Konrad Rejdak

Summary

Affiliation: Medical University of Lublin

Publications

  1. ncbi request reprint Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland Electronic address
    Pharmacol Rep 66:399-403. 2014
  2. doi request reprint Neurofilament heavy chain and heat shock protein 70 as markers of seizure-related brain injury
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, Jaczewskiego 8, Lublin, Poland
    Epilepsia 53:922-7. 2012
  3. ncbi request reprint Astrocytic activation in relation to inflammatory markers during clinical exacerbation of relapsing-remitting multiple sclerosis
    K Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland
    J Neural Transm 114:1011-5. 2007
  4. ncbi request reprint Cerebrospinal fluid brain specific proteins in relation to nitric oxide metabolites during relapse of multiple sclerosis
    K Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland
    Mult Scler 14:59-66. 2008
  5. ncbi request reprint Acute stroke-elicited epilepsia partialis continua responsive to intravenous sodium valproate
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, Lublin
    Neurol Neurochir Pol 42:157-60. 2008
  6. doi request reprint Decreased cerebrospinal fluid hypocretin-1 (orexin A) in patients after repetitive generalized tonic-clonic seizures
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland
    Epilepsia 50:1641-4. 2009
  7. doi request reprint Urinary neopterin and nitric oxide metabolites as markers of interferon beta-1a activity in primary progressive multiple sclerosis
    K Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland
    Mult Scler 16:1066-72. 2010
  8. doi request reprint Orphenadrine induces secondarily generalized convulsive status epilepticus in rats
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, 8 Jaczewskiego Str, Lublin, Poland
    Brain Res Bull 84:389-93. 2011
  9. doi request reprint Analysis of ventricular late potentials in signal-averaged ECG of people with epilepsy
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland
    Epilepsia 52:2118-24. 2011
  10. doi request reprint Patterns of muscle activation during generalized tonic and tonic-clonic epileptic seizures
    Isa Conradsen
    Danish Epilepsy Centre, Department of Neurophysiology, Dianalund, Denmark
    Epilepsia 52:2125-32. 2011

