Guangxun Meng

Summary

Publications

  1. Guo C, Chen M, Fa Z, Lu A, Fang W, Sun B, et al. Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome. Microbes Infect. 2014;16:845-54 pubmed publisher
    ..neoformans prevents recognition of the fungus by host NLRP3 inflammasome and indicate that manipulation of inflammasome activity maybe a novel approach to control C. neoformans infection. ..
  2. Chen M, Xing Y, Lu A, Fang W, Sun B, Chen C, et al. Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes. J Immunol. 2015;195:4962-72 pubmed publisher
    ..Collectively, these findings uncover a number of novel signaling pathways for the innate immune response of host cells to C. neoformans infection and suggest that manipulating NLRP3 signaling may help to control fungal challenge. ..
  3. Javed N, Xue G, Lu A, Xing Y, Iwakura Y, Xiao H, et al. Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy. Cytokine. 2016;81:101-8 pubmed publisher
    ..This cross reactivity generates exaggerated false positive signals which can be a source of discrepancy for the understanding of real immune responses against S. aureus infection by host immune cells. ..
  4. Lu A, Li H, Niu J, Wu S, Xue G, Yao X, et al. Hyperactivation of the NLRP3 Inflammasome in Myeloid Cells Leads to Severe Organ Damage in Experimental Lupus. J Immunol. 2017;198:1119-1129 pubmed publisher
    ..Taken together, our study demonstrates a critical role for NLRP3 in the development of SLE and suggests that modulating the inflammasome signal may help to control the inflammatory damage in autoimmune diseases, including lupus. ..
  5. Li Z, Wang H, Chen Y, Niu J, Guo Q, Leng Q, et al. Interleukin-18 protects mice from Enterovirus 71 infection. Cytokine. 2017;96:132-137 pubmed publisher
    ..Thus, our results revealed a protective role for IL-18 against EV71 challenge, and indicated a novel therapeutic application for IL-18 in EV71 associated hand, foot, and mouth disease (HFMD). ..
  6. Xing Y, Yao X, Li H, Xue G, Guo Q, Yang G, et al. Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome. J Immunol. 2017;199:1561-1566 pubmed publisher
    ..Our findings thus extended cognition on the mechanism of NLRP3 inflammasome activation, and provided a novel target for controlling NLRP3-related diseases. ..
  7. Ren R, Wu S, Cai J, Yang Y, Ren X, Feng Y, et al. The H7N9 influenza A virus infection results in lethal inflammation in the mammalian host via the NLRP3-caspase-1 inflammasome. Sci Rep. 2017;7:7625 pubmed publisher
    ..Therefore, fine-tuning the activity of NLRP3 inflammasome or IL-1 signaling may be beneficial for the host to control H7N9 associated lethal pathogenesis. ..
  8. Yao X, Meng G. Inflammasomes in the Gut Mucosal Homeostasis. Adv Exp Med Biol. 2017;1024:133-151 pubmed publisher
    ..This book chapter aims to summarize the current knowledge of how inflammasomes contribute to gut mucosal homeostasis. ..
  9. Yao X, Zhang C, Xing Y, Xue G, Zhang Q, Pan F, et al. Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis. Nat Commun. 2017;8:1896 pubmed publisher
    ..Our data show that NLRP3R258W-induced remodelling of the gut microbiota, induces local Tregs to maintain homeostasis and compensate for otherwise-detrimental intestinal inflammation. ..