René Drucker-Colín

Summary

Country: Mexico

Publications

  1. pmc Narcolepsy and orexins: an example of progress in sleep research
    Alberto K De la Herrán-Arita
    Departamento de Neuropatología Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México México D F, Mexico
    Front Neurol 2:26. 2011
  2. pmc Cellular viability effects of fatty acid amide hydrolase inhibition on cerebellar neurons
    Kathia Lueneberg
    Department of Neurology, Philipps University, D 35033 Marburg, Germany
    Int Arch Med 4:28. 2011
  3. ncbi Transplant of cultured neuron-like differentiated chromaffin cells in a Parkinson's disease patient. A preliminary report
    R Drucker-Colin
    Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico UNAM, Mexico, D F
    Arch Med Res 30:33-9. 1999
  4. ncbi Cell transplantation for Parkinson's disease: present status
    René Drucker-Colín
    Depto de Neurociencias, Instituto de Fisiologia Celular, UNAM, Mexico, DF
    Cell Mol Neurobiol 24:301-16. 2004
  5. ncbi Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats
    Eric Murillo-Rodriguez
    Depto de Neurociencias, Instituto de Fisiologia Celular, Ciudad Universitaria, Circuito Interior, Universidad Nacional Autonoma de Mexico, Mexico DF, CP 04510, Mexico
    FEBS Lett 580:4337-45. 2006
  6. ncbi Is nicotine protective against Parkinson's disease? An experimental analysis
    José Rubén García-Montes
    Departamento de Neuropatología Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, D F, Mexico
    CNS Neurol Disord Drug Targets 11:897-906. 2012
  7. ncbi Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats
    Eric Murillo-Rodriguez
    Depto de Neurociencias, Instituto de Fisiologia Celular, Ciudad Universitaria, Circuito Interior, Universidad Nacional Autonoma de Mexico, C P 04510, Mexico D F, Mexico
    Behav Brain Res 176:353-7. 2007
  8. doi Dynamics of the Parkinsonian striatal microcircuit: entrainment into a dominant network state
    Omar Jáidar
    Instituto de Fisiologia Celular, Division de Neurociencias, Universidad Nacional Autonoma de Mexico, Mexico City, DF CP 04510 México
    J Neurosci 30:11326-36. 2010
  9. ncbi Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats
    Carmen Frías-Dominguez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, 04510 Mexico DF, Mexico
    Brain Res Bull 98:10-22. 2013
  10. ncbi Neuronal precursors within the adult rat subventricular zone differentiate into dopaminergic neurons after substantia nigra lesion and chromaffin cell transplant
    Oscar Arias-Carrión
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    J Neurosci Res 84:1425-37. 2006

Collaborators

  • Eric Murillo-Rodriguez
  • O Prospero-Garcia
  • Robyn Hudson
  • Limei Zhang
  • Juan Fernandez-Ruiz
  • Arturo Hernandez
  • Cynthia Hall-Haro
  • Fabio Garcia-Garcia
  • Dolores Martinez-Gonzalez
  • G J Wang
  • Jorge L Armony
  • Oscar Arias-Carrión
  • R Mechoulam
  • Mónica Ambriz-Tututi
  • Jose Bargas
  • Alberto K De la Herrán-Arita
  • Roman Vidaltamayo
  • Elvira Galarraga
  • Eduardo Blanco-Hernández
  • Pablo Valle-Leija
  • Luis Carrillo-Reid
  • Stefan Mihailescu
  • Carmen Frías-Dominguez
  • Marco Guarneros
  • Bianca J Vizcarra-Chacón
  • Marcel Pérez-Morales
  • José Rubén García-Montes
  • Violeta Sánchez-González
  • Magdalena Guerra-Crespo
  • Gabriel Gutiérrez-Ospina
  • Kathia Lueneberg
  • Marcela Palomero-Rivero
  • Nadia González-García
  • G Aleph Prieto
  • Dagoberto Tapia
  • Omar Jáidar
  • Arturo Hernandez-Cruz
  • Patricia Vieyra-Reyes
  • Ana Moreno-Coutiño
  • Tatiana Olivares-Bañuelos
  • Reyes Haro
  • Aleph A Corona-Morales
  • Mireya Alcaraz-Zubeldia
  • Maria B Pérez-Ramírez
  • Alejandra E Ruiz-Contreras
  • Nahum Ortiz-Romo
  • Julieta Garduño
  • Salvador Hernandez
  • Mónica Méndez-Díaz
  • Mario A Arias-García
  • Edén Flores-Barrera
  • Fernanda Monjaraz-Fuentes
  • Ana María López-Colomé
  • Alejandra Boronat-García
  • Viviana Zomosa-Signoret
  • Marco A Alegría
  • Guadalupe Dominguez
  • David Trejo
  • Julio Moran
  • Julian Soto
  • Diana Millán-Aldaco
  • Azucena Perez-Burgos
  • Luis Covarrubias
  • Yann S Mineur
  • Isaac Tunez
  • Fatuel Tecuapetla
  • Marina R Picciotto
  • Carmen Calderón-Ezquerro
  • Alicia Gonzalez
  • Luz Navarro
  • Andrés Castell
  • Alfonso Escobar
  • María del Carmen Frías Domínguez
  • Ruben Guzman-Marin

