Agnes Fleury

Summary

Country: Mexico

Publications

  1. ncbi Neurocysticercosis is still prevalent in Mexico
    Agnes Fleury
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, DF, Mexico
    Salud Publica Mex 54:632-6. 2012
  2. pmc Neurocysticercosis: HP10 antigen detection is useful for the follow-up of the severe patients
    Agnes Fleury
    Unidad Periférica, Instituto de Investigaciones Biomedicas, UNAM Instituto Nacional de Neurología y Neurocirugía, Colonia La Fama, Delegacion Tlalpan, Mexico DF, Mexico
    PLoS Negl Trop Dis 7:e2096. 2013
  3. pmc Detection of HP10 antigen in serum for diagnosis and follow-up of subarachnoidal and intraventricular human neurocysticercosis
    A Fleury
    Instituto Nacional de Neurologia y Neurocirugia, Insurgentes Sur 3877, Col La Fama, CP 14269, Mexico, DF Mexico
    J Neurol Neurosurg Psychiatry 78:970-4. 2007
  4. ncbi Application of synthetic peptides to the diagnosis of neurocysticercosis
    Agnes Fleury
    Instituto Nacional de Neurologia y Neurocirugia, Mexico, DF Mexico
    Trop Med Int Health 8:1124-30. 2003
  5. ncbi Symptomatic human neurocysticercosis--age, sex and exposure factors relating with disease heterogeneity
    Agnes Fleury
    Instituto Nacional de Neurologia y Neurocirugia, Insurgentes Sur 3877, Col La Fama, 14269, Mexico, D F
    J Neurol 251:830-7. 2004
  6. doi Subarachnoid basal neurocysticercosis: a focus on the most severe form of the disease
    Agnes Fleury
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico UNAM, Mexico City, Mexico
    Expert Rev Anti Infect Ther 9:123-33. 2011
  7. pmc Neurocysticercosis, a persisting health problem in Mexico
    Agnes Fleury
    Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico
    PLoS Negl Trop Dis 4:e805. 2010
  8. doi Clinical heterogeneity of human neurocysticercosis results from complex interactions among parasite, host and environmental factors
    Agnes Fleury
    Instituto Nacional de Neurologia y Neurocirugia, SSA, Laboratorio de Investigaciones Clínicas, Insurgentes Sur 3877, Col La Fama, Mexico, DF 14269, Mexico
    Trans R Soc Trop Med Hyg 104:243-50. 2010
  9. ncbi Subarachnoidal and intraventricular human neurocysticercosis: application of an antigen detection assay for the diagnosis and follow-up
    Raul J Bobes
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D F, Mexico
    Trop Med Int Health 11:943-50. 2006
  10. doi Development of the S3Pvac vaccine against porcine Taenia solium cysticercosis: a historical review
    Edda Sciutto
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    J Parasitol 99:686-92. 2013

Collaborators

Detail Information

Publications43

  1. ncbi Neurocysticercosis is still prevalent in Mexico
    Agnes Fleury
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, DF, Mexico
    Salud Publica Mex 54:632-6. 2012
    ..Whereas efficient tools have been developed for the diagnosis and prevention of cysticercosis, we strongly recommend further measures allowing the control and eventual eradication of this parasite in Mexico...
  2. pmc Neurocysticercosis: HP10 antigen detection is useful for the follow-up of the severe patients
    Agnes Fleury
    Unidad Periférica, Instituto de Investigaciones Biomedicas, UNAM Instituto Nacional de Neurología y Neurocirugía, Colonia La Fama, Delegacion Tlalpan, Mexico DF, Mexico
    PLoS Negl Trop Dis 7:e2096. 2013
    ..Assay performance was compared with that of Magnetic Resonance Imaging (MRI). In addition, the robustness of the HP10 Ag-ELISA was evaluated independently at two different institutions...
