- Analogy for explaining intermediate metabolismGerardo Gamba
Molecular Physiology Unit, , , , Tlalpan 14000, Mexico City, Mexico
Adv Physiol Educ 27:156-7. 2003
- [Genomic medicine and the physiopathology of arterial hypertension]Gerardo Gamba
, , ,
Rev Invest Clin 54:68-76. 2002
- Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSRGerardo Gamba
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Pflugers Arch 458:61-76. 2009..The present review discusses these functions and their genetic and molecular regulation...
- WNK kinases, renal ion transport and hypertensionPedro San-Cristobal
Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Am J Nephrol 28:860-70. 2008..Observations discussed in the present work place WNK1 and WNK4 as genes involved in the genesis of essential hypertension and as potential targets for the development of antihypertensive drugs...
- Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathwayPedro San-Cristobal
Molecular Physiology Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Universidad Nacional Autonoma de Mexico, Tlalpan 14000 Mexico City, Mexico
Proc Natl Acad Sci U S A 106:4384-9. 2009..These findings place WNK4 in the signaling pathway between AngII and NCC, and provide a mechanism by which hypovolemia maximizes renal salt reabsoprtion without concomitantly increasing K(+) secretion...
- WNK lies upstream of kinases involved in regulation of ion transportersGerardo Gamba
Molecular Physiology Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Universidad Nacional Autonoma de Mexico, Tlalpan 14000, Mexico City, Mexico
Biochem J 391:e1-3. 2005..The phosphorylation site involved in SPAK or OSR1 activation is identified as a threonine residue within the T-loop...
- Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertensionGerardo Gamba
Molecular Physiology Unit, Instituto de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No 15, Tlalpan 14000, Mexico City, Mexico
Am J Physiol Renal Physiol 288:F245-52. 2005..These dual effects of WNK4 mutations fit with proposed mechanisms for developing electrolyte abnormalities and hypertension in PHA-II and point to WNK4 as a multifunctional regulator of diverse ion transporters...
- A novel protein kinase signaling pathway essential for blood pressure regulation in humansKristopher T Kahle
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Trends Endocrinol Metab 19:91-5. 2008..The current evidence supports a model in which WNK4 coordinates the activities of diverse aldosterone-sensitive mediators of ion transport in the distal nephron to promote normal homeostasis in response to physiological perturbation...
- Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4Frederick H Wilson
Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 100:680-4. 2003..Together, these findings demonstrate that WNK4 negatively regulates surface expression of NCCT and implicate loss of this regulation in the molecular pathogenesis of an inherited form of hypertension...
- TRPV4: a new target for the hypertension-related kinases WNK1 and WNK4Gerardo Gamba
Am J Physiol Renal Physiol 290:F1303-4. 2006
- Molecular Physiology of the renal Na-Cl cotransporterGerardo Gamba; Fiscal Year: 2007....