Detail Information

Publications37

  1. pmc Narcolepsy and orexins: an example of progress in sleep research
    Alberto K De la Herrán-Arita
    Departamento de Neuropatología Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México México D F, Mexico
    Front Neurol 2:26. 2011
    ..Through an evaluation of the scientific literature we traced an updated picture of narcolepsy and orexins in order to provide insight into the means by which neurobiological knowledge is constructed...
  2. pmc Cellular viability effects of fatty acid amide hydrolase inhibition on cerebellar neurons
    Kathia Lueneberg
    Department of Neurology, Philipps University, D 35033 Marburg, Germany
    Int Arch Med 4:28. 2011
    ..In addition, if cultured with OEA (25 nM) or PEA (100 nM), cellular death was found. These results further suggest that URB597, OEA or PEA promote cellular death...
  3. ncbi Transplant of cultured neuron-like differentiated chromaffin cells in a Parkinson's disease patient. A preliminary report
    R Drucker-Colin
    Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico UNAM, Mexico, D F
    Arch Med Res 30:33-9. 1999
    ..However, the difficulties inherent in using the patient's own adrenal gland, or the difficulty in obtaining human fetal tissue, has generated the need to find alternative methods...
  4. ncbi Cell transplantation for Parkinson's disease: present status
    René Drucker-Colín
    Depto de Neurociencias, Instituto de Fisiologia Celular, UNAM, Mexico, DF
    Cell Mol Neurobiol 24:301-16. 2004
    ..In spite of new molecular techniques and some 20 years of experience, the transplantation therapy for PD has today the same problems and results as the first reports which used neural fetal tissue or adrenal grafts...
  5. ncbi Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats
    Eric Murillo-Rodriguez
    Depto de Neurociencias, Instituto de Fisiologia Celular, Ciudad Universitaria, Circuito Interior, Universidad Nacional Autonoma de Mexico, Mexico DF, CP 04510, Mexico
    FEBS Lett 580:4337-45. 2006
    ..Also, CBD increases DA levels as measured by microdialysis and HPLC procedures. Since CBD induces alertness, it might be of therapeutic value in sleep disorders such as excessive somnolence...
  6. ncbi Is nicotine protective against Parkinson's disease? An experimental analysis
    José Rubén García-Montes
    Departamento de Neuropatología Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, D F, Mexico
    CNS Neurol Disord Drug Targets 11:897-906. 2012
    ..Our results show that chronic nicotine does not specifically protect against degeneration, but rather modifies DA receptor dynamics, suggesting that it could be used as a therapeutic element in PD pathology...
  7. ncbi Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats
    Eric Murillo-Rodriguez
    Depto de Neurociencias, Instituto de Fisiologia Celular, Ciudad Universitaria, Circuito Interior, Universidad Nacional Autonoma de Mexico, C P 04510, Mexico D F, Mexico
    Behav Brain Res 176:353-7. 2007
    ..We conclude that MOD enhances the extracellular levels of DA, promotes W and its effects on sleep are partially blocked by ANA...
  8. doi Dynamics of the Parkinsonian striatal microcircuit: entrainment into a dominant network state
    Omar Jáidar
    Instituto de Fisiologia Celular, Division de Neurociencias, Universidad Nacional Autonoma de Mexico, Mexico City, DF CP 04510 México
    J Neurosci 30:11326-36. 2010
    ..Abnormal synchronization and "locking" into a dominant state may represent the basic neuronal mechanism that underlies movement disorders at the microcircuit level...
  9. ncbi Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats
    Carmen Frías-Dominguez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, 04510 Mexico DF, Mexico
    Brain Res Bull 98:10-22. 2013
    ..These data indicate that, in the experimental model of adrenalectomised rats implanted with corticosterone pellets, nicotine increases the function of 5-HT1A receptors of 5-HT DRN neurons. ..
