Mark Mercola

Summary

Publications

  1. pmc Induced pluripotent stem cells in cardiovascular drug discovery
    Mark Mercola
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Circ Res 112:534-48. 2013
  2. pmc Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment
    Wenqing Cai
    Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Genes Dev 27:2332-44. 2013
  3. pmc A Nodal-to-TGFβ cascade exerts biphasic control over cardiopoiesis
    Wenqing Cai
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Circ Res 111:876-81. 2012
  4. pmc Quantitative transcriptomics using designed primer-based amplification
    Vipul Bhargava
    Bioinformatics and Systems Biology Graduate Program, University of California at San Diego, La Jolla, CA, USA
    Sci Rep 3:1740. 2013
  5. pmc BAF60 A, B, and Cs of muscle determination and renewal
    Pier Lorenzo Puri
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Genes Dev 26:2673-83. 2012
  6. pmc Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm
    Erik Willems
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Circ Res 109:360-4. 2011
  7. pmc Serum-free generation of multipotent mesoderm (Kdr+) progenitor cells in mouse embryonic stem cells for functional genomics screening
    Wesley L McKeithan
    Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Curr Protoc Stem Cell Biol . 2012
  8. pmc Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis
    Alexandre R Colas
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Genes Dev 26:2567-79. 2012
  9. pmc Technical variations in low-input RNA-seq methodologies
    Vipul Bhargava
    Bioinformatics and Systems Biology Graduate Program, University of California at San Diego, La Jolla, California, USA
    Sci Rep 4:3678. 2014
  10. pmc Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells
    Erik Willems
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Cell Stem Cell 11:242-52. 2012

Research Grants

Collaborators

Detail Information

Publications11

  1. pmc Induced pluripotent stem cells in cardiovascular drug discovery
    Mark Mercola
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Circ Res 112:534-48. 2013
    ..Here we review recent progress in generating induced pluripotent stem cell-based models of cardiovascular disease and their multiple applications in drug development...
  2. pmc Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment
    Wenqing Cai
    Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Genes Dev 27:2332-44. 2013
    ..This is the first demonstration that cues from the progenitor cell environment direct the subunit variant composition of SWI/SNF to remodel the transcriptional landscape for lineage-specific differentiation...
  3. pmc A Nodal-to-TGFβ cascade exerts biphasic control over cardiopoiesis
    Wenqing Cai
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Circ Res 111:876-81. 2012
    ..The transforming growth factor-β (TGFβ) family member Nodal promotes cardiogenesis, but the mechanism is unclear despite the relevance of TGFβ family proteins for myocardial remodeling and regeneration...
  4. pmc Quantitative transcriptomics using designed primer-based amplification
    Vipul Bhargava
    Bioinformatics and Systems Biology Graduate Program, University of California at San Diego, La Jolla, CA, USA
    Sci Rep 3:1740. 2013
    ....
  5. pmc BAF60 A, B, and Cs of muscle determination and renewal
    Pier Lorenzo Puri
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Genes Dev 26:2673-83. 2012
    ....
  6. pmc Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm
    Erik Willems
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Circ Res 109:360-4. 2011
    ..Although the initiating step of mesoderm formation is well characterized, the subsequent steps that promote for cardiac lineages are poorly understood and limit the yield of cardiomyocytes...
  7. pmc Serum-free generation of multipotent mesoderm (Kdr+) progenitor cells in mouse embryonic stem cells for functional genomics screening
    Wesley L McKeithan
    Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Curr Protoc Stem Cell Biol . 2012
    ..Technical limitations, troubleshooting, and potential applications of these methods are discussed...
  8. pmc Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis
    Alexandre R Colas
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Genes Dev 26:2567-79. 2012
    ..These findings suggest a crucial role for the let-7 and miR-18 families in germ layer specification and reveal a remarkable conservation of function from amphibians to mammals...
  9. pmc Technical variations in low-input RNA-seq methodologies
    Vipul Bhargava
    Bioinformatics and Systems Biology Graduate Program, University of California at San Diego, La Jolla, California, USA
    Sci Rep 4:3678. 2014
    ..High technical variations ultimately masked subtle biological differences mandating the development of improved amplification-based strategies for quantitative transcriptomics from limiting amounts of mRNA. ..
  10. pmc Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells
    Erik Willems
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Cell Stem Cell 11:242-52. 2012
    ..ITD-1 is a highly selective TGF-β inhibitor and reveals an unexpected role for TGF-β signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors...
  11. pmc A chemical biology approach to myocardial regeneration
    Erik Willems
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Cardiovasc Transl Res 4:340-50. 2011
    ....

Research Grants1