  3. pmc Detection of HP10 antigen in serum for diagnosis and follow-up of subarachnoidal and intraventricular human neurocysticercosis
    A Fleury
    Instituto Nacional de Neurologia y Neurocirugia, Insurgentes Sur 3877, Col La Fama, CP 14269, Mexico, DF Mexico
    J Neurol Neurosurg Psychiatry 78:970-4. 2007
    ..Detection of the secreted metacestode antigen HP10 in cerebrospinal fluid is a sensitive and specific method for the diagnosis of these severe NC cases...
  4. ncbi Application of synthetic peptides to the diagnosis of neurocysticercosis
    Agnes Fleury
    Instituto Nacional de Neurologia y Neurocirugia, Mexico, DF Mexico
    Trop Med Int Health 8:1124-30. 2003
    ..Examining the results of the individual peptide assays in combination, in some instances, improved the sensitivity to 100%...
  5. ncbi Symptomatic human neurocysticercosis--age, sex and exposure factors relating with disease heterogeneity
    Agnes Fleury
    Instituto Nacional de Neurologia y Neurocirugia, Insurgentes Sur 3877, Col La Fama, 14269, Mexico, D F
    J Neurol 251:830-7. 2004
    ..To evaluate the relevance of exposure and host biological factors in the heterogeneity of the clinical, radiological and inflammatory picture of neurocysticercosis (NCC)...
  6. doi Subarachnoid basal neurocysticercosis: a focus on the most severe form of the disease
    Agnes Fleury
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico UNAM, Mexico City, Mexico
    Expert Rev Anti Infect Ther 9:123-33. 2011
    ..We provide a critical review of the central epidemiological, clinical, diagnostic and therapeutic features of this particular form of the disease, which is still associated with unacceptably high rates of morbidity and mortality...
  7. pmc Neurocysticercosis, a persisting health problem in Mexico
    Agnes Fleury
    Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico
    PLoS Negl Trop Dis 4:e805. 2010
    ..The ongoing epidemiological transition in Mexico minimizes the relative impact of neurocysticercosis (NC) on public health. However, hard data on the disease frequency are not available...
  8. doi Clinical heterogeneity of human neurocysticercosis results from complex interactions among parasite, host and environmental factors
    Agnes Fleury
    Instituto Nacional de Neurologia y Neurocirugia, SSA, Laboratorio de Investigaciones Clínicas, Insurgentes Sur 3877, Col La Fama, Mexico, DF 14269, Mexico
    Trans R Soc Trop Med Hyg 104:243-50. 2010
    ..Devising new medical interventions through the use of molecular regulators of the innate and adaptive immune responses of the host is a largely unexplored approach that could improve the existing forms of treatment...
  9. ncbi Subarachnoidal and intraventricular human neurocysticercosis: application of an antigen detection assay for the diagnosis and follow-up
    Raul J Bobes
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D F, Mexico
    Trop Med Int Health 11:943-50. 2006
    ..Among various immunological tests, the detection of HP10 antigen in cerebral spinal fluid (CSF) has proved to be a useful tool for the diagnosis of NC in the case of viable but not dead parasites...
  10. doi Development of the S3Pvac vaccine against porcine Taenia solium cysticercosis: a historical review
    Edda Sciutto
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    J Parasitol 99:686-92. 2013
    ..The data also support the validity of T. crassiceps murine cysticercosis as an effective tool to identify vaccine candidates against some metacestode infections...
  11. doi Inexpensive anti-cysticercosis vaccine: S3Pvac expressed in heat inactivated M13 filamentous phage proves effective against naturally acquired Taenia solium porcine cysticercosis
    Julio Morales
    Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Mexico, D F 04510, Mexico
    Vaccine 26:2899-905. 2008
    ..Vaccination reduced 70% the frequency of tongue cysticercosis and, based on necropsy, 54% of muscle-cysticercosis and by 87% the number of cysticerci...
  12. pmc Spatial distribution of Taenia solium porcine cysticercosis within a rural area of Mexico
    Julio Morales
    Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico
    PLoS Negl Trop Dis 2:e284. 2008
    ..Extensive geographic dispersal of the risk of cysticercosis makes it imperative that control measures be applied indiscriminately to all pigs and humans living in this endemic area...
