Treatment with anti-inflammatory drugs in community-acquired pneumoniaS C A Meijvis
Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
J Intern Med 272:25-35. 2012
..The aim of this review is to summarize the inflammatory response during pneumonia and discuss the current knowledge and future perspectives regarding the anti-inflammatory treatment options for patients with pneumonia...
- Microbial evaluation of proton-pump inhibitors and the risk of pneumonia
S C A Meijvis
Dept of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
Eur Respir J 38:1165-72. 2011
..This study reaffirmed that use of PPIs is associated with an increased risk of CAP, especially when treatment has recently been started. Neither protopathic bias nor shifts in microbial aetiology seem to explain the association...
- Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial
Sabine C A Meijvis
Department of Internal Medicine, St Antonius Hospital, Nieuwegein, Netherlands
Lancet 377:2023-30. 2011
..We aimed to assess effect of addition of dexamethasone on length of stay in this group, which might result in earlier resolution of pneumonia through dampening of systemic inflammation...
Dexamethasone downregulates the systemic cytokine response in patients with community-acquired pneumoniaHilde H F Remmelts
Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
Clin Vaccine Immunol 19:1532-8. 2012
..This effect seems to be dependent on the causative microorganism. This study provides insight into which patients with CAP might benefit most from adjunctive dexamethasone...
- Prognostic value of serum angiotensin-converting enzyme activity for outcome of community-acquired pneumonia
Sabine C A Meijvis
Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
Clin Chem Lab Med 49:1525-32. 2011
..The present study aims to further assess the prognostic value of serum ACE activity for outcome of community-acquired pneumonia...
- Addition of vitamin D status to prognostic scores improves the prediction of outcome in community-acquired pneumonia
Hilde H F Remmelts
Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
Clin Infect Dis 55:1488-94. 2012
..Vitamin D deficiency is common worldwide. The prognostic value of vitamin D levels in pneumonia is unknown. In this study, we aimed to investigate the impact of vitamin D status on outcome in community-acquired pneumonia (CAP)...
- Longitudinal analysis of pneumococcal antibodies during community-acquired pneumonia reveals a much higher involvement of Streptococcus pneumoniae than estimated by conventional methods alone
Suzan P Van Mens
Department of Medical Microbiology and Immunology, Sint Antonius Hospital, P O Box 2500, 3430 EM Nieuwegein, The Netherlands
Clin Vaccine Immunol 18:796-801. 2011
..A substantial fraction of pneumococcal pneumonia patients do not elicit a serotype-specific immune response...
- Dexamethasone treatment has no effect on the formation of pneumococcal antibodies during community-acquired pneumonia
Suzan P Van Mens
Department of Medical Microbiology and Immunology, St Antonius Hospital, Nieuwegein, The Netherlands
Clin Vaccine Immunol 19:811-3. 2012
..No differences between CAP patients receiving dexamethasone as additional therapy and patients receiving a placebo were found with respect to immune response rates and mean baseline and convalescent-phase antibody concentrations...
- Mannose-binding lectin (MBL2) and ficolin-2 (FCN2) polymorphisms in patients on peritoneal dialysis with staphylococcal peritonitis
Sabine C A Meijvis
Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
Nephrol Dial Transplant 26:1042-5. 2011
..We studied the role of polymorphisms in the MBL2 and FCN2 genes as a risk factor for developing CAPD peritonitis caused by staphylococci...