Detail Information

Publications30

  1. ncbi request reprint Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland Electronic address
    Pharmacol Rep 66:399-403. 2014
    ..The current study was aimed at assessing the efficacy of a new generation antiepileptic drugs (AEDs) and some of the experimental agents in suppressing ORPH-evoked seizures in rats...
  2. doi request reprint Neurofilament heavy chain and heat shock protein 70 as markers of seizure-related brain injury
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, Jaczewskiego 8, Lublin, Poland
    Epilepsia 53:922-7. 2012
    ....
  3. ncbi request reprint Astrocytic activation in relation to inflammatory markers during clinical exacerbation of relapsing-remitting multiple sclerosis
    K Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland
    J Neural Transm 114:1011-5. 2007
    ..Our study suggests the activation of the kynurenine pathway leading to the increase of neuroprotective KYNA in the CSF of MS patients during acute relapse what contrasts with chronic phases of the disease...
  4. ncbi request reprint Cerebrospinal fluid brain specific proteins in relation to nitric oxide metabolites during relapse of multiple sclerosis
    K Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland
    Mult Scler 14:59-66. 2008
    ....
  5. ncbi request reprint Acute stroke-elicited epilepsia partialis continua responsive to intravenous sodium valproate
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, Lublin
    Neurol Neurochir Pol 42:157-60. 2008
    ....
  6. doi request reprint Decreased cerebrospinal fluid hypocretin-1 (orexin A) in patients after repetitive generalized tonic-clonic seizures
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland
    Epilepsia 50:1641-4. 2009
    ..The current results suggest that the hypocretin-1 system deficiency contributes to the complex pathophysiology of repetitive GTC seizures and status epilepticus (SE) and could be associated with typical somnolence after seizure attacks...
  7. doi request reprint Urinary neopterin and nitric oxide metabolites as markers of interferon beta-1a activity in primary progressive multiple sclerosis
    K Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland
    Mult Scler 16:1066-72. 2010
    ..However, using more sensitive indicators of a treatment response, such as biomarkers, might help to identify sub-groups of patients who may benefit from therapy...
  8. doi request reprint Orphenadrine induces secondarily generalized convulsive status epilepticus in rats
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, 8 Jaczewskiego Str, Lublin, Poland
    Brain Res Bull 84:389-93. 2011
    ..001) dose-dependently suppressed seizure activity. All the above characteristics make the new model, a useful, easy to perform experimental tool to study the pathophysiology of SE as well as the effects of new AEDs...
  9. doi request reprint Analysis of ventricular late potentials in signal-averaged ECG of people with epilepsy
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland
    Epilepsia 52:2118-24. 2011
    ..The aim of this exploratory study was to screen epilepsy patients who were treated with established doses of antiepileptic drugs (AEDs) on the presence of VLPs...
  10. doi request reprint Patterns of muscle activation during generalized tonic and tonic-clonic epileptic seizures
    Isa Conradsen
    Danish Epilepsy Centre, Department of Neurophysiology, Dianalund, Denmark
    Epilepsia 52:2125-32. 2011
    ..The aim of our study was to elucidate the pathomechanism of the tonic muscle activation during epileptic seizures...
  11. ncbi request reprint Increased urinary excretion of nitric oxide metabolites in longitudinally monitored migraine patients
    K Rejdak
    Department of Neuroinflammation, Institute of Neurology, London, UK
    Eur J Neurol 13:1346-51. 2006
    ..Although there is a difference in the pattern of urinary NO(x) excretion between control and migraine populations, the variable temporal association of NO(x) peaks and headaches suggests a complex role of NO in this condition...
  12. ncbi request reprint Decreased level of kynurenic acid in cerebrospinal fluid of relapsing-onset multiple sclerosis patients
    Konrad Rejdak
    Department of Neurology, Medical University, 8 Jaczewskiego Street, 20 090, Lublin, Poland
    Neurosci Lett 331:63-5. 2002
    ..41 (0.3-0.5) pmol/ml, n=26 vs. 0.67 (0.5-1.1), n=23, P<0.01 and 1.7 (1.5-2.6), n=16, P<0.001, respectively). These results provide further evidence of the alterations in the kynurenine pathway during remitting-onset MS...
  13. ncbi request reprint CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis
    K Rejdak
    Department of Neuroinflammation, Institute of Neurology, London, UK
    Neurology 63:1439-45. 2004
    ..To investigate the relationship of CSF and the serum nitric oxide metabolites nitrite and nitrate (NOx) to disease activity and progression in patients with multiple sclerosis (MS)...
  14. ncbi request reprint Treatment response in relation to inflammatory and axonal surrogate marker in multiple sclerosis
    A Petzold
    Institute of Neurology, Department of Neuroimmunology, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:281-3. 2004
    ..This study aimed to investigate if treatment response could retrospectively be related to inflammatory or axonal pathology as measured by plasma surrogate markers...
  15. doi request reprint The prognostic value of brain extracellular fluid nitric oxide metabolites after traumatic brain injury
    Martin M Tisdall
    Department of Neuroanaesthesia, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Neurocrit Care 19:65-8. 2013
    ..We investigate the prognostic value of brain ECF NO metabolites in patients with traumatic brain injury (TBI)...