  13. doi Recombinant S3Pvac-phage anticysticercosis vaccine: Simultaneous protection against cysticercosis and hydatid disease in rural pigs
    Julio Morales
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, Mexico
    Vet Parasitol 176:53-8. 2011
    ..Thus, the costs of two different vaccination programs would be reduced to a single one with significant reduction in both zoonoses...
  14. ncbi Population genetic structure of Taenia solium from Madagascar and Mexico: implications for clinical profile diversity and immunological technology
    Rodrigo Vega
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Circuito Interior S N, Ciudad Universitaria, Mexico DF 04510, Mexico
    Int J Parasitol 33:1479-85. 2003
    ..It may also explain difficulties in the development of vaccines and tools for immunodiagnosis...
  15. ncbi TH2 profile in asymptomatic Taenia solium human neurocysticercosis
    Anahi Chavarria
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, UNAM, AP70228, Mexico D F 04510, Mexico
    Microbes Infect 5:1109-15. 2003
    ..This is the first study reporting the immunological profile associated with the asymptomatic form of NC...
  16. doi Development of the S3Pvac vaccine against murine Taenia crassiceps cysticercosis: a historical review
    Edda Sciutto
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    J Parasitol 99:693-702. 2013
    ..Statistical analyses of the data lead confidently to the strong inference that S3Pvac is indeed an effective vaccine against EIMTcC via specific and non-specific mechanisms of protection...
  17. doi Human neurocysticercosis: in vivo expansion of peripheral regulatory T cells and their recruitment in the central nervous system
    Laura Adalid-Peralta
    Instituto Nacional de Neurologia y Neurocirugia, Insurgentes Sur 3877, Col La Fama, Mexico DF, Mexico
    J Parasitol 98:142-8. 2012
    ..A positive significant correlation between peripheral and local Tregs was observed. Here, we report for the first time data that support the possible contribution of local and systemic Tregs in limiting neuroinflammation in NC...
  18. pmc Cysticerci drive dendritic cells to promote in vitro and in vivo Tregs differentiation
    Laura Adalid-Peralta
    Instituto Nacional de Neurologia y Neurocirugia, Insurgentes Sur 3877, Col La Fama, 14269 Mexico, DF, Mexico
    Clin Dev Immunol 2013:981468. 2013
    ..Our findings suggest that cysticerci may modulate DC to favor a suppressive environment, which may help parasite establishment, minimizing the excessive inflammation, which may lead to tissue damage...
  19. ncbi A depressed peripheral cellular immune response is related to symptomatic neurocysticercosis
    Anahi Chavarria
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, UNAM, AP70228, Mexico D F 04510, Mexico
    Microbes Infect 8:1082-9. 2006
    ..This evidence supports the existence of two clear different immune profiles according to neurocysticercosis that is asymptomatic or symptomatic...
  20. doi Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters
    Graciela Cárdenas
    Instituto Nacional de Neurologia y Neurocirugia, Mexico DF, Mexico
    Int J Parasitol 42:171-6. 2012
    ..These results provide a stimulating background to analyse the repercussions of these changes on the course of the disease and on patient reproductive health...
  21. pmc Subarachnoidal Neurocysticercosis non-responsive to cysticidal drugs: a case series
    Graciela Cárdenas
    Instituto Nacional de Neurologia y Neurocirugia, Mexico DF, Mexico
    BMC Neurol 10:16. 2010
    ..Cysticidal drugs, albendazole and praziquantel, are generally effective when parasites localize in the parenchyma. In contrast, parasites lodged in the subarachnoid basal cisterns are less responsive to treatment...
  22. doi Human neurocysticercosis: immunological features involved in the host's susceptibility to become infected and to develop disease
    Edda Sciutto
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, DF 04510, Mexico
    Microbes Infect 15:524-30. 2013
    ..Herein, the immunological and endocrinological features involved in resistance to infection and severe forms of the disease are reviewed, and their clinical relevance is discussed...
