of claudins changes with development
    Jose Luis Reyes
    Center for Research and Advanced Studies CINVESTAV, Department of Physiology, Biophysics and Neurosciences, Mexico City, Mexico
    Kidney Int 62:476-87. 2002
    ..We studied the differential expression of occludin and several claudins in isolated renal tubules from newborn and adult rabbits...
  26. pmc Cyclin D1 is transcriptionally down-regulated by ZO-2 via an E box and the transcription factor c-Myc
    Miriam Huerta
    Departamentos de Genética y Biología Molecular and Fisiología, Biofisica y Neurociencias, Cinvestav Zacatenco, Mexico D F 07360, Mexico
    Mol Biol Cell 18:4826-36. 2007
    ..We conclude that ZO-2 down-regulates cyclin D1 transcription by interacting with the c-Myc/E box element and by recruiting HDAC1...
  27. doi request reprint CRTAM: A molecule involved in epithelial cell adhesion
    Erika Garay
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico City, Mexico
    J Cell Biochem 111:111-22. 2010
    ..Hence we conclude that CRTAM is a molecule involved in epithelial cell adhesion...
  28. ncbi request reprint Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia
    Samuel Liévano
    Gynecology and Obstetrics Hospital, La Raza Medical Center, Mexican Institute of Social Security IMSS, Mexico D F, Mexico
    Cell Tissue Res 324:433-48. 2006
    ..Since claudin 16 functions as a paracellular channel for Mg2+, its diffuse pattern in preeclamptic placentae suggests the altered paracellular transport of Mg2+ between the maternal blood and the placental tissue...
  29. ncbi request reprint Presence of claudins mRNA in the brain. Selective modulation of expression by kindling epilepsy
    Monica Lamas
    Departamento de Fisiologi a, Biofi sica y Nuerociencias, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico, Mexico
    Brain Res Mol Brain Res 104:250-4. 2002
    ..These results link for the first time the modulation of expression of a tight junction protein to abnormal neuronal synchronization that could probably be reflected in permeability changes of the blood-brain barrier or edema...
  30. doi request reprint Zona occludens-2 protects against podocyte dysfunction induced by ADR in mice
    Pablo Bautista-García
    Dept of Physiology, Biophysics, and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Mexico
    Am J Physiol Renal Physiol 304:F77-87. 2013
    ..These results suggest that ZO-2 could be a new target for the regulation of hyperactive Wnt/β-catenin signaling in proteinuric kidney diseases...
  31. pmc The cytokine response of U937-derived macrophages infected through antibody-dependent enhancement of dengue virus disrupts cell apical-junction complexes and increases vascular permeability
    Henry Puerta-Guardo
    Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies CINVESTAV, Mexico City, DF, Mexico
    J Virol 87:7486-501. 2013
    ....
  32. doi request reprint Papillomavirus E6 oncoprotein up-regulates occludin and ZO-2 expression in ovariectomized mice epidermis
    Jesús Hernández-Monge
    Department of Genetics and Molecular Biology, Center for Research and Advanced Studies CINVESTAV, Mexico City, Mexico
    Exp Cell Res 319:2588-603. 2013
    ..These results reinforce the view of 17β-estradiol and E6 as risk factors for the development of cancer through effects on expression and mislocalization of TJ proteins...
  33. ncbi request reprint Changes in the distribution of ZO-1, occludin, and claudins in the rat uterine epithelium during the estrous cycle
    C Adriana Mendoza-Rodríguez
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico UNAM, Mexico, DF 04510, Mexico
    Cell Tissue Res 319:315-30. 2005
    ....
  34. ncbi request reprint The tight junction proteins claudin-7 and -8 display a different subcellular localization at Henle's loops and collecting ducts of rabbit kidney
    Lorenza Gonzalez-Mariscal
    Department of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies, CINVESTAV, Ave Instituto Politecnico Nacional 2508, Mexico, DF 07360, Mexico
    Nephrol Dial Transplant 21:2391-8. 2006
    ..Here, we have analysed the distribution of claudins-7 and -8 in Henle's loops and collecting ducts isolated from rabbit kidneys...