J Mendoza



  1. Mendoza J. Eating Rewards the Gears of the Clock. Trends Endocrinol Metab. 2019;30:299-311 pubmed publisher
    ..g., diabetes, obesity) and neurological diseases (e.g., mental, neurodegenerative). ..
  2. Salaberry N, Hamm H, Felder Schmittbuhl M, Mendoza J. A suprachiasmatic-independent circadian clock(s) in the habenula is affected by Per gene mutations and housing light conditions in mice. Brain Struct Funct. 2019;224:19-31 pubmed publisher
    ..The relevance of the Hb timing might reside in the regulation of circadian functions linked to motivational (reward) and emotional (mood) processes. ..
  3. Mendoza J. Food intake and addictive-like eating behaviors: Time to think about the circadian clock(s). Neurosci Biobehav Rev. 2018;: pubmed publisher
    ..Therefore, food intake is regulated by the central circadian-metabolic-hedonic network, which is functionally interconnected to avoid perturbing the eating behavior physiology. ..
  4. Mendoza J, van Diepen H, Pereira R, Meijer J. Time-shifting effects of methylphenidate on daily rhythms in the diurnal rodent Arvicanthis ansorgei. Psychopharmacology (Berl). 2018;235:2323-2333 pubmed publisher
    ..Knowing the circadian modulation on the effects of MPH in behavior could give new insights in the treatment of ADHD. ..
  5. Mendoza J, Clesse D, Pevet P, Challet E. Food-reward signalling in the suprachiasmatic clock. J Neurochem. 2010;112:1489-99 pubmed publisher
    ..In conclusion, this study establishes an underlying sensitivity of the master circadian clock to changes in motivational states related to palatable food intake. ..
  6. Itzhacki J, Clesse D, Goumon Y, Van Someren E, Mendoza J. Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod. Brain Struct Funct. 2018;223:2641-2652 pubmed publisher
    ..This last point might be crucial for understanding the mechanisms of non-pharmacological treatment in SAD. ..
  7. Mendoza J, Gourmelen S, Dumont S, Sage Ciocca D, Pevet P, Challet E. Setting the main circadian clock of a diurnal mammal by hypocaloric feeding. J Physiol. 2012;590:3155-68 pubmed publisher
    ..The Arvicanthis model has relevance for the potential use of HF to manipulate circadian rhythms in diurnal species including humans. ..
  8. Mendoza J, Challet E. Circadian insights into dopamine mechanisms. Neuroscience. 2014;282:230-42 pubmed publisher
    ..These studies give new insights into the role of the brain circadian system in DA-related neurologic pathologies, such as Parkinson's disease, attention deficit/hyperactive disorder and drug addiction. ..
  9. Salaberry N, Mateo M, Mendoza J. The Clock Gene Rev-Erb? Regulates Methamphetamine Actions on Circadian Timekeeping in the Mouse Brain. Mol Neurobiol. 2017;54:5327-5334 pubmed publisher
    ..Together, the present results implicate Rev-Erb? in the modulation of the circadian responses to METH and may provide a better comprehension into the mechanisms underlying circadian alterations provoked by drug addiction. ..

More Information


  1. Mendoza J, Albrecht U, Challet E. Behavioural food anticipation in clock genes deficient mice: confirming old phenotypes, describing new phenotypes. Genes Brain Behav. 2010;9:467-77 pubmed publisher
    ..Moreover, we show that in a genetically rescued SCN clock (Per2(Brdm1);Cry2(-/-)), food is a powerful zeitgeber to entrain behavioural rhythms, leading the SCN to be more sensitive to feeding cues than in wild-type littermates. ..
  2. Bainier C, Mateo M, Felder Schmittbuhl M, Mendoza J. Circadian rhythms of hedonic drinking behavior in mice. Neuroscience. 2017;349:229-238 pubmed publisher
    ..These data indicate that the expression of circadian rhythms of hedonic feeding behaviors may be controlled by brain circadian clocks and Per gene expression. ..
  3. Mendoza J. Circadian neurons in the lateral habenula: Clocking motivated behaviors. Pharmacol Biochem Behav. 2017;162:55-61 pubmed publisher
    ..g., feeding, drug intake) and depression (with circadian disruptions and altered motivation) will be discussed. ..
  4. Blancas Velazquez A, la Fleur S, Mendoza J. Effects of a free-choice high-fat high-sugar diet on brain PER2 and BMAL1 protein expression in mice. Appetite. 2017;117:263-269 pubmed publisher
    ..These findings confirm previous observations in rats showing disrupted daily patterns of feeding behavior under a fcHFHS diet exposure, and extend our insights on the effects of the diet on circadian gene expression in brain clocks. ..