  10. ncbi Neuronal precursors within the adult rat subventricular zone differentiate into dopaminergic neurons after substantia nigra lesion and chromaffin cell transplant
    Oscar Arias-Carrión
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    J Neurosci Res 84:1425-37. 2006
    ..Additionally, the release of DA in a Ca(2+)-dependent manner and the attraction of synaptic afferents from neighboring neuronal networks gives further significance to the overall findings, whose potential importance is discussed...
  11. ncbi Mechanisms of nicotine actions on dorsal raphe serotoninergic neurons
    Stefan Mihailescu
    Facultad de Medicina, Departamento de Fisiologia, Instituto de Fisiologia Celular, UNAM, Mexico City, Mexico DF, Mexico
    Eur J Pharmacol 452:77-82. 2002
    ....
  12. doi Stem cell therapy for Parkinson's disease: a road map for a successful future
    Roman Vidaltamayo
    Depto de Neurociencias and Instituto de Fisiología Celular, Universidad Nacional Autonoma de Mexico, Mexico
    Stem Cells Dev 19:311-20. 2010
    ....
  13. doi 2-AG into the lateral hypothalamus increases REM sleep and cFos expression in melanin concentrating hormone neurons in rats
    Marcel Pérez-Morales
    Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico, D F, Mexico
    Pharmacol Biochem Behav 108:1-7. 2013
    ..These results suggest that endocannabinoid activation of the CB1R in the lateral hypothalamus, which activates MCH neurons, is one mechanism by which REMS is triggered...
  14. ncbi Fullerene C60 and ascorbic acid protect cultured chromaffin cells against levodopa toxicity
    Aleph A Corona-Morales
    Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico D F, Mexico
    J Neurosci Res 71:121-6. 2003
    ..Chemical properties of fullerene related to biological uses are discussed...
  15. ncbi Survival rates through time of hypocretin grafted neurons within their projection site
    Oscar Arias-Carrión
    Depto de Neurociencias Instituto de Fisiología Celular, Universidad Nacional Autonoma de Mexico, Circuito Interior, Ciudad Universitaria, Mexico DF, Mexico
    Neurosci Lett 404:93-7. 2006
    ..This study highlights the potential use of transplants as a therapeutical tool in order to treat narcolepsy...
  16. ncbi The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent
    Eric Murillo-Rodriguez
    Facultad de Medicina, Laboratorio de Neurobiologia, Universidad Autonoma de Campeche, Campeche, Mexico
    Behav Neurosci 122:1378-82. 2008
    ..Additionally, CBD increased c-Fos expression in LH or DRN. These findings suggest that this cannabinoid is a wake-inducing compound that presumably activates neurons in LH and DRN...
  17. doi Growth hormone improves hippocampal adult cell survival and counteracts the inhibitory effect of prolonged sleep deprivation on cell proliferation
    Fabio Garcia-Garcia
    Instituto de Ciencias de la Salud, Departamento de Biomedicina, Universidad Veracruzana, Col Industrial Animas, Xalapa, Veracruz, Mexico, C P, Mexico
    Brain Res Bull 84:252-7. 2011
    ..Our findings indicate that GH strongly promotes cell proliferation in the adult brain and also protects the hippocampal neuronal precursors against the deleterious effect of prolonged sleep loss...
  18. ncbi Effects of long-term administration of nicotine and fluoxetine on sleep in depressed patients
    Reyes Haro
    Clínica de Trastornos de Sueño, Facultad de Medicina, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City
    Arch Med Res 35:499-506. 2004
    ..The long-term effects of transdermal nicotine and fluoxetine on sleep and major depression were investigated...
  19. doi Transcranial magnetic stimulation reduces nociceptive threshold in rats
    Mónica Ambriz-Tututi
    Departamento de Neuropatología Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico D F, Mexico
    J Neurosci Res 90:1085-95. 2012
