Gloria Benitez-King

Summary

Country: Mexico

Publications

  1. ncbi request reprint PKC activation by melatonin modulates vimentin intermediate filament organization in N1E-115 cells
    G Benitez-King
    Instituto Mexicano de Psiquiatria, Departamento de Neurofarmacologia, DIC, Lorenzo Huipulco, Mexico, DF
    J Pineal Res 29:8-14. 2000
  2. ncbi request reprint Melatonin as a cytoskeletal modulator: implications for cell physiology and disease
    Gloria Benitez-King
    Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
    J Pineal Res 40:1-9. 2006
  3. ncbi request reprint The neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophrenia
    G Benitez-King
    Instituto Nacional de Psiquiatria, Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Mexico, D F, Mexico
    Curr Drug Targets CNS Neurol Disord 3:515-33. 2004
  4. ncbi request reprint Melatonin modulates microfilament phenotypes in epithelial cells: implications for adhesion and inhibition of cancer cell migration
    G Benitez-King
    Neuropharmacology Department, Division of Clinical Investigations, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico, DF Mexico
    Histol Histopathol 24:789-99. 2009
  5. ncbi request reprint Phosphorylation-dephosphorylation imbalance of cytoskeletal associated proteins in neurodegenerative diseases
    Gloria Benitez-King
    Instituto Nacional de Psiquiatria, Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Mexico, D F, Mexico
    Recent Pat CNS Drug Discov 1:219-30. 2006
  6. doi request reprint Haloperidol causes cytoskeletal collapse in N1E-115 cells through tau hyperphosphorylation induced by oxidative stress: Implications for neurodevelopment
    Gloria Benitez-King
    Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico, D F, Mexico
    Eur J Pharmacol 644:24-31. 2010
  7. ncbi request reprint Melatonin prevents cytoskeletal alterations and oxidative stress induced by okadaic acid in N1E-115 cells
    G Benitez-King
    Instituto Nacional de Psiquiatria, Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Calz México Xochimilco No 101, Col San Lorenzo Huipulco, 14370, Mexico, D F, CP, Mexico
    Exp Neurol 182:151-9. 2003
  8. doi request reprint A non-invasive method to isolate the neuronal linage from the nasal epithelium from schizophrenic and bipolar diseases
    G Benitez-King
    Departamento de Neurofarmacologia, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
    J Neurosci Methods 201:35-45. 2011
  9. ncbi request reprint Melatonin activates PKC-alpha but not PKC-epsilon in N1E-115 cells
    G Benitez-King
    Departamento de Neurofarmacologia, SIC, Instituto Nacional de Psiquiatria, Ramón de la Fuente Muñiz, Calz México Xochimilco No 101, CP 14370, Col San Lorenzo Huipulco, D F, Mexico
    Neurochem Int 39:95-102. 2001
  10. ncbi request reprint Melatonin stimulates calmodulin phosphorylation by protein kinase C
    Elena Soto-Vega
    Depto Neurofarmacología, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatria, Mexico
    J Pineal Res 37:98-106. 2004