  23. ncbi Relationship between the clinical heterogeneity of neurocysticercosis and the immune-inflammatory profiles
    Anahi Chavarria
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, UNAM, AP70228, Mexico D F 04510, Mexico
    Clin Immunol 116:271-8. 2005
    ..These results constitute an integrative insight to understand the immune-inflammatory response that underlies symptomatic neurocysticercosis...
  24. doi Neurocysticercosis: local and systemic immune-inflammatory features related to severity
    Brenda Saenz
    Unidad Periférica del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Med Microbiol Immunol 201:73-80. 2012
    ..These results provide evidences to support the systemic proliferative response as a biomarker to monitor the level of neuroinflammation, of possible value in the patients' follow-up during treatment...
  25. ncbi Neurocysticercosis: clinical, radiologic, and inflammatory differences between children and adults
    Brenda Saenz
    Instituto de Investigaciones Biomedicas, UNAM, Mexico, DF, Mexico
    Pediatr Infect Dis J 25:801-3. 2006
    ..NC is clinically heterogeneous, ranging from asymptomatic infection to severely incapacitating and even fatal presentations. Although NC affects adults and children, age-related factors have not been thoroughly studied...
  26. ncbi Improvement of the synthetic tri-peptide vaccine (S3Pvac) against porcine Taenia solium cysticercosis in search of a more effective, inexpensive and manageable vaccine
    Edda Sciutto
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, D F 04510, Mexico
    Vaccine 25:1368-78. 2007
    ..This review highlights the development of several versions of S3Pvac aimed to increase effectiveness, reduce costs and increase feasibility by novel delivery systems and alternative routes of administration...
  27. ncbi Subarachnoid hemorrhage in neurocysticercosis: a direct or serendipitous association?
    Graciela Cárdenas
    Departamento de Neuroinfectología, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico DF, Mexico
    Neurologist 18:324-8. 2012
    ..Alterations of inflammatory cytokines in cerebrospinal fluid and sera correlate with vasospasm in SAH; these inflammatory mediators in NC may induce aneurysm formation...
  28. ncbi Impact of naturally acquired Taenia solium cysticercosis on the hormonal levels of free ranging boars
    N Pena
    Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Mexico, DF, Mexico
    Vet Parasitol 149:134-7. 2007
    ..Results suggest that T. solium cysticercosis significantly affects the hormonal status of its porcine host independently of their antibody response...
  29. ncbi Evolution, molecular epidemiology and perspectives on the research of taeniid parasites with special emphasis on Taenia solium
    Raul J Bobes
    Dept of Immunology, Institute for Biomedical Research, Universidad Nacional Autonoma de Mexico, 04510 Mexico D F, Mexico
    Infect Genet Evol 23:150-60. 2014
    ..The need to revise the current control and management strategies for this tropical neglected disease. ..
  30. pmc Genetic variation in the Cytb gene of human cerebral Taenia solium cysticerci recovered from clinically and radiologically heterogeneous patients with neurocysticercosis
    Héctor Palafox-Fonseca
    Universidad Nacional Autonoma de Mexico, Instituto de Investigaciones Biomedicas, MéxicoDF, Mexico
    Mem Inst Oswaldo Cruz 108:914-20. 2013
    ..Overall, this study establishes the presence of genetic differences in the Cytb gene of T. solium isolated from human cysticerci and suggests that parasite variation could contribute to NC heterogeneity. ..
  31. ncbi Taenia solium disease in humans and pigs: an ancient parasitosis disease rooted in developing countries and emerging as a major health problem of global dimensions
    E Sciutto
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, UNAM, AP70228, D F 04510, Mexico
    Microbes Infect 2:1875-90. 2000
    ..Our opinions on the most urgent needs for further research are also presented...
  32. ncbi The immune response in Taenia solium cysticercosis: protection and injury
    E Sciutto
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, UNAM, Mexico DF, Mexico
    Parasite Immunol 29:621-36. 2007
    ....