    ..The results suggest that high-frequency TMS can alter the nociceptive threshold and produce allodynia in the rats; results suggest the involvement of NMDA and AMPA/KA receptors on TMS-induced allodynia in the rat...
  20. doi Upregulation of D2-class signaling in dopamine-denervated striatum is in part mediated by D3 receptors acting on Ca V 2.1 channels via PIP2 depletion
    G Aleph Prieto
    Instituto de Fisiologia Celular Neurociencias, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    J Neurophysiol 105:2260-74. 2011
    ....
  21. pmc Contribution of different classes of glutamate receptors in the corticostriatal polysynaptic responses from striatal direct and indirect projection neurons
    Bianca J Vizcarra-Chacón
    Division de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico, DF, Mexico
    BMC Neurosci 14:60. 2013
    ..One hypothesis was: if prolonged synaptic activation distributed along time was present, then it would be mainly generated from the cortex, and not from the striatum...
  22. ncbi Differentiation of chromaffin cells elicited by ELF MF modifies gene expression pattern
    Tatiana Olivares-Bañuelos
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 600, Mexico, D F 04510, Mexico
    Cell Biol Int 28:273-9. 2004
    ....
  23. ncbi Olfactory dysfunction in hereditary ataxia and basal ganglia disorders
    Juan Fernandez-Ruiz
    Depto Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico D F, AP 70 250
    Neuroreport 14:1339-41. 2003
    ..The results show an olfactory deficit in both basal ganglia and hereditary ataxia patients. Further exploration of the olfactory capacities in hereditary ataxia is necessary to elucidate the specific nature of the deficits...
  24. doi Chromaffin cell transplants: from the lab to the clinic
    Mónica Ambriz-Tututi
    Departamento de Neuropatología Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico
    Life Sci 91:1243-51. 2012
    ..The present review gives an update on recent advances of chromaffin cell transplants and their future in the clinic...
  25. doi Encoding network states by striatal cell assemblies
    Luis Carrillo-Reid
    Departamento de Biofisica, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City, DF 04510 Mexico
    J Neurophysiol 99:1435-50. 2008
    ..The network dynamics set into action by NMDA in the striatal network may reveal important properties of striatal microcircuits under normal and pathological conditions...
  26. doi Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats
    Eric Murillo-Rodriguez
    Laboratorio de Neurobiologia, Facultad de Medicina, Universidad Autonoma de Campeche, Campeche, Mexico
    Neurosci Lett 436:283-7. 2008
    ..Finally, c-Fos expression was found increased into either AH or the PPTg. Collectively, these results suggest that MOD induces waking via the activity of two wake-related brain areas such as AH and the PPTg...
  27. ncbi Long-term changes in sleep and depressive symptoms of smokers in abstinence
    Ana Moreno-Coutiño
    Depto de Neurociencias, Instituto de Fisiología Celular y Clínica de Trastornos del Sueño, Universidad Nacional Autonoma de Mexico, Mexico
    Nicotine Tob Res 9:389-96. 2007
    ..Nicotine abstinence reduced latency to rapid eye movement (REM) sleep and increased HAM-D scores, suggesting that chronic smokers have depressive symptoms that may be controlled by nicotine administration...
  28. ncbi Nonoccupational environmental exposure to manganese is linked to deficits in peripheral and central olfactory function
    Marco Guarneros
    Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, AP 70 600, CP 04510, Distrito Federal, Mexico
    Chem Senses 38:783-91. 2013
    ..We conclude that nonoccupational exposure to airborne manganese is associated with decrements in both peripheral and central olfactory function. ..
  29. doi Effects of rTMS on Parkinson's disease: a longitudinal fMRI study
    Nadia González-García