Collaborators

Detail Information

Publications22

  1. ncbi request reprint PKC activation by melatonin modulates vimentin intermediate filament organization in N1E-115 cells
    G Benitez-King
    Instituto Mexicano de Psiquiatria, Departamento de Neurofarmacologia, DIC, Lorenzo Huipulco, Mexico, DF
    J Pineal Res 29:8-14. 2000
    ..Similar effects to those caused by melatonin were obtained with the protein kinase C activator phorbol 12-myristate 13-acetate. Data support the idea that melatonin modulates vimentin organization through protein kinase C activation...
  2. ncbi request reprint Melatonin as a cytoskeletal modulator: implications for cell physiology and disease
    Gloria Benitez-King
    Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
    J Pineal Res 40:1-9. 2006
    ..Moreover, we discuss the implications of an altered cytoskeletal organization for neurodegenerative and psychiatric illnesses and its re-establishment by melatonin...
  3. ncbi request reprint The neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophrenia
    G Benitez-King
    Instituto Nacional de Psiquiatria, Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Mexico, D F, Mexico
    Curr Drug Targets CNS Neurol Disord 3:515-33. 2004
    ....
  4. ncbi request reprint Melatonin modulates microfilament phenotypes in epithelial cells: implications for adhesion and inhibition of cancer cell migration
    G Benitez-King
    Neuropharmacology Department, Division of Clinical Investigations, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico, DF Mexico
    Histol Histopathol 24:789-99. 2009
    ..Moreover, we will discuss the implications of the cytoskeleton as therapeutic target for cancer cells...
  5. ncbi request reprint Phosphorylation-dephosphorylation imbalance of cytoskeletal associated proteins in neurodegenerative diseases
    Gloria Benitez-King
    Instituto Nacional de Psiquiatria, Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Mexico, D F, Mexico
    Recent Pat CNS Drug Discov 1:219-30. 2006
    ..Finally we discuss current strategies and patents that could contribute to re-establish a balance in the brain of patients with dementia...
  6. doi request reprint Haloperidol causes cytoskeletal collapse in N1E-115 cells through tau hyperphosphorylation induced by oxidative stress: Implications for neurodevelopment
    Gloria Benitez-King
    Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico, D F, Mexico
    Eur J Pharmacol 644:24-31. 2010
    ..Data suggest that extrapiramidal symptoms in schizophrenic patients can be produced by cytoskeletal disorganization during adult brain neurodevelopment after prolonged haloperidol treatment that can be prevented by melatonin...
  7. ncbi request reprint Melatonin prevents cytoskeletal alterations and oxidative stress induced by okadaic acid in N1E-115 cells
    G Benitez-King
    Instituto Nacional de Psiquiatria, Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Calz México Xochimilco No 101, Col San Lorenzo Huipulco, 14370, Mexico, D F, CP, Mexico
    Exp Neurol 182:151-9. 2003
    ..The results support the hypothesis that melatonin can be useful in the treatment of neurodegenerative diseases...
  8. doi request reprint A non-invasive method to isolate the neuronal linage from the nasal epithelium from schizophrenic and bipolar diseases
    G Benitez-King
    Departamento de Neurofarmacologia, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
    J Neurosci Methods 201:35-45. 2011
    ..Data support that neural precursors obtained from a nasal exfoliate are an excellent experimental model to later approach studies on biomarkers, neural development and cellular alterations in the pathophysiology of SZ and BD...
  9. ncbi request reprint Melatonin activates PKC-alpha but not PKC-epsilon in N1E-115 cells
    G Benitez-King
    Departamento de Neurofarmacologia, SIC, Instituto Nacional de Psiquiatria, Ramón de la Fuente Muñiz, Calz México Xochimilco No 101, CP 14370, Col San Lorenzo Huipulco, D F, Mexico
    Neurochem Int 39:95-102. 2001
    ..The results showed that melatonin selectively activates the Ca(2+)-dependent alpha isoform of PKC and suggest that PKC-alpha activation by melatonin underlies IF rearrangements and participates in neurite formation in N1E-115 cells...
  10. ncbi request reprint Melatonin stimulates calmodulin phosphorylation by protein kinase C
    Elena Soto-Vega
    Depto Neurofarmacología, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatria, Mexico
    J Pineal Res 37:98-106. 2004
    ..Modification of CaM by melatonin can be another route to inhibit CaM interaction with its target enzymes...
  11. ncbi request reprint Melatonin induced cyclic modulation of vectorial water transport in kidney-derived MDCK cells
    Gerardo Ramirez-Rodriguez
    Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatria, Ramón de la Fuente Muñiz, Mexico D F Mexico
    Kidney Int 63:1356-64. 2003
    ..Moreover, changes in urine production and osmolarity have been observed in the kidney during the night. However, the precise mechanisms by which plasma-circulating melatonin modifies renal physiology are not clearly understood...