  16. ncbi request reprint Cerebrospinal fluid nitrite/nitrate correlated with oxyhemoglobin and outcome in patients with subarachnoid hemorrhage
    Konrad Rejdak
    Department Neuroinflammation, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Sci 219:71-6. 2004
    ....
  17. doi request reprint CSF hypocretin-1 concentrations correlate with the level of fatigue in multiple sclerosis patients
    Ewa Papuc
    Department of Neurology, Medical University of Lublin, 8 Jaczewskiego Str, 20 954 Lublin, Poland
    Neurosci Lett 474:9-12. 2010
    ....
  18. doi request reprint A novel biomarker for retinal degeneration: vitreous body neurofilament proteins
    Axel Petzold
    Department of Neuroimmunology, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neural Transm 116:1601-6. 2009
    ..The method can be applied for investigating the dynamics of retinal degeneration and the response to neuroprotective strategies in a broad range of retinal diseases in either clinical or experimental research...
  19. ncbi request reprint Biventricular versus right ventricular pacing decreases immune activation and augments nitric oxide production in patients with chronic heart failure
    Andrzej Rubaj
    Department of Cardiology, Medical University of Lublin, Poland
    Eur J Heart Fail 8:615-20. 2006
    ..We aimed to test the hypothesis that upgrading from right ventricular pacing (RVp) to biventricular pacing (BiVp) can counteract these phenomena...
  20. doi request reprint Multiple sclerosis: a practical overview for clinicians
    Konrad Rejdak
    Department of Neurology, Medical University of Lublin, Lublin, Poland
    Br Med Bull 95:79-104. 2010
    ..The development of neuroprotective therapies for MS is required to prevent the devastating effects of long-term disability as a result of progressive disease...
  21. ncbi request reprint Oral citicoline treatment improves visual pathway function in glaucoma
    Robert Rejdak
    2nd Department of Ophthalmology, Medical University, Lublin, Poland
    Med Sci Monit 9:PI24-8. 2003
    ..An improvement in VEP latency and amplitude has been reported following repeated intramuscular injections of citicoline, a neuroprotective drug. Our aim was to find whether citicoline given orally would produce a similar effect...
  22. ncbi request reprint Bilateral paramedian thalamic infarction with hypothalamic dysfunction
    Ewa Papuc
    Department of Neurology, Medical University of Lublin, 8 Jaczewskiego St, 20 954 Lublin, Poland
    Neurol Neurochir Pol 46:279-83. 2012
    ..Hypothalamic dysfunction may accompany thalamic infarcts; thus hypothalamo-pituitary function should be routinely assessed in bithalamic infarcts...
  23. pmc Axonal degeneration and inflammation in acute optic neuritis
    A Petzold
    Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, UK
    J Neurol Neurosurg Psychiatry 75:1178-80. 2004
    ..To investigate whether plasma biomarkers for axonal injury and inflammation are related to loss and recovery of visual function in acute optic neuritis (ON)...
  24. ncbi request reprint Serum and urine nitrate and nitrite are not reliable indicators of intrathecal nitric oxide production in acute brain injury
    K Rejdak
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Sci 208:1-7. 2003
    ..Serum and urinary NO(x) levels cannot be used as a reliable index to assess intrathecal NO production...
  25. ncbi request reprint Axonal pathology in subarachnoid and intracerebral hemorrhage
    A Petzold
    Department of Neuroimmunology, Institute of Neurology, University College London, London, United Kingdom
    J Neurotrauma 22:407-14. 2005
    ..CSF NfH phosphoforms might emerge as a putative surrogate marker for monitoring the development for secondary axonal degeneration in neurocritical care and guiding targeted neuroprotective strategies...
  26. ncbi request reprint Relationship between the area of isopters and Vigabatrin dosage during two years of observation
    Katarzyna Nowomiejska
    Department of General Ophthalmology, Medical University, ul, Chmielna 1, 20 079 Lublin, Poland
    BMC Ophthalmol 14:56. 2014
    ....
  27. ncbi request reprint Humoral response against glial derived antigens in Parkinson's disease
    Ewa Papuc
    Department of Neurology, Medical University of Lublin, Poland Electronic address
    Neurosci Lett 566:77-81. 2014
    ..Our study provides the evidence for the presence of humoral response against some glial derived antigens in PD. The increasing levels of anti MBP IgG and IgM might point to the value of this marker for monitoring disease progression. ..
  28. ncbi request reprint IL-6 and sIL-6R concentration in the cerebrospinal fluid and serum of MS patients
    Z Stelmasiak
    Department of Neurology, Medical University, Lublin, Poland
    Med Sci Monit 7:914-8. 2001
    ..The aim of this study was to determine the concentration of cytokine IL-6 in correlation with its soluble receptor sIL-6R in the serum and CSF of MS patients...
  29. ncbi request reprint [The assessment of development of binding antibodies to interferon beta during interferon beta 1a treatment of multiple sclerosis]
    Halina Bartosik-Psujek
    Katedry i Kliniki Neurologii A M w Lublinie
    Neurol Neurochir Pol 37:799-809. 2003
    ..No statistically significant relationship was found either between elevated BAb levels and the number of relapses during the IFN-beta treatment (including relapses that required steroid therapy)...
  30. ncbi request reprint [Role of matrix metalloproteinases in the pathogenesis of multiple sclerosis]
    Jacek Kurzepa
    Katedra i Zakład Biochemii, Katedra i Klinika Neurologii, Akademia Medyczna im prof Feliksa Skubiszewskiego w Lublinie, ul Jaczewskiego 8, 20 954 Lublin, Poland
    Neurol Neurochir Pol 39:63-7. 2005
    ..The drugs used in MS treatment decrease MMPs expression. Multiple actions of MMPs prove their involvement in the pathogenesis and treatment of MS...