Gerardo Gamba

Summary

Country: Mexico

Publications

  1. ncbi Analogy for explaining intermediate metabolism
    Gerardo Gamba
    Molecular Physiology Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Tlalpan 14000, Mexico City, Mexico
    Adv Physiol Educ 27:156-7. 2003
  2. ncbi [Genomic medicine and the physiopathology of arterial hypertension]
    Gerardo Gamba
    Unidad de Fisiología Molecular, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico
    Rev Invest Clin 54:68-76. 2002
  3. pmc Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSR
    Gerardo Gamba
    Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    Pflugers Arch 458:61-76. 2009
  4. pmc WNK kinases, renal ion transport and hypertension
    Pedro San-Cristobal
    Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Am J Nephrol 28:860-70. 2008
  5. pmc Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway
    Pedro San-Cristobal
    Molecular Physiology Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Universidad Nacional Autonoma de Mexico, Tlalpan 14000 Mexico City, Mexico
    Proc Natl Acad Sci U S A 106:4384-9. 2009
  6. pmc WNK lies upstream of kinases involved in regulation of ion transporters
    Gerardo Gamba
    Molecular Physiology Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Universidad Nacional Autonoma de Mexico, Tlalpan 14000, Mexico City, Mexico
    Biochem J 391:e1-3. 2005
  7. ncbi Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension
    Gerardo Gamba
    Molecular Physiology Unit, Instituto de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No 15, Tlalpan 14000, Mexico City, Mexico
    Am J Physiol Renal Physiol 288:F245-52. 2005
  8. doi A novel protein kinase signaling pathway essential for blood pressure regulation in humans
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Endocrinol Metab 19:91-5. 2008
  9. pmc Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4
    Frederick H Wilson
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:680-4. 2003
  10. ncbi TRPV4: a new target for the hypertension-related kinases WNK1 and WNK4
    Gerardo Gamba
    Am J Physiol Renal Physiol 290:F1303-4. 2006

Collaborators

  • Ciaran Richardson
  • Pedro San-Cristobal
  • Kristopher T Kahle
  • Steven C Hebert
  • Richard P Lifton
  • Frederick H Wilson
  • Divya Chari
  • Qiang Leng
  • Diana Pacheco-Alvarez
  • Aaron M Ring
  • Norma A Bobadilla
  • Norma Vazquez
  • Fatema H Rafiqi
  • Dario R Alessi
  • Jesse Rinehart
  • Jose Ponce-Coria
  • Paola de los Heros
  • Erika Moreno
  • Gerhard Giebisch
  • Ernesto Sabath
  • Robert S Hoover
  • Alicia K Rapson
  • Maria D Lalioti

Detail Information

Publications10

  1. ncbi Analogy for explaining intermediate metabolism
    Gerardo Gamba
    Molecular Physiology Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Tlalpan 14000, Mexico City, Mexico
    Adv Physiol Educ 27:156-7. 2003
  2. ncbi [Genomic medicine and the physiopathology of arterial hypertension]
    Gerardo Gamba
    Unidad de Fisiología Molecular, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico
    Rev Invest Clin 54:68-76. 2002
  3. pmc Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSR
    Gerardo Gamba
    Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    Pflugers Arch 458:61-76. 2009
    ..The present review discusses these functions and their genetic and molecular regulation...
  4. pmc WNK kinases, renal ion transport and hypertension
    Pedro San-Cristobal
    Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Am J Nephrol 28:860-70. 2008
    ..Observations discussed in the present work place WNK1 and WNK4 as genes involved in the genesis of essential hypertension and as potential targets for the development of antihypertensive drugs...
  5. pmc Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway
    Pedro San-Cristobal
    Molecular Physiology Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Universidad Nacional Autonoma de Mexico, Tlalpan 14000 Mexico City, Mexico
    Proc Natl Acad Sci U S A 106:4384-9. 2009
    ..These findings place WNK4 in the signaling pathway between AngII and NCC, and provide a mechanism by which hypovolemia maximizes renal salt reabsoprtion without concomitantly increasing K(+) secretion...
  6. pmc WNK lies upstream of kinases involved in regulation of ion transporters
    Gerardo Gamba
    Molecular Physiology Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Universidad Nacional Autonoma de Mexico, Tlalpan 14000, Mexico City, Mexico
    Biochem J 391:e1-3. 2005
    ..The phosphorylation site involved in SPAK or OSR1 activation is identified as a threonine residue within the T-loop...
  7. ncbi Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension
    Gerardo Gamba
    Molecular Physiology Unit, Instituto de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No 15, Tlalpan 14000, Mexico City, Mexico
    Am J Physiol Renal Physiol 288:F245-52. 2005
    ..These dual effects of WNK4 mutations fit with proposed mechanisms for developing electrolyte abnormalities and hypertension in PHA-II and point to WNK4 as a multifunctional regulator of diverse ion transporters...
  8. doi A novel protein kinase signaling pathway essential for blood pressure regulation in humans
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Endocrinol Metab 19:91-5. 2008
    ..The current evidence supports a model in which WNK4 coordinates the activities of diverse aldosterone-sensitive mediators of ion transport in the distal nephron to promote normal homeostasis in response to physiological perturbation...
  9. pmc Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4
    Frederick H Wilson
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:680-4. 2003
    ..Together, these findings demonstrate that WNK4 negatively regulates surface expression of NCCT and implicate loss of this regulation in the molecular pathogenesis of an inherited form of hypertension...
  10. ncbi TRPV4: a new target for the hypertension-related kinases WNK1 and WNK4
    Gerardo Gamba
    Am J Physiol Renal Physiol 290:F1303-4. 2006

Research Grants5

  1. Molecular Physiology of the renal Na-Cl cotransporter
    Gerardo Gamba; Fiscal Year: 2004
    ....
  2. Molecular Physiology of the renal Na-Cl cotransporter
    Gerardo Gamba; Fiscal Year: 2005
    ....
  3. Molecular Physiology of the renal Na-Cl cotransporter
    Gerardo Gamba; Fiscal Year: 2006
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  4. Molecular Physiology of the renal Na-Cl cotransporter
    Gerardo Gamba; Fiscal Year: 2007
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  5. Molecular Physiology of the renal Na-Cl cotransporter
    Gerardo Gamba; Fiscal Year: 2008
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