  12. doi request reprint ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration
    Leonardo Ortíz-López
    Instituto Nacional de Psiquiatria, Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Mexico D F, Mexico
    J Pineal Res 46:15-21. 2009
    ..These results support the notion that melatonin inhibits cancer cell invasion and metastasis formation via ROCK-regulated microfilament and microtubule organization that converge in a migration/anchorage switch...
  13. ncbi request reprint Melatonin increases stress fibers and focal adhesions in MDCK cells: participation of Rho-associated kinase and protein kinase C
    Gerardo Ramirez-Rodriguez
    Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
    J Pineal Res 42:180-90. 2007
    ..Data also document that melatonin modulates water transport through modifications of the cytoskeletal structure...
  14. ncbi request reprint Melatonin induces neuritogenesis at early stages in N1E-115 cells through actin rearrangements via activation of protein kinase C and Rho-associated kinase
    Alfredo Bellon
    Instituto Nacional de Psiquiatria, Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Mexico D F, Mexico
    J Pineal Res 42:214-21. 2007
    ..Data also indicate that PKC and ROCK are involved at initial stages of neurite formation in the mechanism by which melatonin recruits cells for later differentiation...
  15. doi request reprint Melatonin increases dendritogenesis in the hilus of hippocampal organotypic cultures
    Aline Domínguez-Alonso
    Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico, D F
    J Pineal Res 52:427-36. 2012
    ..Evidence strongly suggests that melatonin may be useful in the treatment of neuropsychiatric diseases to repair the loss of dendrites and re-establish lost synaptic connections...
  16. doi request reprint Melatonin supplementation delays the decline of adult hippocampal neurogenesis during normal aging of mice
    Gerardo Ramirez-Rodriguez
    Laboratory of Neurogenesis, Division of Clinical Research, National Institute of Psychiatry, Mexico, D F, Mexico
    Neurosci Lett 530:53-8. 2012
    ..Our results indicate that melatonin also modulates the neurogenic process in the hippocampus during normal aging of mice. Together, the data support melatonin as one of the positive endogenous regulators of neurogenesis during aging...
  17. doi request reprint Melatonin modulates cytoskeletal organization in the rat brain hippocampus
    Graciela Jiménez-Rubio
    Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
    Neurosci Lett 511:47-51. 2012
    ..Together, the data support that cytoskeletal organization is regulated rhythmically by melatonin in synchrony with the photoperiod...
  18. ncbi request reprint IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers
    Dodanim Talavera
    Departamento de Biomedicina Molecular, Centro de Investigacion y de Estudios Avanzados del IPN, Apartado Postal 14 740, Mexico, DF 07360, Mexico
    J Gen Virol 85:1801-13. 2004
    ..These findings suggest that IL8 production by infected monolayers contributes to the virus-induced effect on the cytoskeleton and tight junctions and thereby modifies transendothelial permeability...
  19. ncbi request reprint Dynamics of endocytic traffic of Entamoeba histolytica revealed by confocal microscopy and flow cytometry
    Isaura Meza
    Departamento de Biomedicina Molecular, CINVESTAV del IPN, Mexico DF, Mexico
    Cell Motil Cytoskeleton 59:215-26. 2004
    ..A striking feature of the trophozoites was the great heterogeneity of their endocytic behavior...
  20. ncbi request reprint 2,3-butanedione monoxime (BDM), a potent inhibitor of actin-myosin interaction, induces ion and fluid transport in MDCK monolayers
    Aida M Castillo
    Department of Biologia Celular, Centro de Investigacion y de Estudios Avanzados del IPN, Apartado 14 740, Mexico, DF 07000, Mexico
    J Muscle Res Cell Motil 23:223-34. 2002
    ..These results point to the relevant role or actin-myosin dynamics and actin organization in the regulation of ion and water channel activity in these cells...
  21. ncbi request reprint Signal transduction in Entamoeba histolytica induced by interaction with fibronectin: presence and activation of phosphokinase A and its possible relation to invasiveness
    Elizabeth Franco
    Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados CINVESTAV del Instituto Politécnico Nacional, Mexico City, Mexico
    Arch Med Res 33:389-97. 2002
    ..histolytica trophozoites with ECM proteins. They also indicate that adhesion and secretion in conjunction with motile activities are related to invasion processes...
  22. ncbi request reprint The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways
    Isaura Meza
    Departamentos de Biomedicina Molecular, Centro de Investigacion y de Estudios, Avanzados del IPN, Mexico D F, Mexico
    Arch Med Res 37:234-43. 2006
    ..The purpose of this review is to evaluate current knowledge about the cytoskeleton of E. histolytica and the ways in which the parasite controls motility...