Effect of aceclofenac on pharmacokinetic of phenytoinBikash Medhi
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Pak J Pharm Sci 25:295-9. 2012
..These results suggest that aceclofenac alter the pharmacokinetics of phenytoin. Confirmation of these results in human studies will warrant changes in phenytoin dose or frequency when aceclofenac is co-administered with it...
Bacteria in cancer therapy: a novel experimental strategyS Patyar
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
J Biomed Sci 17:21. 2010
..Although it has shown successful results in vivo yet further investigation about the targeting mechanisms of the bacteria are required to make it a complete therapeutic approach in cancer treatment...
Comparative evaluation of different doses of green tea extract alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in ratsD S Prasad Byrav
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Dig Dis Sci 56:1369-78. 2011
..The present study was conducted to evaluate the effect of green tea in experimentally induced inflammatory bowel disease...
- Seasonal variation in plasma levels of lithium in the Indian population: is there a need to modify the dose?
B Medhi
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Singapore Med J 49:724-7. 2008
..Variability in the lithium level can lead to lack of efficacy or toxicity, making seasonal variation clinically relevant...
- Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats
B Medhi
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
Indian J Exp Biol 46:583-90. 2008
..The results indicate the additive effect of Manuka honey with sulfasalazine in colitis...
- Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model
Bikash Medhi
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
J Pharm Pharmacol 61:1359-64. 2009
..The aim of the study was to evaluate the correlation between colitis and susceptibility to seizures...
- Recent advances in the pharmacotherapy of chronic anal fissure: an update
Bikash Medhi
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Asian J Surg 31:154-63. 2008
..2% GTN ointment but was associated with fewer side effects. Other drugs that have been tried are lidocaine, the alpha-adrenergic antagonist indoramin, and the potassium channel opener minoxidil...
- Comparative clinical trial of castor oil and diclofenac sodium in patients with osteoarthritis
B Medhi
Department of Pharmacology and Physical Medicine and Rehabilitation, Postgraduate Institute of Medical Education Research, Chandigarh and All India Institute of Medical Sciences, New Delhi, India
Phytother Res 23:1469-73. 2009
..The present study indicates that castor oil can be used as an effective therapy in primary knee osteoarthritis...
- Effects of etoricoxib on the pharmacokinetics of phenytoin
Bikash Medhi
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Pharmacol Rep 60:233-7. 2008
..These results suggest that etoricoxib alters the pharmacokinetics of phenytoin. Confirmation of these results in human studies will warrant changes in phenytoin dose or frequency when etoricoxib is co-administered with it...
- Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice
Bikash Medhi
Indian J Exp Biol 48:793-9. 2010
..Pioglitazone showed neuroprotection against ischemic insult suggesting the role of PPARgamma agonist in neuroprotective agents...
- Effect of different doses of thalidomide in experimentally induced inflammatory bowel disease in rats
Om Prakash
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Basic Clin Pharmacol Toxicol 103:9-16. 2008
..001). Our results indicate efficacy of thalidomide in TNBS induce experimental colitis model in rats but present findings requires further investigation to establish the real safety and efficacy in human beings...
- Effects of artemisinin, artemether, and arteether on the pharmacokinetics of phenytoin
M Sukhija
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Methods Find Exp Clin Pharmacol 28:89-94. 2006
..Confirmation of these results in human studies will warrant changes in phenytoin dose or frequency, when either of these antimalarials is coadministered with it...
- Neuroprotective effect of progesterone on acute phase changes induced by partial global cerebral ischaemia in mice
Raman Aggarwal
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
J Pharm Pharmacol 60:731-7. 2008
..The results demonstrate the neuroprotective effect of progesterone against ischaemic insult, suggesting a role for the steroid as a neuroprotective agent...
- Effects of artemisinin, artemether, arteether on the pharmacokinetics of carbamazepine
Manpreet Sukhija
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Pharmacology 76:110-6. 2006
..Confirmation of these results in human studies will warrant changes in carbamazepine dose or frequency when either of these antimalarials is co-administered with it...
- Correlation of seizures and biochemical parameters of oxidative stress in experimentally induced inflammatory rat models
Ramya S Rao
Department of Pharmacology, Postgraduate Institute of Medical Education and Research PIGMER, Chandigarh 160012, India
Fundam Clin Pharmacol 24:325-31. 2010
..As it increased lipid peroxidation and reduced SOD and GPx, further evaluation is necessary with respect to oxidative stress...