  33. ncbi Further evaluation of the synthetic peptide vaccine S3Pvac against Taenia solium cysticercosis in pigs in an endemic town of Mexico
    E Sciutto
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, AP 70228, Ciudad Universitaria, 04510 Mexico, DF Mexico
    Parasitology 134:129-33. 2007
    ..Thus, this investigation shows the limited usefulness of single vaccination as the sole means of interrupting Taenia solium transmission in an endemic region...
  34. ncbi Taenia solium: the complex interactions, of biological, social, geographical and commercial factors, involved in the transmission dynamics of pig cysticercosis in highly endemic areas
    J Morales
    Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, A P 70228, Mexico, Distrito Federal 04510, Mexico
    Ann Trop Med Parasitol 100:123-35. 2006
    ..The road transport of pigs needs to be better regulated, and the vaccination and genetic improvement of the rural pigs, and delaying the castration of the boars, should all be considered...
  35. pmc Severe cysticercal meningitis: clinical and imaging characteristics
    Graciela Cárdenas
    Department of Neuropsychopharmacology, Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico
    Am J Trop Med Hyg 82:121-5. 2010
    ..It is likely that SCM often goes unrecognized. Its correct identification may reduce morbidity and risks of unnecessary surgery in patients with chronic NC and CSF shunts...
  36. doi Neurocysticercosis: detection of Taenia solium DNA in human cerebrospinal fluid using a semi-nested PCR based on HDP2
    M Hernandez
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, DF, Mexico
    Ann Trop Med Parasitol 102:317-23. 2008
    ..The 36 patients known to have neurological problems other than NC were found PCR-negative. The HDP2 PCR offers a new tool in the diagnosis of NC and in exploring the pathogenesis of this serious disease...
  37. doi Human and porcine neurocysticercosis: differences in the distribution and developmental stages of cysticerci
    B Saenz
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Trop Med Int Health 13:697-702. 2008
    ..To describe and compare the clinical impacts of neurocysticercosis (NC) caused by Taenia solium in humans and pigs...
  38. ncbi Medical treatment for neurocysticercosis: drugs, indications and perspectives
    Helgi Jung
    Instituto Nacional de Neurología y Neurocirugía Laboratorio de Investigaciones Clínicas, Insurgentes Sur 3877, CP 14269, Mexico DF, Mexico
    Curr Top Med Chem 8:424-33. 2008
    ..This article revises and discusses the pharmacological aspects of cysticidal treatment and summarizes current indications for the different types of the disease...
  39. ncbi Detection of secreted cysticercal antigen: a useful tool in the diagnosis of inflammatory neurocysticercosis
    A Fleury
    Instituto Nacional de Neurologia y Neurocirugia, Mexico DF, Mexico
    Trans R Soc Trop Med Hyg 97:542-6. 2003
    ..Thus, antigen detection may be of particular value in the assessment of symptomatic patients, who may potentially benefit from rapid treatment...
  40. doi Human neurocysticercosis: rightward hemisphere asymmetry in the cerebral distribution of a single cysticercus
    R Romero
    Instituto Nacional de Neurologia y Neurocirugia, Del Tlalpan, CP 14269, DF, Mexico
    J Parasitol 93:1238-40. 2007
    ..Factors related with the differences in the inflammatory response and in the regional cerebral blood flow between genders could be involved...
  41. ncbi An epidemiological study of familial neurocysticercosis in an endemic Mexican community
    A Fleury
    Instituto Nacional de Neurologia y Neurocirugia, Insurgentes Sur 3877, Col La Fama, Delegacion Tlalpan, 14269 Mexico, DF, Mexico
    Trans R Soc Trop Med Hyg 100:551-8. 2006
    ..Rather, our results point to a complex interaction of genetic and environmental factors involved in NC...
  42. ncbi Preferential growth of Taenia crassiceps cysticerci in female mice holds across several laboratory mice strains and parasite lines
    G Fragoso
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, A P 70228, Mexico, D F, C P 04510, Mexico
    J Parasitol 94:551-3. 2008
    ....