Krister Melen

Summary

Publications

  1. pmc No serological evidence of influenza A H1N1pdm09 virus infection as a contributing factor in childhood narcolepsy after Pandemrix vaccination campaign in Finland
    Krister Melen
    Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 8:e68402. 2013
  2. pmc Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin
    Krister Melen
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virol J 9:167. 2012
  3. ncbi request reprint TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells
    Ville Veckman
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virology 345:96-104. 2006
  4. ncbi request reprint Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Biol Chem 278:28193-200. 2003
  5. ncbi request reprint NF-kappaB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules
    Riku Fagerlund
    Department of Viral Diseases and Immunology, National Public Health Institute, FIN 00300, Helsinki, Finland
    Cell Signal 20:1442-51. 2008
  6. pmc Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    Pasi Kaukinen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Virol J 3:66. 2006
  7. doi request reprint Hepatitis C virus proteins interfere with the activation of chemokine gene promoters and downregulate chemokine gene expression
    Maarit Sillanpää
    Department of Viral Diseases and Immunology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Gen Virol 89:432-43. 2008
  8. ncbi request reprint NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4
    Riku Fagerlund
    Departments of Viral Diseases and Immunology and Epidemiology and Health Promotion, National Public Health Institute, FIN 00300, Helsinki, Finland
    J Biol Chem 280:15942-51. 2005
  9. doi request reprint Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions
    Pasi Kaukinen
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Helsinki, Finland
    J Med Virol 85:71-82. 2013
  10. ncbi request reprint Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Med Virol 73:536-47. 2004

Detail Information

Publications19

  1. pmc No serological evidence of influenza A H1N1pdm09 virus infection as a contributing factor in childhood narcolepsy after Pandemrix vaccination campaign in Finland
    Krister Melen
    Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 8:e68402. 2013
    ..The analysis was based on the presence or absence of antibody response against non-structural protein 1 (NS1) from H1N1pdm09 virus, which was not a component of Pandemrix vaccine...
  2. pmc Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin
    Krister Melen
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virol J 9:167. 2012
    ....
  3. ncbi request reprint TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells
    Ville Veckman
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virology 345:96-104. 2006
    ..Our results suggest that IFN-alpha and TNF-alpha have a significant role in priming epithelial cells for higher cytokine and chemokine production in influenza A virus infection...
  4. ncbi request reprint Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Biol Chem 278:28193-200. 2003
    ....
  5. ncbi request reprint NF-kappaB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules
    Riku Fagerlund
    Department of Viral Diseases and Immunology, National Public Health Institute, FIN 00300, Helsinki, Finland
    Cell Signal 20:1442-51. 2008
    ..Moreover, we show that the nuclear import of p52/RelB heterodimers is mediated exclusively by the NLS of RelB. In addition, we found that the NLS of p52 mediates the nuclear import of p52/p65 heterodimers...
  6. pmc Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    Pasi Kaukinen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Virol J 3:66. 2006
    ..Previously, the serine protease NS3/4A was shown to inhibit IFN-beta gene expression by blocking dsRNA-activated retinoic acid-inducible gene I (RIG-I) and Toll-like receptor 3 (TLR3)-mediated signaling pathways...
  7. doi request reprint Hepatitis C virus proteins interfere with the activation of chemokine gene promoters and downregulate chemokine gene expression
    Maarit Sillanpää
    Department of Viral Diseases and Immunology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Gen Virol 89:432-43. 2008
    ..These results indicate that NS3/4A alone or as part of the HCV polyprotein disturbs the expression of IRF1- and IRF3-regulated genes, as well as affecting mitogen-activated protein kinase kinase- and NF-kappaB-regulated genes...
  8. ncbi request reprint NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4
    Riku Fagerlund
    Departments of Viral Diseases and Immunology and Epidemiology and Health Promotion, National Public Health Institute, FIN 00300, Helsinki, Finland
    J Biol Chem 280:15942-51. 2005
    ..The present study demonstrates that the nuclear import of NF-kappaB is a highly regulated process mediated by a subset of importin alpha molecules...
  9. doi request reprint Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions
    Pasi Kaukinen
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Helsinki, Finland
    J Med Virol 85:71-82. 2013
    ..The present study identified HCV NS2 as a potent interferon antagonist, and describes an explanation of how NS2 downregulates the major signaling pathways involved in the development of host innate antiviral responses...
  10. ncbi request reprint Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Med Virol 73:536-47. 2004
    ..The results demonstrate a novel mechanism by which HCV gene expression may interfere with IFN-mediated host defence systems...
  11. doi request reprint Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling
    Leena S Heikkinen
    Department of Virology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 3 POB 21, FIN 00014, Helsinki, Finland
    J Biol Chem 283:5719-27. 2008
    ..Thus, the Spanish Flu virus resembles avian influenza A viruses in its ability to recruit Crk/CrkL to modulate host cell signaling...
  12. pmc Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes
    Krister Melen
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    J Virol 81:5995-6006. 2007
    ..It is likely that the evolutionarily well-conserved nucleolar targeting function of NS1A protein plays a role in the pathogenesis of influenza A virus...
  13. ncbi request reprint The monopartite nuclear localization signal of autoimmune regulator mediates its nuclear import and interaction with multiple importin alpha molecules
    Tanja Ilmarinen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    FEBS J 273:315-24. 2006
    ..Our findings strongly suggest that the nuclear import of AIRE is mediated by the classical importin alpha/beta pathway through binding to several importin alpha family members...
  14. pmc Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection
    Maarit Sillanpää
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, FI 00271 Helsinki, Finland
    Virol J 6:84. 2009
    ....
  15. ncbi request reprint Expression of HCV structural proteins impairs IFN-mediated antiviral response
    Päivi Keskinen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virology 299:164-71. 2002
    ..In this model cell system NS3A-NS4A complex and NS5A showed no inhibition of IFN-alpha-induced antiviral activity. Our results indicate that the expression of structural proteins of HCV may impair the antiviral activity of IFNs...
  16. pmc Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry
    Pamela Osterlund
    Department of Infectious Disease Surveillance and Control, Virology Unit, National Institute for Health and Welfare, Helsinki, Finland
    J Virol 86:11183-93. 2012
    ..Collectively, our data provide new evidence of a novel antiviral evasion strategy for influenza A virus without a contribution of the viral NS1 protein, and this opens up new insights into different influenza virus pathogenicities...
  17. pmc Severe acute respiratory syndrome coronavirus fails to activate cytokine-mediated innate immune responses in cultured human monocyte-derived dendritic cells
    Thedi Ziegler
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Virol 79:13800-5. 2005
    ..Our data strongly suggest that SCV fails to activate host cell cytokine gene expression in human macrophages and DCs...
  18. ncbi request reprint Serum antibodies to putative proteinase maturation protein A in children with acute otitis media
    Anni Vainio
    Department of Bacterial and Inflammatory Diseases, National Public Health Institute KTL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Vaccine 24:1792-9. 2006
    ..We conclude that PpmA is immunogenic in humans, and therefore an interesting antigen to study further in developing pneumococcal multicomponent protein vaccines...
  19. ncbi request reprint Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5
    Riku Fagerlund
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Biol Chem 277:30072-8. 2002
    ..Our results demonstrate that specific NLSs in STATs mediate direct interactions of STAT dimers with importin alpha, which activates the nuclear import process...