- Antiepileptic TDM pattern at a tertiary care hospital in India
Vinu Mulavarickal Jose
Department of Pharmacology, Postgraduate Institute of Medical, Education and Research, Chandigarh, India
Nepal Med Coll J 8:107-10. 2006
..The number of abnormal values of phenytoin, phenobarbitone and carbamazepine did not show any significant difference over the years. The pattern was similar to that observed in other countries...
- Dose-finding study with nicotine as a proconvulsant agent in PTZ-induced seizure model in mice
Nimisha Sood
Department of Pharmacology, Indira Gandhi Medical College, Shimla, 171001, India
J Biomed Sci 15:755-65. 2008
..The study bears significant clinical relevance particularly amongst epileptic smokers who may show failure of efficacy of antiepileptic agents and present with breakthrough seizure attacks on exposure to nicotine...
- Role of vinpocetine in cerebrovascular diseases
Sazal Patyar
Department of Pharmacology and Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, Chandigarh, India
Pharmacol Rep 63:618-28. 2011
..This vasoactive alkaloid is widely marketed as a supplement for vasodilation and as a nootropic for the improvement of memory. The present review focuses on studies investigating the role of vinpocetine in cerebrovascular diseases...
- Dual inhibition: a novel promising pharmacological approach for different disease conditions
Sazal Patyar
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, Delhi, India
J Pharm Pharmacol 63:459-71. 2011
..This review article focuses on the conventional drugs used in different diseases which possess dual inhibition activity as well as those which are still in the preclinical/clinical phase...
- Pharmacokinetic and toxicological profile of artemisinin compounds: an update
Bikash Medhi
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India drbikashus yahoo com
Pharmacology 84:323-32. 2009
..Moreover, it occurs in humans at very high doses. However, as a matter of precaution, the use of artemisinins in the first trimester of pregnancy has been contraindicated...
- Lacosamide, a newer antiepileptic
Sazal Patyar
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Neurosciences (Riyadh) 15:3-6. 2010
..Other potential indications of LCM are being investigated...
- Short-course of prednisolone in solitary cysticercus granuloma: a randomized, double-blind, placebo-controlled trial
Monika Singla
Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Epilepsia 52:1914-7. 2011
..To determine the effect of administration of a short course of prednisolone on seizure and radiologic outcome in patients with solitary cysticercus granuloma (SCG)...
- Longterm efficacy of topical nonsteroidal antiinflammatory drugs in knee osteoarthritis: metaanalysis of randomized placebo controlled clinical trials
Shibadas Biswal
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
J Rheumatol 33:1841-4. 2006
..28, 95% CI -0.42 to -0.14). CONCLUSION: Topical NSAID are effective for pain relief in knee OA for a longer duration; however, this may not hold true for all the preparations...
- Drug therapy in autism: a present and future perspective
Baldeep Kumar
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Pharmacol Rep 64:1291-304. 2012
..New classes of drugs with novel mechanisms of action should be there so that this disorder will become less prevalent in the future...
- Natural product and drugs interactions, its clinical implication in drug therapy management
Rupa Joshi
Department of Clinical Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Saudi Med J 29:333-9. 2008
..In this review, we describe details of drugs interaction with natural products and its impact on drug therapy management...
- Comparative study of low pressure versus standard pressure pneumoperitoneum in laparoscopic cholecystectomy--a randomised controlled trial
Deepaesh Benjamin Kanwer
Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
Trop Gastroenterol 30:171-4. 2009
..Our study proposes to compare the use of low pressure pneumoperitoneum with the use of standard pressure pneumoperitoneum...
- Comparison of observational and controlled clinical trials of diltiazem in the treatment of chronic anal fissure
Bikash Medhi
Department of Pharmacology and General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India Department of Clinical Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Indian J Surg 73:427-31. 2011
....
- Effect of esomeprazole on the pharmacokinetics of carbamazepine
Bikash Medhi
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Indian J Pharmacol 43:73-5. 2011
..Present study was carried out to evaluate effect of esomeprazole on the pharmacokinetics of carbamazepine in rabbits...
