Philipp Mertins

Summary

Publications

  1. pmc Integrated proteomic analysis of post-translational modifications by serial enrichment
    Philipp Mertins
    The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Methods 10:634-7. 2013
  2. pmc Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator
    Philip Vlaicu
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    BMC Cancer 13:197. 2013
  3. pmc Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments
    Namrata D Udeshi
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Mol Cell Proteomics 12:825-31. 2013
  4. pmc iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics
    Philipp Mertins
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell Proteomics 11:M111.014423. 2012
  5. pmc Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition
    Namrata D Udeshi
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell Proteomics 11:148-59. 2012
  6. ncbi request reprint Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5' Sites
    Schraga Schwartz
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell Rep 8:284-96. 2014
  7. doi request reprint Large-scale identification of ubiquitination sites by mass spectrometry
    Namrata D Udeshi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Protoc 8:1950-60. 2013
  8. pmc Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach
    Mark N Lee
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Immunol 14:179-85. 2013
  9. pmc Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming
    Amit Choudhary
    Society of Fellows, Harvard University, Cambridge, Massachusetts, United States of America Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America
    PLoS ONE 9:e95194. 2014
  10. pmc High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis
    Schraga Schwartz
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell 155:1409-21. 2013

Collaborators

  • Namrata D Udeshi
  • Tarjei S Mikkelsen
  • Aviv Regev
  • Shao En Ong
  • Judy Lieberman
  • Feng Zhang
  • Schraga Schwartz
  • Steven A Carr
  • Amit Choudhary
  • Maxwell R Mumbach
  • Marko Jovanovic
  • Nir Hacohen
  • Eric S Lander
  • Rahul Satija
  • Mark N Lee
  • Philip Vlaicu
  • Elizaveta Freinkman
  • G Guy Bushkin
  • Paul A Clemons
  • Michael E Pacold
  • Dina Fomina-Yadlin
  • Tim Wang
  • Stuart L Schreiber
  • Vlado Dancik
  • Neville E Sanjana
  • Kaihui Hu He
  • Dmitry Ter-Ovanesyan
  • Karolina Maciag
  • Naomi Habib
  • Bridget K Wagner
  • Davide Cacchiarelli
  • Stefan Kubicek
  • Gary Ruvkun
  • Weibo Li
  • Bernhard Högel
  • Matthew Roy
  • Yuval Tabach
  • Thomas Mayr
  • Gerald R Fink
  • Alexandra Chloe Villani
  • Jayita Sen
  • Farokh Dotiwala
  • Megan H Orzalli
  • David M Knipe
  • Axel Ullrich
  • Beyhan Ataseven
  • Wolfgang Eiermann
  • Sudeep D Agarwala
  • Pjotr Knyazev
  • John G Doench
  • Igor Kramnik
  • Alexander Shishkin
  • Peter Widschwendter

Detail Information

Publications10

  1. pmc Integrated proteomic analysis of post-translational modifications by serial enrichment
    Philipp Mertins
    The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Methods 10:634-7. 2013
    ....
  2. pmc Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator
    Philip Vlaicu
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    BMC Cancer 13:197. 2013
    ..We sought to analyze which EGFR- and STAT3-activating factors are secreted by monocytes/macrophages exposed to tumor cell-secreted factors...
  3. pmc Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments
    Namrata D Udeshi
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Mol Cell Proteomics 12:825-31. 2013
    ..This refined and practical workflow enables routine identification and quantification of ∼20,000 distinct endogenous ubiquitination sites in a single SILAC experiment using moderate amounts of protein input...
  4. pmc iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics
    Philipp Mertins
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell Proteomics 11:M111.014423. 2012
    ..Spike-in experiments using peptides of defined ratios in a background of nonregulated peptides show that iTRAQ quantification is less accurate but not as variable as mTRAQ quantification...
  5. pmc Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition
    Namrata D Udeshi
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell Proteomics 11:148-59. 2012
    ..We attribute this finding to the low stoichiometry of the majority ubiquitination sites identified in this study...
  6. ncbi request reprint Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5' Sites
    Schraga Schwartz
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell Rep 8:284-96. 2014
    ..Our data shed light on the proteomic and transcriptional underpinnings of this RNA modification. ..
  7. doi request reprint Large-scale identification of ubiquitination sites by mass spectrometry
    Namrata D Udeshi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Protoc 8:1950-60. 2013
    ..After cell or tissue samples have been prepared for lysis, the described protocol can be completed in ∼5 d. ..
  8. pmc Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach
    Mark N Lee
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Immunol 14:179-85. 2013
    ....
  9. pmc Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming
    Amit Choudhary
    Society of Fellows, Harvard University, Cambridge, Massachusetts, United States of America Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America
    PLoS ONE 9:e95194. 2014
    ..Knock-down of these kinases in alpha cells resulted in expression of key beta-cell markers. These results provide evidence that perturbation of the kinome may be important for lineage reprogramming of alpha cells to beta cells. ..
  10. pmc High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis
    Schraga Schwartz
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell 155:1409-21. 2013
    ..Our data illuminate a conserved, dynamically regulated methylation program in yeast meiosis and provide an important resource for studying the function of this epitranscriptomic modification. ..