    Depto de Neuropatología Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Apdo Postal 70 600, 04510 Mexico, D F, Mexico
    J Neurol 258:1268-80. 2011
    ..These results show a potential beneficial effect of repetitive transcranial magnetic stimulation on bradykinesia in Parkinson's disease which is substantiated by neural changes observed in functional magnetic resonance imaging...
  30. pmc Supernumerary formation of olfactory glomeruli induced by chronic odorant exposure: a constructivist expression of neural plasticity
    Pablo Valle-Leija
    Departamento de Neuropatología Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico Distrito Federal, Mexico
    PLoS ONE 7:e35358. 2012
    ..Overall, our results support that sensory experience indeed instructs the permanent formation of specific glomeruli in the mouse olfactory bulb by means of constructivist processes...
  31. pmc Odor memory stability after reinnervation of the olfactory bulb
    Eduardo Blanco-Hernández
    Departamento de Neuropatología Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Distrito Federal, Mexico
    PLoS ONE 7:e46338. 2012
    ..Our findings show that regeneration of neuronal circuits in the olfactory system can be achieved with remarkable precision and underscore the importance of glomerular organization to evoke memory traces stored in the brain...
  32. ncbi Effects of the fatty acid amide hydrolase inhibitor URB597 on the sleep-wake cycle, c-Fos expression and dopamine levels of the rat
    Eric Murillo-Rodriguez
    Depto de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Eur J Pharmacol 562:82-91. 2007
    ..Alternative approaches to treat sleep disorders such as excessive somnolence might consider the use of the URB597, oleoylethanolamide or palmitoylethanolamide since all compounds enhance waking...
  33. ncbi Effects of nicotine on alcohol intake in a rat model of depression
    Dolores Martinez-Gonzalez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Apdo Postal 70 600, Mexico, DF 04510, Mexico
    Pharmacol Biochem Behav 72:355-64. 2002
    ..These results indicate that nicotine reverted some depression signs and reduced alcohol self-administration in the CLI model of depression...
  34. doi Models for narcolepsy with cataplexy drug discovery
    Alberto K De la Herrán-Arita
    Departamento de Neuropatología Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico
    Expert Opin Drug Discov 7:155-64. 2012
    ..Nowadays, it is well known that narcolepsy results from alterations in the genes involved in the physiology of the orexin ligand or its receptor...
  35. ncbi Prism adaptation in spinocerebellar ataxia type 2
    Juan Fernandez-Ruiz
    Laboratorio de Neuropsicología, Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico
    Neuropsychologia 45:2692-8. 2007
    ..Our results suggest that the neural areas subserving spatial realignment are spared in this form of spinocerebellar ataxia...
  36. pmc Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression
    Patricia Vieyra-Reyes
    Depto de Neurociencias Instituto de Fisiología Celular, Universidad Nacional Autonoma de Mexico, Circuito Interior, Ciudad Universitaria, CP 04510 Mexico, D F, Mexico
    Brain Res Bull 77:13-8. 2008
    ..In conclusion, our results support the idea that there are possible innate differences for depression susceptibility and that nicotine and TMS may be useful in the treatment of this syndrome...
  37. doi Chromaffin cell transplant in spinal cord reduces secondary allodynia induced by formalin in the rat. Role of opioid receptors and α₂-adrenoceptors
    Mónica Ambriz-Tututi
    Departamento de Neuropatología Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico
    Eur J Pharmacol 668:147-54. 2011
    ..Our data suggest that chromaffin cells release neuroactive substances including opioid peptides and adrenergic amines that reduce secondary allodynia in rats through activation of their receptors...